H. Sintim

发表

Isothermal amplified detection of DNA and RNA.

Jie Zhou, Yue Zheng, Shizuka Nakayama, 2014, Molecular bioSystems.

Effects on membrane lateral pressure suggest permeation mechanisms for bacterial quorum signaling molecules.

W. Bentley, S. Sukharev, Varnika Roy, 2011, Biochemistry.

Fluorescence, Phosphorescence, and Chemiluminescence.

Tony E. Karam, C. D. Geddes, G. Patonay, 2016, Analytical chemistry.

Nucleic acid detection using G-quadruplex amplification methodologies

Benjamin T. Roembke, Shizuka Nakayama, H. Sintim, 2013, Methods.

Agents that inhibit bacterial biofilm formation.

Yue Zheng, H. Sintim, Nira Rabin, 2015, Future medicinal chemistry.

Multiple ways to kill bacteria via inhibiting novel cell wall or membrane targets.

George A. Naclerio, H. Sintim, 2020, Future medicinal chemistry.

Insightful directed evolution of Escherichia coli quorum sensing promoter region of the lsrACDBFG operon: a tool for synthetic biology systems and protein expression

Kristina T. Stephens, W. Bentley, M. Ostermeier, 2016, Nucleic acids research.

Biofilms as “Connectors” for Oral and Systems Medicine: A New Opportunity for Biomarkers, Molecular Targets, and Bacterial Eradication

U. Gürsoy, H. Sintim, 2016, Omics : a journal of integrative biology.

Dialkylamino-2,4-dihydroxybenzoic acids as easily synthesized analogues of platensimycin and platencin with comparable antibacterial properties.

H. Sintim, Jingxin Wang, 2011, Chemistry.

Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine.

E. Kool, H. Sintim, 2006, Journal of the American Chemical Society.

Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules.

Jie Zhou, Yue Zheng, H. Sintim, 2016, Chemical communications.

Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover

Vincent T. Lee, C. Waters, V. Lee, 2015, Proceedings of the National Academy of Sciences.

Identification of bromophenol thiohydantoin as an inhibitor of DisA, a c-di-AMP synthase, from a 1000 compound library, using the coralyne assay.

Jie Zhou, Yue Zheng, H. Sintim, 2014, Chemical communications.

Nonpolar nucleoside mimics as active substrates for human thymidine kinases.

E. Kool, S. Eriksson, H. Sintim, 2009, Journal of the American Chemical Society.

Structure–activity relationship studies of c-di-AMP synthase inhibitor, bromophenol-thiohydantoin

Jie Zhou, Yue Zheng, H. Sintim, 2016 .

“Rolling out” High‐Molecular‐Weight Proteins, which Contain Repeating Polypeptide Motif, by Using Rolling Circle Amplification

Yue Zheng, H. Sintim, 2013, Chembiochem : a European journal of chemical biology.

Antibacterial Small Molecules That Potently Inhibit Staphylococcus aureus Lipoteichoic Acid Biosynthesis

George A. Naclerio, H. Sintim, Clement Opoku-Temeng, 2019, ChemMedChem.

Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms

U. Gürsoy, M. Gürsoy, E. Könönen, 2017, Front. Cell. Infect. Microbiol..

Lipoteichoic Acid Biosynthesis Inhibitors as Potent Inhibitors of S. aureus and E. faecalis Growth and Biofilm Formation

George A. Naclerio, H. Sintim, K. Onyedibe, 2020, Molecules.

Hydroxybenzylidene-indolinones, c-di-AMP synthase inhibitors, have antibacterial and anti-biofilm activities and also re-sensitize resistant bacteria to methicillin and vancomycin

Neetu Dayal, H. Sintim, Jacob Miller, 2017 .

Interrupting cyclic dinucleotide-cGAS-STING axis with small molecules.

Modi Wang, H. Sintim, C. Mikek, 2019, MedChemComm.

Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides

Jie Zhou, U. Gürsoy, M. Gürsoy, 2018, Journal of oral microbiology.

Detection of single-stranded nucleic acids via colorimetric means, using G-quadruplex probes.

Shizuka Nakayama, H. Sintim, 2013, Methods in molecular biology.

Inhibitors of Intracellular Gram-positive Bacteria Growth Synthesized via Povarov-Doebner Reactions.

M. Zeller, Modi Wang, M. Seleem, 2019, ACS infectious diseases.

N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria.

M. Seleem, George A. Naclerio, Nader S. Abutaleb, 2018, European journal of medicinal chemistry.

Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding.

Jie Zhou, E. Lewis, Shizuka Nakayama, 2014, Molecular bioSystems.

Fluorescent analogs of cyclic and linear dinucleotides as phosphodiesterase and oligoribonuclease activity probes

Jie Zhou, Yue Zheng, Benjamin T. Roembke, 2017 .

Nicotinamide–Ponatinib Analogues as Potent Anti-CML and Anti-AML Compounds

H. Sintim, Elizabeth Larocque, Elizabeth Fei Yin Chu, 2020, ACS omega.

Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide

Jie Zhou, U. Gürsoy, M. Gürsoy, 2020, Pathogens.

DNA-based peroxidation catalyst--what is the exact role of topology on catalysis and is there a special binding site for catalysis?

Shizuka Nakayama, H. Sintim, Jingxin Wang, 2011, Chemistry.

A STING-based fluorescent polarization assay for monitoring activities of cyclic dinucleotide metabolizing enzymes

H. Sintim, Caroline W Karanja, Kofi S Yeboah, 2020, RSC chemical biology.

c-di-GMP Induces COX-2 Expression in Macrophages in a STING-Independent Manner.

Modi Wang, H. Sintim, Wilson W S Ong, 2021, ACS chemical biology.

STING Ligand c-di-GMP Improves Cancer Vaccination against Metastatic Breast Cancer

Jie Zhou, D. Karaolis, Y. Hayakawa, 2014, Cancer Immunology Research.

Nicotinamide-Ponatinib, HSN748, a Potent Anti-CML and Anti-AML Compound with Better Kinase Selectivity than Ponatinib

H. Sintim, Elizabeth Larocque, N. Naganna, 2018 .

Efforts towards the identification of simpler platensimycin analogues--the total synthesis of oxazinidinyl platensimycin.

V. Lee, H. Sintim, Jingxin Wang, 2009, Chemistry.

A concise total synthesis of (+/-)-1-epiaustraline.

T. Donohoe, H. Sintim, 2004, Organic letters.

An Efficient Synthesis of Lactacystinβ-Lactone

T. Donohoe, J. Harling, H. Sintim, 2004 .

An Efficient Synthesis of Lactacystin β‐Lactone

T. Donohoe, J. Harling, H. Sintim, 2004 .

Alkylation of lithiated dimethyl tartrate acetonide with unactivated alkyl halides and application to an asymmetric synthesis of the 2,8-dioxabicyclo[3.2.1]octane core of squalestatins/zaragozic acids

H. Sintim, D. M. Hodgson, Hamad H. Al Mamari, 2019, Beilstein journal of organic chemistry.

Synthesis of (-)-6,7-Dideoxysqualestatin H5 by Carbonyl Ylide Cycloaddition-Rearrangement and Cross-electrophile Coupling.

H. Sintim, D. M. Hodgson, Hamad H. Al Mamari, 2017, Organic letters.

Inhibition of cyclic diadenylate cyclase, DisA, by polyphenols

H. Sintim, Clement Opoku-Temeng, 2016, Scientific Reports.

Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin.

H. Sintim, Clement Opoku-Temeng, 2016, Chemical communications.

Berenil Binds Tightly to Parallel and Mixed Parallel/Antiparallel G-Quadruplex Motifs with Varied Thermodynamic Signatures

E. Lewis, Neetu Dayal, H. Sintim, 2018, ACS omega.

Alkyne-substituted diminazene as G-quadruplex binders with anticancer activities.

Jie Zhou, E. Lewis, Benjamin T. Roembke, 2016, European journal of medicinal chemistry.

Supramolecular polymer formation by cyclic dinucleotides and intercalators affects dinucleotide enzymatic processing

H. Szmacinski, Jie Zhou, Yue Zheng, 2016, Future science OA.

Evidence of magnetic isotope effects during thermochemical sulfate reduction

A. J. Kaufman, G. Cody, J. Farquhar, 2011, Proceedings of the National Academy of Sciences.

Isothermal detection of RNA with restriction endonucleases.

Lei Yan, Shizuka Nakayama, H. Sintim, 2011, Chemical communications.

Unraveling Curcumin Degradation

P. B. Luis, H. Sintim, C. Schneider, 2015, The Journal of Biological Chemistry.

Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase.

W. Bishai, G. Lamichhane, Jie Zhou, 2017, Nature chemical biology.

3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo.

V. Kryštof, P. Řezáčová, M. Lepšík, 2021, Journal of Medicinal Chemistry.

Identification of New FLT3 Inhibitors That Potently Inhibit AML Cell Lines via an Azo Click-It/Staple-It Approach.

G. Chopra, Xiaochu Ma, Jonathan A Fine, 2017, ACS medicinal chemistry letters.

Targeting Cyclic Dinucleotide Signaling with Small Molecules

H. Sintim, Clement Opoku-Temeng, 2020 .

Potent suppression of c-di-GMP synthesis via I-site allosteric inhibition of diguanylate cyclases with 2'-F-c-di-GMP.

Jie Zhou, V. Lee, S. Watt, 2013, Bioorganic & medicinal chemistry.

A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues.

Lei Yan, H. Sintim, I. Kiburu, 2008, Molecular bioSystems.

Discriminating cyclic from linear nucleotides - CRISPR/Cas-related cyclic hexaadenosine monophosphate as a case study.

Modi Wang, H. Sintim, 2019, Analytical biochemistry.

Inhibition of P. aeruginosa c-di-GMP phosphodiesterase RocR and swarming motility by a benzoisothiazolinone derivative† †Electronic supplementary information (ESI) available: All experimental, spectroscopic details and supplemental figures. See DOI: 10.1039/c6sc02103d

Yue Zheng, H. Sintim, Genichiro Tsuji, 2016, Chemical science.

STING Ligand cdi-GMP Improves Cancer Vaccination against Metastatic Breast Cancer

Jie Zhou, D. Karaolis, Y. Hayakawa, 2014 .

The difluorotoluene debate--a decade later.

E. Kool, H. Sintim, 2006, Chemical communications.

Remarkable sensitivity to DNA base shape in the DNA polymerase active site.

E. Kool, H. Sintim, 2006, Angewandte Chemie.

Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs.

H. Sintim, Jingxin Wang, Ryan Hudson, 2012, Future medicinal chemistry.

Construction and characterization of a multilayered gingival keratinocyte culture model: the TURK-U model

S. Syrjänen, V. Uitto, E. Könönen, 2016, Cytotechnology.

HSD1787, a Tetrahydro-3H-Pyrazolo[4,3-f]Quinoline Compound Synthesized via Povarov Reaction, Potently Inhibits Proliferation of Cancer Cell Lines at Nanomolar Concentrations

Modi Wang, Neetu Dayal, H. Sintim, 2020, ACS omega.

Comparative Studies to Uncover Mechanisms of Action of N-(1,3,4-Oxadiazol-2-yl)benzamide Containing Antibacterial Agents.

U. Aryal, George A. Naclerio, H. Sintim, 2022, ACS infectious diseases.

Squarate desymmetrisation–ozonolysis as an approach to β-substituted-α-ketosuccinates and squalestatin synthesis

H. Sintim, D. M. Hodgson, Anne Valade, 2019, Tetrahedron.

On the ozonolysis of unsaturated tosylhydrazones as a direct approach to diazocarbonyl compounds.

T. Claridge, H. Sintim, D. M. Hodgson, 2018, Organic & biomolecular chemistry.

A noncarbohydrate based approach to polyhydroxylated pyrrolidizines: total syntheses of the natural products hyacinthacine A1 and 1-epiaustraline.

T. Donohoe, H. Sintim, J. Hollinshead, 2005, The Journal of organic chemistry.

Remote C-H functionalization: using the N-O moiety as an atom-economical tether to obtain 1,5- and the rare 1,7-C-H insertions.

Deana Jaber, B. Štefane, H. Sintim, 2010, Angewandte Chemie.

Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules.

Lei Yan, Shizuka Nakayama, H. Sintim, 2010, Future medicinal chemistry.

Alkaloid Synthesis via Carbenoid Intermediates

Xiaochu Ma, H. Sintim, S. M. Cooper, 2015 .

Utility of the ammonia-free Birch reduction of electron-deficient pyrroles: total synthesis of the 20s proteasome inhibitor, clasto-lactacystin beta-lactone.

T. Donohoe, J. Harling, A. Cowley, 2005, Chemistry.

Small Molecule Inhibitors of AI-2 Signaling in Bacteria: State-of-the-Art and Future Perspectives for Anti-Quorum Sensing Agents

Yue Zheng, Herman O. Sintim, Sonja Gamby, 2013, International journal of molecular sciences.

N-O tethered carbenoid cyclopropanation facilitates the synthesis of a functionalized cyclopropyl-fused pyrrolidine.

H. Sintim, Min Guo, Dimpy Kalia, 2013, The Journal of organic chemistry.

Use of High-Throughput Tools for Telescoped Continuous Flow Synthesis of an Alkynylnaphthyridine Anticancer Agent, HSN608

Shruti A. Biyani, Qingqing Qi, Jingze Wu, 2020 .

Molecular fluorescence, phosphorescence, and chemiluminescence spectrometry.

G. Patonay, Susmita Das, I. Warner, 1988, Analytical chemistry.

Unexpected Complex Formation between Coralyne and Cyclic Diadenosine Monophosphate Providing a Simple Fluorescent Turn-on Assay to Detect This Bacterial Second Messenger

H. Szmacinski, Jie Zhou, Yue Zheng, 2014, Analytical chemistry.

Biofilm formation mechanisms and targets for developing antibiofilm agents.

Yue Zheng, H. Sintim, Nira Rabin, 2015, Future medicinal chemistry.

Proteomic analysis of bacterial response to a 4-hydroxybenzylidene indolinone compound, which re-sensitizes bacteria to traditional antibiotics.

U. Aryal, H. Sintim, Clement Opoku-Temeng, 2019, Journal of proteomics.

Dipeptidyl peptidase IV and quorum sensing signaling in biofilm-related virulence of Prevotella aurantiaca.

Xiaochu Ma, M. Peurla, E. Söderling, 2017, Anaerobe.

Targeting c-di-GMP Signaling, Biofilm Formation, and Bacterial Motility with Small Molecules.

H. Sintim, Clement Opoku-Temeng, 2017, Methods in molecular biology.

Evidence of link between quorum sensing and sugar metabolism in Escherichia coli revealed via cocrystal structures of LsrK and HPr

Kristina T. Stephens, W. Bentley, Xiaochu Ma, 2018, Science Advances.

Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis.

Jie Zhou, Yiling Luo, Yue Zheng, 2013, Chemical Society reviews.

ENPP1, an Old Enzyme with New Functions, and Small Molecule Inhibitors—A STING in the Tale of ENPP1

Modi Wang, H. Sintim, K. Onyedibe, 2019, Molecules.

Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine.

E. Kool, H. Sintim, 2006, Journal of the American Chemical Society.

Conservative change to the phosphate moiety of cyclic diguanylic monophosphate remarkably affects its polymorphism and ability to bind DGC, PDE, and PilZ proteins.

Jie Zhou, V. Lee, G. P. Donaldson, 2011, Journal of the American Chemical Society.

A C-di-GMP-proflavine-hemin supramolecular complex has peroxidase activity--implication for a simple colorimetric detection.

V. Lee, Shizuka Nakayama, H. Sintim, 2012, Molecular bioSystems.

Bacterial Secretions of Nonpathogenic Escherichia coli Elicit Inflammatory Pathways: a Closer Investigation of Interkingdom Signaling

W. Bentley, G. Payne, D. Quan, 2015, mBio.

Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions

V. Lee, H. Sintim, Jingxin Wang, 2011, Proceedings of the National Academy of Sciences.

Colorimetric split G-quadruplex probes for nucleic acid sensing: improving reconstituted DNAzyme's catalytic efficiency via probe remodeling.

Shizuka Nakayama, Shizuka Nakayama, H. Sintim, 2009, Journal of the American Chemical Society.

Junction probes - sequence specific detection of nucleic acids via template enhanced hybridization processes.

Herman O. Sintim, Shizuka Nakayama, Lei Yan, 2008, Journal of the American Chemical Society.

Dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations potently inhibits acute myeloid leukemia cell lines

Neetu Dayal, H. Sintim, R. Lapidus, 2018, Future medicinal chemistry.

Aminoisoquinoline benzamides, FLT3 and Src-family kinase inhibitors, potently inhibit proliferation of acute myeloid leukemia cell lines.

G. Chopra, Xiaochu Ma, H. Sintim, 2017, Future medicinal chemistry.

RET aberrant cancers and RET inhibitor therapies: Current state-of-the-art and future perspectives.

A. Addeo, Sendurai A Mani, P. den Hollander, 2023, Pharmacology & therapeutics.

Homologous quorum sensing regulatory circuit (hQSRC): A dual-input genetic controller for modulating quorum sensing (QS)-mediated protein expression in E. coli.

Kristina T. Stephens, W. Bentley, Eric VanArsdale, 2020, ACS synthetic biology.

Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant Gram-positive bacteria.

M. Seleem, George A. Naclerio, Nader S. Abutaleb, 2020, RSC medicinal chemistry.

Nanomolar fluorescent detection of c-di-GMP using a modular aptamer strategy.

Jie Zhou, Shizuka Nakayama, Jie Zhou, 2012, Chemical communications.

Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels.

Modi Wang, H. Sintim, Clement Opoku-Temeng, 2018, Future medicinal chemistry.

Zwitterionic liquid crystalline polythiophene as an antibiofouling biomaterial.

Jian Xu, Hyowon Lee, H. Sintim, 2020, Journal of materials chemistry. B.

Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice

Modi Wang, B. Elzey, H. Sintim, 2019, EBioMedicine.

AI-2 analogs and antibiotics: a synergistic approach to reduce bacterial biofilms

Reza Ghodssi, Mariana T. Meyer, William E. Bentley, 2012, Applied Microbiology and Biotechnology.

Crystal structures of the LsrR proteins complexed with phospho-AI-2 and two signal-interrupting analogues reveal distinct mechanisms for ligand recognition.

Kyoung-Seok Ryu, William E Bentley, Alexander Grishaev, 2013, Journal of the American Chemical Society.

Altering the communication networks of multispecies microbial systems using a diverse toolbox of AI-2 analogues.

William E Bentley, Sonja Gamby, Jingxin Wang, 2012, ACS chemical biology.

Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor.

Neetu Dayal, H. Sintim, Clement Opoku-Temeng, 2018, Chemical communications.

Synthetic analogs tailor native AI-2 signaling across bacterial species.

W. Bentley, J. E. Stewart, Varnika Roy, 2010, Journal of the American Chemical Society.

A rapid assay for affinity and kinetics of molecular interactions with nucleic acids

Yiling Luo, V. Lee, G. P. Donaldson, 2011, Nucleic acids research.

Bacterial Cyclic Dinucleotides and the cGAS–cGAMP–STING Pathway: A Role in Periodontitis?

U. Gürsoy, M. Gürsoy, E. Könönen, 2021, Pathogens.

Antibiotics That Disrupt Cell Wall and Bacterial Membrane Formation and Integrity

H. Sintim, J. Wang, 2014 .

Cyclic dinucleotide detection with riboswitch-G-quadruplex hybrid.

H. Sintim, Genichiro Tsuji, 2016, Molecular bioSystems.

A cyclic dinucleotide containing 2-aminopurine is a general fluorescent sensor for c-di-GMP and 3',3'-cGAMP.

Jie Zhou, Yue Zheng, Benjamin T. Roembke, 2014, Molecular bioSystems.

Quorum sensing molecules regulate epithelial cytokine response and biofilm-related virulence of three Prevotella species.

Xiaochu Ma, U. Gürsoy, M. Gürsoy, 2018, Anaerobe.

Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp Signaling in Bacteria and Implications in Pathogenesis

Jie Zhou, Yue Zheng, Herman O. Sintim, 2013 .

c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators.

Ilana Kelsey, Shizuka Nakayama, H. Sintim, 2011, Chemical communications.

Isoquinoline Antimicrobial Agent: Activity against Intracellular Bacteria and Effect on Global Bacterial Proteome

M. Seleem, U. Aryal, Nader S. Abutaleb, 2022, Molecules.

Ligand-Based Stability Changes in Duplex DNA Measured with a Microscale Electrochemical Platform

Jon R. Askim, S. Semancik, H. Sintim, 2019, Biosensors.

Cyclic Dinucleotide (c‐di‐GMP, c‐di‐AMP, and cGAMP) Signalings Have Come of Age to Be Inhibited by Small Molecules

Yue Zheng, H. Sintim, Jie-Xing Zhou, 2016 .

Investigating the interactions between cations, peroxidation substrates and G-quadruplex topology in DNAzyme peroxidation reactions using statistical testing.

Shizuka Nakayama, H. Sintim, 2012, Analytica chimica acta.

Proteomic analysis of RAW macrophages treated with cGAMP or c-di-GMP reveals differentially activated cellular pathways

U. Aryal, U. Gursoy, H. Sintim, 2018, RSC advances.

One-step Large-scale Nanotexturing of Non-planar PTFE Surfaces to Induce Bactericidal and Anti-inflammatory Properties.

Hyowon Lee, H. Sintim, T. Fischer, 2020, ACS applied materials & interfaces.

E88, a new cyclic-di-GMP class I riboswitch aptamer from Clostridium tetani, has a similar fold to the prototypical class I riboswitch, Vc2, but differentially binds to c-di-GMP analogs.

Jie Zhou, Yiling Luo, H. Sintim, 2014, Molecular bioSystems.

N-(1,3,4-Oxadiazol-2-yl)Benzamides as Antibacterial Agents against Neisseria gonorrhoeae

M. Seleem, George A. Naclerio, Nader S. Abutaleb, 2021, International journal of molecular sciences.

Global Proteomic Analyses of STING‐Positive and ‐Negative Macrophages Reveal STING and Non‐STING Differentially Regulated Cellular and Molecular Pathways

Modi Wang, U. Aryal, T. Sobreira, 2020, Proteomics. Clinical applications.

Octameric G8 c-di-GMP is an efficient peroxidase and this suggests that an open G-tetrad site can effectively enhance hemin peroxidation reactions

Benjamin T. Roembke, Shizuka Nakayama, H. Sintim, 2013 .

Synthesis of a biotinylated photocleavable nucleotide monophosphate for the preparation of natively folded RNAs.

Yiling Luo, H. Sintim, T. Dayie, 2014, Methods in enzymology.

RNAs synthesized using photocleavable biotinylated nucleotides have dramatically improved catalytic efficiency

Yiling Luo, H. Sintim, N. V. Eldho, 2011, Nucleic acids research.

Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors.

George A. Naclerio, Neetu Dayal, H. Sintim, 2019, European journal of medicinal chemistry.

Alkynylnicotinamide‐Based Compounds as ABL1 Inhibitors with Potent Activities against Drug‐Resistant CML Harboring ABL1(T315I) Mutant Kinase

H. Sintim, Clement Opoku-Temeng, Elizabeth Larocque, 2018, ChemMedChem.

Biomolecule detection with peroxidase-mimicking DNAzymes; expanding detection modality with fluorogenic compounds.

Shizuka Nakayama, H. Sintim, 2009, Molecular bioSystems.

Membrane Affinity of Platensimycin and Its Dialkylamine Analogs

S. Sukharev, H. Sintim, I. Rowe, 2015, International journal of molecular sciences.

Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP.

Ilana Kelsey, Shizuka Nakayama, H. Sintim, 2012, Bioorganic & medicinal chemistry letters.

Rapid nucleic acid melting analyses using a microfabricated electrochemical platform.

Steve Semancik, S. Semancik, H. Sintim, 2015, Analytica chimica acta.

Identification of nicotinamide aminonaphthyridine compounds as potent RET kinase inhibitors and antitumor activities against RET rearranged lung adenocarcinoma.

Modi Wang, H. Sintim, N. Naganna, 2019, Bioorganic chemistry.

SF5- and SCF3-substituted tetrahydroquinoline compounds as potent bactericidal agents against multidrug-resistant persister Gram-positive bacteria.

Neetu Dayal, H. Sintim, K. Onyedibe, 2021, RSC Medicinal Chemistry.

Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP

U. Aryal, U. Gürsoy, E. Könönen, 2021, Journal of oral microbiology.

Ultrapotent inhibitor of Clostridioides difficile growth, which suppresses recurrence in vivo.

M. Seleem, George A. Naclerio, Nader S. Abutaleb, 2020, Journal of medicinal chemistry.

Re-sensitization of Multidrug-Resistant and Colistin-Resistant Gram-Negative Bacteria to Colistin by Povarov/Doebner-Derived Compounds.

R. Melander, C. Melander, R. Ernst, 2023, ACS infectious diseases.

Convenient detection of HPV virus in a clinical sample using concurrent rolling circle and junction probe amplifications.

Lei Yan, H. Sintim, Kai-Jian Liu, 2014, Chemical communications.

Signal-on electrochemical Y or junction probe detection of nucleic acid.

S. Semancik, Shizuka Nakayama, H. Sintim, 2012, Chemical communications.

AI-2 analogs and antibiotics: a synergistic approach to reduce bacterial biofilms

W. Bentley, R. Ghodssi, Varnika Roy, 2013, Applied Microbiology and Biotechnology.

The Difluorotoluene Debate — A Decade Later

E. Kool, H. Sintim, 2007 .

Computational understanding and experimental characterization of twice-as-smart quadruplex ligands as chemical sensors of bacterial nucleotide second messengers

Jie Zhou, C. Fonseca Guerra, G. Paragi, 2016, Scientific Reports.

Zwitterionic Porous Conjugated Polymers as a Versatile Platform for Antibiofouling Implantable Bioelectronics.

Hyowon Lee, H. Sintim, Jinjia Xu, 2020, ACS applied polymer materials.

Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous.

Vincent Lee, Jingxin Wang, V. Lee, 2009, Chemical communications.

Evolved Quorum sensing regulator, LsrR, for altered switching functions.

William E Bentley, Hsuan-Chen Wu, Chen-Yu Tsao, 2014, ACS Synthetic Biology.

Differential binding of 2'-biotinylated analogs of c-di-GMP with c-di-GMP riboswitches and binding proteins.

Jie Zhou, Yiling Luo, V. Lee, 2012, Molecular bioSystems.

Identification of a Mycobacterium tuberculosis Cyclic Dinucleotide Phosphodiesterase Inhibitor.

H. Sintim, Caroline W Karanja, Kofi S Yeboah, 2021, ACS infectious diseases.

Thiazole orange-induced c-di-GMP quadruplex formation facilitates a simple fluorescent detection of this ubiquitous biofilm regulating molecule.

Ilana Kelsey, Yiling Luo, V. Lee, 2011, Journal of the American Chemical Society.

Quorum‐sensing molecule dihydroxy‐2,3‐pentanedione and its analogs as regulators of epithelial integrity

S. Syrjänen, E. Könönen, U. Gursoy, 2018, Journal of periodontal research.

3-Aminooxazolidinone AHL analogs as hydrolytically-stable quorum sensingagonists in Gram-negative bacteria

Xiaochu Ma, Yue Zheng, H. Sintim, 2015 .

A Pro-Drug Approach for Selective Modulation of AI-2-Mediated Bacterial Cell-to-Cell Communication

Min Guo, Jacqueline Smith, Sonja Gamby, 2012, Sensors.

Endo-S-c-di-GMP Analogues-Polymorphism and Binding Studies with Class I Riboswitch

Jie Zhou, H. Sintim, Jingxin Wang, 2012, Molecules.

3H-pyrazolo[4,3-f]quinoline haspin kinase inhibitors and anticancer properties.

Neetu Dayal, H. Sintim, Clement Opoku-Temeng, 2018, Bioorganic chemistry.

Autoinducer-2 analogs and electric fields - an antibiotic-free bacterial biofilm combination treatment

W. Bentley, R. Ghodssi, K. Gerasopoulos, 2016, Biomedical microdevices.

Autoinducer-2 analogs and electric fields - an antibiotic-free bacterial biofilm combination treatment

W. Bentley, R. Ghodssi, K. Gerasopoulos, 2016, Biomedical Microdevices.

Geminal dihalogen isosteric replacement in hydrated AI-2 affords potent quorum sensing modulators.

W. Bentley, Yue Zheng, H. Sintim, 2015, Chemical communications.

Molecular fluorescence, phosphorescence, and chemiluminescence spectrometry.

G. Patonay, I. Warner, R. Strongin, 1988, Analytical Chemistry.

A bacterial biofilm combination treatment using a real-time microfluidic platform

W. Bentley, R. Ghodssi, K. Gerasopoulos, 2015, 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS).

Effects on membrane lateral pressure suggest permeation mechanisms for bacterial quorum signaling molecules.

W. Bentley, S. Sukharev, Varnika Roy, 2011, Biochemistry.

Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis.

Jie Zhou, Yiling Luo, Yue Zheng, 2013, Chemical Society reviews.

Thiazole orange-induced c-di-GMP quadruplex formation facilitates a simple fluorescent detection of this ubiquitous biofilm regulating molecule.

Ilana Kelsey, Yiling Luo, V. Lee, 2011, Journal of the American Chemical Society.

Unraveling Curcumin Degradation

H. Sintim, C. Schneider, Odaine N. Gordon, 2015, The Journal of Biological Chemistry.

Miniaturized whole-cell bacterial bioreporter assay for identification of quorum sensing interfering compounds.

Xiaochu Ma, Polina Ilina, H. Sintim, 2018, Journal of microbiological methods.

A REAL-TIME BACTERIAL BIOFILM CHARACTERIZATION PLATFORM USING A MICROFLUIDIC SYSTEM

W. Bentley, R. Ghodssi, H. Sintim, 2014 .

Global proteomics insights for a novel small compound targeting the non-integrin Laminin Receptor in a macrophage cell model

T. Lescun, Manoel Figueiredo Neto, M. Figueiredo, 2023, Frontiers in Drug Discovery.

A concise total synthesis of (+/-)-1-epiaustraline.

T. Donohoe, H. Sintim, 2004, Organic letters.

Alkynyl nicotinamides show antileukemic activity in drug-resistant acute myeloid leukemia

U. Aryal, Baskar Ramdas, R. Kapur, 2024, The Journal of clinical investigation.

Non-kinase off-target inhibitory activities of clinically-relevant kinase inhibitors.

H. Sintim, Delmis E Hernandez, Nickolas R Brauer, 2024, European journal of medicinal chemistry.

Chloride Homeostasis Regulates cGAS-STING Signaling

Costel C. Darie, H. Sintim, Danielle Whitham, 2024, bioRxiv.

N-O tethered carbenoid cyclopropanation facilitates the synthesis of a functionalized cyclopropyl-fused pyrrolidine.

H. Sintim, Min Guo, Dimpy Kalia, 2013, The Journal of organic chemistry.