C. Dees

发表

Oliver Distler, Georg Schett, G. Schett, 2011 .

Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis.

M. Mattson, J. Zwerina, G. Schett, 2011, Arthritis and rheumatism.

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis

S. Wirtz, B. Spencer, C. Scholtysek, 2012, Annals of the rheumatic diseases.

Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis

G. Schett, O. Distler, R. Lafyatis, 2020, Science Translational Medicine.

Inhibition of glycogen synthase kinase 3β induces dermal fibrosis by activation of the canonical Wnt pathway

J. Zwerina, G. Schett, O. Distler, 2011, Annals of the rheumatic diseases.

68Ga-FAPI-04 PET-CT for molecular assessment of fibroblast activation and risk evaluation in systemic sclerosis-associated interstitial lung disease: a single-centre, pilot study.

G. Schett, O. Distler, O. Prante, 2021, The Lancet. Rheumatology.

From pathogenesis to therapy--Perspective on treatment strategies in fibrotic diseases.

J. Distler, C. Dees, A. Ramming, 2015, Pharmacological research.

Morphogen pathways as molecular targets for the treatment of fibrosis in systemic sclerosis

J. Distler, C. Beyer, C. Dees, 2012, Archives of Dermatological Research.

Type 2 innate lymphoid cell counts are increased in patients with systemic sclerosis and correlate with the extent of fibrosis

G. Schett, O. Distler, M. Englbrecht, 2015, Annals of the rheumatic diseases.

Dipeptidylpeptidase 4 as a Marker of Activated Fibroblasts and a Potential Target for the Treatment of Fibrosis in Systemic Sclerosis

R. Horch, I. Ludolph, G. Schett, 2020, Arthritis & rheumatology.

Composition of TWIST1 dimers regulates fibroblast activation and tissue fibrosis

G. Schett, O. Distler, A. Liebl, 2016, Annals of the rheumatic diseases.

Activating transcription factor 3 regulates canonical TGFβ signalling in systemic sclerosis

Tsonwin Hai, G. Schett, O. Distler, 2015, Annals of the rheumatic diseases.

Poly(ADP-ribose) polymerase-1 regulates fibroblast activation in systemic sclerosis

R. Horch, I. Ludolph, G. Schett, 2018, Annals of the rheumatic diseases.

Targeting of canonical WNT signaling ameliorates experimental sclerodermatous chronic graft-versus-host disease.

S. Krauss, A. Mackensen, S. Karrer, 2021, Blood.

Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis

G. Schett, O. Distler, J. Avouac, 2015, Annals of the rheumatic diseases.

Nintedanib inhibits macrophage activation and ameliorates vascular and fibrotic manifestations in the Fra2 mouse model of systemic sclerosis

C. Maier, G. Schett, O. Distler, 2017, Annals of the rheumatic diseases.

The transcription factor JunD mediates transforming growth factor β-induced fibroblast activation and fibrosis in systemic sclerosis

M. Yaniv, G. Schett, O. Distler, 2011, Annals of the rheumatic diseases.

Activation of pregnane X receptor inhibits experimental dermal fibrosis

G. Schett, O. Distler, A. Skapenko, 2013, Annals of the rheumatic diseases.

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis

C. Scholtysek, G. Schett, O. Distler, 2012, Annals of the rheumatic diseases.

Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis.

J. Zwerina, G. Schett, O. Distler, 2010, Arthritis and rheumatism.

Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease.

F. Egberts, G. Schett, O. Distler, 2012, Blood.

Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis

M. Mattson, F. Dell’Accio, M. Stock, 2016, Annals of the rheumatic diseases.

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis

D. Metzger, C. Scholtysek, G. Schett, 2015, Nature Medicine.

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

B. de Crombrugghe, M. Taketo, G. Schett, 2012, Annals of the Rheumatic Diseases.

The transcription factor GLI2 as a downstream mediator of transforming growth factor-β-induced fibroblast activation in SSc

G. Schett, O. Distler, D. Krasowska, 2016, Annals of the rheumatic diseases.

Dysbalance of angiogenic and angiostatic mediators in patients with mixed connective tissue disease

U. Müller-Ladner, D. Huscher, S. Gay, 2011, Annals of the rheumatic diseases.

Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors

R. Gay, S. Gay, D. Abraham, 2013, Annals of the rheumatic diseases.

Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling

C. Maier, G. Schett, O. Distler, 2014, Annals of the Rheumatic Diseases.

Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis.

G. Schett, O. Distler, Y. Allanore, 2011, Arthritis & Rheumatism.

PGC-1α regulates autophagy to promote fibroblast activation and tissue fibrosis

R. Horch, I. Ludolph, G. Schett, 2020, Annals of the Rheumatic Diseases.

Induction of apoptosis in circulating angiogenic cells by microparticles.

D. Pisetsky, S. Gay, G. Schett, 2011, Arthritis and rheumatism.

Decreased lymphatic vessel counts in patients with systemic sclerosis: association with fingertip ulcers.

J. Zwerina, G. Schett, D. Kerjaschki, 2010, Arthritis and rheumatism.

Acyltransferase skinny hedgehog regulates TGFβ-dependent fibroblast activation in SSc

G. Schett, D. Krasowska, J. Distler, 2019, Annals of the rheumatic diseases.

Cardiomyopathy in Murine Models of Systemic Sclerosis

L. Czirják, G. Schett, O. Distler, 2015, Arthritis & rheumatology.

Combined inhibition of c-Abl and PDGF receptors for prevention and treatment of murine sclerodermatous chronic graft-versus-host disease.

F. Egberts, G. Schett, O. Distler, 2012, The American journal of pathology.

Protein kinases G are essential downstream mediators of the antifibrotic effects of sGC stimulators

F. Hofmann, G. Schett, O. Distler, 2018, Annals of the rheumatic diseases.

Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis

J. Varga, G. Schett, O. Distler, 2013, Annals of the rheumatic diseases.

JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment

G. Schett, O. Distler, D. Mielenz, 2017, Annals of the rheumatic diseases.

Vitamin D receptor regulates TGF-β signalling in systemic sclerosis.

G. Schett, O. Distler, J. Distler, 2015, Annals of the rheumatic diseases.

S100A4 amplifies TGF-β-induced fibroblast activation in systemic sclerosis

M. Grigorian, G. Schett, O. Distler, 2014, Annals of the rheumatic diseases.

Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages

C. Maier, S. Rose-John, Simon A. Jones, 2014, Annals of the rheumatic diseases.

The Nuclear Receptor Constitutive Androstane Receptor/NR1I3 Enhances the Profibrotic Effects of Transforming Growth Factor β and Contributes to the Development of Experimental Dermal Fibrosis

G. Schett, O. Distler, Y. Allanore, 2014, Arthritis & rheumatology.

Canonical Wnt signalling as a key regulator of fibrogenesis – implications for targeted therapies?

J. Distler, C. Dees, J. Distler, 2013, Experimental dermatology.

Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis

G. Schett, O. Distler, V. Marquez, 2012, Annals of the rheumatic diseases.

The cannabinoid receptor CB2 exerts antifibrotic effects in experimental dermal fibrosis.

J. Zwerina, G. Schett, O. Distler, 2009, Arthritis & Rheumatism.

Lack of inhibitory effects of the anti-fibrotic drug imatinib on endothelial cell functions in vitro and in vivo

S. Gay, J. Zwerina, G. Schett, 2008, Journal of cellular and molecular medicine.

Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse

B. Léger, O. Distler, H. Ruetten, 2020, British journal of pharmacology.

Stimulators of soluble guanylate cyclase (sGC) inhibit experimental skin fibrosis of different aetiologies

G. Schett, O. Distler, J. Distler, 2015, Annals of the rheumatic diseases.

The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis

G. Schett, D. Abraham, O. Distler, 2017, Annals of the rheumatic diseases.

Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis

G. Schett, O. Distler, J. Distler, 2014, Annals of the rheumatic diseases.

Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1

B. Cravatt, G. Schett, O. Distler, 2012, Annals of the rheumatic diseases.

Stimulation of soluble guanylate cyclase reduces experimental dermal fibrosis

G. Schett, O. Distler, J. Distler, 2012, Annals of the rheumatic diseases.

Microparticles stimulate angiogenesis by inducing ELR+ CXC-chemokines in synovial fibroblasts

J. Zwerina, G. Schett, O. Distler, 2010, Journal of cellular and molecular medicine.

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis

W. Birchmeier, Jianping Lin, G. Schett, 2018, Nature Communications.

FRI0400 The ap1 transcription factor cjun amplifies hedgehog-induced fibroblast activation and tissue fibrosis

G. Schett, A. Bozec, J. Distler, 2018, FRIDAY, 15 JUNE 2018.

Platelet-derived serotonin links vascular disease and tissue fibrosis

N. Alenina, S. Gay, J. Zwerina, 2011, The Journal of experimental medicine.

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

Oliver Distler, Georg Schett, O. MacDougald, 2012, Nature Communications.

TGFβ-induced epigenetic deregulation of SOCS3 facilitates STAT3-signaling to promote fibrosis.

R. Jaenisch, A. Yoshimura, G. Schett, 2020, The Journal of clinical investigation.

Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis

Oliver Distler, Georg Schett, J. Zwerina, 2011, Annals of the rheumatic diseases.

SPI1/PU.1 controls fibroblast polarization and tissue fibrosis

C. Maier, A. Ekici, M. Kaplan, 2019, Nature.

The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis

G. Schett, O. Distler, J. Distler, 2013, Annals of the rheumatic diseases.

Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis

G. Schett, B. Bennett, O. Distler, 2012, Annals of the rheumatic diseases.

Inactivation of evenness interrupted (EVI) reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling

G. Schett, O. Distler, A. Weidemann, 2013, Annals of the rheumatic diseases.

Cellular and molecular mechanisms in fibrosis

J. Distler, C. Dees, D. Chakraborty, 2020, Experimental dermatology.

Pomalidomide is effective for prevention and treatment of experimental skin fibrosis

G. Schett, O. Distler, P. Schafer, 2012, Annals of the rheumatic diseases.

The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis.

S. Gay, J. Zwerina, G. Schett, 2010, Arthritis and rheumatism.

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis.

J. Zwerina, G. Schett, O. Distler, 2012, Arthritis and rheumatism.

JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis.

J. Zwerina, G. Schett, O. Distler, 2012, Arthritis and rheumatism.

X-linked inhibitor of apoptosis protein (XIAP) inhibition in systemic sclerosis (SSc)

G. Schett, M. Ziemer, R. Coras, 2021, Annals of the Rheumatic Diseases.

Assessment of myocardial fibrosis in patients with systemic sclerosis using [68Ga]Ga-FAPI-04-PET-CT

M. Uder, G. Schett, O. Prante, 2022, European Journal of Nuclear Medicine and Molecular Imaging.

Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis.

Oliver Distler, Georg Schett, Nicole Busch, 2009, Arthritis and rheumatism.

SPI1/PU.1 controls fibroblast polarization and tissue fibrosis

C. Maier, A. Ekici, M. Kaplan, 2019, Nature.

Dual inhibition of c‐abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis

Oliver Distler, Georg Schett, S. Gay, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis.

Oliver Distler, Georg Schett, Shunichi Shiozawa, 2012, Arthritis and rheumatism.

Engrailed 1 coordinates cytoskeletal reorganization to induce myofibroblast differentiation

Chunguang Liang, R. Horch, I. Ludolph, 2021, The Journal of experimental medicine.

Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts.

Oliver Distler, Georg Schett, J. Zwerina, 2008, Arthritis and rheumatism.

AB0195 Type 2 Innate Lymphoid Cell Counts Are Increased in Patients with Systemic Sclerosis and Correlate with the Extent of Fibrosis

G. Schett, O. Distler, K. Gelse, 2015 .

OP0051 Dipeptidyl-Peptidase-4 (DPP4) Characterizes A Subpopulation of Fibrosis-Promoting Fibroblasts and Is A Molecular Target for The Treatment of Fibrosis

G. Schett, J. Distler, N. Lin, 2016 .

Src kinases in systemic sclerosis: central roles in fibroblast activation and in skin fibrosis.

J. Zwerina, G. Schett, O. Distler, 2008, Arthritis and rheumatism.

Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling

G. Schett, O. Distler, A. Weidemann, 2012, Annals of the rheumatic diseases.

Inhibition of sumoylation prevents experimental fibrosis

Veronika Lang, Oliver Distler, Georg Schett, 2012, Annals of the rheumatic diseases.

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

M. Taketo, G. Schett, O. Distler, 2012, Annals of the rheumatic diseases.

TGFβ-induced epigenetic deregulation of SOCS3 facilitates STAT3-signaling to promote fibrosis.

R. Jaenisch, A. Yoshimura, G. Schett, 2020, The Journal of clinical investigation.

Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis

G. Schett, O. Distler, J. Avouac, 2015, Annals of the rheumatic diseases.

Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling

C. Maier, G. Schett, O. Distler, 2014, Annals of the rheumatic diseases.

Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages

C. Maier, S. Rose-John, Simon A. Jones, 2014, Annals of the rheumatic diseases.

The cannabinoid receptor CB2 exerts antifibrotic effects in experimental dermal fibrosis.

J. Zwerina, G. Schett, O. Distler, 2009, Arthritis and rheumatism.

Basic and translational research

C. Beyer, A. Horn, T. Kireva, 2011 .