S. Osawa

发表

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin

P. Wong, T. Kodama, T. Iwatsubo, 2012, Oncogene.

Phosphoinositides Suppress γ-Secretase in Both the Detergent-soluble and -insoluble States*

Y. Ihara, S. Funamoto, Masafumi Shimojo, 2008, Journal of Biological Chemistry.

Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition.

T. Iwatsubo, T. Tomita, Nobuki Kato, 2013, Journal of medicinal chemistry.

Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library.

T. Iwatsubo, T. Tomita, H. Miyachi, 2010, Bioorganic & medicinal chemistry letters.

Equimolar Production of Amyloid β-Protein and Amyloid Precursor Protein Intracellular Domain from β-Carboxyl-terminal Fragment by γ-Secretase*

Y. Ihara, S. Funamoto, N. Dohmae, 2006, Journal of Biological Chemistry.

FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons

T. Iwatsubo, T. Tomita, S. Osawa, 2013, PloS one.

Two Novel Mutations in the First Transmembrane Domain of Presenilin1 Cause Young-Onset Alzheimer's Disease.

W. Jagust, B. Reed, J. Ringman, 2017, Journal of Alzheimer's Disease.

Single Chain Variable Fragment against Nicastrin Inhibits the γ-Secretase Activity*

P. Wong, T. Kodama, T. Iwatsubo, 2009, The Journal of Biological Chemistry.

Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.

Y. Ihara, S. Funamoto, N. Dohmae, 2006, The Journal of biological chemistry.

Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation

T. Iwatsubo, T. Tomita, T. Fukuyama, 2014, Molecular Neurodegeneration.

Modulation of Lipid Kinase PI4KIIα Activity and Lipid Raft Association of Presenilin 1 Underlies γ-Secretase Inhibition by Ginsenoside (20S)-Rg3*

D. Berman, Y. Ihara, Hyun-Ok Yang, 2013, The Journal of Biological Chemistry.

Activity-Dependent Proteolytic Cleavage of Neuroligin-1

N. Matsuki, K. Horiuchi, T. Iwatsubo, 2012, Neuron.

Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities*

E. Futai, S. Ishiura, T. Tomita, 2015, The Journal of Biological Chemistry.

Phenylpiperidine‐type γ‐secretase modulators target the transmembrane domain 1 of presenilin 1

T. Iwatsubo, O. Berezovska, T. Tomita, 2011, The EMBO journal.

Cooperative Roles of Hydrophilic Loop 1 and the C-Terminus of Presenilin 1 in the Substrate-Gating Mechanism of γ-Secretase

T. Iwatsubo, T. Tomita, S. Osawa, 2015, The Journal of Neuroscience.

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

J. Trojanowski, T. Iwatsubo, T. Tomita, 2011, The Journal of Neuroscience.

Comparison of the pharmacokinetics of erlotinib administered in complete fasting and 2 h after a meal in patients with lung cancer

Y. Ohe, H. Utsumi, T. Tamura, 2015, Cancer Chemotherapy and Pharmacology.

Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator

Takeshi Iwatsubo, Satoko Osawa, Shigeyuki Yokoyama, 2014, Proceedings of the National Academy of Sciences.

Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.

T. Iwatsubo, T. Tomita, S. Osawa, 2013, Biochemistry.