W. Maruyama

发表

Neuromelanin induces oxidative stress in mitochondria through release of iron: mechanism behind the inhibition of 26S proteasome

P. Riederer, M. Gerlach, M. Naoi, 2006, Journal of Neural Transmission.

Cell death of dopamine neurons in aging and Parkinson’s disease

M. Naoi, W. Maruyama, 1999, Mechanisms of Ageing and Development.

M. Carrillo, W. Maruyama, K. Kitani, 2007 .

Mitochondrial genome variation in eastern Asia and the peopling of Japan.

Hidetoshi Shimodaira, N. Hattori, S. Ohta, 2004, Genome research.

N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2

M. Naoi, K. Iwasa, W. Maruyama, 2005, Journal of Neural Transmission.

Mitochondrial permeability transition mediates apoptosis induced by N‐methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl‐2 and rasagiline, N‐propargyl‐1(R)‐aminoindan

Y. Akao, Y. Nakagawa, Y. Tsujimoto, 2002, Journal of neurochemistry.

The anti-parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells

M. Naoi, M. Youdim, W. Maruyama, 2002, Journal of Neural Transmission.

Transfection‐enforced Bcl‐2 overexpression and an anti‐Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde‐3‐phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N‐methyl(R)salsolinol

Y. Akao, M. Naoi, M. Youdim, 2001, Journal of neurochemistry.

Neuroprotection by (−)-deprenyl and related compounds

M. Naoi, W. Maruyama, 1999, Mechanisms of Ageing and Development.

Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat.

M. Carrillo, M. Naoi, M. Youdim, 2000, Life sciences.

Mechanism underlying anti-apoptotic activity of a (−)deprenyl-related propargylamine, rasagiline

M. Carrillo, M. Naoi, M. Youdim, 2000, Mechanisms of Ageing and Development.

Immunohistochemical detection of dityrosine in lipofuscin pigments in the aged human brain

M. Naoi, T. Osawa, Y. Hashizume, 1998, FEBS letters.

Effects of various tetrahydroisoquinoline derivatives on mitochondrial respiration and the electron transfer complexes

M. Naoi, Y. Kotake, P. Dostert, 1998, Journal of Neural Transmission.

Inhibition of tryptophan hydroxylase by dopamine and the precursor amino acids.

M. Naoi, H. Parvez, W. Maruyama, 1994, Biochemical pharmacology.

Role of lipid peroxide in the neurodegenerative disorders.

M. Naoi, T. Osawa, W. Maruyama, 2014, Sub-cellular biochemistry.

An Animal Model of Parkinson’s Disease Prepared by Endogenous N -Methyl(R)Salsolinol

M. Naoi, P. Dostert, W. Maruyama, 1998 .

SIRT1 Suppresses the Senescence-Associated Secretory Phenotype through Epigenetic Gene Regulation

K. Takimoto, N. Motoyama, W. Maruyama, 2015, PloS one.

Disease-modifying treatment of Parkinson’s disease by phytochemicals: targeting multiple pathogenic factors

M. Naoi, M. Shamoto-Nagai, W. Maruyama, 2021, Journal of Neural Transmission.

Food-derived heterocyclic amines, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and related amines, as inhibitors of monoamine metabolism.

M. Naoi, A. Ota, T. Nagatsu, 1994, Journal of neural transmission. Supplementum.

Formation of Dopamine Adducts Derived from Brain Polyunsaturated Fatty Acids

Xuebo Liu, T. Osawa, W. Maruyama, 2008, Journal of Biological Chemistry.

Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: occurrence, metabolism and function in human brains.

M. Naoi, W. Maruyama, G. Nagy, 2004, Neurotoxicology.

Glyceraldehyde-3-phospate dehydrogenase is translocated into nuclei through Golgi apparatus during apoptosis induced by 6-hydroxydopamine in human dopaminergic SH-SY5Y cells

M. Naoi, T. Osawa, M. Shamoto-Nagai, 2002, Neuroscience Letters.

The effect of neuromelanin on the proteasome activity in human dopaminergic SH-SY5Y cells.

P. Riederer, M. Naoi, M. Shamoto-Nagai, 2006, Journal of neural transmission. Supplementum.

Neuromelanin inhibits enzymatic activity of 26S proteasome in human dopaminergic SH-SY5Y cells

Y. Akao, P. Riederer, M. Gerlach, 2004, Journal of Neural Transmission.

Assay for the (R)- and (S)-enantiomers of salsolinols in biological samples and foods with ion-pair high-performance liquid chromatography using beta-cyclodextrin as a chiral mobile phase additive.

Yulin Deng, M. Naoi, P. Dostert, 1997, Journal of chromatography. B, Biomedical sciences and applications.

N-methyl(R)salsolinol, a dopamine neurotoxin, in Parkinson's disease.

M. Naoi, W. Maruyama, 1999, Advances in neurology.

A novel enzyme enantio-selectively synthesizes (R)salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl(R)salsolinol

M. Naoi, P. Dostert, W. Maruyama, 1996, Neuroscience Letters.

Determination of the (R)- and (S)-enantiomers of salsolinol and N-methylsalsolinol by use of a chiral high-performance liquid chromatographic column.

M. Naoi, P. Dostert, W. Maruyama, 1995, Journal of chromatography. B, Biomedical applications.

N‐Methylation of Dopamine‐Derived 6,7‐Dihydroxy‐1,2,3,4‐Tetrahydroisoquinoline, (R)‐Salsolinol, in Rat Brains: In Vivo Microdialysis Study

M. Naoi, D. Nakahara, T. Nagatsu, 1992, Journal of neurochemistry.

Identification of 3-nitro-L-tyrosine, a product of nitric oxide and superoxide, as an indicator of oxidative stress in the human brain.

M. Naoi, K. Matsubara, Y. Hashizume, 1996, Journal of chromatography. B, Biomedical applications.

Phytochemicals prevent mitochondrial membrane permeabilization and protect SH-SY5Y cells against apoptosis induced by PK11195, a ligand for outer membrane translocator protein

M. Naoi, T. Osawa, M. Shamoto-Nagai, 2016, Journal of Neural Transmission.

Rasagiline and selegiline suppress calcium efflux from mitochondria by PK11195-induced opening of mitochondrial permeability transition pore: a novel anti-apoptotic function for neuroprotection

M. Naoi, T. Osawa, W. Maruyama, 2015, Journal of Neural Transmission.

A new metabolic pathway of L-threo-3,4-dihydroxyphenylserine, a precursor amino acid of norepinephrine, in the brain Studies by in vivo microdialysis

M. Naoi, D. Nakahara, W. Maruyama, 1994, Journal of neural transmission. Parkinson's disease and dementia section.

An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic Bcl-2 in human dopaminergic SH-SY5Y cells

Y. Akao, M. Youdim, M. Naoi, 2002, Neuroscience Letters.

Neurotrophic function of phytochemicals for neuroprotection in aging and neurodegenerative disorders: modulation of intracellular signaling and gene expression

M. Naoi, M. Shamoto-Nagai, W. Maruyama, 2017, Journal of Neural Transmission.

Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells: suppression of apoptosis by N-(2-heptyl)-N-methylpropargylamine

M. Naoi, P. Dostert, A. Boulton, 2001, Journal of Neural Transmission.

Antiapoptotic Properties of Rasagiline, N‐Propargylamine‐1(R)‐aminoindan, and Its Optical (S)‐Isomer, TV1022

M. Naoi, M. Youdim, W. Maruyama, 2001, Annals of the New York Academy of Sciences.

Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopamine neurons.

M. Naoi, H. Parvez, W. Maruyama, 2000, Toxicology.

Apoptosis by an Endogenous Neurotoxin, N-Methyl(R)Salsolinol: Relevance to Parkinson’s Disease

Y. Nakagawa, M. Naoi, Tsutomu Takahashi, 2000 .

Dopaminergic neurotoxins, 6,7-dihydroxy-1-(3′,4′-dihydroxybenzyl)-isoquinolines, cause different types of cell death in SH-SY5Y cells: apoptosis was induced by oxidized papaverolines and necrosis by reduced tetrahydropapaverolines

M. Naoi, P. Dostert, M. Kawai, 2000, Neuroscience Letters.

Involvement of endogenous N-methyl(R)salsolinol in Parkinson's disease: induction of apoptosis and protection by (-)deprenyl.

M. Naoi, W. Maruyama, Y. Akao, 2000, Journal of neural transmission. Supplementum.

Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, is mediated by activation of caspase 3

Y. Nakagawa, M. Naoi, Tsutomu Takahashi, 1999, Neuroscience Letters.

An endogenous MPTP-like dopaminergic neurotoxin, N-methyl(R)salsolinol, in the cerebrospinal fluid decreases with progression of Parkinson's disease

H. Tohgi, M. Naoi, W. Maruyama, 1999, Neuroscience Letters.

N-Methyl(R)Salsolinol: A Neurotoxin Candidate to Induce Parkinson’s Disease Causes Apoptosis in Dopamine Cells

M. Naoi, W. Maruyama, 1998 .

(−)‐Deprenyl Protects Human Dopaminergic Neuroblastoma SH‐SY5Y Cells from Apoptosis Induced by Peroxynitrite and Nitric Oxide

M. Naoi, W. Maruyama, T. Takahashi, 1998, Journal of neurochemistry.

A neurotoxin N-methyl(R)salsolinol induces apoptotic cell death in differentiated human dopaminergic neuroblastoma SH-SY5Y cells

M. Naoi, Tsutomu Takahashi, W. Maruyama, 1997, Neuroscience Letters.

Type B and A monoamine oxidase and their inhibitors regulate the gene expression of Bcl-2 and neurotrophic factors in human glioblastoma U118MG cells: different signal pathways for neuroprotection by selegiline and rasagiline

M. Naoi, M. Shamoto-Nagai, W. Maruyama, 2017, Journal of Neural Transmission.

Involvement of type A monoamine oxidase in neurodegeneration: regulation of mitochondrial signaling leading to cell death or neuroprotection.

Y. Akao, M. Naoi, W. Maruyama, 2006, Journal of neural transmission. Supplementum.

Cell death in Parkinson's disease

M. Naoi, W. Maruyama, 2002, Journal of Neurology.

Peroxynitrite induces neuronal cell death in aging and age-associated disorders: A review

M. Naoi, Y. Hashizume, W. Maruyama, 2001, Journal of the American Aging Association.

Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells

Y. Sato, M. Naoi, M. Shamoto-Nagai, 2002, Journal of Neural Transmission.

Erratum: Apoptosis induced by an endogenous neurotoxin, N- methyl(R)salsolinol, is mediated by activation of caspase 3 (Neuroscience Letters (1999) 267 (153-156) PII: S0304394099003614)

Y. Akao, Y. Nakagawa, M. Naoi, 1999 .

Mitogen-activated protein kinase pathway mediates peroxynitrite-induced apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells.

K. Isobe, M. Naoi, W. Maruyama, 1999, Biochemical and biophysical research communications.

Overexpression of amyloid precursor protein induces susceptibility to oxidative stress in human neuroblastoma SH-SY5Y cells

M. Naoi, M. Shamoto-Nagai, W. Maruyama, 2006, Journal of Neural Transmission.

Do Antioxidant Strategies Work against Aging and Age‐associated Disorders?

M. Carrillo, W. Maruyama, K. Kitani, 2001, Annals of the New York Academy of Sciences.

Common properties for propargylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: implications for the life prolonging effect of (-)deprenyl.

M. Carrillo, W. Maruyama, K. Kitani, 2000, Journal of neural transmission. Supplementum.

Biological Role of Neuromelanin in the Human Brain and Its Importance in Parkinson's Disease

P. Riederer, K. Double, M. Gerlach, 2011 .

Neuromelanin selectively induces apoptosis in dopaminergic SH‐SY5Y cells by deglutathionylation in mitochondria: involvement of the protein and melanin component

Y. Akao, P. Riederer, M. Gerlach, 2008, Journal of neurochemistry.

Binding of 1,2(N)-dimethyl-6,7-dihydroxy-isoquinolinium ion to melanin: Effects of ferrous and ferric ion on the binding

M. Naoi, P. Dostert, W. Maruyama, 1994, Neuroscience Letters.

Cytotoxicity of endogenous isoquinolines to human dopaminergic neuroblastoma SH-SY5Y cells

M. Naoi, P. Dostert, D. Nakahara, 2005, Journal of Neural Transmission.

Novel toxins and Parkinson's disease: N-methylation and oxidation as metabolic bioactivation of neurotoxin.

M. Naoi, T. Niwa, T. Nagatsu, 1994, Journal of neural transmission. Supplementum.

Mitochondria in Neuroprotection by Phytochemicals: Bioactive Polyphenols Modulate Mitochondrial Apoptosis System, Function and Structure

M. Naoi, M. Shamoto-Nagai, W. Maruyama, 2019, International journal of molecular sciences.

Glutathione redox status in mitochondria and cytoplasm differentially and sequentially activates apoptosis cascade in dopamine-melanin-treated SH-SY5Y cells

Y. Akao, P. Riederer, M. Gerlach, 2009, Neuroscience Letters.

Oxidative stress in mitochondria

Y. Akao, M. Naoi, Masashi Tanaka, 2007, Molecular Neurobiology.

Anti-apoptotic function of propargylamine inhibitors of type-B monoamine oxidase

M. Naoi, A. Boulton, W. Maruyama, 2004, InflammoPharmacology.

Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies

M. Naoi, W. Maruyama, M. Shamoto‐Nagai, 2022, International journal of molecular sciences.

N-methyl(R)salsolinol produces hydroxyl radicals: involvement to neurotoxicity.

M. Naoi, P. Dostert, K. Matsubara, 1995, Free radical biology & medicine.

Oxidation of N-methyl(R)salsolinol: involvement to neurotoxicity and neuroprotection by endogenous catechol isoquinolines.

M. Naoi, P. Dostert, W. Maruyama, 1998, Journal of neural transmission. Supplementum.

An Endogenous Dopaminergic Neurotoxin, N‐Methyl‐(R)‐Salsolinol, Induces DNA Damage in Human Dopaminergic Neuroblastoma SH‐SY5Y Cells

M. Naoi, P. Dostert, Y. Hashizume, 1997, Journal of neurochemistry.

N-methyl-(R)salsolinol as a dopaminergic neurotoxin: from an animal model to an early marker of Parkinson's disease.

M. Naoi, P. Dostert, Y. Hashizume, 1997, Journal of neural transmission. Supplementum.

Type A monoamine oxidase is the target of an endogenous dopaminergic neurotoxin, N‐methyl(R)salsolinol, leading to apoptosis in SH‐SY5Y cells

Y. Akao, M. Naoi, J. Shih, 2006, Journal of neurochemistry.

A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neuroblastoma SH-SY5Y cells.

Y. Akao, Y. Nakagawa, M. Naoi, 2004, Bioorganic & medicinal chemistry.

Type B monoamine oxidase and neurotoxins.

M. Naoi, W. Maruyama, 1993, European neurology.

Generation of reactive oxygen species accounts for cytotoxicity of an endogenous dopaminergic neurotoxin, (R)-N-methylsalsolinol, to differentiated dopaminergic SH-SY5Y cells

M. Naoi, D. Nakahara, W. Maruyama, 1998, Journal of Neural Transmission.

Dopamine-derived endogenous 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies

M. Naoi, Tsutomu Takahashi, P. Dostert, 1996, Brain Research.

Dopamine‐Derived 1‐Methyl‐6,7‐Dihydroxyisoquinolines as Hydroxyl Radical Promoters and Scavengers in the Rat Brain: In Vivo and In Vitro Studies

M. Naoi, P. Dostert, W. Maruyama, 1995, Journal of neurochemistry.

Dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines; oxidation and neurotoxicity.

M. Naoi, P. Dostert, W. Maruyama, 1995, Progress in brain research.

Norharman, an indoleamine-derived beta-carboline, but not Trp-P-2, a gamma-carboline, induces apoptotic cell death in human neuroblastoma SH-SY5Y cells.

M. Naoi, K. Matsubara, H. Shiono, 2001, Journal of neural transmission.

N-methyl(R)salsolinol and a neutral N-methyltransferase as pathogenic factors in Parkinson's disease.

M. Naoi, W. Maruyama, M. Strolin-Benedetti, 2000, Neurobiology.

Type A and B monoamine oxidase in age-related neurodegenerative disorders: their distinct roles in neuronal death and survival.

M. Naoi, W. Maruyama, Keiko Inaba-Hasegawa, 2012, Current topics in medicinal chemistry.

Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria.

Y. Akao, K. Ozawa, M. Naoi, 2002, Journal of biomedical science.

Salsolinol is a Putative Endogenous Neuro‐intermediate Lobe Prolactin‐Releasing Factor

M. Naoi, G. Nagy, F. Fülöp, 2001, Journal of neuroendocrinology.

Mechanism of enantioseparation of salsolinols, endogenous neurotoxins in human brain, with ion-pair chromatography using beta-cyclodextrin as a mobile phase additive.

M. Naoi, P. Dostert, H. Yamamura, 1996, Analytical Chemistry.

Rasagiline: Neurodegeneration, neuroprotection, and mitochondrial permeability transition

M. Youdim, T. Amit, M. Youdim, 2005, Journal of neuroscience research.

Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes.

Y. Akao, M. Naoi, M. Carrillo, 2002, Neurotoxicology and teratology.

Stereospecific occurrence of a parkinsonism-inducing catechol isoquinoline, n-methyl(R)salsolinol, in the human intraventricular fluid

M. Naoi, P. Dostert, W. Maruyama, 2005, Journal of Neural Transmission.

Dopamine-derived endogenous N-methyl-(R)-salsolinol: its role in Parkinson's disease.

Y. Akao, M. Naoi, W. Maruyama, 2002, Neurotoxicology and teratology.

N-Methyl-(R) Salsolinol and the Enzymes Catalyzing its Synthesis and Metabolism in Parkinson’s Disease

M. Naoi, W. Maruyama, 2014 .

(R) salsolinol N‐methyltransferase activity increases in parkinsonian lymphocytes

M. Naoi, W. Maruyama, M. Benedetti, 1998, Annals of neurology.

A neutral N-methyltransferase activity in the striatum determines the level of an endogenous MPP+-like neurotoxin, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, in the substantia nigra of human brains

M. Naoi, K. Matsubara, Y. Hashizume, 1997, Neuroscience Letters.

A dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl(R)salsolinol, and its oxidation product, 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigro-striatal system of the human brain

G. Sobue, M. Naoi, P. Dostert, 1997, Neuroscience Letters.

A dopaminergic neurotoxin, (R)‐N‐methylsalsolinol, increases in parkinsonian cerebrospinal fluid

H. Tohgi, M. Naoi, P. Dostert, 1996, Annals of neurology.

Enzymatic oxidation of the dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, into 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion.

M. Naoi, P. Dostert, W. Maruyama, 1995, Life sciences.

Inhibition of Tyrosine Hydroxylase by R and S Enantiomers of Salsolinol, 1‐Methyl‐6,7‐Dihydroxy‐1,2,3,4‐ Tetrahydroisoquinoline

M. Naoi, P. Dostert, T. Nagatsu, 1992, Journal of neurochemistry.

Norharman, an indoleamine-derived β-carboline, but not Trp-P-2, a γ-carboline, induces apoptotic cell death in human neuroblastoma SH-SY5Y cells

M. Naoi, K. Matsubara, H. Shiono, 2001, Journal of Neural Transmission.

Bioactive Dietary Compounds Regulate Mitochondrial Apoptosis Signaling in Ambivalent Way to Function as Neuroprotective or Antitumor Agents

M. Naoi, W. Maruyama, Yuqiu Wu, 2016 .

Enantio-selective occurrence of (S)-tetrahydropapaveroline in human brain

M. Naoi, P. Dostert, M. Kawai, 2000, Neuroscience Letters.

The mechanism of perturbation in monoamine metabolism by L-DOPA therapy: in vivo and in vitro studies

M. Naoi, D. Nakahara, W. Maruyama, 2005, Journal of Neural Transmission / General Section JNT.

Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson’s disease

M. Naoi, W. Maruyama, 2009, Expert review of neurotherapeutics.

Inhibition of tyrosine hydroxylase by a dopamine neurotoxin, 1-methyl-4-phenylpyridinium ion: depletion of allostery to the biopterin cofactor.

M. Naoi, W. Maruyama, 1994, Life sciences.

Simultaneous determination of in vivo hydroxylation of tyrosine and tryptophan in rat striatum by microdialysis-HPLC: relationship between dopamine and serotonin biosynthesis

M. Naoi, D. Nakahara, W. Maruyama, 2005, Journal of Neural Transmission / General Section JNT.

Allosteric effect of tetrahydrobiopterin cofactors on tyrosine hydroxylase activity.

M. Naoi, T. Nagatsu, W. Maruyama, 1992, Life sciences.

Reduction of enzymatic activity of tyrosine hydroxylase by a heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole (Trp-P-1), was due to reduced affinity to a cofactor biopterin

M. Naoi, Tsutomu Takahashi, A. Ota, 1991, Neuroscience Letters.

Oxidation of 1-amino-4-phenyl-1,2,3,6-tetrahydropyridine, a 1-amino analog of MPTP, by type A and B monoamine oxidase

S. Aoyama, M. Naoi, W. Maruyama, 1998, Journal of Neural Transmission.

Modulation of monoamine oxidase (MAO) expression in neuropsychiatric disorders: genetic and environmental factors involved in type A MAO expression

P. Riederer, M. Naoi, W. Maruyama, 2016, Journal of Neural Transmission.

Revelation in the neuroprotective functions of rasagiline and selegiline: the induction of distinct genes by different mechanisms

M. Naoi, W. Maruyama, Keiko Inaba-Hasegawa, 2013, Expert review of neurotherapeutics.

Type A monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis

M. Naoi, W. Maruyama, M. Shamoto‐Nagai, 2017, Journal of Neural Transmission.

Neuroprotection of multifunctional phytochemicals as novel therapeutic strategy for neurodegenerative disorders: antiapoptotic and antiamyloidogenic activities by modulation of cellular signal pathways

M. Naoi, W. Maruyama, M. Shamoto‐Nagai, 2019, Future Neurology.

Mitochondria determine the survival and death in apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, and neuroprotection by propargylamines

M. Naoi, W. Maruyama, H. Yi, 2002, Journal of Neural Transmission.

Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022.

Y. Akao, M. Naoi, M. Youdim, 2000, Journal of neural transmission. Supplementum.

In parkinsonian substantia nigra, α-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity

P. Riederer, M. Naoi, T. Osawa, 2007, Journal of Neural Transmission.

Rasagiline and selegiline modulate mitochondrial homeostasis, intervene apoptosis system and mitigate α-synuclein cytotoxicity in disease-modifying therapy for Parkinson’s disease

M. Naoi, W. Maruyama, M. Shamoto‐Nagai, 2020, Journal of Neural Transmission.

Nutrition in Brain Aging: Its Relevance to Age-Associated Neurodegeneration

M. Naoi, W. Maruyama, M. Shamoto‐Nagai, 2022, NeuroPsychopharmacotherapy.

N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-κB transcription factor

Y. Akao, T. Nabeshima, S. Furukawa, 2004, Neurochemistry International.

Inhibition of type A and B monoamine oxidase by 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines and their N-methylated derivatives

M. Naoi, P. Dostert, T. Nagatsu, 2005, Journal of Neural Transmission / General Section JNT.

An inhibitor of mitochondrial complex I, rotenone, inactivates proteasome by oxidative modification and induces aggregation of oxidized proteins in SH‐SY5Y cells

Ken-ichi Isobe, Toshihiko Osawa, K. Isobe, 2003, Journal of neuroscience research.

Golden mean to longevity: Rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease

Noriyuki Fuku, Nobutaka Hattori, Yoshikuni Mizuno, 2002, Journal of neuroscience research.

Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport system

M. Naoi, P. Dostert, M. Kawai, 2005, Journal of Neural Transmission / General Section JNT.

Modification of α-synuclein by lipid peroxidation products derived from polyunsaturated fatty acids promotes toxic oligomerization: its relevance to Parkinson disease

M. Naoi, W. Maruyama, S. Hisaka, 2018, Journal of clinical biochemistry and nutrition.

T. Tabira, H. Shoji, K. Mizoguchi, 2009, Neuroscience.

Aging attenuates glucocorticoid negative feedback in rat brain

T. Tabira, H. Shoji, R. Ikeda, 2009, Neuroscience.

Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced dysfunction of glucocorticoid negative feedback system in rat brain

T. Tabira, Y. Kase, K. Mizoguchi, 2007, Pharmacology Biochemistry and Behavior.

Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced anxiety in rats: comparison with diazepam

T. Tabira, H. Shoji, R. Ikeda, 2008, Journal of Natural Medicines.

Systemic disorders of calcium dynamics in rats with adenine‐induced renal failure: Implication for chronic kidney disease‐related complications

R. Ikeda, K. Mizoguchi, W. Maruyama, 2010, Nephrology.

Neuroprotective function of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane, [R-(-)-BPAP], against apoptosis induced by N-methyl(R)salsolinol, an endogenous dopaminergic neurotoxin, in human dopaminergic neuroblastoma SH-SY5Y cells.

M. Naoi, Tsutomu Takahashi, K. Iwasa, 2004, Life sciences.

Future of neuroprotection in Parkinson's disease.

M. Naoi, W. Maruyama, 2001, Parkinsonism & related disorders.

The metabolism of l-DOPA and l-threo-3,4-dihydroxyphenylserine and their effects on monoamines in the human brain: analysis of the intraventricular fluid from parkinsonian patients

M. Naoi, W. Maruyama, Wakako Maruyama, 1996, Journal of the Neurological Sciences.

Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor

Yukiko Nakamura, A. Matsuura, N. Motoyama, 2011, Aging.

Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival

Y. Akao, M. Naoi, W. Maruyama, 2009, Journal of Neural Transmission.

Neuroprotection by propargylamines in Parkinson's disease: intracellular mechanism underlying the anti-apoptotic function and search for clinical markers.

M. Naoi, W. Maruyama, H. Yi, 2007, Journal of neural transmission. Supplementum.

Gene Therapy for Mitochondrial Disease by Delivering Restriction Endonuclease SmaI into Mitochondria

Y. Akao, K. Ozawa, M. Naoi, 2002, Journal of Biomedical Science.

Cytotoxicity of 1-amino-4-phenyl-1,2,3,6-tetrahydropyridine and 1-amino-4-phenylpyridinium ion, 1-amino analogues of MPTP and MPP+, to clonal pheochromocytoma PC12 cells.

S. Aoyama, M. Naoi, W. Maruyama, 1998, Chemical Research in Toxicology.

Characterization of the in vivo actionof(R)-salsolino, an endogenous metabolite of alcohol, on serotonin and dopamine metabolism: A microdialysis study

M. Naoi, D. Nakahara, W. Maruyama, 1994, Brain Research.

Rasagiline and selegiline, inhibitors of type B monoamine oxidase, induce type A monoamine oxidase in human SH-SY5Y cells

Y. Akao, M. Naoi, Yukihiro Akao, 2013, Journal of Neural Transmission.

Ginseng and Ginsenosides in Depression

M. Naoi, W. Maruyama, M. Nagai, 2020, NeuroPsychopharmacotherapy.

TCM Substances in Neuropsychopharmacotherapy: Basic Aspects with a Focus on Depression

P. Riederer, M. Naoi, W. Maruyama, 2021 .

Modulation of tryptophan hydroxylase activity in vitro by ethanol depends on biopterin cofactor concentration.

M. Naoi, K. Matsubara, W. Maruyama, 1996, Alcohol.

Rasagiline prevents apoptosis induced by PK11195, a ligand of the outer membrane translocator protein (18 kDa), in SH-SY5Y cells through suppression of cytochrome c release from mitochondria

M. Naoi, W. Maruyama, H. Yi, 2013, Journal of Neural Transmission.

Type A monoamine oxidase regulates life and death of neurons in neurodegeneration and neuroprotection.

Y. Akao, M. Naoi, W. Maruyama, 2011, International review of neurobiology.

Suppression of glucocorticoid secretion enhances cholinergic transmission in rat hippocampus

T. Tabira, H. Shoji, R. Ikeda, 2008, Brain Research Bulletin.

‘‘70th Birthday Professor Riederer’’ Induction of glial cell line-derived and brain-derived neurotrophic factors by rasagiline and (−)deprenyl: a way to a disease-modifying therapy?

M. Naoi, W. Maruyama, 2012, Journal of Neural Transmission.

Structural studies of condensation products of biogenic amines as inhibitors of trytophan hydroxylase

M. Naoi, Tsutomu Takahashi, K. Matsubara, 1994, Brain Research.

Neuropharmacological, neuroprotective and amyloid precursor processing properties of selective MAO-B inhibitor antiparkinsonian drug, rasagiline.

M. Youdim, W. Maruyama, M. Naoi, 2005, Drugs of today.

A Ganglioside-induced Toxic Soluble Aβ Assembly

S. Maeda, E. Matsubara, A. Takashima, 2007, Journal of Biological Chemistry.

N-Methyl-4-phenylpyridinium and an endogenously formed analog, N-methylated β-carbolinium, inhibit striatal tyrosine hydroxylation in freely moving rats

M. Naoi, D. Nakahara, K. Matsubara, 1995, Neuroscience Letters.

Type A and B monoamine oxidases distinctly modulate signal transduction pathway and gene expression to regulate brain function and survival of neurons

M. Naoi, W. Maruyama, M. Shamoto‐Nagai, 2018, Journal of Neural Transmission.

Type A monoamine oxidase is associated with induction of neuroprotective Bcl-2 by rasagiline, an inhibitor of type B monoamine oxidase

Y. Akao, M. Naoi, W. Maruyama, 2012, Journal of Neural Transmission.

Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor

M. Youdim, M. Naoi, M. Weinstock, 2003, Neuroscience Letters.

Future drug therapy

M. Naoi, W. Maruyama, 2012 .

Monoamine oxidase inhibitors as neuroprotective agents in age-dependent neurodegenerative disorders.

M. Naoi, W. Maruyama, Wakako Maruyama, 2010, Current pharmaceutical design.

Parkinsonian Toxins: From MPTP to Endogenous Neurotoxins

M. Naoi, W. Maruyama, M. Shamoto‐Nagai, 2020 .

Naturally-occurring isoquinolines perturb monoamine metabolism in the brain: studied by in vivo microdialysis

M. Naoi, P. Dostert, D. Nakahara, 2005, Journal of Neural Transmission / General Section JNT.

Introduction to the special issue on monoamine oxidase A and B: eternally enigmatic isoenzymes

P. Riederer, M. Naoi, W. Maruyama, 2018, Journal of Neural Transmission.

Inhibition of type a monoamine oxidase by 2(N)-methyl-6,7-dihydroxyisoquinolinium ions

Yulin Deng, M. Naoi, Tsutomu Takahashi, 1994, Neurochemistry International.

Selective release of serotonin by endogenous alkaloids, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, (R)- and (S)salsolinol, in the rat striatum; in vivo microdialysis study

M. Naoi, P. Dostert, D. Nakahara, 1993, Neuroscience Letters.

Dopamine-Derived Isoquinolines as Dopaminergic Neurotoxins and Oxidative Stress

M. Naoi, Tsutomu Takahashi, P. Dostert, 1995 .

Cytotoxicity of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines.

M. Naoi, P. Dostert, T. Nagatsu, 1993, Advances in neurology.

The effect of a heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), on tyrosine hydroxylase mRNA in PC12h cells

M. Naoi, Tsutomu Takahashi, A. Ota, 1993, Neuroscience Letters.

A ganglioside-induced toxic soluble Abeta assembly. Its enhanced formation from Abeta bearing the Arctic mutation.

S. Maeda, E. Matsubara, A. Takashima, 2007, The Journal of biological chemistry.

Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson’s disease

M. Naoi, W. Maruyama, 2009, Expert review of neurotherapeutics.

Type A monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis

M. Naoi, W. Maruyama, M. Shamoto‐Nagai, 2017, Journal of Neural Transmission.

Propargylamines Protect Dopamine Cells from Apoptosis Induced by a Neurotoxin, N-Methyl(R) Salsolinol

M. Naoi, W. Maruyama, M. Youdim, 2000 .

Anti-Apoptotic Function of Propargylamines

M. Youdim, M. Naoi, A. Boulton, 2002 .

Models of Parkinson’s Disease

M. Naoi, W. Maruyama, 2002 .

Toxic interactions between dopamine, α-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson's disease.

M. Naoi, W. Maruyama, M. Shamoto‐Nagai, 2024, Journal of neural transmission.