M. Wittman

发表

Direct‐drive laser‐fusion experiments with the OMEGA, 60‐beam, >40 kJ, ultraviolet laser system

Stephen D. Jacobs, Paul A. Jaanimagi, Samuel A. Letzring, 1996 .

Publications and Conference Presentations

P. B. Radha, R. Town, O. Gotchev, 1995 .

The National Direct-Drive Inertial Confinement Fusion Program

P. B. Radha, T. C. Sangster, Gilbert W. Collins, 2018, Nuclear Fusion.

Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile.

M. Gottardis, R. Attar, A. Greer, 2007, Bioorganic & medicinal chemistry letters.

Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.

Chiehying Y Chang, M. Gottardis, R. Attar, 2005, Journal of medicinal chemistry.

Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R).

D. Langley, J. Sack, Chiehying Y Chang, 2007, Bioorganic & medicinal chemistry letters.

2-(1H-Imidazol-4-yl)ethanamine and 2-(1H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924.

D. Langley, M. Gottardis, R. Attar, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development.

G. Trainor, A. Mathur, D. Langley, 2009, Journal of medicinal chemistry.

Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one.

G. Trainor, M. Gottardis, A. Greer, 2010, Bioorganic & medicinal chemistry letters.

Three-Dimensional Characterization of Spherical Cryogenic Targets Using Ray-Trace Analysis of Multiple Shadowgraph Views

L. M. Elasky, R. Craxton, D. Harding, 2007 .

Effect of experimentally observed hydrogenic fractionation on inertial confinement fusion ignition target performance

D. Harding, P. McKenty, M. Wittman, 2006 .

Forming cryogenic targets for direct-drive experimentsa)

T. H. Hinterman, L. M. Elasky, D. Meyerhofer, 2006 .

Producing Cryogenic Deuterium Targets for Experiments on OMEGA

T. C. Sangster, T. H. Hinterman, L. M. Elasky, 2005 .

Monochromatic backlighting of direct-drive cryogenic DT implosions on OMEGA

P. B. Radha, T. C. Sangster, D. T. Michel, 2017 .

The National Direct-Drive Program: OMEGA to the National Ignition Facility

P. B. Radha, T. C. Sangster, D. T. Michel, 2018 .

Enhanced laser-energy coupling with small-spot distributed phase plates (SG5-650) in OMEGA DT cryogenic target implosions

P. B. Radha, T. C. Sangster, Shailaja Keyur Sampat, 2022, Physics of Plasmas.

Inertial confinement fusion experiments with OMEGA-A 30-kJ, 60-beam UV laser

J. Knauer, D. Meyerhofer, M. Shoup, 1999 .

Effect of Tritium-Induced Damage on Plastic Targets from High-Density DT Permeation

D. Harding, M. Bonino, D. Edgell, 2018 .

Requirements and Capabilities for Fielding Cryogenic DT-Containing Fill-Tube Targets for Direct-Drive Experiments on OMEGA

J. Lambropoulos, D. Harding, M. Bonino, 2018 .

OMEGA ICF experiments and preparation for direct drive ignition on NIF

Paul A. Jaanimagi, Jonathan D. Zuegel, John Kelly, 2001 .

The Role of the Laboratory for Laser Energetics in the National Ignition Facility Project

J. Knauer, D. Meyerhofer, M. Shoup, 1996 .

Considerations and Requirements for Providing Cryogenic Targets for Direct-Drive Inertial Fusion Implosions at the National Ignition Facility

D. Harding, D. Edgell, M. Wittman, 2013 .

Uniform liquid‐fuel layer produced in a cryogenic inertial fusion target by a time‐dependent thermal gradient

H. Kong, R. Craxton, J. Soures, 1990 .

Characterization of cryogenic direct-drive ICF targets during layering studies and just prior to shot time

L. M. Elasky, R. Craxton, D. Harding, 2006 .

Comparison of Shadowgraphy and X-Ray Phase Contrast Methods for Characterizing a DT Ice Layer in an Inertial Confinement Fusion Target

D. Harding, D. Edgell, M. Wittman, 2020 .

Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor

E. Lees, R. Bhadra, J. Hunt, 2021, Journal for ImmunoTherapy of Cancer.

Inertial confinement fusion target insertion via augmented mass free fall

R. Stephens, L. Brown, R. Fagaly, 1995, Proceedings of 16th International Symposium on Fusion Engineering.

Characterization of thick cryogenic fuel layers using convergent-beam interferometry: A numerical investigation

V. Goncharov, P. McKenty, M. Wittman, 2000 .

Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors.

P. Ross-Macdonald, H. de Silva, Isaac Neuhaus, 2012, Bioorganic & Medicinal Chemistry.

Cryogenic Target Characterization at LLE

Robert L. Keck, R. S. Craxton, D. Weiner, 2003 .

Three-Dimensional Characterization of Cryogenic Target Ice Layers Using Multiple Shadowgraph Views

R. S. Craxton, D. H. Edgell, L. D. Lund, 2006 .

SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors.

S. P. Seitz, M. Gottardis, R. Attar, 2010, Bioorganic & medicinal chemistry letters.

Chapter 14 Recent Progress in the Development of Small Molecule Inhibitors of Insulin-Like Growth Factor-1 Receptor Kinase

M. Wittman, Upender Velaparthi, D. Vyas, 2009 .

Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase.

Chiehying Y Chang, M. Gottardis, R. Attar, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and antitumor activity of novel C-7 paclitaxel ethers: discovery of BMS-184476.

C. Fairchild, J. Kadow, F. Lee, 2001, Journal of medicinal chemistry.

Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase.

J. Sack, Chiehying Y Chang, A. Greer, 2010, Bioorganic & medicinal chemistry letters.

Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors.

D. Langley, M. Gottardis, R. Attar, 2008, Bioorganic & medicinal chemistry letters.

Constitutively Active Insulin-Like Growth Factor I Receptor Tumor Development by Transgenic Expression of a

Adrian V. Lee, F. Lee, D. Bol, 2005 .

Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activ

Zheng Yang, Sean Kim, Praveen Balimane, 2008, Journal of medicinal chemistry.

The [2,3] Wittig rearrangement of tertiary allylic ethers. Application to the synthesis of the C12C25 subunit of zincophorin

M. Wittman, M. Balestra, J. Kallmerten, 1988 .

Synthesis of the Core Trisaccharide of Esperamicin: Corroboration of the Proposed Structure for Its Rearrangement Product and Stabilization of the Core Trisaccharide Domain.

R. Halcomb, S. Danishefsky, S. Olson, 1991 .

Synthesis and Antiviral Evaluation of 3′-Branched Nucixoside Analogues

M. Wittman, M. Hitchcock, Hyekyung Yang, 1991 .

Conjugate addition-aldol approach to the simple bicyclic-diynene core structure found in the esperamicins and calicheamicins

J. Kadow, T. Doyle, M. Wittman, 1992 .

In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417.

C. Conover, F. Lee, D. Loegering, 2006, Cancer research.

On the conversion of biologically interesting amines to hydroxylamines

R. Halcomb, S. Danishefsky, M. Wittman, 1990 .

A route to glycals in the allal and gulal series: synthesis of the thiosugar of esperamicin A1

R. Halcomb, S. Danishefsky, M. Wittman, 1990 .

Facile Synthesis of a Simplified Bicyclo[7.3.1] Esperamicin-Calicheamicin Enediyne Core

D. Langley, J. Kadow, T. Doyle, 1994 .

Stereocontrolled synthesis of highly oxygenated acyclic systems via the enolate Claisen rearrangement of O-protected allylic glycolates

M. Wittman, M. Balestra, J. Kallmerten, 1987 .

Synthesis of the oudemansins, naturally occurring β-methoxyacrylates from basidomycetes

M. Wittman, J. Kallmerten, 1987 .

Synthesis of oudehansins A and B

M. Wittman, J. Kallmerten, 1986 .

Diastereoselective [2,3] wittig rearrangement of tertiary allylic ethers

M. Wittman, J. Kallmerten, 1988 .

Stereospecific synthesis of the major human metabolite of paclitaxel

J. Kadow, M. Wittman, D. Vyas, 2000 .

BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR

Zheng Yang, G. Trainor, F. Lee, 2009, Molecular Cancer Therapeutics.

Synthesis and antitumor activity of novel paclitaxel-chlorambucil hybrids.

J. Kadow, K. Johnston, W. Rose, 2001, Bioorganic & medicinal chemistry letters.

Stereospecific synthesis of 7-deoxy-6-hydroxy paclitaxel

C. Fairchild, J. Kadow, M. Wittman, 1999 .

THE SYNTHESIS AND BIOLOGICAL ACTIVITY OF ENEDIYNE MINOR GROOVE BINDING HYBRIDS

D. Langley, J. Kadow, W. Rose, 1995 .

The effect of propargylic substitution on the activation and aromatization of enediynes

J. Kadow, W. Rose, M. Wittman, 1994 .

Interferometric Microscopy — An Overview of the Optical Characterization of Inertial-fusion Targets

H. Kim, M. Wittman, 1994 .

X-Ray Microscopy — Its Application to Biological Sciences

P. Cheng, D. Shinozaki, K. Tan, 1988 .

Microwave-assisted synthesis of primary amine HX salts from halides and 7 M ammonia in methanol

M. Wittman, Upender Velaparthi, K. Zimmermann, 2004 .

Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor.

Adrian V. Lee, F. Lee, D. Bol, 2005, Cancer research.

Targeting Insulin-Like Growth Factor Receptor 1 (IGF-1R) and Insulin Receptor Signaling by Tyrosine Kinase Inhibitors in Cancer

F. Huang, J. Carboni, M. Wittman, 2012 .

The Laboratory for Laser Energetics’ Hydrogen Isotope Separation System

W. Shmayda, M. Wittman, R. Earley, 2016 .

Crystallographic Determination of the Stereochemistry of C‐6,7 Epoxy Paclitaxel.

J. Kadow, M. Wittman, Qi Gao, 1998 .

Causes of fuel–ablator mix inferred from modeling of monochromatic time-gated radiography of OMEGA cryogenic implosions

M. Shoup, V. Goncharov, D. Harding, 2022, Physics of Plasmas.

Demonstration of Fuel Hot-Spot Pressure in Excess of 50 Gbar for Direct-Drive, Layered Deuterium-Tritium Implosions on OMEGA.

V N Goncharov, S P Obenschain, A J Schmitt, 2016, Physical review letters.

Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1

Alan S. Futran, S. Sheriff, B. Pearce, 2021, ACS medicinal chemistry letters.

Simulation and analysis of time-gated monochromatic radiographs of cryogenic implosions on OMEGA

R. Betti, M. Shoup, V. Goncharov, 2017 .

K. Liu, R. Halcomb, S. Danishefsky, 1995 .