Linxiang Zhao

发表

Small molecules targeting γ-secretase and their potential biological applications.

Jiachen Wen, Dan Liu, Linxiang Zhao, 2022, European journal of medicinal chemistry.

Combating P-glycoprotein-mediated multidrug resistance with 10-O-phenyl dihydroartemisinin ethers in MCF-7 cells.

Xuan Zhao, Dan Liu, Linxiang Zhao, 2016, European journal of medicinal chemistry.

Synthesis and Antiproliferative Activities of 5-Azacytidine Analogues in Human Leukemia Cells

Yu Liu, Dan Liu, Linxiang Zhao, 2008, Molecules.

The Synthesis of Glycyrrhetinic Acid Derivatives Containing A Nitrogen Heterocycle and Their Antiproliferative Effects in Human Leukemia Cells

Dan Liu, Linxiang Zhao, Y. Jing, 2010, Molecules.

Down-regulation of c-FLIP, XIAP and Mcl-1 protein as well as depletion of reduced glutathione contribute to the apoptosis induction of glycyrrhenitic acid derivatives in leukemia cells

Dan Liu, Linxiang Zhao, Y. Jing, 2010, Cancer biology & therapy.

Dihydroartemisinin and its derivative induce apoptosis in acute myeloid leukemia through Noxa-mediated pathway requiring iron and endoperoxide moiety

S. Waxman, Xuan Zhao, Dan Liu, 2015, Oncotarget.

Discovery and structure-activity relationship studies of novel Bcl-2/Mcl-1 dual inhibitors with indole scaffold.

Zhenwei Zhang, Jiying Pei, Dan Liu, 2022, Bioorganic chemistry.

A 18β-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects.

M. Huang, Linxiang Zhao, P. Gong, 2019, European journal of medicinal chemistry.

Synthesis and biological evaluation of substituted 1,2,3-benzotriazines and pyrido[3,2-d]-1,2,3-triazines as inhibitors of vascular endothelial growth factor receptor-2.

Dan Liu, Linxiang Zhao, Y. Jing, 2013, Bioorganic & medicinal chemistry.

Design and synthesis of substituted pyrido[3,2-d]-1,2,3-triazines as potential Pim-1 inhibitors.

Min Huang, Jiachen Wen, Dan Liu, 2016, Bioorganic & medicinal chemistry letters.

Artesunate improves venetoclax plus cytarabine AML cell targeting by regulating the Noxa/Bim/Mcl-1/p-Chk1 axis

Yuetong Wang, S. Waxman, Zhenwei Zhang, 2022, Cell death & disease.

Disulfide Bond Bridge Insertion Turns Hydrophobic Anticancer Prodrugs into Self-Assembled Nanomedicines

F. Liu, Matthew T. Haynes, Xing-gang Yang, 2014, Nano letters.

Usnic acid is a novel Pim-1 inhibitor with the abilities of inhibiting growth and inducing apoptosis in human myeloid leukemia cells

M. Huang, Yu Cao, Jiachen Wen, 2016 .

Studying Histone Deacetylase Inhibition and Apoptosis Induction of Psammaplin A Monomers with Modified Thiol Group.

Jian Wang, Baichun Hu, Dan Liu, 2021, ACS medicinal chemistry letters.

Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents.

Jian Wang, Jiang Liu, Jiachen Wen, 2016, Bioorganic & medicinal chemistry letters.

Synthesis of methyl 2-cyano-3,12-dioxo-18β-olean-1,9(11)-dien-30-oate analogues to determine the active groups for inhibiting cell growth and inducing apoptosis in leukemia cells.

Yuetong Wang, Dan Liu, Linxiang Zhao, 2014, Organic & biomolecular chemistry.

Progress on Mcl-1 small molecule inhibitors

Dan Liu, Linxiang Zhao, Shenglin Luan, 2015 .

Design and synthesis of novel 6-hydroxy-4-methoxy-3-methylbenzofuran-7-carboxamide derivatives as potent Mnks inhibitors by fragment-based drug design.

Min Huang, J. Zang, Shuxiang Wang, 2018, Bioorganic & medicinal chemistry.

Novel 2-(E)-substituted benzylidene-6-(N-substituted aminomethyl)cyclohexanones and cyclohexanols as analgesic and anti-inflammatory agents

Dan Liu, Linxiang Zhao, Jingjing Li, 2013, Medicinal Chemistry Research.

Synthesis and biological evaluation of quinoline derivatives as potential anti-prostate cancer agents and Pim-1 kinase inhibitors.

Jiachen Wen, Dan Liu, Linxiang Zhao, 2016, Bioorganic & medicinal chemistry.

Application of sulfoximines in medicinal chemistry from 2013 to 2020.

Jian Zhang, Yu Zhang, Dan Liu, 2020, European journal of medicinal chemistry.

Synthesis, anticancer evaluation and pharmacokinetic study of novel 10-O-phenyl ethers of dihydroartemisinin.

Xuan Zhao, Dan Liu, Linxiang Zhao, 2017, European journal of medicinal chemistry.

Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions

Xu Zhang, Hong Liu, Yu Zhou, 2015, Beilstein journal of organic chemistry.

Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors.

Dan Liu, Linxiang Zhao, Shenglin Luan, 2017, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Antitumor Activities of Some Novel Substituted 1,2,3-Benzotriazines

Dan Liu, Linxiang Zhao, Y. Jing, 2008, Molecules.

The synthesis of 18beta-glycyrrhetinic acid derivatives which have increased antiproliferative and apoptotic effects in leukemia cells.

Dan Liu, Linxiang Zhao, Y. Jing, 2007, Bioorganic & medicinal chemistry.

Discovery of novel (+)-Usnic acid derivatives as potential anti-leukemia agents with pan-Pim kinases inhibitory activity.

Jian Zhang, J. Zang, Shuxiang Wang, 2019, Bioorganic chemistry.

Ethacrynic acid butyl-ester induces apoptosis in leukemia cells through a hydrogen peroxide mediated pathway independent of glutathione S-transferase P1-1 inhibition.

Linxiang Zhao, Y. Jing, Rui Wang, 2007, Cancer research.

HDAC and Ku70 axis- an effective target for apoptosis induction by a new 2-cyano-3-oxo-1,9-dien glycyrrhetinic acid analogue

Dan Liu, Linxiang Zhao, P. Gong, 2018, Cell Death & Disease.

Synthesis and cytotoxicity of a novel 1-alkylaminomethyl-2,4-diaryl-butadiene-1,3 fragment integrated within cyclohex(pent)enes.

M. Tisdale, Linxiang Zhao, C. Schwalbe, 2004, Farmaco.

Development of a series of novel Mcl-1 inhibitors bearing an indole carboxylic acid moiety.

Hong Zhang, Liang Liu, Jinbo Li, 2022, Bioorganic chemistry.

Design, synthesis and biological evaluation of novel indole derivatives as potential HDAC/BRD4 dual inhibitors and anti-leukemia agents.

Dan Liu, Linxiang Zhao, Z. Wang, 2019, Bioorganic chemistry.

Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy.

Jiachen Wen, Dan Liu, Linxiang Zhao, 2016, European journal of medicinal chemistry.

Ethacrynic Acid Oxadiazole Analogs Induce Apoptosis in Malignant Hematologic Cells through Downregulation of Mcl-1 and c-FLIP, Which Was Attenuated by GSTP1-1

Yuetong Wang, Yuetong Wang, Linxiang Zhao, 2013, Molecular Cancer Therapeutics.

Trends in targeting Bcl-2 anti-apoptotic proteins for cancer treatment.

Zhenwei Zhang, Dan Liu, Linxiang Zhao, 2022, European journal of medicinal chemistry.

Design and synthesis of novel 2-substituted 11-keto-boswellic acid heterocyclic derivatives as anti-prostate cancer agents with Pin1 inhibition ability.

Shuxiang Wang, Dan Liu, Linxiang Zhao, 2017, European journal of medicinal chemistry.

Synthesis and antitumor effects of novel 18β-glycyrrhetinic acid derivatives featuring an exocyclic α,β-unsaturated carbonyl moiety in ring A.

Yuetong Wang, Dan Liu, Linxiang Zhao, 2020, Bioorganic chemistry.

Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study.

Jiang Liu, Jiachen Wen, Dan Liu, 2016, Bioorganic & medicinal chemistry letters.

Design, Synthesis and Bioactivity Evaluation of 4,6-Disubstituted Pyrido[3,2-d]pyrimidine Derivatives as Mnk and HDAC Inhibitors

Jian Zhang, Dan Liu, Linxiang Zhao, 2020, Molecules.

Synthesis and Antitumor Activity of 3-Methyl-4-oxo-3,4-dihydroimidazo [5,1-d][1,2,3,5]tetrazine-8-carboxylates and -carboxamides

Dan Liu, Linxiang Zhao, Jie Cheng, 2010, Molecules.

Synthesis and Cytotoxic and Mechanistic Studies of α-Arylidenecyclohex(pent)anone or α-Arylcyclohexanone α′-Mannich Bases and Their Deoxo Bisaryl Cyclohex(pent)ene Analogs

Linxiang Zhao, Yongfeng Wang, Kejun Zhao, 2004, Pharmaceutical Chemistry Journal.

Synthesis of the Marine Bromotyrosine Psammaplin F and Crystal Structure of a Psammaplin A Analogue

Dan Liu, Linxiang Zhao, De-yang Sun, 2010, Molecules.

Design, synthesis and biological evaluation of ring A modified 11-keto-boswellic acid derivatives as Pin1 inhibitors with remarkable anti-prostate cancer activity.

Dan Liu, Linxiang Zhao, Y. Jing, 2018, Bioorganic & medicinal chemistry letters.

Conjugates of 18β-glycyrrhetinic acid derivatives with 3-(1H-benzo[d]imidazol-2-yl)propanoic acid as Pin1 inhibitors displaying anti-prostate cancer ability.

Jingjing Cai, Dan Liu, Linxiang Zhao, 2017, Bioorganic & medicinal chemistry.

Synthesis of the novel elemonic acid derivatives as Pin1 inhibitors.

Lei Li, N. Zhang, Dan Liu, 2014, Bioorganic & medicinal chemistry letters.

Structure-Based Design of Novel Benzimidazole Derivatives as Pin1 Inhibitors

Jian Zhang, J. Zang, Shuxiang Wang, 2019, Molecules.

Design, synthesis and biological evaluation of benzimidazole derivatives as novel human Pin1 inhibitors.

Dan Liu, Linxiang Zhao, Feng Zhao, 2019, Bioorganic & medicinal chemistry letters.

Rational design, synthesis and biological evaluation of benzo[d]isoxazole derivatives as potent BET bivalent inhibitors for potential treatment of prostate cancer.

Yan Zhang, Yong Xu, Qiu-ping Xiang, 2023, Bioorganic chemistry.

Optimization of 4,6-Disubstituted Pyrido[3,2-d]pyrimidines as Dual MNK/PIM Inhibitors to Inhibit Leukemia Cell Growth.

Yuetong Wang, Jian Zhang, Xiaoxiao Gao, 2021, Journal of medicinal chemistry.

Synthesis and anticancer activity of 2-alkylaminomethyl-5-diaryl-methylenecyclopentanone hydrochlorides and related compounds.

Min Lu, Linxiang Zhao, Y. Jing, 2005, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of novel hydroxamic acid based histone deacetylase 6 selective inhibitors bearing phenylpyrazol scaffold as surface recognition motif.

Shuxiang Wang, Dan Liu, Linxiang Zhao, 2017, Bioorganic & medicinal chemistry.

Synthesis of a series of novel dihydroartemisinin derivatives containing a substituted chalcone with greater cytotoxic effects in leukemia cells.

Junjie Tan, Dan Liu, Linxiang Zhao, 2009, Bioorganic & medicinal chemistry letters.

[Design, synthesis and antiproliferative activity in cancer cells of novel dihydropyrazolyl and pyrazolyl artemisinin-phenyl ethers].

Dan Liu, Linxiang Zhao, Hang Zhong, 2018, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[Design, synthesis and antiproliferative activities of artemisinin derivatives substituted by N-heterocycles].

Dan Liu, Linxiang Zhao, Hang Zhong, 2015, Yao xue xue bao = Acta pharmaceutica Sinica.

Design, Synthesis and Antiproliferative Activities of Artemisinin Derivatives Containing a Substituted Piperazine

Dan Liu, Linxiang Zhao, Y. Jing, 2009 .

Optimization of BAX trigger site activator BTSA1 with improved antitumor potency and in vitro ADMET properties.

Jiying Pei, Dan Liu, Linxiang Zhao, 2023, European journal of medicinal chemistry.

Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis.

Shuainan Liu, Linxiang Zhao, Bailing Xu, 2021, ACS medicinal chemistry letters.

Design, synthesis and biological evaluation of selective histone deacetylase 6 (HDAC6) inhibitors bearing benzoindazole or pyrazoloindazole scaffold as surface recognition motif.

Xiaoxiao Gao, Yan-hua Mou, Dan Liu, 2021, Bioorganic chemistry.

Targeting Myeloid Leukemia-1 in Cancer Therapy: Advances and Directions.

Jiachen Wen, Dan Liu, Linxiang Zhao, 2024, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel selective thiol-based histone deacetylase(HDAC) VI inhibitors bearing indeno[1,2-c]pyrazole or benzoindazole scaffold

Yijun Cai, Dan Liu, Linxiang Zhao, 2018, Chemical Research in Chinese Universities.