A. Fauq

发表

Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4+ T Cells

T. Golde, L. Minter, B. Osborne, 2014, Front. Immunol..

Monoclonal antibodies against a phencyclidine derivative are used to investigate protein-ligand interactions.

A. Kozikowski, K. Krueger, A. Fauq, 1993, European journal of pharmacology.

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity.

S. Weggen, T. Golde, E. Koo, 2003, The Journal of biological chemistry.

Cisplatin and dimethyl sulfoxide react to form an adducted compound with reduced cytotoxicity and neurotoxicity.

L. Benson, Stephen Naylor, A. Windebank, 2008, Neurotoxicology.

NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome

T. Golde, L. Minter, B. Osborne, 2014, Front. Immunol..

An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.

D. Walsh, C. Sala Frigerio, T. Golde, 2009, Biochemistry.

Celastrol Inhibits Hsp90 Chaperoning of Steroid Receptors by Inducing Fibrillization of the Co-chaperone p23*

M. Ramirez-Alvarado, M. Botuyan, G. Mer, 2009, The Journal of Biological Chemistry.

Peptide-based, irreversible inhibitors of γ-secretase activity

T. Golde, M. Murphy, Victor G. Howard, 2003 .

Synthesis of 1D-3-deoxy-, 1D-2,3-dideoxy-, and 1D-2,3,6-trideoxy-myo-inositol 1,4,5-trisphosphate from quebrachitol, their binding affinities, and calcium release activity

A. Kozikowski, V. Ognyanov, A. Fauq, 1993 .

Deoxygenated inositol 1,4,5-trisphosphate analogues and their interaction with metabolic enzymes. (1R,2R,4R)-cyclohexane-1,2,4-tris(methylenesulfonate): a potent selective 5-phosphatase inhibitor.

A. Kozikowski, V. Ognyanov, A. Fauq, 1993, Journal of medicinal chemistry.

A Small Molecule Inhibitor of Signal Peptide Peptidase Inhibits Plasmodium Development in the Liver and Decreases Malaria Severity

M. Mota, T. Golde, M. Prudêncio, 2009, PloS one.

A novel synthetic 1,3-phenyl bis-thiourea compound targets microtubule polymerization to cause cancer cell death

J. Sarkaria, R. Bram, J. Choi, 2014, Cancer biology & therapy.

Regulation of Steady-state β-Amyloid Levels in the Brain by Neprilysin and Endothelin-converting Enzyme but Not Angiotensin-converting Enzyme*

C. Eckman, K. Bernstein, A. Fauq, 2006, Journal of Biological Chemistry.

Notch1 augments NF-kappaB activity by facilitating its nuclear retention.

G. Sonenshein, T. Golde, L. Minter, 2006, The EMBO journal.

maintenance of peripheral regulatory T cells 1 cooperatively regulate Foxp3 expression and the β Notch1 and TGF

T. Golde, L. Minter, B. Osborne, 2013 .

Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells.

T. Golde, L. Minter, B. Osborne, 2008, Blood.

Notch 1 and TGF 1 cooperatively regulate Foxp 3 expression and the maintenance of peripheral regulatory T cells

T. Golde, L. Minter, B. Osborne, 2008 .

Pharmacokinetics and tissue distribution of a peptide nucleic acid after intravenous administration.

E. Richelson, A. Fauq, J. Lipsky, 2002, Antisense & nucleic acid drug development.

Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

T. Golde, L. Minter, B. Osborne, 2005, Nature Immunology.

Iothalamate quantification by tandem mass spectrometry to measure glomerular filtration rate.

T. Larson, J. Lieske, Jesse C. Seegmiller, 2010, Clinical chemistry.

Differential accumulation of secreted AbetaPP metabolites in ocular fluids.

N. Greig, Z. Ablonczy, M. Pappolla, 2010, Journal of Alzheimer's disease : JAD.

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage.

P. Fraser, T. Golde, M. Murphy, 2000, The Journal of biological chemistry.

The FASEB Journal express article 10.1096/fj.00-0286fje. Published online October 6, 2000. Cell-free assays for γ-secretase activity

T. Golde, M. Murphy, P. Lewis, 2022 .

Design and chemical synthesis of a magnetic resonance contrast agent with enhanced in vitro binding, high blood-brain barrier permeability, and in vivo targeting to Alzheimer's disease amyloid plaques.

G. Curran, T. Wengenack, J. Poduslo, 2004, Biochemistry.

Peptide nucleic acids targeted to the neurotensin receptor and administered i.p. cross the blood-brain barrier and specifically reduce gene expression.

C. L. Douglas, K. Jansen, E. Richelson, 1999, Proceedings of the National Academy of Sciences of the United States of America.

S-methyl N,N-diethylthiocarbamate sulfone, a potential metabolite of disulfiram and potent inhibitor of low Km mitochondrial aldehyde dehydrogenase.

Stephen Naylor, K. Veverka, Z. Shriver, 1995, Biochemical pharmacology.

S-methyl-N,N-diethylthiocarbamate sulfoxide and S-methyl-N,N-diethylthiocarbamate sulfone, two candidates for the active metabolite of disulfiram.

A. Fauq, J. Lipsky, D. Mays, 1996, Alcoholism, clinical and experimental research.

D-3-Deoxy-3-substitutedmyo-inositol analogues as inhibitors of cell growth

G. Powis, A. Kozikowski, S. Aksoy, 1991, Cancer Chemotherapy and Pharmacology.

Cellular pharmacology ofd-3-azido-3-deoxy-myo-inositol, an inhibitor of phosphatidylinositol signaling having antiproliferative activity

G. Powis, A. Gallegos, A. Kozikowski, 2004, Cancer Chemotherapy and Pharmacology.

Quantitative measurement of porphobilinogen in urine by stable-isotope dilution liquid chromatography-tandem mass spectrometry.

J. Mcconnell, A. Fauq, M. J. Magera, 2001, Clinical chemistry.

Antiparkinson-like effects of a novel neurotensin analog in unilaterally 6-hydroxydopamine lesioned rats.

E. Richelson, A. Fauq, D. Mccormick, 2001, European journal of pharmacology.

Notch1 and TGF β 1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells

T. Golde, L. Minter, B. Osborne, 2008 .

Down-regulation of amyloid precursor protein by peptide nucleic acid in vivo

E. Richelson, A. Fauq, Katrina Williams, 2007, Journal of Molecular Neuroscience.

Epidermal Growth Factor Receptor and Notch Pathways Participate in the Tumor Suppressor Function of γ-Secretase*

H. Wen, D. Price, P. Wong, 2007, Journal of Biological Chemistry.

A Signal Peptide Peptidase (SPP) Reporter Activity Assay Based on the Cleavage of Type II Membrane Protein Substrates Provides Further Evidence for an Inverted Orientation of the SPP Active Site Relative to Presenilin*

T. Golde, K. Jansen, A. Fauq, 2004, Journal of Biological Chemistry.

An Empirical Model of γ‐Secretase Activity

P. Fraser, T. Golde, M. Murphy, 2000 .

Synthesis of D-3-deoxy-myo-inositol 1,4,5-trisphosphate and its effect on Ca2+ release in NIH 3T3 cells

G. Powis, A. Kozikowski, A. Fauq, 1990 .

Mammalian branched-chain acyl-CoA dehydrogenases: molecular cloning and characterization of recombinant enzymes.

J. Vockley, A. Fauq, J. Willard, 2000, Methods in enzymology.

Systemic and intestinal pharmacokinetics of methotrexate in patients with inflammatory bowel disease

W. Sandborn, W. Tremaine, A. Fauq, 1999, Clinical pharmacology and therapeutics.

A Concise, High Yield Synthesis of the Selective ECE‐Inhibitor, CGS 35066

C. Eckman, A. Fauq, M. Khan, 2004 .

Synthesis of novel metabolically stable analogues of D-myo-inositol 1,4,5-trisphosphate

C. Erneux, A. Kozikowski, A. Fauq, 1996 .

Chemical synthesis and biological evaluation of 1 d-1,2,4,5-InsP 4 and its 3-fluorinated counterpart 1 d-3-F-1,2,4,5-InsP 4 — potent 1 d-1,4,5-InsP 3-like calcium mobilizing analogues

A. Kozikowski, A. Fauq, S. Nahorski, 1995 .

Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia

T. Golde, J. Roderick, L. Minter, 2013, The Journal of experimental medicine.

Notch Regulates Cytolytic Effector Function in CD8+ T Cells1

T. Golde, L. Minter, B. Osborne, 2009, Journal of Immunology.

A novel neurotensin peptide analog given extracranially decreases food intake and weight in rodents

E. Richelson, A. Fauq, D. Mccormick, 2000, Brain Research.

Inositol Analogs as Potential Anticancer Therapeutics

G. Powis, A. Kozikowski, M. Malaska, 1994, Current Medicinal Chemistry.

Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.

H. Wen, D. Price, P. Wong, 2007, The Journal of biological chemistry.

Intraperitoneal injection of antisense peptide nucleic acids targeted to the mu receptor decreases response to morphine and receptor protein levels in rat brain

E. Richelson, A. Fauq, D. Mccormick, 2001, Brain Research.

Probing the D-1,4,5-IP3/D-1,3,4,5-IP4 functional interface. Synthesis and pharmacology of novel D-3-modified myo-inositol trisphosphate analogues

A. Kozikowski, V. Ognyanov, A. Fauq, 1994 .

N,N‐Diethylaminosulfur Trifluoride

A. Fauq, 2001 .

Peptide nucleic acids specifically cause antigene effects in vivo by systemic injection.

E. Richelson, A. Fauq, D. Mccormick, 2002, Life sciences.

A multigram chemical synthesis of the γ-secretase inhibitor LY411575 and its diastereoisomers

Pritam Das, Todd E. Golde, T. Golde, 2007 .

Total synthesis of (+)-desepoxyasperdiol

M. Tius, A. Fauq, 1986 .

Rationally designed dehydroalanine (ΔAla)‐containing peptides inhibit amyloid‐β (Aβ) peptide aggregation

T. Rosenberry, Vijayaraghavan Rangachari, Ghulam M. Maharvi, 2009, Biopolymers.

Cationic cyclopentaannelation: an efficient methylenomycin synthesis

M. Tius, A. Fauq, S. Trehan, 1986 .

A synthesis of the γ-secretase inhibitor BMS-708163

Ghulam M. Maharvi, A. Fauq, 2010 .

Copper(I)-catalyzed reactions of .beta.,.gamma.-epoxy alcohols with Grignard reagents

M. Tius, A. Fauq, 1983 .

Synthesis of the first optically pure, fluorinated inositol 1,4,5-trisphosphate of myo-inositol stereochemistry and its effect on Ca2+ release in Swiss 3T3 cells

G. Powis, A. Kozikowski, A. Fauq, 1990 .

Efficient synthetic routes to fluorinated isosteres of inositol and their effects on cellular growth

G. Powis, A. Kozikowski, A. Fauq, 1990 .

The novel Ins(1,4,5)P3 analogue 3-amino-3-deoxy-Ins(1,4,5)P3: a pH-dependent Ins(1,4,5)P3 receptor partial agonist in SH-SY5Y neuroblastoma cells.

R. Challiss, A. Kozikowski, A. Fauq, 1994, Journal of medicinal chemistry.

Pharmacological and Biochemical Profiles of Unique Neurotensin 8-13 Analogs Exhibiting Species Selectivity, Stereoselectivity, and Superagonism (*)

Y. Pang, E. Richelson, A. Fauq, 1995, The Journal of Biological Chemistry.

Locating the binding sites of anticancer tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen on bovine serum albumin.

H. Tajmir-Riahi, T. Thomas, Ghulam M. Maharvi, 2011, European journal of medicinal chemistry.

Binding of antitumor tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen to human serum albumin.

H. Tajmir-Riahi, T. Thomas, Ghulam M. Maharvi, 2011, Biochimie.

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

D. Selkoe, L. Cantley, B. Turk, 2010, PloS one.

Effects of a novel neurotensin peptide analog given extracranially on CNS behaviors mediated by apomorphine and haloperidol

E. Richelson, A. Fauq, D. Mccormick, 2000, Brain Research.

Chemical modification of ring c of himbacine: Discovery of a pharmacophoric element for M2-selectivity

P. Aagaard, A. Kozikowski, M. Malaska, 1995 .

Alzheimer's therapy: an approach to novel muscarinic ligands based upon the naturally occurring alkaloid himbacine.

A. Kozikowski, A. Fauq, M. Mckinney, 1992 .

Chemical Modification of Ring C of Himbacine: Discovery of a Pharmacophoric Element for M2-Selectivity.

P. Aagaard, A. Kozikowski, M. Malaska, 1995 .

Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate.

M. Davies, T. Rosenberry, A. Fauq, 2003, Biochemistry.

Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG Trial N01CC1.

P. Novotny, J. Sloan, C. Loprinzi, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Inhibition of recombinant human mitochondrial aldehyde dehydrogenase by two intermediate metabolites of disulfiram.

A. Fauq, J. Lipsky, D. Mays, 1998, Biochemical pharmacology.

Molecular recognition at the myo-inositol 1,4,5-trisphosphate receptor. 3-position substituted myo-inositol 1,4,5-trisphosphate analogues reveal the binding and Ca2+ release requirements for high affinity interaction with the myo-inositol 1,4,5-trisphosphate receptor.

R. Challiss, A. Kozikowski, J. Traynor, 1994, The Journal of biological chemistry.

A simplified route to the phosphatidylinositol cascade inhibitor --- (-)-1L-1-deoxy-1-fluoro-Myo-inositol

A. Kozikowski, A. Fauq, J. Rusnak, 1989 .

Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.

J. Aster, T. Golde, L. Minter, 2009, Blood.

Notch signaling is activated by TLR stimulation and regulates macrophage functions

S. Kaufmann, T. Golde, B. Osborne, 2008, European journal of immunology.

Pigment Epithelium-derived Factor Maintains Retinal Pigment Epithelium Function by Inhibiting Vascular Endothelial Growth Factor-R2 Signaling through γ-Secretase*

Z. Ablonczy, C. Crosson, A. Fauq, 2009, The Journal of Biological Chemistry.

Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis*♦

B. Blagg, A. Chadli, A. Fauq, 2013, The Journal of Biological Chemistry.

Neurobiology of Disease Liver X Receptor Agonist Treatment Ameliorates Amyloid Pathology and Memory Deficits Caused by High-fat Diet in App23 Mice

N. Fitz, I. Lefterov, R. Koldamova, 2022 .

Substrate-targeting γ-secretase modulators

M. Wolfe, D. Walsh, T. Golde, 2008, Nature.

Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production

Pritam Das, Sascha Weggen, S. Weggen, 2005, Nature Medicine.

The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia

E. Richelson, A. Fauq, Katrina Williams, 2011, Behavioural Brain Research.

Selective tolerance to the hypothermic and anticataleptic effects of a neurotensin analog that crosses the blood–brain barrier

E. Richelson, A. Fauq, D. Mccormick, 2003, Brain Research.

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology

T. Golde, L. Minter, B. Osborne, 2012, Molecular Neurodegeneration.

Notch1 augments NF‐κB activity by facilitating its nuclear retention

G. Sonenshein, T. Golde, L. Minter, 2006 .

A γ-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains

S. Prusiner, E. Huang, S. DeArmond, 2008, Proceedings of the National Academy of Sciences.

A novel neurotensin analog blocks cocaine- and D-amphetamine-induced hyperactivity.

E. Richelson, A. Fauq, D. Mccormick, 2001, European journal of pharmacology.

Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice

N. Fitz, Muzamil Saleem, I. Lefterov, 2012, The Journal of Neuroscience.

In vitro binding and CNS effects of novel neurotensin agonists that cross the blood–brain barrier

Y. Pang, C. L. Douglas, E. Richelson, 1999, Neuropharmacology.

Synthesis of (2S)-2-amino-3-(1H-4-indolyl)propanoic acid, a novel tryptophan analog for structural modification of bioactive peptides

E. Richelson, A. Fauq, B. Cusack, 1998 .

A convenient synthesis of (Z)-4-hydroxy-N-desmethyltamoxifen (endoxifen).

Ghulam M. Maharvi, A. Fauq, D. Sinha, 2010, Bioorganic & medicinal chemistry letters.

Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575

B. Hyman, M. Garcia-Alloza, B. Bacskai, 2009, Molecular Neurodegeneration.

γ-Secretase Processing and Effects of γ-Secretase Inhibitors and Modulators on Long Aβ Peptides in Cells*

T. Golde, P. Cruz, K. Felsenstein, 2013, The Journal of Biological Chemistry.

Peptide nucleic acids targeted to the amyloid precursor protein

S. Younkin, L. Younkin, E. Richelson, 2007, Journal of Molecular Neuroscience.

Using peptide nucleic acids as gene-expression modifiers to reduce β-amyloid levels

S. Younkin, L. Younkin, E. Richelson, 2002, Journal of Molecular Neuroscience.

The intraflavin hydrogen bond in human electron transfer flavoprotein modulates redox potentials and may participate in electron transfer.

A. Bacher, F. Frerman, A. Fauq, 1999, Biochemistry.

Altering behavioral responses and dopamine transporter protein with antisense peptide nucleic acids.

E. Richelson, A. Fauq, D. Mccormick, 2001, Biochemical pharmacology.

Decarbamoylation of acetylcholinesterases is markedly slowed as carbamoyl groups increase in size.

T. Rosenberry, A. Fauq, B. Cusack, 2018, Archives of biochemistry and biophysics.

Hydrolysis of low concentrations of the acetylthiocholine analogs acetyl(homo)thiocholine and acetyl(nor)thiocholine by acetylcholinesterase may be limited by selective gating at the enzyme peripheral site.

T. Rosenberry, Veena Beri, Jeffrey T. Auletta, 2013, Chemico-biological interactions.

Inhibitors Tethered Near the Acetylcholinesterase Active Site Serve as Molecular Rulers of the Peripheral and Acylation Sites*

Thomas Hughes, T. Rosenberry, A. Spatola, 2003, Journal of Biological Chemistry.

Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid β42 Production by Direct Modulation of γ-Secretase Activity*

S. Weggen, T. Golde, E. Koo, 2003, Journal of Biological Chemistry.

Total synthesis of (−)-asperdiol

M. Tius, A. Fauq, 1986 .

Total Synthesis of (-)-Asperdiol

M. Tius, A. Fauq, 1987 .

Synthesis of acid-cleavable light isotope-coded affinity tags (ICAT-L) for potential use in proteomic expression profiling analysis.

Irving E. Vega, A. Fauq, M. Khan, 2006, Bioconjugate chemistry.

A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers.

T. Golde, P. Das, Ghulam M. Maharvi, 2007, Bioorganic & medicinal chemistry letters.

Synthesis of D‐3‐Deoxy‐myo‐inositol 1,4,5‐Triphosphate and Its Effect of Ca2+ Release in NIH 3T3 Cells.

G. Powis, A. Kozikowski, A. Fauq, 1991 .

Synthesis of a DOTA (Gd3+)-conjugate of proton-pump inhibitor pantoprazole for gastric wall imaging studies.

A. Bharucha, Ghulam M. Maharvi, A. Fauq, 2013, Bioorganic & medicinal chemistry letters.

[125I]thienylphencyclidine, a novel ligand for the NMDA receptor.

A. Kozikowski, I. Reynolds, S. Rajdev, 1992, European journal of pharmacology.

Tools for Cell Signaling: Synthesis of the 3-Phosphatase-Resistant 1,3,4,5-InsP4 Mimic, 1D-myo-Inositol 1,4,5-Trisphosphate 3-Phosphorothioate

A. Kozikowski, A. Fauq, S. Nahorski, 1994 .

Tools for Cell Signaling: Synthesis of the 3-Phosphatase-Resistant 1,3, 4,5-InsP4 Mimic, 1D-myo-Inositol 1,4,5-Trisphosphate 3- Phosphorothioate.

A. Kozikowski, A. Fauq, S. Nahorski, 1994 .

PiB PET/CT identification of meningiomas is not due to presence of amyloid-beta within tumors

V. Lowe, J. Parisi, C. Mathis, 2012 .

Cloning of a cDNA for short/branched chain acyl-Coenzyme A dehydrogenase from rat and characterization of its tissue expression and substrate specificity.

R. Rozen, J. Vockley, P. V. Van Veldhoven, 1996, Archives of biochemistry and biophysics.

Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity.

Amy L. Lane, M. Leissring, Clémence Claussin, 2013, Journal of medicinal chemistry.

Synthesis of the First Optically Pure, Fluorinated Inositol 1,4,5‐ Trisphosphate of myo‐Inositol. Stereochemistry and Its Effect on Ca2+ Release in Swiss 3T3 Cells.

G. Powis, A. Kozikowski, A. Fauq, 1991 .

Neurotensin analog selective for hypothermia over antinociception and exhibiting atypical neuroleptic-like properties

E. Richelson, A. Fauq, D. Mccormick, 2001, Brain Research.

Presenilin 1 Regulates Pharmacologically Distinct γ-Secretase Activities

P. Fraser, T. Golde, M. Murphy, 2000, The Journal of Biological Chemistry.

Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

T. Golde, L. Minter, B. Osborne, 2005, Nature Immunology.

Peptidic and Non-Peptidic Neurotensin Analogues

E. Richelson, A. Fauq, B. Cusack, 1998 .