J. Lemos

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Many Means to a Common End: the Intricacies of (p)ppGpp Metabolism and Its Control of Bacterial Homeostasis

A. Gaca, C. Colomer-Winter, J. Lemos, 2015, Journal of bacteriology.

clpB, a class III heat-shock gene regulated by CtsR, is involved in thermotolerance and virulence of Enterococcus faecalis.

M. Giambiagi-deMarval, A. Gaca, J. Lemos, 2011, Microbiology.

The Molecular Alarmone (p)ppGpp Mediates Stress Responses, Vancomycin Tolerance, and Virulence in Enterococcus faecalis

J. Abranches, D. Garsin, J. Lemos, 2009, Journal of bacteriology.

Survival of the Fittest: The Relationship of (p)ppGpp With Bacterial Virulence

C. Colomer-Winter, J. Lemos, S. Kundra, 2020, Frontiers in Microbiology.

Deficiency of MecA in Streptococcus mutans Causes Major Defects in Cell Envelope Biogenesis, Cell Division, and Biofilm Formation

Z. Wen, A. De, W. Beatty, 2018, Front. Microbiol..

Inactivation of the spxA1 or spxA2 gene of Streptococcus mutans decreases virulence in the rat caries model

J. Abranches, H. Koo, J. Lemos, 2017, Molecular oral microbiology.

Stress Responses of Streptococci

E. Tsakalidou, K. Papadimitriou, J. Lemos, 2011 .

Manganese acquisition is essential for virulence of Enterococcus faecalis

K. L. Frank, S. Hultgren, A. Flores-Mireles, 2018, bioRxiv.

Three gene products govern (p)ppGpp production by Streptococcus mutans

M. Nascimento, R. Burne, J. Abranches, 2007, Molecular microbiology.

The oligopeptide (opp) gene cluster of Streptococcus mutans: identification, prevalence, and characterization.

R. Burne, L. Ferreira, M. B. Tavares, 2007, Oral microbiology and immunology.

Association of Metal Homeostasis and (p)ppGpp Regulation in the Pathophysiology of Enterococcus faecalis

A. Gaca, C. Colomer-Winter, J. Lemos, 2017, Infection and Immunity.

Organization of heat shock dnaK and groE operons of the nosocomial pathogen Enterococcus faecium.

R. Burne, M. Giambiagi-deMarval, J. Lemos, 2006, Research in microbiology.

Transcriptional analysis of the groE and dnaK heat-shock operons of Enterococcus faecalis.

R. Burne, J. Lemos, M. Laport, 2004, Research in microbiology.

Expression of the Major Heat Shock Proteins DnaK and GroEL in Streptococcus pyogenes: A Comparison to Enterococcus faecalis and Staphylococcus aureus

M. Giambiagi-deMarval, J. Lemos, M. Laport, 2001, Current Microbiology.

Increased Oxidative Stress Tolerance of a Spontaneously Occurring perR Gene Mutation in Streptococcus mutans UA159

J. Abranches, P. Zuber, J. Lemos, 2021, Journal of Bacteriology.

Increased oxidative stress tolerance of a spontaneously-occurring perR gene mutation in Streptococcus mutans UA159

J. Abranches, P. Zuber, J. Lemos, 2020 .

Whole genome sequence and phenotypic characterization of a Cbm+ serotype e strain of Streptococcus mutans

J. Miller, J. Abranches, J. Lemos, 2018, Molecular oral microbiology.

Simultaneous spatiotemporal mapping of in situ pH and bacterial activity within an intact 3D microcolony structure

Dongyeop Kim, Yuan Liu, G. Hwang, 2016, Scientific Reports.

Modification of Streptococcus mutans Cnm by PgfS Contributes to Adhesion, Endothelial Cell Invasion, and Virulence

P. Simpson‐Haidaris, J. Abranches, J. H. Miller, 2014, Journal of bacteriology.

Basal levels of (p)ppGpp differentially affect the pathogenesis of infective endocarditis in Enterococcus faecalis.

K. L. Frank, O. N. Chuang-Smith, A. Gaca, 2018, Microbiology.

Expression of heat-shock proteins in Streptococcus pyogenes and their immunoreactivity with sera from patients with streptococcal diseases.

M. Giambiagi-deMarval, J. Lemos, A. C. Castro, 1998, Journal of medical microbiology.

Association of Candida albicans and Cbp+Streptococcus mutans with early childhood caries recurrence

J. Abranches, S. Tomar, L. Roesch, 2021, Scientific Reports.

Association of Streptococcus mutans harboring bona-fide collagen binding proteins and Candida albicans with early childhood caries recurrence

J. Abranches, S. Tomar, L. Roesch, 2021, medRxiv.

Heterologous expression of Streptococcus mutans Cnm in Lactococcus lactis promotes intracellular invasion, adhesion to human cardiac tissues and virulence

P. Simpson‐Haidaris, J. Abranches, Peter A. Knight, 2017, Virulence.

Enterococcus faecalis Antagonizes Pseudomonas aeruginosa Growth in Mixed-Species Interactions

G. Biuković, J. Lemos, K. Kline, 2022, Journal of bacteriology.

The CtsR regulator controls the expression of clpC, clpE and clpP and is required for the virulence of Enterococcus faecalis in an invertebrate model

M. Giambiagi-deMarval, J. Lemos, Jaqueline Abranches, 2016, Antonie van Leeuwenhoek.

Biology of Oral Streptococci

V. P. Richards, J. Abranches, Z. Wen, 2019, Gram-Positive Pathogens.

Detection of Streptococcus mutans in symptomatic and asymptomatic infected root canals

J. Abranches, J. Lemos, B. Gomes, 2020, Clinical Oral Investigations.

Molecular cloning, purification and immunological responses of recombinants GroEL and DnaK from Streptococcus pyogenes.

R. Burne, J. Lemos, A. C. Castro, 2000, FEMS immunology and medical microbiology.

ZccE is a Novel P-type ATPase That Protects Streptococcus mutans Against Zinc Intoxication

J. Abranches, J. Lemos, T. Ganguly, 2022, bioRxiv.

Manganese Uptake, Mediated by SloABC and MntH, Is Essential for the Fitness of Streptococcus mutans

G. Spatafora, J. Abranches, J. Lemos, 2019, mSphere.

Role of (p)ppGpp in Biofilm Formation by Enterococcus faecalis

L. E. Chávez de Paz, J. Lemos, C. Sedgley, 2011, Applied and Environmental Microbiology.

Quantitative Analysis of Biofilm Removal Following Instrumentation with TRUShape and Vortex Blue File Systems: Microbiological Study.

S. Wallet, J. Abranches, J. Lemos, 2022, Frontiers in bioscience.

Characteristics of Streptococcus mutans strains lacking the MazEF and RelBE toxin-antitoxin modules.

R. Burne, J. Abranches, J. Lemos, 2005, FEMS microbiology letters.

The Collagen Binding Protein Cnm Contributes to Oral Colonization and Cariogenicity of Streptococcus mutans OMZ175

W. Bowen, J. Abranches, A. Progulske-Fox, 2015, Infection and Immunity.

Streptococcus mutans: a new Gram-positive paradigm?

J. Abranches, R. Quivey, H. Koo, 2013, Microbiology.

Ex vivo Model of Human Aortic Valve Bacterial Colonization.

J. Abranches, J. Lemos, P. L. Rosalen, 2017, Bio-protocol.

Characterization of the Streptococcus sobrinus acid-stress response by interspecies microarrays and proteomics.

J. Abranches, J. Lemos, J. K. Kajfasz, 2010, Molecular oral microbiology.

Transcriptional profile of glucose-shocked and acid-adapted strains of Streptococcus mutans.

J. Abranches, R. Faustoferri, R. Quivey, 2015, Molecular oral microbiology.

Two Spx Proteins Modulate Stress Tolerance, Survival, and Virulence in Streptococcus mutans

J. Abranches, R. Quivey, J. Lemos, 2010, Journal of bacteriology.

Regulatory circuits controlling Spx levels in Streptococcus mutans

J. Abranches, J. Lemos, T. Ganguly, 2020, Molecular microbiology.

Phenotypic Heterogeneity of Genomically-Diverse Isolates of Streptococcus mutans

M. Stanhope, S. Palmer, V. P. Richards, 2013, PloS one.

The Biology of Streptococcus mutans.

S. Palmer, J. Abranches, L. Brady, 2019, Microbiology spectrum.

Correction: Phenotypic Heterogeneity of Genomically-Diverse Isolates of Streptococcus mutans

M. Stanhope, S. Palmer, V. P. Richards, 2013, PLoS ONE.

Protocols to study the physiology of oral biofilms.

R. Burne, J. Abranches, H. Koo, 2010, Methods in molecular biology.

Stress Physiology of Lactic Acid Bacteria

M. Kleerebezem, J. Kok, F. Turroni, 2016, Microbiology and Molecular Reviews.

Novel Antibiofilm Chemotherapy Targets Exopolysaccharide Synthesis and Stress Tolerance in Streptococcus mutans To Modulate Virulence Expression In Vivo

H. Koo, J. Lemos, M. Klein, 2012, Antimicrobial Agents and Chemotherapy.

Post-translational modification by the Pgf glycosylation machinery modulates Streptococcus mutans physiology and virulence

C. Szymanski, P. Azadi, J. Abranches, 2022, bioRxiv.

Amyloid Aggregation of Streptococcus mutans Cnm Influences Its Collagen-Binding Activity

J. Abranches, L. Brady, J. Lemos, 2021, bioRxiv.

Phenotypic and genotypic characterization of Streptococcus mutans strains isolated from endodontic infections.

J. Abranches, A. R. Walker, J. Lemos, 2020, Journal of endodontics.

Collagen-binding proteins of Streptococcus mutans and related streptococci.

J. Miller, J. Abranches, J. Lemos, 2017, Molecular oral microbiology.

The Collagen-Binding Protein Cnm Is Required for Streptococcus mutans Adherence to and Intracellular Invasion of Human Coronary Artery Endothelial Cells

P. Simpson‐Haidaris, R. Burne, J. Abranches, 2011, Infection and Immunity.

Zinc Import Mediated by AdcABC is Critical for Colonization of the Dental Biofilm by Streptococcus mutans in an Animal Model

J. Abranches, J. Lemos, T. Ganguly, 2021, bioRxiv.

Adaptation to Adversity: the Intermingling of Stress Tolerance and Pathogenesis in Enterococci

A. Gaca, J. Lemos, Anthony Gaca, 2019, Microbiology and Molecular Biology Reviews.

A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents.

Marisa A. Fuse, D. Kallifidas, Shouguang Jin, 2021, Journal of medicinal chemistry.

Biology of Oral Streptococci

S. Palmer, V. P. Richards, J. Abranches, 2018, Microbiology spectrum.

A model of efficiency: stress tolerance by Streptococcus mutans.

R. Burne, Robert A Burne, J. Lemos, 2008, Microbiology.

The Cell Wall-Targeting Antibiotic Stimulon of Enterococcus faecalis

J. Abranches, A. Gaca, J. Lemos, 2013, PloS one.

The Spx Regulator Modulates Stress Responses and Virulence in Enterococcus faecalis

J. Abranches, J. H. Miller, M. Wellington, 2012, Infection and Immunity.

Dynamics of Streptococcus mutans Transcriptome in Response to Starch and Sucrose during Biofilm Development

B. Hamaker, G. Xie, H. Koo, 2010, PloS one.

Transcriptional and Phenotypic Characterization of Novel Spx-Regulated Genes in Streptococcus mutans

J. Abranches, K. Scott-Anne, J. H. Miller, 2015, PloS one.

The Biology ofStreptococcus mutans

J. Abranches, Z. Wen, J. Lemos, 2019, Gram-Positive Pathogens.

Adaptive Acid Tolerance Response of Streptococcus sobrinus

M. Nascimento, R. Burne, J. Abranches, 2004, Journal of bacteriology.

Functional Genomics of Streptococcus mutans

S. Ahn, R. Burne, J. Abranches, 2011 .

A New Perspective of an Old Villain: Revisiting Biomarkers of Caries Development

J. Abranches, J. Lemos, I. A. Freires, 2017, EBioMedicine.

Streptococcus mutans NADH Oxidase Lies at the Intersection of Overlapping Regulons Controlled by Oxygen and NAD+ Levels

M. MacGilvray, Z. Wen, R. Faustoferri, 2014, Journal of bacteriology.

From (p)ppGpp to (pp)pGpp: Characterization of Regulatory Effects of pGpp Synthesized by the Small Alarmone Synthetase of Enterococcus faecalis

V. Hauryliuk, K. Potrykus, M. Cashel, 2015, Journal of bacteriology.

CovR and VicRKX Regulate Transcription of the Collagen Binding Protein Cnm of Streptococcus mutans

Erika N. Harth-Chu, R. MATTOS-GRANER, J. Abranches, 2018, Journal of bacteriology.

Cnm is a major virulence factor of invasive Streptococcus mutans and part of a conserved three-gene locus.

J. Miller, P. Simpson‐Haidaris, J. Abranches, 2014, Molecular oral microbiology.

Responses of cariogenic streptococci to environmental stresses.

R. Burne, J. Abranches, Robert A Burne, 2005, Current issues in molecular biology.

Identification of Multiple Iron Uptake Mechanisms in Enterococcus faecalis and Their Relationship to Virulence

C. Colomer-Winter, J. Lemos, Debra N. Brunson, 2022, bioRxiv.

Opportunities for Disrupting Cariogenic Biofilms

M. Nascimento, R. Burne, J. Abranches, 2009, Advances in dental research.

Role of HtrA in Growth and Competence of Streptococcus mutans UA159

S. Ahn, R. Burne, J. Lemos, 2005, Journal of bacteriology.

Enterococcus faecalis antagonizes Pseudomonas aeruginosa growth in polymicrobial biofilms

G. Biuković, J. Lemos, K. Kline, 2022, bioRxiv.

Transcriptome responses of Streptococcus mutans to peroxide stress: identification of novel antioxidant pathways regulated by Spx

J. Abranches, J. Lemos, T. Ganguly, 2017, Scientific Reports.

Global transcriptional analysis of the stringent response in Enterococcus faecalis.

J. Abranches, A. Gaca, J. Lemos, 2012, Microbiology.

PepO is a target of the two-component systems VicRK and CovR required for systemic virulence of Streptococcus mutans

Erika N. Harth-Chu, R. MATTOS-GRANER, J. Abranches, 2020, Virulence.

Transcriptome analysis reveals that ClpXP proteolysis controls key virulence properties of Streptococcus mutans.

J. Abranches, J. Lemos, Jessica K. Kajfasz, 2011, Microbiology.

Role of Clp Proteins in Expression of Virulence Properties of Streptococcus mutans

J. Abranches, R. Quivey, H. Koo, 2009, Journal of bacteriology.

Global Regulation by (p)ppGpp and CodY in Streptococcus mutans

M. Nascimento, R. Burne, J. Abranches, 2008, Journal of bacteriology.

Osmotic stress responses of Streptococcus mutans UA159.

R. Burne, J. Abranches, J. Lemos, 2006, FEMS microbiology letters.

Osmotic stress responsesofStreptococcusmutansUA 159

R. Burne, J. Abranches, J. Lemos, 2006 .

A Hypothetical Protein of Streptococcus mutans Is Critical for Biofilm Formation

S. Ahn, R. Burne, Yi-Ywan M. Chen, 2005, Infection and Immunity.

Effects of RelA on Key Virulence Properties of Planktonic and Biofilm Populations of Streptococcus mutans

R. Burne, J. Lemos, T. A. Brown, 2004, Infection and Immunity.

Transcription of Oxidative Stress Genes Is Directly Activated by SpxA1 and, to a Lesser Extent, by SpxA2 in Streptococcus mutans

J. Abranches, K. Scott-Anne, J. Lemos, 2015, Journal of bacteriology.

The AdcACB/AdcAII system is essential for zinc homeostasis and an important contributor of Enterococcus faecalis virulence

A. Flores-Mireles, J. Lemos, Debra N. Brunson, 2021, bioRxiv.

Intestinal ischemia-reperfusion is attenuated by treatment with atenolol in rabbits.

A. Caricati‐Neto, R. Simões, J. Lemos, 2010, Transplantation Proceedings.

Disruption of the adh (Acetoin Dehydrogenase) Operon Has Wide-Ranging Effects on Streptococcus mutans Growth and Stress Response

M. Nakano, P. Zuber, J. Lemos, 2022, Journal of bacteriology.

Basal Levels of (p)ppGpp in Enterococcus faecalis: the Magic beyond the Stringent Response

J. Abranches, J. H. Miller, A. Gaca, 2013, mBio.

Regulation and Physiological Significance of ClpC and ClpP in Streptococcus mutans

R. Burne, J. Lemos, 2002, Journal of bacteriology.

Physiologic Effects of Forced Down-Regulation of dnaK and groEL Expression in Streptococcus mutans

R. Burne, J. Lemos, Yaima Luzardo, 2006, Journal of bacteriology.

Genetic and Physiologic Analysis of thegroE Operon and Role of the HrcA Repressor in Stress Gene Regulation and Acid Tolerance in Streptococcus mutans

R. Burne, Yi-Ywan M. Chen, J. Lemos, 2001, Journal of bacteriology.

(p)ppGpp and CodY Promote Enterococcus faecalis Virulence in a Murine Model of Catheter-Associated Urinary Tract Infection

S. Hultgren, A. Flores-Mireles, C. Colomer-Winter, 2019, mSphere.

Biofilm Assays on Fibrinogen-coated Silicone Catheters and 96-well Polystyrene Plates.

A. Flores-Mireles, C. Colomer-Winter, J. Lemos, 2019, Bio-protocol.

Transcriptome Analysis of Enterococcus faecalis during Mammalian Infection Shows Cells Undergo Adaptation and Exist in a Stringent Response State

K. L. Frank, P. Schlievert, G. Dunny, 2014, PloS one.

c-di-AMP Is Essential for the Virulence of Enterococcus faecalis

J. Abranches, A. Flores-Mireles, J. Lemos, 2021, bioRxiv.

Transcriptome responses of Streptococcus mutans to peroxide stress: identification of novel antioxidant pathways regulated by Spx

J. Abranches, J. Lemos, T. Ganguly, 2017, Scientific Reports.

Dual species biofilms are enhanced by metabolite cross-feeding.

J. Lemos, Debra N. Brunson, Ling Ning Lam, 2022, Trends in microbiology.

Characterization of the pgf operon involved in the posttranslational modification of Streptococcus mutans surface proteins

J. Abranches, L. Brady, C. Deivanayagam, 2018, Scientific Reports.

Disruption of a Novel Iron Transport System Reverses Oxidative Stress Phenotypes of a dpr Mutant Strain of Streptococcus mutans

J. Abranches, J. H. Miller, J. Lemos, 2018, Journal of bacteriology.

Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas.

G. Wang, R. Tsien, K. Tarczy-Hornoch, 1998, Biochemistry.

The CtsR regulator controls the expression of clpC, clpE and clpP and is required for the virulence of Enterococcus faecalis in an invertebrate model

M. Giambiagi-deMarval, J. Lemos, Jaqueline Abranches, 2016, Antonie van Leeuwenhoek.

Stress Physiology of Lactic Acid Bacteria

M. Kleerebezem, J. Kok, F. Turroni, 2016, Microbiology and Molecular Reviews.

The Collagen-Binding Protein Cnm Is Required for Streptococcus mutans Adherence to and Intracellular Invasion of Human Coronary Artery Endothelial Cells

R. Burne, J. Abranches, J. H. Miller, 2011, Infection and Immunity.