T. Ostendorf

发表

Notch‐3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury

P. Boor, C. Cohen, J. Floege, 2012, The Journal of pathology.

Detection of activated parietal epithelial cells on the glomerular tuft distinguishes early focal segmental glomerulosclerosis from minimal change disease.

P. Boor, V. D’Agati, B. Smeets, 2014, The American journal of pathology.

Pathways to recovery and loss of nephrons in anti-Thy-1 nephritis.

N. Gretz, J. Floege, B. Kränzlin, 2003, Journal of the American Society of Nephrology : JASN.

IL-6 Trans-Signaling Drives Murine Crescentic GN.

P. Boor, D. Salant, S. Rose-John, 2016, Journal of the American Society of Nephrology : JASN.

Mesangial cell expression of proto-oncogene Ets-1 during progression of mesangioproliferative glomerulonephritis.

T. Rauen, J. Floege, P. Mertens, 2004, Kidney international.

PDGF and the progression of renal disease.

P. Boor, J. Floege, T. Ostendorf, 2014, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Biological responses to PDGF-BB versus PDGF-DD in human mesangial cells.

I. Behrmann, J. Floege, F. Strutz, 2006, Kidney international.

Anti-interleukin-6 therapy through application of a monogenic protein inhibitor via gene delivery

G. Müller-Newen, J. Scheller, J. Floege, 2015, Scientific Reports.

Improved survival and amelioration of nephrotoxic nephritis in intercellular adhesion molecule-1 knockout mice.

F. Eitner, H. Hedrich, J. Floege, 1998, Journal of the American Society of Nephrology : JASN.

Renal fibrosis: novel insights into mechanisms and therapeutic targets

P. Boor, J. Floege, T. Ostendorf, 2010, Nature Reviews Nephrology.

Complement C5 mediates experimental tubulointerstitial fibrosis.

P. Boor, F. Lammert, F. Eitner, 2007, Journal of the American Society of Nephrology : JASN.

Growth arrest-specific protein 1 is a novel endogenous inhibitor of glomerular cell activation and proliferation.

P. Boor, C. Cohen, F. Eitner, 2013, Kidney international.

The map kinase ERK regulates renal activity of cyclin-dependent kinase 2 in experimental glomerulonephritis.

P. Boor, C. Müller, J. Floege, 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

The chemokine receptor 5 Delta32 mutation is associated with increased renal survival in patients with IgA nephropathy.

J. Floege, U. Panzer, B. Krämer, 2005, Kidney international.

No association of the -2518 MCP-1 A/G promoter polymorphism with incidence and clinical course of IgA nephropathy.

J. Floege, U. Panzer, R. Stahl, 2004, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Antagonism of PDGF-D by human antibody CR002 prevents renal scarring in experimental glomerulonephritis.

P. Boor, F. Eitner, J. Floege, 2006, Journal of the American Society of Nephrology : JASN.

PDGF-D inhibition by CR002 ameliorates tubulointerstitial fibrosis following experimental glomerulonephritis.

P. Boor, J. Floege, L. Villa, 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Gp130-dependent signaling in the podocyte.

P. Boor, C. Trautwein, G. Müller-Newen, 2014, American journal of physiology. Renal physiology.

The Effects of Platelet-Derived Growth Factor Antagonism in Experimental Glomerulonephritis Are Independent of the Transforming Growth Factor–β System

S. Dooley, N. Janjić, F. Eitner, 2002 .

The role of PDGF-D in mesangioproliferative glomerulonephritis.

P. Boor, J. Floege, T. Ostendorf, 2007, Contributions to nephrology.

PDGF-C mediates glomerular capillary repair.

P. Boor, F. Eitner, J. Floege, 2010, The American journal of pathology.

A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and antimesangioproliferative effects.

P. Boor, C. Trautwein, J. Floege, 2012, The American journal of pathology.

Pro-Angiogenic and Antimesangioproliferative Effects

P. Boor, C. Trautwein, J. Floege, 2012 .

Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes.

G. Brabant, J. Floege, H. Gröne, 2000, Kidney international.

A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury.

F. Grosveld, I. Grigorieva, C. Cohen, 2019, Journal of the American Society of Nephrology : JASN.

Inducible nitric oxide synthase-derived nitric oxide promotes glomerular angiogenesis via upregulation of vascular endothelial growth factor receptors.

J. Floege, Emile de Heer, D. Kerjaschki, 2004, Journal of the American Society of Nephrology : JASN.

High-fat diet-induced obesity causes an inflammatory microenvironment in the kidneys of aging Long-Evans rats

J. Floege, T. Bertsch, C. Fellner, 2019, Journal of Inflammation.

Role of interleukin-6 in mediating mesangial cell proliferation and matrix production in vivo.

F. Eitner, J. Floege, H. Gröne, 1997, Kidney international.

In vivo identification of the mitogen-activated protein kinase cascade as a central pathogenic pathway in experimental mesangioproliferative glomerulonephritis.

P. Boor, J. Floege, D. Kerjaschki, 2002, Journal of the American Society of Nephrology : JASN.

PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases.

C. Cohen, M. Kretzler, F. Eitner, 2003, Journal of the American Society of Nephrology : JASN.

CXCR5 is critically involved in progression of lupus through regulation of B cell and double‐negative T cell trafficking

F. Tacke, K. Tenbrock, T. Ostendorf, 2016, Clinical and experimental immunology.

Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension.

P. Boor, F. Eitner, J. Floege, 2019, Kidney international.

PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis.

P. Boor, F. Eitner, J. Floege, 2008, Journal of the American Society of Nephrology.

Cytokines and Growth Factors

J. Floege, T. Ostendorf, 2008 .

CCN3 is a novel endogenous PDGF-regulated inhibitor of glomerular cell proliferation.

P. Boor, F. Eitner, J. Floege, 2008, Kidney international.

PDGF-D and renal disease: yet another one of those growth factors?

F. Eitner, J. Floege, T. Ostendorf, 2003, Journal of the American Society of Nephrology : JASN.

A fully human monoclonal antibody (CR002) identifies PDGF-D as a novel mediator of mesangioproliferative glomerulonephritis.

B. Keyt, J. Peterson, F. Eitner, 2003, Journal of the American Society of Nephrology : JASN.

Platelet-derived growth factor: a new clinical target on the horizon.

J. Floege, T. Ostendorf, 2001, Kidney international.

Differential activation of mitogen-activated protein kinases in experimental mesangioproliferative glomerulonephritis.

J. Floege, M. Lindemann, T. Ostendorf, 2000, Journal of the American Society of Nephrology : JASN.

Cisplatin-induced injury of the renal distal convoluted tubule is associated with hypomagnesaemia in mice

P. Boor, C. Henkel, G. Müller-Newen, 2013 .

Selective cyclooxygenase-2 inhibition impairs glomerular capillary healing in experimental glomerulonephritis.

F. Eitner, J. Floege, D. Kerjaschki, 2002, Journal of the American Society of Nephrology : JASN.

Results Effects of Selective COX-2 Inhibitors on Mesangiolytic Injury and Albuminuria

F. Eitner, J. Floege, D. Kerjaschki, 2002 .

Renal side effects of anti-VEGF therapy in man: a new test system.

J. Floege, T. Ostendorf, A. D. De Vriese, 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Extracellular YB-1 Blockade in Experimental Nephritis Upregulates Notch-3 Receptor Expression and Signaling

P. Boor, T. Rauen, J. Floege, 2011, Nephron Experimental Nephrology.

The nucleic acid binding protein YB-1-controlled expression of CXCL-1 modulates kidney damage in liver fibrosis.

T. Rauen, J. Floege, R. Weiskirchen, 2019, Kidney international.

Characterization of a dam Mutant ofSerratia marcescens and Nucleotide Sequence of thedam Region

W. Wackernagel, P. Cherepanov, J. de Vries, 1999, Journal of bacteriology.

VEGF(165) mediates glomerular endothelial repair.

N. Janjić, F. Eitner, J. Floege, 1999, The Journal of clinical investigation.

Bacterial and Sterile Inflammation In Vivo YB-1 Is an Early and Central Mediator of

Frye, P. Boor, F. Tacke, 2013 .

Pro-fibrogenic potential of PDGF-D in liver fibrosis.

A. Gressner, J. Floege, R. Weiskirchen, 2007, Journal of hepatology.

Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis.

P. Boor, F. Eitner, J. Floege, 2013, The American journal of pathology.

Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats.

P. Boor, K. Šebeková, N. Prónayová, 2009, Metabolism: clinical and experimental.

Complement C5a receptors C5L2 and C5aR in renal fibrosis.

P. Boor, F. Lammert, J. Floege, 2018, American journal of physiology. Renal physiology.

Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes.

P. Boor, G. Müller-Newen, F. Eitner, 2007, Journal of the American Society of Nephrology : JASN.

Glomerular oxidative and antioxidative systems in experimental mesangioproliferative glomerulonephritis.

W. Gwinner, K. Koch, T. Ostendorf, 2002, Journal of the American Society of Nephrology : JASN.

The platelet-derived growth factor system in renal disease: an emerging role of endogenous inhibitors.

J. Floege, C. V. van Roeyen, T. Ostendorf, 2012, European journal of cell biology.

The PDGF family in renal fibrosis

F. Eitner, J. Floege, T. Ostendorf, 2012, Pediatric Nephrology.

Y-box protein 1 mediates PDGF-B effects in mesangioproliferative glomerular disease.

F. Eitner, P. Mertens, B. Lüscher, 2005, Journal of the American Society of Nephrology : JASN.

Expression of a novel PDGF isoform, PDGF-C, in normal and diseased rat kidney.

F. Eitner, J. Floege, H. Gröne, 2002, Journal of the American Society of Nephrology : JASN.

Platelet-derived growth factors (PDGFs) in glomerular and tubulointerstitial fibrosis

P. Boor, J. Floege, T. Ostendorf, 2014, Kidney international supplements.

Calcineurin-mediated YB-1 Dephosphorylation Regulates CCL5 Expression during Monocyte Differentiation*

J. Bernhagen, T. Rauen, J. Floege, 2014, The Journal of Biological Chemistry.

Y-Box Binding Protein-1 Mediates Profibrotic Effects of Calcineurin Inhibitors in the Kidney

P. Boor, T. Rauen, J. Floege, 2011, The Journal of Immunology.

YB-1 increases glomerular, but decreases interstitial fibrosis in CNI-induced nephropathy.

C. Cohen, T. Rauen, J. Floege, 2018, Clinical immunology.

C-type natriuretic peptide inhibits mesangial cell proliferation and matrix accumulation in vivo.

J. Floege, K. Koch, J. Floege, 1998, Kidney international.

CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis.

B. Smeets, J. Deegens, J. Wetzels, 2017, Kidney international.

CD 44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segment

B. Smeets, J. Deegens, J. Wetzels, 2017 .

Subtotal ablation of parietal epithelial cells induces crescent formation.

B. Smeets, J. Wetzels, J. Floege, 2012, Journal of the American Society of Nephrology : JASN.

Common histological patterns in glomerular epithelial cells in secondary focal segmental glomerulosclerosis.

P. Boor, B. Smeets, J. Floege, 2015, Kidney international.

The peroxisome proliferator-activated receptor-α agonist, BAY PP1, attenuates renal fibrosis in rats.

P. Boor, A. Heidland, K. Šebeková, 2011, Kidney international.

Gene-polymorphisms of angiotensin converting enzyme and endothelial nitric oxide synthase in patients with primary glomerulonephritis.

V. Kliem, J. Floege, T. Ostendorf, 1997, Clinical nephrology.

Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D.

P. Boor, C. Alpers, F. Eitner, 2011, Kidney international.

Treatment targets in renal fibrosis.

P. Boor, J. Floege, K. Šebeková, 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

New Aspects of Kidney Fibrosis–From Mechanisms of Injury to Modulation of Disease

P. Boor, E. Latz, J. Floege, 2022, Frontiers in Medicine.

Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs.

Victor G. Puelles, K. Patel, P. Boor, 2021, The Journal of clinical investigation.

Upregulation of group IB secreted phospholipase A(2) and its M-type receptor in rat ANTI-THY-1 glomerulonephritis.

J. Pfeilschifter, G. Lambeau, T. Nevalainen, 2006, Kidney international.

Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury

N. Gassler, A. Gressner, J. Floege, 2008, Laboratory Investigation.

Reply from Schubert, Ostendorf and Schmidt

T. Ostendorf, Reinhold E. Schmidt, J. Schubert, 1995 .

Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.

P. Boor, J. Bernhagen, H. Lue, 2016, Journal of the American Society of Nephrology : JASN.

Key metalloproteinase-mediated pathways in the kidney

J. Floege, A. Ludwig, T. Ostendorf, 2021, Nature Reviews Nephrology.

Therapeutic nuclear shuttling of YB-1 reduces renal damage and fibrosis.

D. Enders, T. Rauen, J. Floege, 2016, Kidney international.

Cold Shock Proteins Mediate GN with Mesangioproliferation.

B. Isermann, J. Floege, P. Mertens, 2016, Journal of the American Society of Nephrology : JASN.

YB‐1 orchestrates onset and resolution of renal inflammation via IL10 gene regulation

P. Boor, T. Rauen, J. Floege, 2017, Journal of cellular and molecular medicine.

Heterogeneous PIG-A mutations in different cell lineages in paroxysmal nocturnal hemoglobinuria.

R. Schmidt, J. Schubert, C. Scholz, 1995, Blood.

Biology of GPI anchors and pathogenesis of paroxysmal nocturnal hemoglobinuria.

R. Schmidt, J. Schubert, T. Ostendorf, 1994, Immunology today.

Diffusion‐weighted MRI does not reflect kidney fibrosis in a rat model of fibrosis

P. Boor, C. Kuhl, J. Gieseke, 2015, Journal of magnetic resonance imaging : JMRI.

Role for CD74 and CXCR4 in clathrin-dependent endocytosis of the cytokine MIF.

J. Bernhagen, H. Lue, C. Weber, 2012, European journal of cell biology.

Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts.

P. Boor, C. Henkel, G. Müller-Newen, 2013, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Specific antagonism of PDGF prevents renal scarring in experimental glomerulonephritis.

N. Janjić, J. Floege, H. Kawachi, 2001, Journal of the American Society of Nephrology : JASN.

The YB-1:Notch-3 axis modulates immune cell responses and organ damage in systemic lupus erythematosus.

T. Rauen, J. Floege, V. Jankowski, 2019, Kidney international.

Novel approach to specific growth factor inhibition in vivo: antagonism of platelet-derived growth factor in glomerulonephritis by aptamers.

N. Janjić, S. Gill, J. Floege, 1999, The American journal of pathology.

and matrix production in vivo

J. Floege, U. Rüther, A. Rees, 1997 .

Patients with IgA nephropathy exhibit high systemic PDGF-DD levels.

P. Boor, C. Cohen, F. Eitner, 2009, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Extracellular Actin Impairs Glomerular Capillary Repair in Experimental Mesangioproliferative Glomerulonephritis

F. Eitner, J. Floege, G. Gabbiani, 2003, Nephron Experimental Nephrology.

Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms

P. Boor, C. Cohen, F. Eitner, 2013, The Journal of pathology.

Endothelin signaling via guanine exchange factor C3G in renal glomerular mesangial cells.

A. Sorokin, T. Ostendorf, D. Bokemeyer, 2010, Canadian journal of physiology and pharmacology.

DNA binding protein YB-1 is a part of the neutrophil extracellular trap mediation of kidney damage and cross-organ effects.

J. Floege, Yi Fang, Xiaoqiang Ding, 2023, Kidney international.

YB-1 Is an Early and Central Mediator of Bacterial and Sterile Inflammation In Vivo

P. Boor, F. Tacke, T. Rauen, 2013, The Journal of Immunology.

R-roscovitine (CYC202) alleviates renal cell proliferation in nephritis without aggravating podocyte injury.

F. Eitner, J. Floege, A. Barnett, 2005, Kidney international.

Treatment of experimental mesangioproliferative glomerulonephritis with non-anticoagulant heparin: therapeutic efficacy and safety.

K. Koch, J. Floege, T. Ostendorf, 1997, Laboratory investigation; a journal of technical methods and pathology.

Role of platelet-derived growth factor-CC in capillary rarefaction in renal fibrosis.

Ulf Eriksson, Peter Boor, Jürgen Floege, 2015, The American journal of pathology.

Effects and mechanisms of angiotensin II receptor blockade with telmisartan in a normotensive model of mesangioproliferative nephritis.

P. Boor, F. Eitner, J. Floege, 2011, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Diffusion‐weighted MRI does not reflect kidney fibrosis in a rat model of fibrosis

P. Boor, C. Kuhl, J. Gieseke, 2015, Journal of magnetic resonance imaging : JMRI.

The Effects of Platelet-Derived Growth Factor Antagonism in Experimental Glomerulonephritis Are Independent of the Transforming Growth Factor– (cid:1) System

S. Dooley, N. Janjić, F. Eitner, 2002 .

The Effects of Platelet-Derived Growth Factor Antagonism in Experimental Glomerulonephritis Are Independent of the Transforming Growth Factor– (cid:1) System

S. Dooley, N. Janjić, F. Eitner, 2002 .

Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes.

P. Boor, G. Müller-Newen, F. Eitner, 2007, Journal of the American Society of Nephrology : JASN.

Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts.

P. Boor, C. Henkel, G. Müller-Newen, 2013, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis.

P. Boor, F. Eitner, J. Floege, 2008, Journal of the American Society of Nephrology : JASN.

Role for CD74 and CXCR4 in clathrin-dependent endocytosis of the cytokine MIF.

J. Bernhagen, H. Lue, C. Weber, 2012, European journal of cell biology.

Aptamers: novel tools for specific intervention studies.

N. Janjić, J. Floege, T. Ostendorf, 1999, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Lineage tracing reveals transient phenotypic adaptation of tubular cells during acute kidney injury

Mingbo Cheng, R. Kramann, T. Ostendorf, 2024, iScience.