A. Fukumori

发表

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

T. Kudo, T. Iwatsubo, M. Takeda, 2002, The EMBO journal.

Presenilins mediate a dual intramembranous γ‐secretase cleavage of Notch‐1

T. Kudo, T. Iwatsubo, M. Takeda, 2002 .

Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.

T. Kudo, M. Takeda, Toshihisa Tanaka, 2006, Biochemistry.

Secretion of the Notch-1 Abeta-like peptide during Notch signaling.

M. Takeda, S. Tagami, M. Okochi, 2006, The Journal of biological chemistry.

Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.

Birgit Dümpelfeld, C. Hopf, S. Hobson, 2009, Biochemistry.

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ‐secretase

C. Haass, S. Lichtenthaler, P. Kuhn, 2013, Journal of neurochemistry.

Requirement for small side chain residues within the GxGD‐motif of presenilin for γ‐secretase substrate cleavage

C. Haass, H. Steiner, A. Fukumori, 2010, Journal of neurochemistry.

Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes

R. Morishita, N. Sato, T. Saido, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs

R. Morishita, N. Sato, M. Takeda, 2012, PloS one.

Deletion of B-cell translocation gene 2 (BTG2) alters the responses of glial cells in white matter to chronic cerebral hypoperfusion

N. Sato, T. Mashimo, H. Tomimoto, 2021, Journal of neuroinflammation.

FAD-linked presenilin-1 mutants impede translation regulation under ER stress.

T. Kudo, M. Takeda, M. Tohyama, 2002, Biochemical and biophysical research communications.

Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of γ-Secretase-Mediated Intramembrane Proteolysis

C. Haass, R. Fluhrer, H. Steiner, 2010, The Journal of Neuroscience.

Inhibition of endocytosis activates alternative degradation pathway of βAPP in cultured cells

T. Kudo, M. Takeda, Toshihisa Tanaka, 2006 .

Characterization of Tau ELISAs for Evaluating Tau Accumulation in the Brains With Alzheimer’s Disease

N. Sato, S. Murayama, A. Fukumori, 2021 .

Correction: Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs

R. Morishita, N. Sato, M. Takeda, 2012, PLoS ONE.

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases

E. Kremmer, M. Rossner, C. Haass, 2015, The Journal of Biological Chemistry.

Processes of β-Amyloid and Intracellular Cytoplasmic Domain Generation by Presenilin/γ-Secretase

T. Kudo, M. Takeda, Toshihisa Tanaka, 2008, Neurodegenerative Diseases.

Supplemental Information Semagacestat Is a Pseudo-Inhibitor of g-Secretase

T. Kudo, M. Takeda, Y. Ihara, 2022 .

Effect of valine on the efficiency and precision at S4 cleavage of the Notch‐1 transmembrane domain

M. Takeda, S. Tagami, M. Okochi, 2006, Journal of neuroscience research.

Altered localization of amyloid precursor protein under endoplasmic reticulum stress.

T. Kudo, T. Tabira, M. Takeda, 2006, Biochemical and biophysical research communications.

Novel γ-Secretase Enzyme Modulators Directly Target Presenilin Protein*

C. Haass, K. Baumann, H. Steiner, 2011, The Journal of Biological Chemistry.

β-Amyloid Precursor Protein Mutants Respond to γ-Secretase Modulators*♦

Richard M. Page, C. Haass, R. Page, 2010, The Journal of Biological Chemistry.

Intramembrane Proteolysis of GXGD-type Aspartyl Proteases Is Slowed by a Familial Alzheimer Disease-like Mutation*

E. Kremmer, D. Teplow, C. Haass, 2008, Journal of Biological Chemistry.

Foamy Virus Envelope Protein Is a Substrate for Signal Peptide Peptidase-like 3 (SPPL3)*

E. Kremmer, B. Schröder, C. Haass, 2012, The Journal of Biological Chemistry.

Regulated Intramembrane Proteolysis and Degradation of Murine Epithelial Cell Adhesion Molecule mEpCAM

W. Zimmermann, B. Mack, O. Gires, 2013, PloS one.

Aβ induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum–associated degradation pathway

T. Kudo, T. Tabira, M. Takeda, 2006 .

Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74.

P. Saftig, Susann Hüttl, B. Schröder, 2016, The Biochemical journal.

Cleavage and Cell Adhesion Properties of Human Epithelial Cell Adhesion Molecule (HEPCAM)*

N. Stoecklein, B. Lenarčič, K. Lauber, 2015, The Journal of Biological Chemistry.

Shedding of glycan‐modifying enzymes by signal peptide peptidase‐like 3 (SPPL3) regulates cellular N‐glycosylation

R. Obst, B. Schröder, C. Haass, 2014, The EMBO journal.

Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis

A. Tholey, B. Schröder, Torben Mentrup, 2019, The Journal of experimental medicine.

Rare variants in β-Amyloid precursor protein (APP) and Parkinson’s disease

Christian Gieger, Dietrich Haubenberger, Thomas Meitinger, 2015, European Journal of Human Genetics.

Secretion of the Notch-1 Aβ-like Peptide during Notch Signaling*

M. Takeda, S. Tagami, M. Okochi, 2006, Journal of Biological Chemistry.

Substrate recruitment by γ-secretase.

H. Steiner, A. Fukumori, L. P. Feilen, 2020, Seminars in cell & developmental biology.

Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor

T. Kudo, M. Takeda, Toshihisa Tanaka, 2009, Neurodegenerative Diseases.

Regulation of Notch Signaling by Dynamic Changes in the Precision of S3 Cleavage of Notch-1

T. Kudo, M. Takeda, Toshihisa Tanaka, 2007, Molecular and Cellular Biology.

Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase

S. Tagami, M. Okochi, H. Steiner, 2018, Cell stress.

Development of new screening system for Alzheimer disease, in vitro Aβ sink assay, to identify the dissociation of soluble Aβ from fibrils

Y. Taniyama, T. Ogihara, R. Morishita, 2006, Neurobiology of Disease.

Ribavirin Treatment for Severe Schizophrenia with Anti-Borna Disease Virus 1 Antibodies 30 Years after Onset

K. Tomonaga, K. Yanagida, T. Morihara, 2023, Case reports in psychiatry.

Two Neuropsychiatric Cases Seropositive for Bornavirus Improved by Ribavirin.

T. Uema, K. Tomonaga, T. Honda, 2018, Japanese journal of infectious diseases.

Isotype analysis of human anti-Borna disease virus antibodies in Japanese psychiatric and general population.

M. Takeda, K. Ikuta, K. Tomonaga, 2008, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

C. Haass, R. Feederle, S. Lichtenthaler, 2017, EMBO molecular medicine.

APLP2 is predominantly cleaved by β‐secretase and γ‐secretase in the human brain

T. Kudo, K. Yanagida, S. Tagami, 2023, Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society.

Semagacestat Is a Pseudo-Inhibitor of γ-Secretase.

T. Kudo, M. Takeda, Y. Ihara, 2017, Cell reports.

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.

Richard M. Page, A. Flohr, C. Haass, 2008, The Journal of biological chemistry.

Interaction between APOE genotype and diabetes in cognitive decline

N. Sato, G. Bu, A. Fukumori, 2020, Alzheimer's & dementia.

Aβ43‐producing PS1 FAD mutants cause altered substrate interactions and respond to γ‐secretase modulation

K. Baumann, R. Feederle, H. Steiner, 2019, EMBO Reports.

Substrate recruitment of γ‐secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping

H. Steiner, A. Fukumori, Akio Fukumori, 2016, The EMBO journal.

Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease

E. Kremmer, A. Giese, T. Arzberger, 2016, EMBO molecular medicine.

Generation of Alzheimer Disease-associated Amyloid β42/43 Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness*

F. Kamp, H. Steiner, A. Fukumori, 2012, The Journal of Biological Chemistry.

Generation of Aβ38 and Aβ42 Is Independently and Differentially Affected by Familial Alzheimer Disease-associated Presenilin Mutations and γ-Secretase Modulation*

Richard M. Page, A. Flohr, C. Haass, 2008, Journal of Biological Chemistry.

Attenuated Aβ42 Responses to Low Potency γ-Secretase Modulators Can Be Overcome for Many Pathogenic Presenilin Mutants by Second-generation Compounds*

Richard M. Page, C. Haass, K. Baumann, 2011, The Journal of Biological Chemistry.

ELISA Evaluation of Tau Accumulation in the Brains of Patients with Alzheimer Disease.

N. Sato, S. Murayama, Ghupurjan Gheni, 2021, Journal of neuropathology and experimental neurology.

Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis

M. Zacharias, R. Feederle, H. Steiner, 2022, bioRxiv.

Pathogenic Aβ generation in familial Alzheimer’s disease: novel mechanistic insights and therapeutic implications

H. Steiner, A. Fukumori, J. Trambauer, 2020, Current Opinion in Neurobiology.

Ab43-producing PS1 FAD mutants cause altered substrate interactions and respond to c-secretase modulation

K. Baumann, R. Feederle, H. Steiner, 2019 .

The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance.

M. Schuldiner, E. Kremmer, Michal Breker, 2014, Molecular cell.

Analyzing Amyloid-β Peptide Modulation Profiles and Binding Sites of γ-Secretase Modulators.

H. Steiner, A. Fukumori, B. Kretner, 2017, Methods in enzymology.

Upregulated expression of a subset of genes in APP;ob/ob mice: Evidence of an interaction between diabetes‐linked obesity and Alzheimer’s disease

R. Morishita, N. Sato, M. Kikuchi, 2021, FASEB bioAdvances.