S. Carruthers

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Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial

Joël Ménard, Hans Wedel, J. Ménard, 1998, The Lancet.

Relation of amiodarone hepatic and pulmonary toxicity to serum drug concentrations and superoxide dismutase activity.

S. Carruthers, P. Pollak, P. Pollak, 1990, The American journal of cardiology.

Correlation of amiodarone dosage, heart rate, QT interval and corneal microdeposits with serum amiodarone and desethylamiodarone concentrations.

S. Carruthers, P. Pollak, A. Sharma, 1989, The American journal of cardiology.

Phenytoin-theophylline interaction.

J. Spence, J. Toogood, S. Carruthers, 1982, The New England journal of medicine.

Lifestyle modifications to prevent and control hypertension. 3. Recommendations on alcohol consumption. Canadian Hypertension Society, Canadian Coalition for High Blood Pressure Prevention and Control, Laboratory Centre for Disease Control at Health Canada, Heart and Stroke Foundation of Canada.

N. Campbell, M. Ashley, Y. Lacourciére, 1999, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

The 2013 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension.

Lawrence A Leiter, P. McFarlane, E. Schiffrin, 2013, The Canadian journal of cardiology.

A Truncated Erythropoietin Receptor EPOR‐T Is Associated With Hypertension Susceptibility

S. Carruthers, 2009, Clinical pharmacology and therapeutics.

Influence of intrinsic sympathomimetic activity and cardioselectivity on beta adrenoceptor blockade

R. Shanks, D. Mcdevitt, S. Carruthers, 1977, Clinical pharmacology and therapeutics.

Evaluation of cyclosporin-phenytoin interaction with observations on cyclosporin metabolites.

A. Laupacis, P. Keown, C. Stiller, 1984, British journal of clinical pharmacology.

Cyclosporin-erythromycin interaction in normal subjects.

P. Keown, C. Stiller, S. Carruthers, 1987, British journal of clinical pharmacology.

Grapefruit juice–felodipine interaction in the elderly

G. Dresser, D. Bailey, S. Carruthers, 2000, Clinical pharmacology and therapeutics.

Genetic aspects of variability in superficial vein responsiveness to norepinephrine

S. Carruthers, A. Luthra, K. Borkowski, 1991, Clinical pharmacology and therapeutics.

Assimilating new therapeutic interventions into clinical practice: how does hypertension compare with other therapeutic areas?

S. Carruthers, 1999, American heart journal.

Lipids and lipoproteins during antihypertensive drug therapy. Comparison of doxazosin and atenolol in a randomized, double-blind trial: the Alpha Beta Canada Study.

S. Rabkin, M. Huff, S. Carruthers, 1994, Hypertension.

Reminders in echocardiography reports increased use of blockers in reduced left ventricular ejection fraction.

S. Carruthers, 2007, Evidence-based medicine.

3. Recommendations on alcohol consumption

N. Campbell, M. Ashley, S. Carruthers, 1999 .

1999 Canadian recommendations for the management of hypertension including Case-based applications of the recommendations

Lawrence A Leiter, R. Haynes, J. Spence, 1999 .

Observations on three dosage forms of pindolol.

S. Carruthers, 1982, American heart journal.

Measurement of partial agonist activity of pindolol

S. Carruthers, Y. Twum-Barima, 1981, Clinical pharmacology and therapeutics.

The assessment of β-adrenoceptor blocking drugs in hyperthyroidism.

R. Shanks, J. K. Nelson, D. Mcdevitt, 1974, British journal of clinical pharmacology.

C ardiovascular Risk Factors in Pe

S. Carruthers, 2008 .

Recommendations from the Canadian Hypertension Society Consensus Conference on the Pharmacologic Treatment of Hypertension.

R. Haynes, F. Leenen, M. Myers, 1989, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

Pindolol and propranolol in patients with angina pectoris and normal or near-normal ventricular function. Lack of influence of intrinsic sympathomimetic activity on global and segmental left ventricular function assessed by radionuclide ventriculography.

W. Kostuk, S. Carruthers, D. Manyari, 1983, The American journal of cardiology.

Usefulness of the Aldosterone-to-Renin Ratio for Screening Primary Aldosteronism Diastolic Dysfunction in Hypertensive Heart Disease

R. Haynes, E. Schiffrin, A. Logan, 2003 .

Accelerated systemic hypertension after cardiac transplantation--possible vascular alpha-receptor hypersensitivity.

F. Mckenzie, W. Kostuk, S. Carruthers, 1984, The American journal of cardiology.

Wolff-Parkinson-White Syndrome After Verapamil

G. Klein, S. Carruthers, S. Gulamhusein, 2005 .

Treatment of pruritus in primary biliary cirrhosis with rifampin. Results of a double-blind, crossover, randomized trial.

S. Carruthers, C. Ghent, S. Carruthers, 1988, Gastroenterology.

Interaction between oral verapamil and β‐blockers during submaximal exercise: Relevance of ancillary properties

D. Bailey, S. Carruthers, 1991, Clinical pharmacology and therapeutics.

Synergistic adverse hemodynamic interaction between oral verapamil and propranolol

D. Bailey, D. Freeman, S. Carruthers, 1989, Clinical pharmacology and therapeutics.

The Place of Angiotensin II Antagonists in Relation to the Canadian Hypertension Society Guidelines

S. Carruthers, 1998 .

Respiratory and cardiac effects of metoprolol and bevantolol in patients with asthma

Dildar Ahmad, S. Carruthers, P. Wilcox, 1986, Clinical pharmacology and therapeutics.

Variability in prescription drug utilization: issues for research.

A. Anis, J. Kierulf, A. Carter, 1996, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

Grapefuit Juice‐Felodipine Interaction in Healthy Seniors

G. Dresser, D. Bailey, S. Carruthers, 1999 .

Comparison of the electrophysiologic effects of intravenous and oral verapamil in patients with paroxysmal supraventricular tachycardia.

E. Prystowsky, G. Klein, A. Donner, 1982, The American journal of cardiology.

Verapamil in chronic atrial fibrillation: Variable patterns of response in ventricular rate

G. Klein, A. Donner, S. Carruthers, 1984, Clinical cardiology.

Panel Discussion 2

W. White, M. Myers, S. Carruthers, 1996, Practica oto-rhino-laryngologica. Suppl..

The 2012 Canadian hypertension education program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy.

Lawrence A Leiter, P. McFarlane, E. Schiffrin, 2012, The Canadian journal of cardiology.

Contrasts between pindolol and propranolol concentration-response relationships.

S. Carruthers, W. H. Aellig, W. Pacha, 1985, British journal of clinical pharmacology.

RELATIONSHIPS OF ORAL AND INTRAVENOUS PINDOLOL

S. Carruthers, 2006 .

Cardiac dose-response relationships of oral and intravenous pindolol.

S. Carruthers, 1982, British journal of clinical pharmacology.

Intrinsic heart rate on exercise and the measurement of beta-adrenoceptor blockade.

R. Shanks, D. Mcdevitt, S. Carruthers, 1976, British journal of clinical pharmacology.

Impaired enzyme induction by rifampicin in the elderly.

T. Finnigan, S. Carruthers, R. Cape, 1984, British journal of clinical pharmacology.

Nicorandil reduced coronary events in stable angina

S. Carruthers, 2002, ACP journal club.

Clinical Pharmacology of Pain

S. Carruthers, 1980 .

Creatinine elevation in patients receiving amiodarone correlates with serum amiodarone concentration.

S. Carruthers, P. Pollak, A. Sharma, 1993, British journal of clinical pharmacology.

Simplified liquid-chromotographic analysis for cyclosporin A, and comparison with radioimmunoassay.

A. Laupacis, P. Keown, C. Stiller, 1983, Clinical chemistry.

Evaluation of once daily endralazine in hypertension

J. Spence, S. Carruthers, R. Wu, 2004, European Journal of Clinical Pharmacology.

The Place of Alpha Blockers in the Antihypertensive Armamentarium

S. Carruthers, 1993, Journal of clinical pharmacology.

Quinidine-rifampin interaction.

S. Carruthers, Y. Twum-Barima, 1981, The New England journal of medicine.

Increased Venous Alpha-Adrenoceptor Responsiveness in Patients with Reflex Sympathetic Dystrophy

R. Teasell, S. Carruthers, J. Arnold, 1993, Annals of Internal Medicine.

The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy.

Simon L Bacon, Michael D Hill, Pierre Larochelle, 2010, The Canadian journal of cardiology.

Intrinsic heart rate on exercise and the measurement of β-adrenoceptor blockade

R. Shanks, D. Mcdevitt, S. Carruthers, 1976 .

Blood levels of practolol after oral and parenteral administration and their relationship to exercise heart rate

R. Shanks, S. Carruthers, D. McDevitt, 1974, Clinical pharmacology and therapeutics.

A secondary prevention, randomized trial of suloctidil in patients with a recent history of thromboembolic stroke.

H. Barnett, M. Gent, S. Collins, 1985, Stroke.

Kinetics of pamatolol, a cardioselective beta adrenoreceptor blocker

D. Azarnoff, S. Carruthers, P. Pentikainen, 1979, Clinical pharmacology and therapeutics.

Pamatolol: Phase I evaluation of the pharmacodynamics of a cardioselective beta adrenoceptor blocking drug

D. Azarnoff, S. Carruthers, P. Pentikainen, 1978, Clinical pharmacology and therapeutics.

Acceleration of the Ventricular Response During Atrial Fibrillation in the Wolff‐Parkinson‐White Syndrome After Verapamil

G. Klein, S. Carruthers, S. Gulamhusein, 1982, Circulation.

Adverse Effects of α1-Adrenergic Blocking Drugs

S. Carruthers, 1994 .

Adverse effects of alpha 1-adrenergic blocking drugs.

S. Carruthers, 1994, Drug safety.

Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects.

N. Nagelkerke, M. Nicholls, R. Reed, 2008, Diabetes research and clinical practice.

The 2014 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension.

Simon L Bacon, Michael D Hill, Pierre Larochelle, 2014, The Canadian journal of cardiology.

Plasma and tissue digoxin concentrations in patients undergoing cardiopulmonary bypass.

D. Mcdevitt, S. Carruthers, J. Kelly, 1975, British heart journal.

Plasma digoxin concentrations in patients on admission to hospital.

D. Mcdevitt, S. Carruthers, J. Kelly, 1974, British heart journal.

Report of the Canadian Hypertension Society Consensus Conference: 1. Introduction.

R. Haynes, E. Schiffrin, S. Carruthers, 1993, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

The 2011 Canadian Hypertension Education Program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy.

Simon L Bacon, Martin G Myers, Michael D Hill, 2011, The Canadian journal of cardiology.

The influence of age on dorsal hand vein responsiveness to norepinephrine.

S. Carruthers, S. A. Martin, S. Alexieva, 1987, Clinical pharmacology and therapeutics.

Influence of cardioselectivity and respiratory disease on pulmonary responsiveness to beta-blockade

S. Carruthers, H. Clague, D. Ahmad, 2004, European Journal of Clinical Pharmacology.

Ineffectiveness of beta‐adrenergic blockers on ventilatory response to carbon dioxide

S. Carruthers, J. T. Hamilton, D. Ahmad, 1982, Clinical pharmacology and therapeutics.

Prevalence of diabetes mellitus and its complications in a population-based sample in Al Ain, United Arab Emirates.

N. Nagelkerke, M. Agarwal, M. Nicholls, 2007, Diabetes research and clinical practice.

Correlation between plasma diphenhydramine level and sedative and antihistamine effects.

C. Hignite, D. Azarnoff, S. Carruthers, 1979, Clinical pharmacology and therapeutics.

Biliary excretion and enterohepatic recirculation of practolol in man

D. Mcdevitt, S. Carruthers, J. Kelly, 1976, Irish journal of medical science.

Relationships between heart rate and PR interval during physiological and pharmacological interventions.

S. Carruthers, R. Wu, S G Carruthers, 1987, British journal of clinical pharmacology.

Familial studies of heritability of α1‐adrenergic receptor responsiveness in superficial veins

S. Carruthers, A. Gupta, 1997, Clinical pharmacology and therapeutics.

Evaluation and application of the linear variable differential transformer technique for the assessment of human dorsal hand vein alpha‐receptor activity

S. Carruthers, S G Carruthers, A O Alradi, 1985, Clinical pharmacology and therapeutics.

Correlation between plasma diphenhydramine level and sedative and antihistamine effects

C. Hignite, D. Azarnoff, S. Carruthers, 1978 .

A double-blind, randomized trial of PY108-068 in acute ischemic cerebral infarction.

J. Bogousslavsky, V. Hachinski, H. Barnett, 1989, Stroke.

The diabetic hypertensive (or hypertensive diabetic)--a compelling need to optimize blood pressure.

S. Carruthers, 2001, Advances in experimental medicine and biology.

Correlation of reduction of exercise heart rate with blood levels of atenolol after oral and intravenous administration.

R. Shanks, D. Mcdevitt, S. Carruthers, 1977, Postgraduate medical journal.

Observations on the efficacy and pharmacokinetics of sotalol after oral administration

R. Shanks, D. Mcdevitt, S. Carruthers, 1976, European Journal of Clinical Pharmacology.

An audit of requests for therapeutic drug monitoring of digoxin: problems and pitfalls.

S. Carruthers, H. Clague, Y. Twum-Barima, 1983, Therapeutic drug monitoring.

Simplified liquid-chromatographic assay of amiodarone and desethylamiodarone after solid-phase extraction.

S. Carruthers, P. Pollak, D. Freeman, 1986, Clinical chemistry.

Xylazine hydrochloridine (Rompun) overdose in man.

C. Stiller, S. Carruthers, H. Wexler, 1979, Clinical toxicology.

Mean apical concentration and duration in the comparative bioavailability of slowly absorbed and eliminated drug preparations.

S. Carruthers, P. Pollak, D. Freeman, 1988, Journal of pharmaceutical sciences.

1999 Canadian recommendations for the management of hypertension. Task Force for the Development of the 1999 Canadian Recommendations for the Management of Hypertension.

R B Haynes, J S Floras, M G Myers, 1999, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

Quinidine interaction with nifedipine and felodipine: Pharmacokinetic and pharmacodynamic evaluation

B. Edgar, D. Bailey, D. Freeman, 1993, Clinical pharmacology and therapeutics.

The influence of age on dorsal hand vein responsiveness to norepinephrine

S. Carruthers, S. A. Martin, S. Alexieva, 1986 .

Simplified Liquid-ChromotographicAnalysis for Cyclosporin A, and Comparisonwith Radioimmunoassay

A. Laupacis, P. Keown, J. Freeman, 1983 .

Clinical problem solving based on the 1999 Canadian recommendations for the management of hypertension.

Lawrence A Leiter, A. Logan, R. Haynes, 1999, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

A study of efficacy, tolerance and compliance of once-daily versus twice-daily metoprolol (Betaloc) in hypertension. Betaloc Compliance Canadian Cooperative Study Group.

M. Baird, S. Carruthers, P. Larochelle, 1984, Clinical and investigative medicine. Medecine clinique et experimentale.

The 2014 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension.

Lawrence A Leiter, P. McFarlane, E. Schiffrin, 2014, The Canadian journal of cardiology.

Duration of action of beta-blocking drugs.

R. Shanks, D. Mcdevitt, S. Carruthers, 1973, British medical journal.

Elevation of serum total cholesterol and triglyceride levels during amiodarone therapy.

S. Carruthers, P. Pollak, A. Sharma, 1988, The American journal of cardiology.