L. Warnich

发表

Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans

N. Mulder, A. Choudhury, M. Ramsay, 2017, Nature Communications.

Introduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study

G. Wright, A. Gaedigk, M. Pepper, 2013, BMC Medical Genetics.

Evaluation of predictive CYP2C19 genotyping assays relative to measured phenotype in a South African cohort.

G. Wright, M. Pepper, B. Drögemöller, 2015, Pharmacogenomics.

Variation within voltage-gated calcium channel genes and antipsychotic treatment response in a South African first episode schizophrenia cohort

A. Malhotra, R. Emsley, T. Lencz, 2018, The Pharmacogenomics Journal.

Towards an Ecology of Collective Innovation: Human Variome Project (HVP), Rare Disease Consortium for Autosomal Loci (RaDiCAL) and Data-Enabled Life Sciences Alliance (DELSA).

Yann Joly, Eugene Kolker, Emmanuelle Vaast, 2011, Current pharmacogenomics and personalized medicine.

Public Health Pharmacogenomics and the Design Principles for Global Public Goods - Moving Genomics to Responsible Innovation.

L. Ferguson, M. Masellis, V. Manolopoulos, 2013, Current pharmacogenomics and personalized medicine.

CPPM 2013 Onward: Building a Socio-Technical GPS for Global Personalized Medicine - A Welcome to Editors-In-Chief Adrián LLerena (Spain) and Ross A. McKinnon (Australia)

D. Gurwitz, L. Ferguson, M. Masellis, 2013 .

In silico promoters: modelling of cis-regulatory context facilitates target predictio

M. Venter, L. Warnich, Mauritz Venter, 2008, Journal of cellular and molecular medicine.

Toward a Global Roadmap for Precision Medicine in Psychiatry: Challenges and Opportunities.

Dan J Stein, C. Nievergelt, S. Dalvie, 2016, Omics : a journal of integrative biology.

Modification of the association between antipsychotic treatment response and childhood adversity by MMP9 gene variants in a first-episode schizophrenia cohort

R. Emsley, K. O’Connell, L. Warnich, 2018, Psychiatry Research.

Lack of clinical manifestation of hereditary haemochromatosis in South African patients with multiple sclerosis

M. Kotze, J. Carr, J. D. de Villiers, 2006, Metabolic Brain Disease.

Molecular diagnosis of hereditary hemochromatosis: application of a newly‐developed reverse‐hybridization assay in the South African population

C. Oberkanins, J. D. de Villiers, L. Warnich, 2004, Clinical genetics.

Significance of novel endothelin-B receptor gene polymorphisms in Hirschsprung's disease: predominance of a novel variant (561C/T) in patients with co-existing Down's syndrome.

S. Moore, M. Kotze, L. Warnich, 2003, Molecular and cellular probes.

Association between the MnSOD Ala-9Val polymorphism and development of schizophrenia and abnormal involuntary movements in the Xhosa population

J. Deleuze, W. C. Botes, D. Niehaus, 2007, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

CYP2B6*6 and CYP2B6*18 Predict Long-Term Efavirenz Exposure Measured in Hair Samples in HIV-Positive South African Women.

G. Wright, B. Drögemöller, L. van der Merwe, 2016, AIDS research and human retroviruses.

Toward More Transparent and Reproducible Omics Studies Through a Common Metadata Checklist and Data Publications

Lennart Martens, Stefano Toppo, Geoffrey C. Fox, 2013, Big Data.

Molecular characterisation mutation in exon 8 of the lipoprotein receptor gene of a low-frequency human low-density

M. Kotze, Á., L. Warnich, 2022 .

Two novel point mutations causing receptor-negative familial hypercholesterolemia in a South African Indian homozygote.

D. Rubinsztein, A. Marais, M. Kotze, 1996, Atherosclerosis.

Extended haplotype studies in South African and Dutch variegate porphyria families carrying the recurrent p.R59W mutation confirm a common ancestry

P. Steijlen, B. Drögemöller, J. Frank, 2012, The British journal of dermatology.

Molecular characterisation of a low-frequency mutation in exon 8 of the human low-density lipoprotein receptor gene.

M. Kotze, L. Warnich, E. Langenhoven, 1989, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

The molecular basis and diagnosis of familial hypercholesterolaemia in South African Afrikaners

M. Kotze, L. Warnich, E. Langenhoven, 1991, Annals of human genetics.

Morphological and molecular identification of economically important Tortricidae (Lepidoptera) on deciduous fruit tree crops in South Africa

L. Warnich, A. Timm, H. Geertsema, 2008 .

A call for pharmacogenovigilance and rapid falsification in the age of big data: why not first road test your biomarker?

M. Hutz, L. Endrenyi, G. Patrinos, 2014, Omics : a journal of integrative biology.

Molecular analysis reveals a high mutation frequency in the first untranslated exon of the PPOX gene and largely excludes variegate porphyria in a subset of clinically affected Afrikaner families.

J. Groenewald, M. Kotze, O. Loubser, 1998, Molecular and cellular probes.

Expression of the SLC11A1 (NRAMP1) 5'-(GT)n repeat: opposite effect in the presence of -237C-->T.

K. Robson, M. Kotze, L. Warnich, 2004, Blood cells, molecules & diseases.

Analysis of viral and genetic factors in South African patients with multiple sclerosis

M. Kotze, J. Carr, J. D. de Villiers, 2006, Metabolic Brain Disease.

The Potential Role of Regulatory Genes (DNMT3A, HDAC5, and HDAC9) in Antipsychotic Treatment Response in South African Schizophrenia Patients

R. Emsley, S. Seedat, K. O’Connell, 2019, Front. Genet..

A comparative assessment of DNA fingerprinting techniques (RAPD, ISSR, AFLP and SSR) in tetraploid potato (Solanum tuberosum L.) germplasm

C. McGregor, L. Warnich, C. Lambert, 2000, Euphytica.

Reactions, beliefs and concerns associated with providing hair specimens for medical research among a South African sample: a qualitative approach.

M. Tomlinson, B. Coetzee, A. Kagee, 2012, Future virology.

Variegate porphyria in Western Australian Aboriginal patients

J. Beilby, E. Rossi, L. Warnich, 2002, Internal medicine journal.

Morphological and molecular identification of economically important Tortricidae (Lepidoptera) on tropical and subtropical fruit in South Africa

L. Warnich, A. Timm, H. Geertsema, 2007 .

Gene Flow Among Cydia pomonella (Lepidoptera: Tortricidae) Geographic and Host Populations in South Africa

L. Warnich, A. Timm, H. Geertsema, 2006 .

Cytochrome P450 pharmacogenetics in African populations

M. Pepper, L. Warnich, T. Dodgen, 2013, Drug metabolism reviews.

Pharmacogenetics of Antiretroviral Drug Response and Pharmacokinetic Variations in Indigenous South African Populations.

K. O’Connell, C. Dandara, L. Warnich, 2018, Omics : a journal of integrative biology.

Pharmacogenomic Research in South Africa: Lessons Learned and Future Opportunities in the Rainbow Nation

M. Pepper, B. Drögemöller, C. Dandara, 2011, Current pharmacogenomics and personalized medicine.

A systematic review of genetic variants associated with metabolic syndrome in patients with schizophrenia

R. Emsley, S. Seedat, S. Bardien, 2016, Schizophrenia Research.

Mapping of the variegate porphyria (VP) gene: Contradictory evidence for linkage between VP and microsatellite markers at chromosome 14q32

P. Meissner, C. V. Heerden, R. Hift, 1996, Human Genetics.

Psychiatric genetics in South Africa: cutting a rough diamond.

B. Drögemöller, D. Niehaus, L. Koen, 2011, African journal of psychiatry.

Whole-genome resequencing in pharmacogenomics: moving away from past disparities to globally representative applications.

R. Emsley, B. Drögemöller, D. Niehaus, 2011, Pharmacogenomics.

The genetic architecture of schizophrenia, bipolar disorder, obsessive-compulsive disorder and autism spectrum disorder

R. Emsley, C. Lochner, K. O’Connell, 2018, Molecular and Cellular Neuroscience.

Identification of a novel functional deletion variant in the 5'-UTR of the DJ-1 gene

S. Bardien, L. van der Merwe, J. Carr, 2009, BMC Medical Genetics.

Toward more transparent and reproducible omics studies through a common metadata checklist and data publications.

Lennart Martens, Doron Lancet, Dmitrij Frishman, 2014, Omics : a journal of integrative biology.

DNA methylation and antipsychotic treatment mechanisms in schizophrenia: Progress and future directions

R. Emsley, L. Warnich, N. McGregor, 2018, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

An Appeal to the Global Health Community for a Tripartite Innovation: An "Essential Diagnostics List," "Health in All Policies," and "See-Through 21(st) Century Science and Ethics".

Wei Wang, E. Kolker, E. Vayena, 2015, Omics : a journal of integrative biology.

Genetic diversity of woolly apple aphid Eriosoma lanigerum (Hemiptera: Aphididae) populations in the Western Cape, South Africa

K. Pringle, L. Warnich, A. Timm, 2005, Bulletin of Entomological Research.

Population genetic structure of economically important Tortricidae (Lepidoptera) in South Africa: a comparative analysis

L. Warnich, A. Timm, H. Geertsema, 2009, Bulletin of Entomological Research.

Association study in three different populations between the GPR88 gene and major psychoses

R. Ebstein, J. Mallet, C. Dib, 2013, Molecular genetics & genomic medicine.

Patterns of variation influencing antipsychotic treatment outcomes in South African first-episode schizophrenia patients.

A. Malhotra, R. Emsley, L. van der Merwe, 2014, Pharmacogenomics.

Regional localization of alpha-galactosidase (GLA) to Xpter----q22, hexosaminidase B (HEXB) to 5q13----qter, and arylsulfatase B (ARSB) to 5pter----q13.

M. Fox, L. Warnich, A. Retief, 1984, Cytogenetics and cell genetics.

Dinucleotide repeat polymorphism at the D5S99 locus on chromosome 5q33–34

L. Warnich, A. Retief, I. Groenewald, 1995, Human Genetics.

An anonymous DNA probe E141 (D5S99) on chromosome 5 detects an EcoRI polymorphism.

E. Dietzsch, L. Warnich, J. Herbert, 1990, Nucleic acids research.

Considerations for rare variants in drug metabolism genes and the clinical implications

B. Drögemöller, L. Warnich, Galen E. B. Wright, 2014, Expert opinion on drug metabolism & toxicology.

A pharmacogenetic study of CD4 recovery in response to HIV antiretroviral therapy in two South African population groups

S. Gebhardt, L. Warnich, J. Parathyras, 2009, Journal of Human Genetics.

A microsatellite-based index map of human chromosome 11.

J. Weber, Z. Wang, P. Kramer, 1993, Human molecular genetics.

Linkage disequilibrium analysis in a recently founded population: evaluation of the variegate porphyria founder in South African Afrikaners.

J. Groenewald, L. Warnich, I. Groenewald, 1998, American journal of human genetics.

Overrepresentation of the founder PPOX gene mutation R59W in a South African patient with severe clinical manifestation of porphyria

M. Kotze, J. Frank, J. D. de Villiers, 2005, Experimental dermatology.

Genetic research, behavioural science, and child and adolescent mental health in South Africa: an important new agenda

L. Swartz, M. Tomlinson, L. Warnich, 2008, Journal of child and adolescent mental health.

Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload

K. Robson, M. Kotze, S. Merwe, 2004, Human Genetics.

The −237C→T promoter polymorphism of the SLC11A1 gene is associated with a protective effect in relation to inflammatory bowel disease in the South African population

M. Kotze, L. Warnich, T. Winter, 2006, International Journal of Colorectal Disease.

Association of functional polymorphisms of SLC11A1 with risk of esophageal cancer in the South African Colored population.

T. Victor, M. Kotze, L. Warnich, 2005, Cancer genetics and cytogenetics.

Functional analysis of the 5' regulatory region of the 5-aminolevulinate synthase (ALAS1) gene in response to estrogen.

L. van der Merwe, L. Warnich, A. Sadie, 2009, Cellular and molecular biology.

Chromosome 22q11 in a Xhosa schizophrenia population.

R. Emsley, D. Niehaus, L. Koen, 2012, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

MOLECULAR GENETIC STUDIES ON PEARS (PYRUS SPP.) IN THE WESTERN CAPE

D. Rees, R. Maharaj, L. Warnich, 2005 .

Analysis of the three common mutations in the CARD15 gene (R702W, G908R and 1007fs) in South African colored patients with inflammatory bowel disease.

M. Kotze, L. Warnich, T. Winter, 2005, Molecular and cellular probes.

Predictors of abnormal involuntary movement in an african schizophrenia population.

R. Emsley, D. Niehaus, L. Koen, 2008, The Journal of neuropsychiatry and clinical neurosciences.

Forward Look: Tenth Anniversary of the Human Genome Sequence and 21 Century Postgenomics Global Health - A Close Up on Africa and Women's Health.

Yann Joly, Vural Ozdemir, Sandipan Ray, 2011, Current pharmacogenomics and personalized medicine.

H3Africa and the African life sciences ecosystem: building sustainable innovation.

C. Masimirembwa, I. Okpechi, Farah Huzair, 2014, Omics : a journal of integrative biology.

Bernard Lerer: recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine (Pacific Rim Association for Clinical Pharmacogenetics).

E. Hafen, E. Kolker, E. Vayena, 2014, Omics : a journal of integrative biology.

An anonymous human single copy genomic clone, D5S6 (M4) on chromosome 5 identifies a three allele RFLP.

M. Fox, E. Dietzsch, J. Fricke, 1986, Nucleic acids research.

Translating biotechnology to knowledge-based innovation, peace, and development? Deploy a Science Peace Corps--an open letter to world leaders.

Türkay Dereli, Laszlo Endrenyi, Nicola Luigi Bragazzi, 2014, Omics : a journal of integrative biology.

The identification of novel genetic variants associated with antipsychotic treatment response outcomes in first-episode schizophrenia patients

A. Malhotra, R. Emsley, D. Robinson, 2016, Pharmacogenetics and genomics.

An exon 4 mutation identified in the majority of South African familial hypercholesterolaemics.

M. Kotze, L. Warnich, E. Langenhoven, 1990, Journal of medical genetics.

Fine-mapping of antipsychotic response genome-wide association studies reveals novel regulatory mechanisms.

R. Emsley, B. Drögemöller, L. van der Merwe, 2017, Pharmacogenomics.

Elucidation of CYP2D6 Genetic Diversity in a Unique African Population: Implications for the Future Application of Pharmacogenetics in the Xhosa Population

A. Gaedigk, B. Drögemöller, D. Niehaus, 2010, Annals of human genetics.

Variation within voltage-gated calcium channel genes and antipsychotic treatment response in a South African first episode schizophrenia cohort

A. Malhotra, R. Emsley, T. Lencz, 2018, The Pharmacogenomics Journal.

Next-generation sequencing of pharmacogenes: a critical analysis focusing on schizophrenia treatment

R. Emsley, B. Drögemöller, D. Niehaus, 2013, Pharmacogenetics and genomics.

The identification of two low-density lipoprotein receptor gene mutations in South African familial hypercholesterolaemia.

M. Kotze, L. Warnich, E. Langenhoven, 1989, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Highly informative dinucleotide repeat polymorphism at the D11S29 locus on chromosome 11q23

L. Warnich, L. Theart, A. Retief, 1992, Human Genetics.

An anonymous human single copy genomic clone, D11S29 (L7) at 11q23, identifies a moderately frequent RFLP.

M. Fox, E. Dietzsch, M. Kotze, 1986, Nucleic acids research.

Characterization of the genetic profile of CYP2C19 in two South African populations.

S. Malan, B. Drögemöller, D. Niehaus, 2010, Pharmacogenomics.

End of the Beginning and Public Health Pharmacogenomics: Knowledge in 'Mode 2' and P5 Medicine.

Vural Ozdemir, Erik Fisher, Edward S Dove, 2012, Current pharmacogenomics and personalized medicine.

M102 VARIATION IN VOLTAGE-GATED CALCIUM CHANNEL GENES IS ASSOCIATED WITH ANTIPSYCHOTIC TREATMENT RESPONSE IN A SOUTH AFRICAN FIRST EPISODE SCHIZOPHRENIA COHORT

K. O’Connell, L. Warnich, N. McGregor, 2019, European Neuropsychopharmacology.

Association of MB-COMT polymorphisms with schizophrenia-susceptibility and symptom severity in an African cohort

B. Drögemöller, D. Niehaus, L. Koen, 2012, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Haplotype analysis excludes the functional protoporphyrinogen oxidase promoter polymorphism -1081G>A as a modifying factor in the clinical expression of variegate porphyria.

T. Ohashi, M. Kotze, S. Taketani, 2002, Cellular and molecular biology.

Single nucleotide polymorphisms of the protoporphyrinogen oxidase gene: inter-population heterogeneity of allelic variation.

M. Kotze, J. D. de Villiers, L. Warnich, 2001, Molecular and cellular probes.

Identification of three mutations and associated haplotypes in the protoporphyrinogen oxidase gene in South African families with variegate porphyria.

W. V. D. Van de Ven, E. Schoenmakers, J. Groenewald, 1996, Human molecular genetics.

Characterization of the genetic variation present in CYP3A4 in three South African populations

A. Olckers, S. Gebhardt, B. Drögemöller, 2013, Front. Gene..

Analysis of pharmacogenetic traits in two distinct South African populations

S. Gebhardt, Yuanyuan Xiao, M. Gandhi, 2011, Human Genomics.

Detection of a frequent polymorphism in exon 10 of the low-density lipoprotein receptor gene

M. Kotze, L. Warnich, E. Langenhoven, 1992, Human Genetics.