Xiao-ping Shi

发表

Presenilin-1 and Presenilin-2 Exhibit Distinct yet Overlapping γ-Secretase Activities*

Min Xu, Qian Huang, D. Hazuda, 2003, Journal of Biological Chemistry.

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

A. Simon, S. Stachel, C. Coburn, 2008, The Journal of pharmacology and experimental therapeutics.

Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics.

Amy S. Espeseth, Min Xu, Qian Huang, 2005, The Journal of biological chemistry.

Abetapp secretases are co-expressed with Abetapp in the pancreatic islets.

C. Austin, S. Gardell, Xiao-ping Shi, 2001, Journal of Alzheimer's disease : JAD.

Aβpp secretases are co-expressed with Aβpp in the pancreatic islets

C. Austin, S. Gardell, Xiao-ping Shi, 2001 .

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.

Min Xu, Qian Huang, D. Hazuda, 2003, The Journal of biological chemistry.

Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state

Min Xu, Qian Huang, M. Lai, 2000, Neurobiology of Aging.

Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

Min Xu, Qian Huang, A. Nadin, 2000, Nature.

First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2009, Journal of Pharmacology and Experimental Therapeutics.

In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1

A. Simon, S. Stachel, C. Coburn, 2008, Journal of Pharmacology and Experimental Therapeutics.

First Demonstration of Cerebrospinal Fluid and Plasma A (cid:1) Lowering with Oral Administration of a (cid:1) -Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates □ S

Alison R. Gregro, Amy S. Espeseth, Min Xu, 2008 .

LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease

Shane D. Marine, Amy S. Espeseth, Min Xu, 2006, Proceedings of the National Academy of Sciences.

A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels

Min Xu, Xiao-Ping Shi, Yuanjiang Yu, 2006, Molecular and Cellular Neuroscience.

Characterization of plasma β‐secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease

A. Simon, Katherine Tugusheva, S. Sankaranarayanan, 2012, Journal of neuroscience research.

β-Secretase Cleavage at Amino Acid Residue 34 in the Amyloid β Peptide Is Dependent upon γ-Secretase Activity*

Min Xu, Qian Huang, D. Hazuda, 2003, Journal of Biological Chemistry.

Novel mutations introduced at the β-site of amyloid β protein precursor enhance the production of amyloid β peptide by BACE1 in vitro and in cells

Amy S. Espeseth, Min Xu, Qian Huang, 2005 .

Novel mutations introduced at the β-site of amyloid β protein precursor enhance the productio no famyloi d βpeptid eb yBACE 1in vitr oan di ncells

Amy S. Espeseth, Min Xu, Qian Huang, 2005 .

Biochemical and cell-based assays for characterization of BACE-1 inhibitors.

Xiao-Ping Shi, Amy S Espeseth, Min Xu, 2005, Analytical biochemistry.

Decrease in age-adjusted cerebrospinal fluid beta-secretase activity in Alzheimer's subjects.

A. Simon, V. Devanarayan, Katherine Tugusheva, 2008, Clinical biochemistry.

Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.

Min Xu, Qian Huang, D. Hazuda, 2005, Journal of Alzheimer's disease : JAD.

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.

Min Xu, Qian Huang, Yueming Li, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Activity profile-based siRNA screen to explore the functional genomics of Alzheimer's disease

Shane D. Marine, Amy S. Espeseth, Min Xu, 2007 .