A. Saitoh

发表

Effects of first- and second-generation histamine-H1-receptor antagonists on the pentobarbital-induced loss of the righting reflex in streptozotocin-induced diabetic mice.

J. Kamei, Shoko Hirano, Shigeo Miyata, 2005, Journal of pharmacological sciences.

Gene expression profiling reveals complex changes in the olfactory bulbectomy model of depression after chronic treatment with antidepressants.

J. Kamei, A. Saitoh, Kou Takahashi, 2008, Journal of pharmacological sciences.

Evidence for the modulation of spontaneous locomotor activity by higher serum glucose levels and/or spleen-derived factor(s) in diabetic mice.

J. Kamei, A. Saitoh, 1997, Life sciences.

Discovery of δ opioid receptor full agonists lacking a basic nitrogen atom and their antidepressant-like effects.

Daisuke Yamada, A. Saitoh, Shigeto Hirayama, 2020, Bioorganic & medicinal chemistry letters.

Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept.

H. Nagase, A. Saitoh, 2018, Handbook of experimental pharmacology.

Novel delta opioid receptor agonists with oxazatricyclodecane structure.

Y. Uezono, M. Yamada, H. Nagase, 2014, ACS medicinal chemistry letters.

Involvement of P2X receptor subtypes in ATP-induced enhancement of the cough reflex sensitivity.

J. Kamei, A. Saitoh, Yoshiki Takahashi, 2005, European journal of pharmacology.

Effect of N-arachidonoyl-(2-methyl-4-hydroxyphenyl) amine (VDM11), an anandamide transporter inhibitor, on capsaicin-induced cough in mice

J. Kamei, A. Saitoh, Yuji Yoshikawa, 2006, Cough.

Antitussive effect of NS-398, a selective cyclooxygenase-2 inhibitor, in guinea pigs.

J. Kamei, A. Saitoh, Yasuhiro Matsunawa, 2004, European journal of pharmacology.

Lysophosphatidic acid induces anxiety-like behavior via its receptors in mice

A. Saitoh, M. Yamada, M. Yamada, 2015, Journal of Neural Transmission.

Correspondence and requests for reprints should be addressed to

H. Sakai, Y. Chiba, M. Misawa, 2022 .

Antitussive effect of Bakumondoto (Mai-men-dong-tang) in guinea-pigs exposed to cigarette smoke

A. Saitoh, Yuji Yoshikawa, 亀井淳三, 2005 .

TRK-820, a selective kappa-opioid agonist, produces potent antinociception in cynomolgus monkeys.

J. Kamei, M. Narita, H. Nagase, 2001, Japanese journal of pharmacology.

The antitussive effects of endomorphin-1 and endomorphin-2 in mice.

J. Kamei, H. Nagase, A. Saitoh, 2003, European Journal of Pharmacology.

Antagonistic effect of buprenorphine on the antitussive effect of morphine is mediated via the activation of mu 1-opioid receptors.

J. Kamei, H. Nagase, A. Saitoh, 1995, Life sciences.

Buprenorphine exerts its antinociceptive activity via mu 1-opioid receptors.

M. Misawa, J. Kamei, H. Nagase, 1995, Life sciences.

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain.

Y. Nagumo, H. Nagase, A. Saitoh, 2015, Bioorganic & medicinal chemistry.

Participation of the nucleus accumbens dopaminergic system in the antidepressant-like actions of a diet rich in omega-3 polyunsaturated fatty acids

K. Wada, M. Sekiguchi, Daisuke Yamada, 2020, PloS one.

Cold-restraint stress-induced ultrasonic vocalization as a novel tool to measure anxiety in mice.

Daisuke Yamada, H. Ichikawa, H. Nagase, 2022, Biological & pharmaceutical bulletin.

The voltage-gated sodium channel activator veratrine induces anxiogenic-like behaviors in rats

Leo Gotoh, A. Saitoh, M. Yamada, 2015, Behavioural Brain Research.

Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice

S. Ishihara, Daisuke Yamada, K. Wada, 2021, Scientific Reports.

Selective agonists of the δ-opioid receptor, KNT-127 and SNC80, act differentially on extinction learning of contextual fear memory in mice

Daisuke Yamada, H. Nagase, A. Saitoh, 2019, Neuropharmacology.

Riluzole in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice

A. Saitoh, M. Yamada, M. Yamada, 2014, Psychopharmacology.

Modification of the effects of 7-OH-DPAT, a dopamine D3-receptor agonist, on morphine-induced hyperlocomotion by diabetes.

J. Kamei, A. Saitoh, 1996, Life sciences.

Involvement of dopamine D2 receptor-mediated functions in the modulation of morphine-induced antinociception in diabetic mouse

J. Kamei, A. Saitoh, 1996, Neuropharmacology.

A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice.

H. Nagase, A. Saitoh, M. Yamada, 2018, Journal of pharmacological sciences.

The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice

H. Nagase, A. Saitoh, M. Yamada, 2018, Behavioural Brain Research.

Incidence of Delirium With Different Oral Opioids in Previously Opioid-Naive Patients

Daisuke Yamada, A. Saitoh, R. Tanaka, 2022, The American journal of hospice & palliative care.

Potent antinociceptive effects of TRK-820, a novel κ-opioid receptor agonist

M. Narita, Tsutomu Suzuki, H. Nagase, 1999 .

TRK-820 , a Selective-Opioid Agonist , Produces Potent Antinociception in Cynomolgus Monkeys

J. Kamei, M. Narita, Tsutomu Suzuki, 2001 .

Pharmacokinetic and pharmacodynamic profiles of the antitussive principles of Glycyrrhizae radix (licorice), a main component of the Kampo preparation Bakumondo-to (Mai-men-dong-tang).

Hiroyuki Ichiki, Masayoshi Kubo, J. Kamei, 2005, European journal of pharmacology.

Design and synthesis of a metabolically stable and potent antitussive agent, a novel delta opioid receptor antagonist, TRK-851.

H. Ohno, S. Ueno, H. Nagase, 2008, Bioorganic & Medicinal Chemistry.

Possible involvement of the spinal nitric oxide/cGMP pathway in vincristine-induced painful neuropathy in mice

J. Kamei, A. Saitoh, N. Tamura, 2005, Pain.

Disulfiram Produces Potent Anxiolytic-Like Effects Without Benzodiazepine Anxiolytics-Related Adverse Effects in Mice

Y. Sano, K. Matsushima, Daisuke Yamada, 2022, Frontiers in Pharmacology.

Role of δ-opioid receptor subtypes in anxiety-related behaviors in the elevated plus-maze in rats

J. Kamei, A. Saitoh, K. Onodera, 2005, Psychopharmacology.

The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions

K. Wada, H. Nagase, A. Saitoh, 2011, Behavioural Brain Research.

Effects of the Experimental Diabetes on Dopamine D1 Receptor-Mediated Locomotor-Enhancing Activity in Mice

J. Kamei, A. Saitoh, K. Morita, 1998, Pharmacology Biochemistry and Behavior.

Validity of the Patient Health Questionnaire (PHQ)-9 and PHQ-2 in general internal medicine primary care at a Japanese rural hospital: a cross-sectional study.

T. Furukawa, N. Yonemoto, M. Inagaki, 2013, General hospital psychiatry.

Takashi Iwai, Toshikazu Saito, A. Saitoh, 2013, Journal of neuroscience research.

ROCK inhibition produces anxiety-related behaviors in mice

J. Kamei, A. Saitoh, K. Honda, 2006, Psychopharmacology.

Administration of a delta opioid receptor agonist KNT-127 to the basolateral amygdala has robust anxiolytic-like effects in rats

H. Nagase, A. Saitoh, M. Yamada, 2018, Psychopharmacology.

Post-reexposure administration of riluzole attenuates the reconsolidation of conditioned fear memory in rats

A. Saitoh, M. Yamada, M. Yamada, 2018, Neuropharmacology.

Administration of riluzole to the basolateral amygdala facilitates fear extinction in rats

A. Saitoh, M. Yamada, M. Yamada, 2018, Behavioural Brain Research.

Administration of riluzole into the basolateral amygdala has an anxiolytic-like effect and enhances recognition memory in the rat

A. Saitoh, M. Yamada, M. Yamada, 2017, Behavioural Brain Research.

The function of SARS-CoV-2 spike protein is impaired by disulfide-bond disruption with mutation at cysteine-488 and by thiol-reactive N-acetyl-cysteine and glutathione

S. Miyazaki, K. Noguchi, T. Wakita, 2022, Biochemical and Biophysical Research Communications.

Type II pyrethroid deltamethrin produces antidepressant-like effects in mice

Y. Tabuchi, I. Takasaki, T. Kondo, 2013, Behavioural Brain Research.

Role of spleen or spleen products in the reduced locomotor-enhancing effect of morphine in diabetic mice

J. Kamei, A. Saitoh, 1996, Neuroscience Letters.

Antinociceptive and antitussive effects of morphine in the DA-bg/bg (beige) rat.

J. Kamei, H. Nagase, A. Saitoh, 1996, European journal of pharmacology.

Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in an olfactory bulbectomized rat model

J. Kamei, A. Saitoh, Kou Takahashi, 2008, Brain Research.

Characterization of the antinociceptive effects of oxycodone in diabetic mice.

J. Kamei, A. Saitoh, C. Nozaki, 2006, European journal of pharmacology.

Chronic vicarious social defeat stress attenuates new-born neuronal cell survival in mouse hippocampus

Daisuke Yamada, A. Saitoh, E. Segi-Nishida, 2021, Behavioural Brain Research.

Effect of mexiletine on vincristine-induced painful neuropathy in mice.

J. Kamei, A. Saitoh, C. Nozaki, 2006, European journal of pharmacology.

Tyrosol Reduces Amyloid-β Oligomer Neurotoxicity and Alleviates Synaptic, Oxidative, and Cognitive Disturbances in Alzheimer's Disease Model Mice.

K. Wada, F. Kametani, M. Sekiguchi, 2019, Journal of Alzheimer's disease : JAD.

Antinociceptive effect of oxycodone in diabetic mice.

J. Kamei, A. Saitoh, C. Nozaki, 2005, European journal of pharmacology.

Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents.

J. Kamei, H. Nagase, A. Saitoh, 2004, Journal of pharmacological sciences.

Supraspinal δ1-opioid receptor-mediated antinociceptive properties of (-)-TAN-67 in diabetic mice

J. Kamei, M. Narita, H. Nagase, 1997 .

Modification of mu-opioid agonist-induced locomotor activity and development of morphine dependence by diabetes.

M. Misawa, M. Ohsawa, J. Kamei, 1995, The Journal of pharmacology and experimental therapeutics.

Antinociceptive effects of the selective non-peptidic δ-opioid receptor agonist TAN-67 in diabetic mice

M. Misawa, M. Ohsawa, J. Kamei, 1995 .

DOR2-selective but not DOR1-selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127

H. Nagase, A. Saitoh, M. Yamada, 2014, Neuropharmacology.

Effects of nociceptin on the exploratory behavior of mice in the hole-board test.

J. Kamei, Shigeo Miyata, A. Saitoh, 2004, European journal of pharmacology.

Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice

Daisuke Yamada, Kenjiro Matsumoto, A. Saitoh, 2022, Frontiers in Neuroscience.

Glucagon-like peptide-2-induced memory improvement and anxiolytic effects in mice

M. Tanabe, A. Saitoh, T. Iwai, 2015, Neuropeptides.

Involvement of δ 1-opioid receptors in the antinociceptive effects of mexiletine in mice

J. Kamei, Y. Kasuya, A. Saitoh, 1995, Neuroscience Letters.

Induction of galanin after chronic sertraline treatment in mouse ventral dentate gyrus

M. Inagaki, A. Saitoh, M. Yamada, 2013, Brain Research.

Effects of milnacipran and fluvoxamine on hyperemotional behaviors and the loss of tryptophan hydroxylase-positive cells in olfactory bulbectomized rats

J. Kamei, A. Saitoh, M. Yamada, 2007, Psychopharmacology.

Multiple barriers against successful care provision for depressed patients in general internal medicine in a Japanese rural hospital: a cross-sectional study

M. Inagaki, M. Yamada, A. Saitoh, 2010, BMC psychiatry.

Research and development of κ opioid receptor agonists and δ opioid receptor agonists.

H. Nagase, A. Saitoh, 2019, Pharmacology & therapeutics.

The novel δ opioid receptor agonist KNT-127 produces distinct anxiolytic-like effects in rats without producing the adverse effects associated with benzodiazepines

H. Nagase, M. Inagaki, A. Saitoh, 2013, Neuropharmacology.

Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines

M. Inagaki, A. Saitoh, Kou Takahashi, 2012, Neuropharmacology.

Riluzole rapidly attenuates hyperemotional responses in olfactory bulbectomized rats, an animal model of depression

M. Inagaki, A. Saitoh, Kou Takahashi, 2011, Behavioural Brain Research.

The modulatory effect of (+)-TAN-67 on the antinociceptive effects of the nociceptin/orphanin FQ in mice.

M. Ohsawa, J. Kamei, M. Narita, 1999, European journal of pharmacology.

The infralimbic and prelimbic medial prefrontal cortices have differential functions in the expression of anxiety-like behaviors in mice

A. Saitoh, M. Yamada, M. Yamada, 2016, Behavioural Brain Research.

Effects of diabetes on spontaneous locomotor activity in mice

Hiroshi Nagase, Miwa Misawa, M. Misawa, 1994, Neuroscience Letters.

Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice

M. Yanagisawa, H. Nagase, A. Saitoh, 2018, Pharmacological reports : PR.

Modulation of glutamatergic synaptic transmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid receptors in mice.

Daisuke Yamada, H. Nagase, A. Saitoh, 2021, Biochemical and biophysical research communications.

Selective δ-Opioid Receptor Agonist, KNT-127, Facilitates Contextual Fear Extinction via Infralimbic Cortex and Amygdala in Mice

Daisuke Yamada, H. Nagase, A. Saitoh, 2022, Frontiers in Behavioral Neuroscience.

A selective delta opioid receptor agonist SNC80, but not KNT-127, induced tremor-like behaviors via hippocampal glutamatergic system in mice

Daisuke Yamada, H. Nagase, A. Saitoh, 2021, Brain Research.

Induction of c-Fos immunoreactivity in the amygdala of mice expressing anxiety-like behavior after local perfusion of veratrine in the prelimbic medial prefrontal cortex

A. Saitoh, M. Yamada, M. Yamada, 2015, Journal of Neural Transmission.

Oxytocin reverses Aβ-induced impairment of hippocampal synaptic plasticity in mice.

M. Tanabe, Daisuke Yamada, A. Saitoh, 2020, Biochemical and biophysical research communications.

Supraspinal delta 1-opioid receptor-mediated antinociceptive properties of (-)-TAN-67 in diabetic mice.

J. Kamei, M. Narita, H. Nagase, 1997, European journal of pharmacology.

Effects of methylphenidate on the hyperemotional behavior in olfactory bulbectomized mice by using the hole-board test.

J. Kamei, Shigeo Miyata, A. Saitoh, 2007, Journal of pharmacological sciences.

Post-reexposure administration of d-cycloserine facilitates reconsolidation of contextual conditioned fear memory in rats

A. Saitoh, M. Yamada, J. Oka, 2017, Journal of Neural Transmission.

Activation of the prelimbic medial prefrontal cortex induces anxiety‐like behaviors via N‐Methyl‐D‐aspartate receptor‐mediated glutamatergic neurotransmission in mice

M. Yamada, M. Inagaki, A. Saitoh, 2014, Journal of neuroscience research.

Involvement of glutamatergic N-methyl-d-aspartate receptors in the expression of increased head-dipping behaviors in the hole-board tests of olfactory bulbectomized mice

J. Kamei, A. Saitoh, Noritaka Hirose, 2016, Behavioural Brain Research.

Effects of selective serotonin reuptake inhibitors on immobility time in the tail suspension test in streptozotocin-induced diabetic mice

J. Kamei, H. Takeda, Shigeo Miyata, 2003, Pharmacology Biochemistry and Behavior.

Prazosin inhibits spontaneous locomotor activity in diabetic mice

J. Kamei, A. Saitoh, K. Onodera, 2002, Pharmacology Biochemistry and Behavior.

Changes in emotional behavior of mice in the hole-board test after olfactory bulbectomy.

J. Kamei, A. Saitoh, M. Yamada, 2006, Journal of pharmacological sciences.

High-frequency ultrasound exposure improves depressive-like behavior in an olfactory bulbectomized rat model of depression

Daisuke Yamada, H. Ichikawa, A. Saitoh, 2022, Neuroreport.

Antidepressant-like Effects of δ Opioid Receptor Agonists in Animal Models

A. Saitoh, M. Yamada, 2012, Current neuropharmacology.

Effect of mexiletine on fenvalerate-induced nociceptive response in diabetic mice.

J. Kamei, A. Saitoh, N. Tamura, 2004, Journal of pharmacological sciences.

The impairment in spatial learning and hippocampal LTD induced through the PKA pathway in juvenile-onset diabetes rats are rescued by modulating NMDA receptor function

A. Saitoh, M. Yamada, J. Oka, 2014, Neuroscience Research.

Rhotekin modulates differentiation of cultured neural stem cells to neurons

A. Saitoh, Kou Takahashi, M. Yamada, 2012, Journal of neuroscience research.

Glucagon-like peptide-2 but not imipramine exhibits antidepressant-like effects in ACTH-treated mice

A. Saitoh, T. Iwai, J. Oka, 2013, Behavioural Brain Research.

Systemic administration of a delta opioid receptor agonist, KNT-127, facilitates extinction learning of fear memory in rats.

Leo Gotoh, H. Nagase, A. Saitoh, 2019, Journal of pharmacological sciences.

Systemic administration of riluzole enhances recognition memory and facilitates extinction of fear memory in rats

M. Inagaki, A. Saitoh, M. Yamada, 2015, Neuropharmacology.

articleMultiple barriers against successful care provision for depressed patients in general internal medicine in a Japanese rural hospital : a cross-sectional study

M. Inagaki, M. Yamada, A. Saitoh, 2010 .

Effects of repeated treatment with a delta opioid receptor agonist KNT-127 on hyperemotionality in olfactory-bulbectomized rats

Leo Gotoh, H. Nagase, A. Saitoh, 2017, Behavioural Brain Research.

Effect of Cigarette Smoke Exposure In Vivo on Bronchial Smooth Muscle Contractility In Vitro in Rats

Y. Chiba, M. Misawa, J. Kamei, 2005 .

Potent antinociceptive effects of TRK-820, a novel kappa-opioid receptor agonist.

M. Narita, H. Nagase, A. Saitoh, 1999, Life sciences.

Intracerebroventricular administration of oxytocin and intranasal administration of the oxytocin derivative improve β‐amyloid peptide (25–35)‐induced memory impairment in mice

Daisuke Yamada, A. Saitoh, T. Iwai, 2022, Neuropsychopharmacology reports.

Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats.

M. Inagaki, A. Saitoh, M. Yamada, 2013, Journal of pharmacological sciences.

Alfaxalone improved in acute stress‐induced tactile hypersensitivity and anxiety‐like behavior in mice

Daisuke Yamada, Junpei Kuroda, A. Saitoh, 2022, Neuropsychopharmacology reports.

The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions

K. Wada, H. Nagase, A. Saitoh, 2011, Behavioural Brain Research.

Riluzole in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice

A. Saitoh, M. Yamada, M. Yamada, 2014, Psychopharmacology.

Novel delta opioid receptor agonists with oxazatricyclodecane structure.

Y. Uezono, M. Yamada, H. Nagase, 2014, ACS medicinal chemistry letters.

Investigative Research on the Importance of Collecting and Examining Drug Information from a Scientific and Objective Point of View

M. Nishikawa, A. Saitoh, Masayo Komoda, 2023, Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics.

KNT-127, a selective delta opioid receptor agonist, shows beneficial effects in the hippocampal dentate gyrus of a chronic vicarious social defeat stress mouse model

Daisuke Yamada, H. Nagase, A. Saitoh, 2023, Neuropharmacology.