K. Kimata

M. Ueda, M. Honda, K. Kimata, 2004, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

Rat costochondral cell characteristics on poly (l-lactide-co-ε-caprolactone) scaffolds

M. Ueda, M. Ueda, K. Hata, 2003 .

Turnover of Heparan Sulfate Depends on 2-O-Sulfation of Uronic Acids*

J. Esko, X. Bai, K. Kimata, 1997, The Journal of Biological Chemistry.

A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells.

Y. Ikawa, K. Kimata, T. Atsumi, 1990, Cell differentiation and development : the official journal of the International Society of Developmental Biologists.

Participation of two different mesenchymes in the developing mouse mammary gland: synthesis of basement membrane components by fat pad precursor cells.

T. Sakakura, Y. Inaguma, Y. Nishizuka, 1985, Journal of embryology and experimental morphology.

Identification of Hyaluronan-binding Domains of Aggrecan*

Yoshihiko Yamada, K. Kimata, N. Itano, 1997, The Journal of Biological Chemistry.

Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction

K. Marumo, K. Fujii, K. Kimata, 2004, Arthritis research & therapy.

Heparan Sulfate 2-O-Sulfotransferase Is Required for Triglyceride-rich Lipoprotein Clearance*

D. Song, J. Esko, Lianchun Wang, 2009, The Journal of Biological Chemistry.

A heparin-binding growth factor, midkine, binds to a chondroitin sulfate proteoglycan, PG-M/versican.

K. Zou, T. Muramatsu, K. Kimata, 2000, European journal of biochemistry.

Adaptation of Alphaviruses to Heparan Sulfate: Interaction of Sindbis and Semliki Forest Viruses with Liposomes Containing Lipid-Conjugated Heparin

J. Smit, R. Bittman, J. Wilschut, 2002, Journal of Virology.

Generation and characterization of a series of monoclonal antibodies that specifically recognize [HexA(±2S)-GlcNAc]n epitopes in heparan sulfate

R. Kannagi, Yeong Shik Kim, E. Joo, 2008, Glycoconjugate Journal.

A monoclonal antibody that specifically recognizes a glucuronic acid 2-sulfate-containing determinant in intact chondroitin sulfate chain.

M. Yamagata, N. Maeda, K. Yoshida, 1987, The Journal of biological chemistry.

Antiviral activity of human lactoferrin: inhibition of alphavirus interaction with heparan sulfate.

D. Meijer, J. Smit, R. Bittman, 2005, Virology.

Sequential synthesis of chondroitin oligosaccharides by immobilized chondroitin polymerase mutants

J. Hirabayashi, K. Kimata, Hideto Watanabe, 2008, Glycoconjugate Journal.

Immunofluorescence Localization of Fibronectin in Chondrosarcoma

J. Foidart, H. Kleinman, G. Martin, 1982 .

Immunofluorescence localization of fibronectin in chondrosarcoma cartilage matrix.

J. Foidart, H. Kleinman, G. Martin, 1982, Cancer research.

Modulation of cytokine function by heparan sulfate proteoglycans: sophisticated models for the regulation of cellular responses to cytokines.

D. Adams, S. Eto, Y. Tanaka, 1998, Proceedings of the Association of American Physicians.

A mutant cell library for systematic analysis of heparan sulfate structure-function relationships

J. Esko, P. Azadi, R. Linhardt, 2018, Nature Methods.

Specific inhibition of FGF-2 signaling with 2-O-sulfated octasaccharides of heparan sulfate.

K. Kimata, H. Habuchi, Takashi Kobayashi, 2009, Glycobiology.

Characterization of a Heparan Sulfate 3-O-Sulfotransferase-5, an Enzyme Synthesizing a Tetrasulfated Disaccharide*

H. Narimatsu, M. Gotoh, N. Kikuchi, 2003, Journal of Biological Chemistry.

Heparan sulfate fine structure and specificity of proteoglycan functions.

H. Nakato, K. Kimata, 2002, Biochimica et biophysica acta.

The Occurrence of Three Isoforms of Heparan Sulfate 6-O-Sulfotransferase Having Different Specificities for Hexuronic Acid Adjacent to the TargetedN-Sulfoglucosamine*

K. Yoshida, K. Kimata, H. Habuchi, 2000, The Journal of Biological Chemistry.

Molecular Characterization and Expression of Heparan-sulfate 6-Sulfotransferase

M. Kobayashi, K. Kimata, H. Habuchi, 1998, The Journal of Biological Chemistry.

Handbook of Glycosyltransferases and Related Genes

Gerald W. Hart, Naoyuki Taniguchi, Hisashi Narimatsu, 2014, Springer Japan.

Regulation of cell-substrate adhesion by proteoglycans immobilized on extracellular substrates.

M. Yamagata, K. Yamada, S. Akiyama, 1989, The Journal of biological chemistry.

Proteoglycan-Lb, a small dermatan sulfate proteoglycan expressed in embryonic chick epiphyseal cartilage, is structurally related to osteoinductive factor.

K. Kimata, T. Shinomura, 1992, The Journal of biological chemistry.

Molecular cloning of the mouse osteoglycin-encoding gene.

K. Kimata, T. Shinomura, M. Ujita, 1995, Gene.

Structure of a heparan sulphate oligosaccharide that binds to basic fibroblast growth factor.

K. Yoshida, S. Suzuki, K. Kimata, 1992, The Biochemical journal.

Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1 Is Necessary for Normal Endochondral Ossification and Aggrecan Metabolism*

Satoru Takahashi, M. Ema, Y. Ikehara, 2010, The Journal of Biological Chemistry.

Antitumor effects of 4‐methylumbelliferone, a hyaluronan synthesis inhibitor, on malignant peripheral nerve sheath tumor

N. Ishiguro, T. Ota, Y. Nishida, 2017, International journal of cancer.

Purification, Characterization, and Molecular Cloning of a Novel Keratan Sulfate Hydrolase, Endo-β-N-acetylglucosaminidase, from Bacillus circulans*

K. Yamagishi, M. Kyogashima, K. Kimata, 2003, Journal of Biological Chemistry.

Versican Facilitates Chondrocyte Differentiation and Regulates Joint Morphogenesis*

P. Kongtawelert, K. Kimata, H. Takagi, 2010, The Journal of Biological Chemistry.

Identification and Characterization of Versican/PG-M Aggregates in Cartilage*

K. Shimizu, Kazuaki Matsumoto, Yoshihiko Yamada, 2006, Journal of Biological Chemistry.

Clonal analysis for developmental potential of chick periosteum-derived cells: agar gel culture system.

K. Ono, K. Watanabe, A. Caplan, 1993, Biochemical and biophysical research communications.

A Novel Mechanism for the Inhibition of Hyaluronan Biosynthesis by 4-Methylumbelliferone*

R. Kannagi, I. Kakizaki, Masaki Ito, 2004, Journal of Biological Chemistry.

Assembly of basement membrane in vitro by cooperation between alveolar epithelial cells and pulmonary fibroblasts.

K. Kimata, A. Furuyama, K. Mochitate, 1997, Cell structure and function.

Altered hyaluronan biosynthesis in cancer progression.

K. Kimata, N. Itano, 2008, Seminars in cancer biology.

Mice deficient in heparan sulfate 6-O-sulfotransferase-1.

K. Kimata, H. Habuchi, 2010, Progress in molecular biology and translational science.

Crystal structure of chondroitin polymerase from Escherichia coli K4.

M. Kimura, T. Osawa, Y. Kakuta, 2009, Biochemical and biophysical research communications.

Widespread Expression of Chondroitin Sulfate-type Serglycins with CD44 Binding Ability in Hematopoietic Cells*

M. Miyasaka, N. Toyama-Sorimachi, F. Kitamura, 1997, The Journal of Biological Chemistry.

Hyaluronic acid of wound fluid in adult and fetal rabbits.

S. Kamata, T. Sawai, N. Usui, 1997, Journal of pediatric surgery.

Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer

A. Wakatsuki, K. Kimata, N. Itano, 2011, Obstetrics and gynecology international.

Role of serum-derived hyaluronan-associated protein-hyaluronan complex in ovarian cancer.

A. Wakatsuki, K. Kimata, H. Yabushita, 2008, Oncology reports.

Versican and fibrillin-1 form a major hyaluronan-binding complex in the ciliary body.

D. Keene, L. Sakai, K. Kimata, 2008, Investigative ophthalmology & visual science.

Distinct Interaction of Versican/PG-M with Hyaluronan and Link Protein*

M. Shionyu, K. Shimizu, Kazuaki Matsumoto, 2003, Journal of Biological Chemistry.

Serum inter-alpha-trypsin inhibitor and matrix hyaluronan promote angiogenesis in fibrotic lung injury.

D. Schwartz, K. Brown, L. Lancaster, 2008, American journal of respiratory and critical care medicine.

MS analysis of chondroitin polymerization: effects of Mn2+ ions on the stability of UDP-sugars and chondroitin synthesis.

K. Kimata, N. Sugiura, S. Shimokata, 2007, Analytical biochemistry.

Characterization of Isomeric Unsulfated Glycosaminoglycan Oligosaccharides by Mass Spectrometry/Mass Spectrometry

J. Hirabayashi, Hiroshi A. Maeda, K. Kimata, 2007 .

Cancer esearch oenvironment and Immunology luronan Deficiency in Tumor Stroma Impairs Macrophage R fficking and Tumor Neovascularization

S. Niida, K. Sano, S. Taniguchi, 2010 .

CHAPTER 10 – Altered Hyaluronan Biosynthesis in Cancer Progression

K. Kimata, N. Itano, 2009 .

Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis: pivotal role of a hyaluronan-rich tumor microenvironment.

R. Kannagi, Y. Kawai, T. Ohhashi, 2008, The American journal of pathology.

Essential Role of Heparan Sulfate 2-O-Sulfotransferase in Chick Limb Bud Patterning and Development*

K. Tamura, K. Kimata, H. Habuchi, 2007, Journal of Biological Chemistry.

Versican/PG-M Assembles Hyaluronan into Extracellular Matrix and Inhibits CD44-mediated Signaling toward Premature Senescence in Embryonic Fibroblasts*

P. Kongtawelert, K. Kimata, S. Hatano, 2009, Journal of Biological Chemistry.

Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88.

T. V. van Kuppevelt, G. Jenniskens, S. Rosen, 2010, Glycobiology.

Increased synthesis of hyaluronic acid by mouse mammary carcinoma cell variants with high metastatic potential.

S. Suzuki, K. Kimata, K. Oguri, 1983, Cancer research.

Three Isoforms of Mammalian Hyaluronan Synthases Have Distinct Enzymatic Properties*

P. Lenas, M. Hamaguchi, J. McDonald, 1999, The Journal of Biological Chemistry.

Relationship between hyaluronan production and metastatic potential of mouse mammary carcinoma cells.

K. Kimata, N. Itano, O. Miyaishi, 1999, Cancer research.

Transient accumulation of perisinusoidal chondroitin sulfate proteoglycans during liver regeneration and development.

K. Kimata, N. Koide, T. Yada, 1996, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Selective Expression and Functional Characteristics of Three Mammalian Hyaluronan Synthases in Oncogenic Malignant Transformation*

R. Kannagi, M. Hamaguchi, S. Taniguchi, 2003, Journal of Biological Chemistry.

Mammalian Hyaluronan Synthases

K. Kimata, N. Itano, 2002, IUBMB life.

Synthesis of sulfated phenyl 2-acetamido-2-deoxy-D-galactopyranosides. 4-O-Sulfated phenyl 2-acetamido-2-deoxy-beta-D-galactopyranoside is a competitive acceptor that decreases sulfation of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase.

H. Nakano, Toshihiko Sawada, K. Kimata, 2005, Carbohydrate research.

Chondroitin Sulfate Synthase-2 Is Necessary for Chain Extension of Chondroitin Sulfate but Not Critical for Skeletal Development

K. Shimizu, H. Narimatsu, N. Nagai, 2012, PloS one.

Heparan Sulfate 6-O-Sulfotransferase Isoform-dependent Regulatory Effects of Heparin on the Activities of Various Proteases in Mast Cells and the Biosynthesis of 6-O-Sulfated Heparin*

T. Yokochi, N. Nagai, K. Kimata, 2012, The Journal of Biological Chemistry.

Functional analysis of chick heparan sulfate 6‐O‐sulfotransferases in limb bud development

K. Tamura, K. Kimata, H. Habuchi, 2009, Development, growth & differentiation.

Glucuronyltransferase Activity of KfiC from Escherichia coli Strain K5 Requires Association of KfiA

K. Yamagishi, T. Kusakabe, Y. Kakuta, 2009, The Journal of Biological Chemistry.

Tetrasulfated Disaccharide Unit in Heparan Sulfate

Keiichi Yoshida, K. Kimata, Y. Shibata, 2008, Journal of Biological Chemistry.

Mice Deficient in Heparan Sulfate 6-O-Sulfotransferase-1 Exhibit Defective Heparan Sulfate Biosynthesis, Abnormal Placentation, and Late Embryonic Lethality*

N. Nagai, K. Kimata, R. Stevens, 2007, Journal of Biological Chemistry.

Characterization of Anti-heparan Sulfate Phage Display Antibodies AO4B08 and HS4E4*

D. Spillmann, T. V. van Kuppevelt, S. Kurup, 2007, Journal of Biological Chemistry.

Sulfation pattern in glycosaminoglycan: Does it have a code?

K. Kimata, H. Habuchi, O. Habuchi, 2004, Glycoconjugate Journal.

Substrate specificity of the heparan sulfate hexuronic acid 2-O-sulfotransferase.

K. Kimata, H. Habuchi, U. Lindahl, 2001, Biochemistry.

Enzyme interactions in heparan sulfate biosynthesis: Uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo

J. Esko, K. Kimata, M. Pinhal, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of Heparan Sulfate Oligosaccharides That Bind to Hepatocyte Growth Factor (*)

K. Kimata, H. Habuchi, S. Ashikari, 1995, The Journal of Biological Chemistry.

Inhibition of experimental metastasis and cell adhesion of murine melanoma cells by chondroitin sulfate-derivatized lipid, a neoproteoglycan with anti-cell adhesion activity

Y. Hori, K. Kimata, K. Sakurai, 1997, Clinical & Experimental Metastasis.

Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model

T. Ushida, N. Ishiguro, Y. Nishida, 2017, Scientific Reports.

Isolation of two forms of basement membrane proteoglycans.

H. Kleinman, S. Ledbetter, S. Suzuki, 1985, The Journal of biological chemistry.

The SHAP-HA complex in sera from patients with rheumatoid arthritis and osteoarthritis.

N. Ishiguro, K. Kimata, H. Iwata, 1999, The Journal of rheumatology.

Hyaluronic acid associated with the surfaces of cultured fibroblasts is linked to a serum-derived 85-kDa protein.

S. Suzuki, K. Kimata, M. Yoneda, 1990, The Journal of biological chemistry.

A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor.

L. Huang, K. Kimata, M. Yoneda, 1993, The Journal of biological chemistry.

Expression of sulfotransferases involved in the biosynthesis of chondroitin sulfate E in the bone marrow derived mast cells.

K. Kimata, O. Habuchi, S. Kondo, 2008, Biochimica et biophysica acta.

Ancient origin of mast cells.

N. Satoh, B. Lam, G. W. Wong, 2014, Biochemical and biophysical research communications.

Structure and Function of Inter-α-Trypsin Inhibitor Heavy Chains

K. Kimata, Lisheng Zhuo, Li-sheng Zhuo, 2008, Connective tissue research.

Activin A Binds to Perlecan through Its Pro-region That Has Heparin/Heparan Sulfate Binding Activity*

K. Sekiguchi, S. Hattori, H. Fujisaki, 2010, The Journal of Biological Chemistry.

Differential binding of vascular cell-derived proteoglycans (perlecan, biglycan, decorin, and versican) to the beta-amyloid protein of Alzheimer's disease.

T. Wight, M. G. Kinsella, K. Kimata, 1995, Archives of biochemistry and biophysics.

Expression of PG-M(V3), an Alternatively Spliced Form of PG-M without a Chondroitin Sulfate Attachment Region in Mouse and Human Tissues (*)

K. Ito, K. Kimata, M. Zako, 1995, The Journal of Biological Chemistry.

Abnormal occurrence of a large chondroitin sulfate proteoglycan, PG-M/versican in osteoarthritic cartilage.

Y. Nishida, K. Kimata, H. Iwata, 1994, Osteoarthritis and cartilage.

Sulfated Glycosaminoglycans Control the Extracellular Trafficking and the Activity of the Metalloprotease Inhibitor TIMP-3

H. Nagase, K. Kimata, L. Troeberg, 2014, Chemistry & biology.

Involvement of heparan sulfate 6-O-sulfation in the regulation of energy metabolism and the alteration of thyroid hormone levels in male mice.

T. Imamura, N. Nagai, K. Kimata, 2013, Glycobiology.

Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3

V. Hascall, E. Maytin, Mark E. Lauer, 2011, The Journal of investigative dermatology.

Acute and Temporal Expression of Tumor Necrosis Factor (TNF)-α-stimulated Gene 6 Product, TSG6, in Mesenchymal Stem Cells Creates Microenvironments Required for Their Successful Transplantation into Muscle Tissue*

S. Torihashi, K. Kimata, Nana Takenaka-Ninagawa, 2015, The Journal of Biological Chemistry.

Effects of Dexamethasone on Tissue Injury and Reconstruction in Ethanol/Steroid Injection Therapy for Allergic Rhinitis

M. Takei, K. Kimata, M. Wu, 2012 .

useful marker for neoplastic change of the salivary gland cells, especially for the neoplastic myoepithelial cells of PA.

T. Kameya, K. Kimata, Y. Hiraki, 2007 .

Up-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation.

I. Kakizaki, K. Hanada, M. Yamaguchi, 2008, Archives of biochemistry and biophysics.

Molecular Cloning and Characterization of Chondroitin Polymerase from Escherichia coli Strain K4*

K. Sugimoto, K. Kimata, A. Tawada, 2002, The Journal of Biological Chemistry.

Stem domains of heparan sulfate 6-O-sulfotransferase are required for Golgi localization, oligomer formation and enzyme activity

J. Esko, N. Nagai, K. Kimata, 2004, Journal of Cell Science.

Forced expression of KIAA1199, a novel hyaluronidase, inhibits tumorigenicity of low-grade chondrosarcoma.

T. Ushida, H. Koike, N. Ishiguro, 2020, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Suppression of hyaluronan synthesis attenuates the tumorigenicity of low‐grade chondrosarcoma

T. Ushida, H. Koike, N. Ishiguro, 2018, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo

N. Ishiguro, Y. Nishida, K. Kimata, 2011, British Journal of Cancer.

Mouse aggrecan, a large cartilage proteoglycan: protein sequence, gene structure and promoter sequence.

S. Sugiyama, H. Watanabe, Y. Yamada, 1995, The Biochemical journal.

Secretion of macrophage urokinase plasminogen activator is dependent on proteoglycans.

S. O. Kolset, L. Uhlin‐Hansen, K. Kimata, 2003, European journal of biochemistry.

Molecular Cloning and Characterization of a Novel Chondroitin Sulfate Glucuronyltransferase That Transfers Glucuronic Acid toN-Acetylgalactosamine*

H. Narimatsu, H. Iwasaki, M. Gotoh, 2002, The Journal of Biological Chemistry.

THE GENE STRUCTURE AND PROMOTER SEQUENCE OF MOUSE HYALURONAN SYNTHASE 1 (MHAS1)

P. Lenas, K. Kimata, N. Itano, 1998 .

Purification and Characterization of Heparan Sulfate 6-Sulfotransferase from the Culture Medium of Chinese Hamster Ovary Cells (*)

K. Kimata, H. Habuchi, O. Habuchi, 1995, The Journal of Biological Chemistry.

Hyaluronan Mediates Ozone-induced Airway Hyperresponsiveness in Mice*

W. M. Foster, D. Morgan, D. Schwartz, 2009, Journal of Biological Chemistry.

Evidence for the Covalent Binding of SHAP, Heavy Chains of Inter-α-Trypsin Inhibitor, to Hyaluronan (*)

S. Kurono, Ming Zhao, Y. Ohashi, 1995, The Journal of Biological Chemistry.

Deficiency in the Serum-Derived Hyaluronan-Associated Protein-Hyaluronan Complex Enhances Airway Hyperresponsiveness in a Murine Model of Asthma

V. Hascall, K. Kimata, M. Aronica, 2010, International Archives of Allergy and Immunology.

cDNA cloning of PG-M, a large chondroitin sulfate proteoglycan expressed during chondrogenesis in chick limb buds. Alternative spliced multiforms of PG-M and their relationships to versican.

K. Ito, Y. Nishida, K. Kimata, 1993, The Journal of biological chemistry.

Molecular Cloning and Expression of Chondroitin 4-Sulfotransferase*

K. Kimata, H. Habuchi, M. Fukuta, 2000, The Journal of Biological Chemistry.

Cumulus oophorus extracellular matrix: its construction and regulation.

K. Kimata, Lisheng Zhuo, L. Zhuo, 2001, Cell structure and function.

Mechanisms for dissociating proteoglycan aggregates.

V. Hascall, J. Kimura, K. Kimata, 1982, The Journal of biological chemistry.

Structural analysis of chick-embryo cartilage proteoglycan by selective degradation with chondroitin lyases (chondroitinases) and endo-beta-D-galactosidase (keratanase).

K. Nakazawa, S. Suzuki, K. Kimata, 1980, The Biochemical journal.

Altered proteoglycan synthesis by epiphyseal cartilages in culture at low SO4(2-) concentration.

K. Ito, S. Suzuki, K. Kimata, 1982, The Journal of biological chemistry.

Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate.

T. Imamura, H. Narimatsu, H. Iwasaki, 2003, The Journal of biological chemistry.

Enzymatic Synthesis of Chondroitin with a Novel Chondroitin Sulfate N-Acetylgalactosaminyltransferase That Transfers N-Acetylgalactosamine to Glucuronic Acid in Initiation and Elongation of Chondroitin Sulfate Synthesis*

H. Narimatsu, S. Nishihara, H. Iwasaki, 2002, The Journal of Biological Chemistry.

The Versican G1 Fragment and Serum-Derived Hyaluronan-Associated Proteins Interact and Form a Complex in Granulation Tissue of Pressure Ulcers.

Ken Watanabe, K. Kimata, M. Yoneda, 2017, The American journal of pathology.

Homotypic Versican G1 Domain Interactions Enhance Hyaluronan Incorporation into Fibrillin Microfibrils*

Ken Watanabe, L. Sakai, K. Kimata, 2013, The Journal of Biological Chemistry.

Inhibitory effect of chondroitin sulfate type E on the binding step of human T-cell leukemia virus type 1.

H. Isomura, K. Kimata, Atsushi Jinno-Oue, 2013, AIDS research and human retroviruses.

Heparan-Sulfate 6-O-Sulfotransferase 1-3 (HS6ST1-3)

N. Nagai, K. Kimata, 2014 .

Regulation of Heparan Sulfate 6-O-Sulfation by β-Secretase Activity*

S. Kitazume, N. Nagai, H. Toyoda, 2007, Journal of Biological Chemistry.

Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases.

K. Kimata, H. Habuchi, U. Lindahl, 2003, The Biochemical journal.

Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties.

Y. Matsuda, A. Kuroiwa, Masayuki Tanaka, 2003, The Biochemical journal.

Transforming growth factor-beta 1 stimulates chondrogenesis and inhibits osteogenesis in high density culture of periosteum-derived cells.

K. Ono, A. Caplan, K. Nakata, 1993, Endocrinology.

The Proteoglycan Aggregate : Structure and Function

K. Kimata, H. Watanabe, Kazumitsu Matsumoto, 2003 .

The Presence ofHeparan Sulfate Proteoglycans in the Neuritic Plaques and Congophilic Angiopathy in Alzheimer ' s Disease

Masato Kato, D. Nochlin, T. Wight, 2007 .

The distribution of mesenchyme proteoglycan (PG-M) during wing bud outgrowth

M. Yamagata, K. Kimata, M. Solursh, 2004, Anatomy and Embryology.

Changes in Distribution of the Long Form of Type XII Collagen during Chicken Corneal Development

Y. Akimoto, H. Hirano, H. Kawakami, 2002, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Transient Expression of PG‐M/Versican, a Large Chondroitin Sulfate Proteoglycan in Developing Chicken Retina

K. Kimata, M. Zako, M. Iwaki, 1997, Journal of neurochemistry.

Hyaluronan Expressed by the Hematopoietic Microenvironment Is Required for Bone Marrow Hematopoiesis*

Y. Yamaguchi, S. Iizuka, K. Kimata, 2012, The Journal of Biological Chemistry.

Hyaluronan (HA) and Serum-Derived Hyaluronan-Associated Protein (SHAP)-HA Complex as Predictive Markers of Cervical Ripening in Premature Labor

A. Wakatsuki, K. Kimata, H. Yabushita, 2008, Connective tissue research.

Equivalent Involvement of Inter-α-trypsin Inhibitor Heavy Chain Isoforms in Forming Covalent Complexes with Hyaluronan

K. Kimata, Lisheng Zhuo, H. Watanabe, 2008, Connective tissue research.

The SHAP-hyaluronan complex in serum from patients with chronic liver diseases caused by hepatitis virus infection.

T. Ishikawa, S. Kakumu, T. Nonami, 2006, Hepatology research : the official journal of the Japan Society of Hepatology.

Inter-α-trypsin Inhibitor, a Covalent Protein-Glycosaminoglycan-Protein Complex*

V. Hascall, K. Kimata, Lisheng Zhuo, 2004, Journal of Biological Chemistry.

A physiological function of serum proteoglycan bikunin: The chondroitin sulfate moiety plays a central role

K. Kimata, A. Salustri, Lisheng Zhuo, 2002, Glycoconjugate Journal.

Chapter 9 – Biological Function of SHAP–Hyaluronan Covalent Complex

K. Kimata, Jiwen Wu, N. Itano, 2004 .

A study of inter-alpha-trypsin inhibitor chains expression in liposarcomas.

N. Ishiguro, H. Sugiura, Y. Nishida, 2003, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

The covalent complex formation of hyaluronan with heavy chains of inter-α-trypsin inhibitor family is important for its functions

K. Kimata, M. Yoneda, Naoki Ishiguro, 2002 .

Defect in SHAP-Hyaluronan Complex Causes Severe Female Infertility

K. Kimata, Y. Kitagawa, Lisheng Zhuo, 2001, The Journal of Biological Chemistry.

Expression Cloning and Molecular Characterization of HAS Protein, a Eukaryotic Hyaluronan Synthase (*)

K. Kimata, N. Itano, 1996, The Journal of Biological Chemistry.

Functions of Proteoglycan/Glycosaminoglycan in Liver

K. Kimata, N. Koide, T. Yada, 2003 .

Inter-alpha-trypsin inhibitor, a covalent protein-glycosaminoglycan-protein complex.

V. Hascall, K. Kimata, Lisheng Zhuo, 2004, The Journal of biological chemistry.

In Vitro Synthesis of Hyaluronan by a Single Protein Derived from Mouse HAS1 Gene and Characterization of Amino Acid Residues Essential for the Activity*

M. Yoshida, Y. Yamada, K. Kimata, 2000, The Journal of Biological Chemistry.

Inter-α-Trypsin Inhibitor Attenuates Complement Activation and Complement-Induced Lung Injury1

D. Schwartz, S. Garantziotis, K. Kimata, 2007, The Journal of Immunology.

Inter-alpha-trypsin inhibitor attenuates complement activation and complement-induced lung injury.

D. Schwartz, S. Garantziotis, K. Kimata, 2007, Journal of immunology.

Selective distributions of proteoglycans and their ligands in pericellular matrix of cultured fibroblasts. Implications for their roles in cell-substratum adhesion.

M. Yamagata, S. Saga, Masato Kato, 1993, Journal of cell science.

Molecular cloning of human hyaluronan synthase.

K. Kimata, N. Itano, 1996, Biochemical and biophysical research communications.

Hyaluronan expression as a significant prognostic factor in patients with malignant peripheral nerve sheath tumors

N. Ishiguro, Y. Nishida, K. Kimata, 2014, Clinical & Experimental Metastasis.

Increased synthesis of hyaluronate enhances motility of human melanoma cells.

T. Saida, S. Taniguchi, K. Kimata, 1999, The Journal of investigative dermatology.

Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling

M. Masu, R. Ueda, H. Nakato, 2006, The Journal of cell biology.

Effects of chemically modified heparin on Chlamydia trachomatis serovar L2 infection of eukaryotic cells in culture.

J. Esko, K. Kimata, Y. Noguchi, 2002, Glycobiology.

Heparan/chondroitin/dermatan sulfate primer 2-(6-hydroxynaphthyl)-O-beta-D-xylopyranoside preferentially inhibits growth of transformed cells.

A. Malmström, K. Mani, H. Yamamoto, 1998, Cancer research.

Crucial Role of Hyaluronan in Neointimal Formation after Vascular Injury

J. Koyama, Y. Shiba, Masafumi Takahashi, 2013, PloS one.

Hyaluronan Synthase 1-3 (HAS1-3)

K. Kimata, N. Itano, Theerawut Chanmee, 2014 .

PROTEOGLYCAN ENHANCES THE FORMATION OF THE SHAP-HYALURONAN COMPLEX AND ITS EFFECT IN HYALURONAN-RICH MATRIX

Ming Zhao, Yoshihiko Yamada, K. Kimata, 2002 .

Basic fibroblast growth factor-binding domain of heparan sulfate in the human glomerulosclerosis and renal tubulointerstitial fibrosis.

K. Maeda, T. Shinzato, H. Morita, 1994, Laboratory investigation; a journal of technical methods and pathology.

Annexin 6 is a putative cell surface receptor for chondroitin sulfate chains.

K. Kimata, H. Takagi, N. Yamakawa, 2002, Journal of cell science.

Hyaluronan–CD44 pathway regulates orientation of mitotic spindle in normal epithelial cells

Y. Takai, K. Kimata, N. Sugiura, 2008, Genes to cells : devoted to molecular & cellular mechanisms.

Degradation of type IX collagen by matrix metalloproteinase 3 (stromelysin) from human rheumatoid synovial cells

H. Konomi, H. Nagase, K. Kimata, 1989, FEBS letters.

Occurrence of PG-Lb, a leucine-rich small chondroitin/dermatan sulphate proteoglycan in mammalian epiphyseal cartilage: molecular cloning and sequence analysis of the mouse cDNA.

K. Kurita, K. Kimata, M. Zako, 1996, The Biochemical journal.

Variable expression of heparan sulfate epitopes in crescents of human glomerulonephritis

K. Isobe, K. Maeda, T. Shinzato, 1999, Virchows Archiv.

Tissue variation of two large chondroitin sulfate proteoglycans (PG-M/versican and PG-H/aggrecan) in chick embryos

M. Yamagata, K. Kimata, T. Shinomura, 1993, Anatomy and Embryology.

Sulfated Glycosaminoglycans Are Required for Specific and Sensitive Fibroblast Growth Factor (FGF) 19 Signaling via FGF Receptor 4 and betaKlotho*

Masashi Suzuki, T. Imamura, N. Nagai, 2011, The Journal of Biological Chemistry.

Hyaluronan Synthase-1, -2, and -3

K. Kimata, 2002 .

Laminin A, B1, and B2 Chain Gene Expression in Transected and Regenerating Nerves: Regulation by Axonal Signals

G. Sobue, Yoshihiko Yamada, M. Doyu, 1993, Journal of neurochemistry.

Reticular erythematous mucinosis syndrome with an infiltration of factor XIIIa+ and hyaluronan synthase 2+ dermal dendrocytes

A. Tominaga, S. Tajima, K. Kimata, 2001, The British journal of dermatology.

Presence of atypical laminin on the surface of mouse Lewis lung carcinoma cells.

T. Nukiwa, M. Isemura, K. Kimata, 1996, The Tohoku journal of experimental medicine.

Hyaluronan synthase expression in pleural malignant mesotheliomas

N. Kanomata, A. Ochiai, T. Hasebe, 2005, Virchows Archiv.

Erratum: Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice (The Journal of Biological Chemistry (2009) 284 (11309-11317) DOI: 10.1074/jbc.A116.802400)

W. M. Foster, D. Morgan, D. Schwartz, 2016 .

Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice.

W. M. Foster, D. Morgan, D. Schwartz, 2016, The Journal of Biological Chemistry.

Appearance of distinct types of proteoglycan in a well-defined temporal and spatial pattern during early cartilage formation in the chick limb.

N. Maeda, K. Kimata, T. Shinomura, 1984, Developmental biology.

Gene expression of high- (p140 trk ) and low-affinity nerve growth factor receptor (LNGFR) in the adult and aged human peripheral nervous system

G. Sobue, M. Doyu, Masahiko Yamamoto, 1993, Neuroscience Letters.

SHAP Potentiates the CD44-mediated Leukocyte Adhesion to the Hyaluronan Substratum*

R. Kannagi, M. Hamaguchi, K. Kimata, 2006, Journal of Biological Chemistry.

Hyaluronic acid modulates proliferation of mouse dermal fibroblasts in culture.

M. Yamagata, K. Kimata, M. Yoneda, 1988, Journal of cell science.

Heparan Sulfate : Structure, Biosynthesis, and Functions

K. Kimata, H. Habuchi, Ken Nogami, 2002 .

Geometric response to nerve growth factor is preserved in aged rat sensory neurons: A single-neuron culture study

G. Sobue, T. Mitsuma, T. Yasuda, 1993, Neurobiology of Aging.

Regulated changes in chondroitin sulfation during embryogenesis: an immunohistochemical approach.

K. Kimata, J. Baker, M. Mark, 1990, The International journal of developmental biology.

Isolation and characterization of a third proteoglycan (PG-Lt) from chick embryo cartilage which contains disulfide-bonded collagenous polypeptide.

N. Maeda, S. Suzuki, K. Kimata, 1983, The Journal of biological chemistry.

Repression of a malignant cell-substratum adhesion phenotype by inhibiting the production of the anti-adhesive proteoglycan, PG-M/versican.

M. Yamagata, K. Kimata, 1994, Journal of cell science.

Geometry of adult rat sensory neurons in culture; its modulation by laminin

G. Sobue, T. Mitsuma, T. Yasuda, 1991, Neuroscience Letters.

Versican/PG-M Regulates Chondrogenesis as an Extracellular Matrix Molecule Crucial for Mesenchymal Condensation*

K. Shimizu, N. Kamiya, K. Kimata, 2006, Journal of Biological Chemistry.

Expression of a Chondroitin Sulfate Proteoglycan, Versican (PG-M), During Development of Rat Cornea

T. Gotoh, M. Mori, A. Oohira, 2005, Current eye research.

2B1 antigen characteristically expressed on extracellular matrices of human malignant tumors is a large chondroitin sulfate proteoglycan, PG-M/versican.

D. Heinegård, T. Tsuji, K. Kimata, 1996, Cancer research.

The Gene Structure and Organization of Mouse PG-M, a Large Chondroitin Sulfate Proteoglycan

K. Kimata, M. Zako, T. Shinomura, 1995, The Journal of Biological Chemistry.

Precartilage Condensation during Skeletal Pattern Formation

K. Kimata, T. Shinomura, 1990, Development, growth & differentiation.

Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and low-affinity nerve growth factor receptor (LNGFR) mRNA levels in cultured rat Schwann cells; differential time- and dose-dependent regulation by cAMP

G. Sobue, Masahiko Yamamoto, T. Mitsuma, 1993, Neuroscience Letters.

Glomerular basement membrane (GBM) abnormalities are worth pursuing

H. Morita, K. Kimata, J. Takagi, 2015, Clinical and Experimental Nephrology.

A mapping technique for probing the structure of proteoglycan core molecules.

S. Suzuki, K. Kimata, T. Shinomura, 1982, The Journal of biological chemistry.

Correction of abnormal matrix formed by cmd/cmd chondrocytes in culture by exogenously added cartilage proteoglycan

S. Suzuki, K. Kimata, H. Iwata, 1986, The Journal of cell biology.

Selective removal of heparan sulfate chains from proteoheparan sulfate with a commercial preparation of heparitinase.

S. Suzuki, K. Kimata, M. Kato, 1985, Analytical biochemistry.

Hyaluronic acid-dependent change in the extracellular matrix of mouse dermal fibroblasts that is conducive to cell proliferation.

M. Yamagata, K. Kimata, M. Yoneda, 1988, Journal of cell science.

Proteinase activity in chondroitin lyase (chondroitinase) and endo-beta-D-galactosidase (keratanase) preparations and a method to abolish their proteolytic effect on proteoglycan.

S. Suzuki, K. Kimata, T. Shinomura, 1980, The Biochemical journal.

The occurrence of low buoyant density proteoglycans in embryonic chick cartilage.

K. Ito, S. Suzuki, K. Kimata, 1978, Biochemical and biophysical research communications.

Thy-1 antigen mediates apoptosis of rat glomerular cells in vitro and in vivo.

K. Isobe, Y. Yoshikai, K. Maeda, 1996, Nephron.

Basement membrane proteoglycan in various tissues: characterization using monoclonal antibodies to the Engelbreth-Holm-Swarm mouse tumor low density heparan sulfate proteoglycan

S. Suzuki, K. Kimata, M. Kato, 1988, The Journal of cell biology.

Nephronectin binds to heparan sulfate proteoglycans via its MAM domain.

K. Sekiguchi, M. Yamada, N. Norioka, 2013, Matrix biology : journal of the International Society for Matrix Biology.

Absence of proteoglycan core protein in cartilage from the cmd/cmd (cartilage matrix deficiency) mouse.

H. Barrach, K. Kimata, K. Brown, 1981, The Journal of biological chemistry.

Heparosan-glucuronate 5-epimerase: Molecular cloning and characterization of a novel enzyme.

K. Yamagishi, Yeong Shik Kim, K. Kimata, 2015, Glycobiology.

Inhibition of hyaluronan synthesis alters sulfated glycosaminoglycans deposition during chondrogenic differentiation in ATDC5 cells

Y. Yoshioka, N. Ishiguro, Y. Nishida, 2015, Histochemistry and Cell Biology.

Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.

J. Esko, J. Turnbull, S. Guimond, 2002, Glycobiology.

Moderate repulsive effects of E-unit-containing chondroitin sulfate (CSE) on behavior of retinal growth cones

H. Ichijo, K. Kimata, M. Shimbo, 2013, Brain Research.

Human blood glycosaminoglycans: isolation and analysis.

K. Kimata, Md. Ferdous Anower-E-Khuda, 2015, Methods in molecular biology.

Preparation of lipid-derivatized glycosaminoglycans to probe a regulatory function of the carbohydrate moieties of proteoglycans in cell-matrix interaction.

S. Suzuki, Y. Hori, K. Kimata, 1993, The Journal of biological chemistry.

Role of hyaluronan and hyaluronan synthase in endometrial cancer.

K. Kimata, N. Itano, H. Yabushita, 2005, Oncology reports.

Biosynthesis of Heparan Sulfate and Heparin How Are the Multifunctional Glycosaminoglycans Built up

K. Kimata, H. Habuchi, O. Habuchi, 1998 .

Inter-α-inhibitor Ameliorates Endothelial Inflammation in Sepsis

S. Opal, Y. Lim, S. Garantziotis, 2019, Lung.

Characterization of fibronectin interactions with glycosaminoglycans and identification of active proteolytic fragments.

K. Yamada, K. Kimata, R. Pratt, 1980, The Journal of biological chemistry.

Roles of aggrecan, a large chondroitin sulfate proteoglycan, in cartilage structure and function.

H. Watanabe, Y. Yamada, Yoshihiko Yamada, 1998, Journal of biochemistry.

Inhibition of hyaluronan synthesis in breast cancer cells by 4‐methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo

N. Ishiguro, Y. Nishida, K. Kimata, 2012, International journal of cancer.

Characterization of a motif for specific binding to hyaluronan in chicken SPACR

K. Kimata, M. Yoneda, M. Zako, 2008, Journal of neurochemistry.

Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase

K. Ohno, T. Ushida, H. Koike, 2022, International journal of molecular sciences.

Transcriptome-based systematic identification of extracellular matrix proteins

J. Kawai, Y. Hayashizaki, S. Fukuda, 2008, Proceedings of the National Academy of Sciences.

The occurrence of three different proteoglycan species in chick embryo cartilage. Isolation and characterization of a second proteoglycan (PG-Lb) and its precursor form.

S. Suzuki, K. Kimata, T. Shinomura, 1983, The Journal of biological chemistry.

Rat costochondral cell characteristics on poly (L-lactide-co-epsilon-caprolactone) scaffolds.

M. Ueda, K. Hata, K. Kimata, 2003, Biomaterials.

Solution structure of human acidic fibroblast growth factor and interaction with heparin-derived hexasaccharide

M. Jaye, J. Schlessinger, K. Nagata, 1999, Journal of biomolecular NMR.

4.10 – Knockout Mice and Proteoglycans

K. Kimata, 2007 .

Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration

Takahiro Sawai, Osamu Miyaishi, T. Senga, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Expression and binding activity of the carboxyl-terminal portion of the core protein of PG-M, a large chondroitin sulfate proteoglycan.

K. Ito, K. Kimata, T. Shinomura, 1994, The Journal of biological chemistry.

Characterization of Growth Factor-binding Structures in Heparin/Heparan Sulfate Using an Octasaccharide Library*

Nobuyuki Itoh, A. Reddi, N. Itoh, 2004, Journal of Biological Chemistry.

Identiﬁcation and characterization of photomedins: novel olfactomedin-domain-containing proteins with chondroitin sulphate-E-binding activity

J. Kawai, Y. Hayashizaki, S. Fukuda, 2022 .

Establishment of a mouse model for injury-induced scar formation and the accompanying chronic pain: Comprehensive microarray analysis of molecular expressions in fibrosis and hyperalgesia

T. Ushida, M. Deie, Akinobu Ota, 2019, Molecular pain.

Recombinant Expression and Characterization of a Novel Fibronectin Isoform Expressed in Cartilaginous Tissues*

K. Sekiguchi, J. Gu, H. Yoshikawa, 2003, Journal of Biological Chemistry.

Enhanced expression of fibronectin by cmd/cmd chondrocytes and its modulation by exogenously added proteoglycan.

S. Suzuki, K. Kimata, T. Tsukahara, 1991, Journal of cell science.

Molecular Cloning and Characterization of Chick SPACRCAN*

K. Kimata, M. Yoneda, M. Zako, 2003, Journal of Biological Chemistry.

Molecular Cloning and Characterization of Chick Sialoprotein Associated with Cones and Rods, a Developmentally Regulated Glycoprotein of Interphotoreceptor Matrix*

Yasuhiko Suzuki, K. Kimata, M. Yoneda, 2002, The Journal of Biological Chemistry.

Heparan sulfate proteoglycan on leukemic cells is primarily involved in integrin triggering and its mediated adhesion to endothelial cells

K. Yoshida, S. Eto, Y. Tanaka, 1996, The Journal of experimental medicine.

The influence of p-nitrophenyl beta-d-xyloside on the synthesis of proteochondroitin sulfate by slices of embryonic chick cartilage.

K. Kimata, M. Okayama, S. Suzuki, 1973, Journal of biochemistry.

Brachymorphic mice (bm/bm): a generalized biochemical defect expressed primarily cartilage.

K. Kimata, K. Brown, J. P. Pennypacker, 1981, Developmental biology.

Effect of beta-D-xyloside and cycloheximide on the synthesis of two types of proteochondroitin sulfate in chick embryo cartilage.

K. Ito, S. Suzuki, K. Kimata, 1978, The Journal of biological chemistry.

The dynamics of compartmentalization of embryonic muscle by extracellular matrix molecules.

R. Drushel, M. Yamagata, M. S. Fernández, 1991, Developmental biology.

Heparin Regulates Vascular Endothelial Growth Factor165-dependent Mitogenic Activity, Tube Formation, and Its Receptor Phosphorylation of Human Endothelial Cells

K. Kimata, H. Habuchi, Y. Kariya, 2005, Journal of Biological Chemistry.

Molecular Cloning and Expression of Chick Chondrocyte Chondroitin 6-Sulfotransferase (*)

Megumi Kato, K. Kimata, T. Shinomura, 1995, The Journal of Biological Chemistry.

Presence of link protein in cartilage from cmd/cmd (cartilage matrix deficiency) mice.

H. Barrach, S. Suzuki, K. Kimata, 1983, Archives of biochemistry and biophysics.

Multiple forms of heparan sulfate proteoglycans in the Engelbreth-Holm-Swarm mouse tumor. The occurrence of high density forms bearing both heparan sulfate and chondroitin sulfate side chains.

S. Suzuki, Y. Ito, K. Kimata, 1987, The Journal of biological chemistry.

Morphological and biochemical differentiation of limb bud cells cultured in chemically defined medium.

K. Ito, K. Kimata, S. Suzuki, 1979, Developmental biology.

Cytodifferentiation and proteoglycan biosynthesis

A. Oohira, K. Kimata, M. Okayama, 1973, Molecular and Cellular Biochemistry.

Determination of substrate specificity of sulfotransferases and glycosyltransferases (proteoglycans).

T. Muramatsu, K. Kimata, H. Habuchi, 2006, Methods in enzymology.

Antiviral activity of chondroitin sulphate E targeting dengue virus envelope protein.

K. Morita, Yasuo Suzuki, Takashi Suzuki, 2010, Antiviral research.

Chondroitin Sulfate Synthase-2/Chondroitin Polymerizing Factor Has Two Variants with Distinct Function*

Hisashi Narimatsu, Hideto Watanabe, Masanori Gotoh, 2010, The Journal of Biological Chemistry.

Glycosaminoglycans in the blood of hereditary multiple exostoses patients: Half reduction of heparan sulfate to chondroitin sulfate ratio and the possible diagnostic application.

T. Yokochi, K. Shimizu, Kazu Matsumoto, 2013, Glycobiology.

Purification and Characterization of Heparan Sulfate 2-Sulfotransferase from Cultured Chinese Hamster Ovary Cells (*)

Masaki Saito, K. Kimata, H. Habuchi, 1996, The Journal of Biological Chemistry.

Immunohistochemical evaluation of the small and large proteoglycans in pleomorphic adenoma of salivary glands.

M. Zhao, T. Takata, Ming Zhao, 2007, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

Oligosaccharide Library-based Assessment of Heparan Sulfate 6-O-Sulfotransferase Substrate Specificity*

P. Jemth, K. Kimata, H. Habuchi, 2003, Journal of Biological Chemistry.

Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism

R. Quinton, W. Crowley, S. Van Uum, 2011, Proceedings of the National Academy of Sciences.

Avian neural crest cell migration is diversely regulated by the two major hyaluronan-binding proteoglycans PG-M/versican and aggrecan.

M. Mörgelin, A. Colombatti, M. Bronner‐Fraser, 2000, Development.

Elevated transcript level of hyaluronan synthase1 gene correlates with poor prognosis of human colon cancer

S. Hirohashi, A. Ochiai, H. Narimatsu, 2004, Clinical & Experimental Metastasis.

Mycobacteria Exploit Host Hyaluronan for Efficient Extracellular Replication

S. Matsumoto, Kazuo Kobayashi, T. Udagawa, 2009, PLoS pathogens.

Cancer esearch oenvironment and Immunology luronan Deficiency in Tumor Stroma Impairs Macrophage R fficking and Tumor Neovascularization

S. Niida, K. Sano, S. Taniguchi, 2010 .

Proteoglycans and Sulfated Glycosaminoglycans

J. Esko, J. Couchman, K. Kimata, 2009 .

Molecular Cloning and Expression of Chinese Hamster Ovary Cell Heparan-sulfate 2-Sulfotransferase*

K. Kimata, H. Habuchi, O. Habuchi, 1997, The Journal of Biological Chemistry.

Key Roles of Hyaluronan and Its CD44 Receptor in the Stemness and Survival of Cancer Stem Cells

K. Kimata, N. Itano, Theerawut Chanmee, 2015, Front. Oncol..

Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2

Satoru Takahashi, H. Narimatsu, T. Kudo, 2017, PloS one.

Metabolic activities of partially degenerated hypertrophic chondrocytes: gene expression of hyaluronan synthases

N. Inoue, H. Sakiyama, Toshiyuki Saito, 1999, Cell and Tissue Research.

Chondroitin sulfate immobilized onto culture substrates modulates DNA synthesis, tyrosine aminotransferase induction, and intercellular communication in primary rat hepatocytes.

K. Kimata, N. Akamatsu, T. Kujiraoka, 1995, Cell structure and function.

Impact of the hyaluronan‐rich tumor microenvironment on cancer initiation and progression

K. Kimata, N. Itano, Li-sheng Zhuo, 2008, Cancer science.

Hyperproduction of hyaluronan in neu-induced mammary tumor accelerates angiogenesis through stromal cell recruitment: possible involvement of versican/PG-M.

R. Kannagi, T. Hibi, S. Taniguchi, 2007, The American journal of pathology.

Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts.

Y. Yoshioka, N. Ishiguro, Y. Nishida, 2013, Arthritis and rheumatism.

Versican/PG-M is essential for ventricular septal formation subsequent to cardiac atrioventricular cushion development.

N. Hiraiwa, E. Adachi, M. Kusakabe, 2012, Glycobiology.

Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase

R. Ueda, J. Rhodes, P. Spear, 2004, The Journal of cell biology.

A correlation between synthetic activities for matrix macromolecules and specific stages of cyto-differentiation in developing cartilage.

S. Suzuki, K. Kimata, K. Takata, 1974, The Journal of biological chemistry.

Scleral fibroblasts of the chick embryo differentiate into chondrocytes in soft-agar culture

K. Kimata, Kazuo Watanabe, K. Yagi, 1992, In Vitro Cellular & Developmental Biology - Animal.

Chondroitin Sulfate Synthase-3

H. Narimatsu, H. Iwasaki, M. Gotoh, 2003, Journal of Biological Chemistry.

Chondroitin Sulfate Synthase-2

M. Shionyu, H. Narimatsu, H. Iwasaki, 2003, Journal of Biological Chemistry.

Chondroitin Sulfate Synthase-2 MOLECULAR CLONING AND CHARACTERIZATION OF A NOVEL HUMAN GLYCOSYLTRANSFERASE HOMOLOGOUS TO CHONDROITIN SULFATE GLUCURONYLTRANSFERASE, WHICH HAS DUAL ENZYMATIC ACTIVITIES*

M. Shionyu, H. Narimatsu, H. Iwasaki, 2003 .

Molecular Cloning and Characterization of a Novel Chondroitin Sulfate Glucuronyltransferase That Transfers Glucuronic Acid to N -Acetylgalactosamine*

H. Narimatsu, H. Iwasaki, M. Gotoh, 2002 .

Baculovirus Envelope Protein ODV-E66 Is a Novel Chondroitinase with Distinct Substrate Specificity*

K. Kimata, N. Sugiura, H. Watanabe, 2011, The Journal of Biological Chemistry.

Dwarfism and age-associated spinal degeneration of heterozygote cmd mice defective in aggrecan.

H. Watanabe, Y. Yamada, K. Kimata, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Mouse cartilage matrix deficiency (cmd) caused by a 7 bp deletion in the aggrecan gene

C. Kozak, Yoshihiko Yamada, K. Kimata, 1994, Nature Genetics.

The role of heparan sulfate in the glomerular basement membrane.

H. Morita, K. Kimata, A. Yoshimura, 2008, Kidney international.

The globular domains of PGM/versican modulate the proliferation‐apoptosis equilibrium and invasive capabilities of tumor cells

A. Colombatti, Sabrina Cattaruzza, R. Perris, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Establishment of a Novel Chondrocytic Cell Line N1511 Derived From p53‐Null Mice

C. Damsky, K. Shimizu, N. Kamiya, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Heparan sulfate proteoglycan in diffuse plaques of hippocampus but not of cerebellum in Alzheimer's disease brain.

R. Kalaria, D. Nochlin, K. Kimata, 1994, American Journal of Pathology.

The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.

D. Nochlin, S. Suzuki, T. Wight, 1988, The American journal of pathology.

Glomerulosclerosis in mice transgenic for growth hormone. Increased mesangial extracellular matrix is correlated with kidney mRNA levels

G. Striker, T. Doi, Y. Yamada, 1991, The Journal of experimental medicine.

Serum cartilage‐derived retinoic acid‐sensitive protein (CD‐RAP) levels in Swarm rat chondrosarcoma

S. Kondo, H. Sugiura, Kenji Kobayashi, 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Effects of lipid-derivatized glycosaminoglycans (GAGs), a novel probe for functional analyses of GAGs, on cell-to-substratum adhesion and neurite elongation in primary cultures of fetal rat hippocampal neurons.

A. Oohira, S. Suzuki, Y. Tokita, 2000, Archives of biochemistry and biophysics.

Kinetics of iterative carbohydrate transfer to polysaccharide catalyzed by chondroitin polymerase on a highly sensitive flow-type 27 MHz quartz-crystal microbalance.

Y. Okahata, Toshiaki Mori, Y. Kakuta, 2012, Chemistry.

An enzyme-linked immunoassay for the cartilage proteoglycan.

S. Rennard, V. Hascall, B. Dusemund, 1981, Archives of biochemistry and biophysics.

The histochemistry of complex carbohydrates in certain organs of homozygous brachymorphic (bm/bm) mice

S. Shimizu, K. Kimata, K. Yamada, 1984, The Histochemical Journal.

Characterization of proteoglycans synthesized by murine embryonal carcinoma cells (P19) reveals increased expression of perlecan (heparan sulfate proteoglycan) during neuronal differentiation

T. Wight, K. Fukuchi, K. Kimata, 1994, Journal of neuroscience research.

Changes in proteoglycan composition during development of rat skin. The occurrence in fetal skin of a chondroitin sulfate proteoglycan with high turnover rate.

S. Suzuki, K. Kimata, H. Habuchi, 1986, The Journal of biological chemistry.

Nascent mucopolysaccharides attached to the Golgi membrane of chondrocytes.

S. Suzuki, K. Kimata, M. Okayama, 1971, Biochimica et biophysica acta.

Abnormal collagen fibrillogenesis in epiphyseal cartilage of CMD (cartilage matrix deficiency) mouse.

M. Kobayakawa, K. Kimata, H. Iwata, 1985, Collagen and related research.

Inter‐α‐inhibitor deficiency in the mouse is associated with alterations in anxiety‐like behavior, exploration and social approach

Viktoriya D. Nikolova, S. Garantziotis, S. Moy, 2018, Genes, brain, and behavior.

Minute pleomorphic adenoma of the submandibular gland in patients with oral malignancy: a report of two cases with histological and immunohistochemical examination

H. Watanabe, T. Kameya, K. Kimata, 2007, Histopathology.

Splicing Factor 3b Subunit 4 Binds BMPR-IA and Inhibits Osteochondral Cell Differentiation*

M. Shionyu, K. Kimata, Tomoatsu Kimura, 2007, Journal of Biological Chemistry.

Immunolocalization of heparan sulfate proteoglycans to the prion protein amyloid plaques of Gerstmann-Straussler syndrome, Creutzfeldt-Jakob disease and scrapie.

S. Prusiner, S. DeArmond, D. Nochlin, 1990, Laboratory investigation; a journal of technical methods and pathology.

An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar aβ-amyloid in rat brain

P. Fraser, D. Nochlin, D. Morgan, 1994, Neuron.

Chromosomal localization of the human and mouse hyaluronan synthase genes.

A. Olsen, N. Doggett, J. Inazawa, 1997, Genomics.

Recognition of Sulfation Pattern of Chondroitin Sulfate by Uronosyl 2-O-Sulfotransferase*

K. Kimata, O. Habuchi, Shiori Ohtake, 2005, Journal of Biological Chemistry.

Construction of a Chondroitin Sulfate Library with Defined Structures and Analysis of Molecular Interactions*

H. Narimatsu, Takashi Sato, K. Kimata, 2012, The Journal of Biological Chemistry.

Mice Deficient in N-Acetylgalactosamine 4-Sulfate 6-O-Sulfotransferase Are Unable to Synthesize Chondroitin/Dermatan Sulfate containing N-Acetylgalactosamine 4,6-Bissulfate Residues and Exhibit Decreased Protease Activity in Bone Marrow-derived Mast Cells*

Saori Kakehi, K. Kimata, H. Habuchi, 2010, The Journal of Biological Chemistry.

Molecular cloning of squid N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase and synthesis of a unique chondroitin sulfate containing E-D hybrid tetrasaccharide structure by the recombinant enzyme.

K. Kimata, O. Habuchi, Shiori Ohtake, 2007, Glycobiology.

A Unique Nonreducing Terminal Modification of Chondroitin Sulfate by N-Acetylgalactosamine 4-Sulfate 6-O-Sulfotransferase*

K. Kimata, Osami Habuchi, Koji Kimata, 2003, Journal of Biological Chemistry.

Chondroitin Sulfate N-Acetylgalactosaminyltransferase-1 Plays a Critical Role in Chondroitin Sulfate Synthesis in Cartilage*

K. Shinomiya, H. Narimatsu, M. Gotoh, 2006, Journal of Biological Chemistry.

Versican A-subdomain is required for its adequate function in dermal development

Y. Hosokawa, Akinobu Ota, S. Karnan, 2018, Connective tissue research.

A large chondroitin sulfate proteoglycan (PG-M) synthesized before chondrogenesis in the limb bud of chick embryo.

M. Yamagata, S. Suzuki, K. Kimata, 1986, The Journal of biological chemistry.

[The roles of proteoglycans for cartilage].

K. Kimata, Hiroki Watanabe, H. Watanabe, 2006, Clinical calcium.

Molecular cloning and expression of human chondroitin 6-sulfotransferase.

K. Kimata, M. Fukuta, O. Habuchi, 1998, Biochimica et biophysica acta.

Ultrasound enhances transforming growth factor beta-mediated chondrocyte differentiation of human mesenchymal stem cells.

M. Ueda, K. Hata, K. Kimata, 2004, Tissue engineering.

Large-scale mutational analysis in the EXT1 and EXT2 genes for Japanese patients with multiple osteochondromas

R. Kosaki, H. Akiyama, K. Shimizu, 2016, BMC Genetics.

Alternative Splicing of the Unique “PLUS” Domain of Chicken PG-M/Versican Is Developmentally Regulated*

K. Kimata, M. Zako, T. Shinomura, 1997, The Journal of Biological Chemistry.

Distribution of chondroitin sulphate proteoglycans and peanut agglutinin-binding molecules during bovine fetal palatine ridge formation.

K. Kimata, H. Amasaki, M. Takanosu, 1996, Journal of anatomy.

Inter-α-trypsin Inhibitor Promotes Bronchial Epithelial Repair after Injury through Vitronectin Binding*

John D. Roberts, M. Negishi, S. Garantziotis, 2009, The Journal of Biological Chemistry.

Kupffer cells and activation of endothelial TLR4 coordinate neutrophil adhesion within liver sinusoids during endotoxemia.

P. Kubes, B. McDonald, C. Jenne, 2013, American journal of physiology. Gastrointestinal and liver physiology.

Heterogeneity of proteochondroitin sulfates produced by chondrocytes at different stages of cytodifferentiation.

S. Suzuki, K. Kimata, M. Okayama, 1974, The Journal of biological chemistry.

Potential role of high molecular weight hyaluronan in the anti-Candida activity of human oral epithelial cells.

T. Nishihara, S. Akifusa, T. Takehara, 2007, Medical mycology.

Suppression of pannus-like extension of synovial cells by lipid-derivatized chondroitin sulphate: in vitro and in vivo studies using Escherichia coli-induced arthritic rabbits.

S. Suzuki, Y. Hori, K. Kimata, 1995, International journal of experimental pathology.

Hyaluronan synthase expression in ovarian cancer.

K. Kimata, N. Itano, Y. Noguchi, 2004, Oncology reports.

[Hyaluronan synthase].

K. Kimata, N. Itano, 2003, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

Drosophila Heparan Sulfate 6-O-Sulfotransferase (dHS6ST) Gene

H. Nakato, K. Kimata, H. Habuchi, 2001, The Journal of Biological Chemistry.

The Chondroitin Polymerase K4CP and the Molecular Mechanism of Selective Bindings of Donor Substrates to Two Active Sites*

M. Negishi, Y. Kakuta, K. Kimata, 2008, Journal of Biological Chemistry.

Serum-Derived Hyaluronan-Associated Protein Is a Novel Biomarker for Inflammatory Bowel Diseases

N. Ogasawara, K. Kasugai, M. Sasaki, 2017, Digestion.

The Structural Basis for a Coordinated Reaction Catalyzed by a Bifunctional Glycosyltransferase in Chondroitin Biosynthesis*

M. Negishi, Y. Kakuta, K. Kimata, 2012, The Journal of Biological Chemistry.

Hyaluronan Deficiency Due to Has3 Knock-Out Causes Altered Neuronal Activity and Seizures via Reduction in Brain Extracellular Space

Amaia M. Arranz, S. Hrabetova, J. Hrabe, 2014, The Journal of Neuroscience.

Structural differences among procollagens associated with rough and smooth microsomes from chick embryo cartilage.

A. Oohira, S. Suzuki, K. Kimata, 1979, The Journal of biological chemistry.

CD44 variant exon 6 expressions in colon cancer assessed by quantitative analysis using real time reverse transcriptase-polymerase chain reaction.

Hisashi Narimatsu, Setsuo Hirohashi, S. Hirohashi, 2003, Oncology reports.

Molecular Heterogeneity of the SHAP-Hyaluronan Complex

M. Mörgelin, K. Kimata, M. Yoneda, 2003, Journal of Biological Chemistry.

Basic fibroblast growth factor-heparan sulphate complex in the human dialysis-related amyloidosis

K. Isobe, K. Maeda, T. Shinzato, 1995, Virchows Archiv.

Involvement of CD44 in mast cell proliferation during terminal differentiation

K. Nakayama, Y. Sugimoto, A. Ichikawa, 2009, Laboratory Investigation.

Restriction of mast cell proliferation through hyaluronan synthesis by co-cultured fibroblasts.

K. Nakayama, Y. Sugimoto, A. Ichikawa, 2012, Biological & pharmaceutical bulletin.

Differential regulation by IL-1beta and EGF of expression of three different hyaluronan synthases in oral mucosal epithelial cells and fibroblasts and dermal fibroblasts: quantitative analysis using real-time RT-PCR.

M. Ueda, K. Hata, K. Kimata, 2004, The Journal of investigative dermatology.

Roles of hyaluronan in cardiovascular and nervous system disorders

Q. Dong, N. Ishiguro, Y. Nishida, 2019, Journal of Zhejiang University-SCIENCE B.

Heparan Sulfate 6-O-Sulfotransferase Is Essential for Muscle Development in Zebrafish*

Stephen W. Wilson, R. Geisler, D. Živković, 2003, Journal of Biological Chemistry.

Glycosaminoglycan sulfotransferases in human and animal sera.

H. Inoue, S. Suzuki, K. Kimata, 1986, The Journal of biological chemistry.

Heparan sulfate subdomains that are degraded by Sulf accumulate in cerebral amyloid ß plaques of Alzheimer's disease: evidence from mouse models and patients.

Tony Wyss-Coray, T. Wyss-Coray, M. Britschgi, 2012, The American journal of pathology.

Cartilage formation by cultured chondrocytes in a new scaffold made of poly(L-lactide-ϵ-caprolactone) sponge

M. Ueda, M. Honda, K. Kimata, 2000 .

Effect of environmental sulfate concentration on the synthesis of low and high sulfated chondroitin sulfates by chick embryo cartilage.

K. Ito, S. Suzuki, K. Kimata, 1978, The Journal of biological chemistry.

6-O-Sulfation of Heparan Sulfate Differentially Regulates Various Fibroblast Growth Factor-dependent Signalings in Culture*

N. Nagai, K. Kimata, H. Habuchi, 2008, Journal of Biological Chemistry.

A quantitative method to detect non-antithrombin-binding 3-O-sulfated units in heparan sulfate

E. Suzuki, K. Kimata, H. Mochizuki, 2020, The Journal of biological chemistry.

cAMP-dependent differential regulation of extracellular matrix (ECM) gene expression in cultured rat Schwann cells

G. Sobue, Yoshihiko Yamada, Masahiko Yamamoto, 1994, Brain Research.

Hyaluronan expression as a significant prognostic factor in patients with malignant peripheral nerve sheath tumors

N. Ishiguro, Y. Nishida, K. Kimata, 2014, Clinical & Experimental Metastasis.

The crystal structure of novel chondroitin lyase ODV‐E66, a baculovirus envelope protein

M. Kimura, Y. Kakuta, K. Kimata, 2013, FEBS letters.

Enhanced Expression of Interleukin-18 Receptor α Chain by CD4+ T Cells in Sarcoidosis

M. Nishimura, S. Konno, K. Kimata, 2005 .

Abnormal synthesis of cartilage-characteristic proteoglycan in azaserine-induced micromelial limbs.

K. Kimata, K. Yamada, A. Honda, 1989, The Biochemical journal.

Establishment of a novel chondrocyte‐like cell line derived from transgenic mice harboring the temperature‐sensitive simian virus 40 large T‐antigen gene

N. Mataga, M. Obinata, M. Noda, 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Isolation and characterization of type IX collagen-proteoglycan from the Swarm rat chondrosarcoma.

S. Suzuki, K. Kimata, T. Yada, 1992, Biochimica et biophysica acta.

Occurrence in chick embryo vitreous humor of a type IX collagen proteoglycan with an extraordinarily large chondroitin sulfate chain and short alpha 1 polypeptide.

K. Kobayashi, T. Hoshino, M. Kobayashi, 1990, The Journal of biological chemistry.

Characterization of an anti-decorin monoclonal antibody, and its utility.

T. Tsuji, K. Kimata, T. Shinomura, 2002, Journal of biochemistry.

Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model

T. Ushida, N. Ishiguro, Y. Nishida, 2017, Scientific Reports.

Swarm rat chondrosarcoma proteoglycans. Purification of aggregates by zonal centrifugation of preformed cesium sulfate gradients.

S. Rennard, V. Hascall, J. Kimura, 1982, The Journal of biological chemistry.

Receptor for Hyaluronan‐mediated Motility and CD44 Expressions in Colon Cancer Assessed by Quantitative Analysis Using Real‐time Reverse Transcriptase‐Polymerase Chain Reaction

S. Hirohashi, A. Ochiai, H. Narimatsu, 1999, Japanese journal of cancer research : Gann.