T. Bara

发表

Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.

J. Clader, D. Burnett, E. Parker, 2011, Biochemistry.

Studies to Investigate the in Vivo Therapeutic Window of the γ-Secretase Inhibitor N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-l-alaninamide (LY411,575) in the CRND8 Mouse

Lynn A. Hyde, G. Higgins, J. Clader, 2006, Journal of Pharmacology and Experimental Therapeutics.

Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity.

W. Greenlee, S. Shapiro, A. Palani, 2002, Journal of medicinal chemistry.

Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.

Rebecca T. Ruck, Yongxin Han, J. Howe, 2016, ACS medicinal chemistry letters.

2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

W. Greenlee, H. Guzik, J. Clader, 2007 .

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors.

Lynn A. Hyde, W. Greenlee, Mark D. McBriar, 2013, Bioorganic & medicinal chemistry letters.

Iminoheterocycles as gamma-secretase modulators.

Lynn A. Hyde, J. Voigt, Zhaoning Zhu, 2010, Bioorganic & medicinal chemistry letters.

Novel orally active morpholine N-arylsulfonamides gamma-secretase inhibitors with low CYP 3A4 liability.

Lynn A. Hyde, W. Greenlee, J. Clader, 2009, Bioorganic & medicinal chemistry letters.

Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease

W. Greenlee, J. Clader, A. Nomeir, 2007 .

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease.

W. Greenlee, R. Xu, J. Clader, 2012, ACS medicinal chemistry letters.

Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Ruo Xu, Zhiqiang Zhao, Murali Rajagopalan, 2007 .

Tetrahydroquinoline sulfonamides as γ-secretase inhibitors

Zhiqiang Zhao, Wei Li, William J. Greenlee, 2007 .

Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors.

Zhiqiang Zhao, William J Greenlee, Murali Rajagopalan, 2007, Bioorganic & medicinal chemistry letters.

Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation*

Jay S. Fine, G. Higgins, M. Pinzon-Ortiz, 2004, Journal of Biological Chemistry.

SAR of tricyclic sulfones as γ-secretase inhibitors

Lynn A. Hyde, W. Greenlee, Mark D. McBriar, 2011 .

Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity.

W. Greenlee, Mark D. McBriar, R. Xu, 2010, Bioorganic & medicinal chemistry letters.

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation.

G. Higgins, M. Pinzon-Ortiz, E. Parker, 2004, The Journal of biological chemistry.

Concise formation of 4-benzyl piperidines and related derivatives using a Suzuki protocol.

M. Miller, A. Palani, A. Bauer, 2001, The Journal of organic chemistry.

Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.

Walter A. Korfmacher, W. Greenlee, J. Clader, 2015, Bioorganic & medicinal chemistry letters.

Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo.

Lynn A. Hyde, W. Greenlee, Xiaohong Zhu, 2012, Journal of medicinal chemistry.

The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.

Lynn A. Hyde, W. Greenlee, Wei Zhou, 2013, Bioorganic & medicinal chemistry letters.