T. Asberom

发表

Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.

J. Clader, D. Burnett, E. Parker, 2011, Biochemistry.

Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED.

W. Greenlee, A. Stamford, H. Guzik, 2005, Bioorganic & medicinal chemistry letters.

Tetracyclic sulfones as potent gamma-secretase inhibitors: synthesis and structure-activity relationship studies.

Lynn A. Hyde, W. Greenlee, R. Xu, 2010, Bioorganic & medicinal chemistry letters.

A Highly Efficient Total Synthesis of (+)-Himbacine

R. Davies, T. Asberom, S. Chackalamannil, 1996 .

Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents.

W. Greenlee, C. Foster, D. Doller, 2005, Journal of medicinal chemistry.

2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

W. Greenlee, H. Guzik, J. Clader, 2007 .

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors.

Lynn A. Hyde, W. Greenlee, Mark D. McBriar, 2013, Bioorganic & medicinal chemistry letters.

SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction.

W. Greenlee, A. Stamford, R. Xu, 2004, Bioorganic & medicinal chemistry letters.

The chemistry of cyclic vinyl ethers. 6. Total synthesis of polyether ionophore antibiotics of the calcimycin (A-23187) class

R. K. Boeckman, B. Johnston, T. Asberom, 1991 .

A convergent general synthetic protocol for construction of spirocyclic ketal ionophores: an application to the total synthesis of (-)-A-23187 (calcimycin)

R. K. Boeckman, B. Johnston, T. Asberom, 1987 .

Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease

W. Greenlee, J. Clader, A. Nomeir, 2007 .

Synthesis and structure-activity relationships of M(2)-selective muscarinic receptor ligands in the 1-[4-(4-arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family.

J. Lachowicz, T. Asberom, J. Tagat, 2002, Bioorganic & medicinal chemistry letters.

A Convergent General Synthetic Protocol for Construction of Spirocyclic Ketal Ionophores: An Application to the Total Synthesis of (‐)‐A‐23187 (Calcimycin) (XIII).

R. K. Boeckman, B. Johnston, T. Asberom, 1988 .

The Chemistry of Cyclic Vinyl Ethers. Part 6. Total Synthesis of Polyether Ionophore Antibiotics of the Calcimycin (A-23187) Class.

R. K. Boeckman, B. Johnston, T. Asberom, 1991 .

Total Synthesis of (+)-Himbacine and (+)-Himbeline.

D. Doller, A. McPhail, R. Davies, 1999, The Journal of organic chemistry.

Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Ruo Xu, Zhiqiang Zhao, Murali Rajagopalan, 2007 .

Tetrahydroquinoline sulfonamides as γ-secretase inhibitors

Zhiqiang Zhao, Wei Li, William J. Greenlee, 2007 .

Muscarinic agonists and antagonists in the treatment of Alzheimer's disease.

C. Strader, J. Lachowicz, J. Clader, 2001, Farmaco.

Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors.

Zhiqiang Zhao, William J Greenlee, Murali Rajagopalan, 2007, Bioorganic & medicinal chemistry letters.

Efficient synthesis and reaction pathway studies of novel fused morpholine oxadiazolines for use as gamma secretase modulators

W. Greenlee, Xiaohong Zhu, A. Palani, 2012 .

Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo.

Lynn A. Hyde, W. Greenlee, Xiaohong Zhu, 2012, Journal of medicinal chemistry.

In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

Lynn A. Hyde, G. Higgins, J. Clader, 2013, International journal of Alzheimer's disease.

Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors.

W. Greenlee, A. Stamford, R. Xu, 2002, Bioorganic & medicinal chemistry letters.

Total Synthesis of (+)‐Himbacine and (+)‐Himbeline.

D. Doller, A. McPhail, R. Davies, 1999 .