Jodi Bradley

发表

Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase.

Q. Wang, D. Seiffert, R. Olson, 2002, Biochemical and biophysical research communications.

Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease.

Shannon Rumfelt, N. Chen, S. Hitchcock, 2013, Bioorganic & medicinal chemistry letters.

The Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in vivo Selectivity over BACE2.

D. Whittington, Michael G. Johnson, M. Bartberger, 2020, Journal of medicinal chemistry.

Evidence that thrombocytopenia observed in humans treated with orally bioavailable glycoprotein IIb/IIIa antagonists is immune mediated.

R. Wynn, D. Seiffert, A. Stern, 2002, Blood.

Effects of the glycoprotein IIb/IIIa antagonist Roxifiban on P-selectin expression, fibrinogen binding, and microaggregate formation in a phase I dose-finding study: no evidence for platelet activation during treatment with a glycoprotein IIb/IIIa antagonist

David E. Martin, G. Feuerstein, D. Seiffert, 2003, Platelets.

Elevated total homocysteine is associated with increased platelet activation at the site of microvascular injury: effects of folic acid administration

R. Wynn, R. Aster, P. Coste, 2007 .

Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells

R. Wynn, P. Scherle, Phillip C. C. Liu, 2006, Cancer biology & therapy.

Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease

M. van Lookeren Campagne, M. Colonna, Daniel C. Ellwanger, 2021, Proceedings of the National Academy of Sciences.

Molecular basis for the loss-of-function effects of the Alzheimer's disease–associated R47H variant of the immune receptor TREM2

A. Lim, Zhongqi Zhang, Zhulun Wang, 2018, The Journal of Biological Chemistry.

Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors*

Robert A. Copeland, David W. Robertson, Qian Wang, 2000, The Journal of Biological Chemistry.

Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for receptor dimerization.

J. Lear, M. Pantoliano, D. E. Van Dyk, 1994, Biochemistry.