A. Treston

发表

Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro.

J. Minna, A. Gazdar, J. Mulshine, 1988, The Journal of clinical investigation.

Preclinical evaluation of an anti-autocrine growth factor monoclonal antibody for treatment of patients with small-cell lung cancer.

J. Mulshine, I. Avis, J. Walsh, 1991, Journal of the National Cancer Institute.

Purification and Characterization of a Protein That Permits Early Detection of Lung Cancer

J. Mulshine, Jun Zhou, A M Treston, 1996, The Journal of Biological Chemistry.

Growth factors and other targets for rational application as intervention agents.

J. Mulshine, M. Birrer, I. Avis, 1992, Advances in experimental medicine and biology.

New approaches to the integrated management of early lung cancer.

M. Tockman, J. Mulshine, E. Szabo, 1997, Hematology/oncology clinics of North America.

Recent molecular advances in the approach to early lung cancer detection and intervention.

J. Mulshine, A. Treston, F. Scott, 1997, Environmental health perspectives.

Strategies for lung cancer chemoprevention

J. Mulshine, I. Avis, F. Cuttitta, 1993 .

Scientific basis for cancer prevention intermediate cancer markers

J. Mulshine, I. Avis, M. Jett, 1993, Cancer.

Autocrine growth factors and lung cancer.

E. Sausville, J. Mulshine, I. Avis, 1989, Cancer treatment and research.

Immunocytochemical Mapping of the Amidating Enzyme PAM in the Developing and Adult Mouse Lung

L. Guembe, A. Treston, A. Villaro, 1999, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer

D. Camidge, S. Leong, K. Lewis, 2011, Investigational New Drugs.

GC-072, a Novel Therapeutic Candidate for Oral Treatment of Melioidosis and Infections Caused by Select Biothreat Pathogens

G. Drusano, H. Schweizer, Kelly L. Warfield, 2019, Antimicrobial Agents and Chemotherapy.

Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198

E. Hamel, A. Treston, G. Swartz, 2008, Molecular Cancer Therapeutics.

Synthesis and structure-activity relationships of 16-modified analogs of 2-methoxyestradiol.

A. Treston, T. Lavallee, G. Agoston, 2007, Bioorganic & medicinal chemistry.

Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes with critical stages of mammalian lung development.

J. Mulshine, L. Montuenga, F. Cuttitta, 1998, American journal of respiratory cell and molecular biology.

Expression of peptidyl-glycine alpha-amidating mono-oxygenase (PAM) enzymes in morphological abnormalities adjacent to pulmonary tumors.

L. Montuenga, R. Linnoila, A. Treston, 1996, The American journal of pathology.

Investigational New Drug Enabling Nonclinical Safety Assessment of the Iminosugar UV-4, a Broad-Spectrum Host-Targeted Antiviral Agent

A. Sampath, U. Ramstedt, Kelly L. Warfield, 2022, International journal of toxicology.

In vivo diagnosis and therapy of human tumors with monoclonal antibodies: selection of antibodies and preliminary clinical studies in small cell carcinoma of the lung.

S. Larson, J. Mulshine, I. Avis, 1989, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

Clinical Use of a Monoclonal Antibody to Bombesin‐like Peptide in Patients with Lung Cancer a, b

S. Larson, J. Minna, J. Mulshine, 1988, Annals of the New York Academy of Sciences.

Peptide amidating activity in human bronchoalveolar lavage fluid.

M. Tockman, J. Mulshine, K. Kelly, 1996, Lung cancer.

Prospective trial evaluating immunocytochemical‐based sputum techniques for early lung cancer detection: Assays for promotion factors in the bronchial lavage

M. Tockman, S. Piantadosi, J. Mulshine, 1993, Journal of cellular biochemistry. Supplement.

Lung cancer: rational strategies for early detection and intervention.

J. Mulshine, Y. Nakanishi, F. Cuttitta, 1991, Oncology.

Targeting ER α-glucosidase I with a single-dose iminosugar treatment protects against lethal influenza and dengue virus infections.

R. Dwek, P. Roversi, N. Zitzmann, 2020, Journal of medicinal chemistry.

The metabolism of 2,5-diphenyloxazole (PPO) in human lymphocytes and rat liver microsomes.

A. Treston, J. Ahokas, N. Kärki, 1987, Pharmacology & toxicology.

Localization of amidating enzymes (PAM) in rat gastrointestinal tract.

J. Polak, L. Montuenga, F. Cuttitta, 1993, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Consideration of the Chemistry of Solid‐Phase Matrix Interactions Leads to Improved Quantitation of Neuropeptides a, b

J. Mulshine, I. Avis, Y. Nakanishi, 1988, Annals of the New York Academy of Sciences.

The metabolism of BW2258U89, a GRP receptor antagonist

T. Moody, A. Treston, S. Jakowlew, 2000, Neuropeptides.

Biochemical characterization of peptide alpha-amidation enzyme activities of human neuroendocrine lung cancer cell lines.

R. Mains, J. Mulshine, B. Eipper, 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Solid-phase peptide quantitation assay using labeled monoclonal antibody and glutaraldehyde fixation.

J. Mulshine, I. Avis, Y. Nakanishi, 1988, Analytical biochemistry.

Peptidylglycine α-amidating monooxygenase (PAM) immunoreactivity and messenger RNA in human pituitary and increased expression in pituitary tumours

J. Polak, J. Steel, D. Springall, 1994, Cell and Tissue Research.

Where does amidation take place?

A. Treston, A. Martínez, 1996, Molecular and Cellular Endocrinology.

Immunocytochemical localization of peptidylglycine alpha-amidating monooxygenase enzymes (PAM) in human endocrine pancreas.

J. Polak, L. Montuenga, D. Springall, 1993, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Peptidylglycine α‐amidating monooxygenase‐ and proadrenomedullin‐derived peptide–associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostate

T. H. van der Kwast, F. Schröder, A. Calvo, 2001, International journal of cancer.

Peptide-amidating Enzymes Are Expressed in the Stellate Epithelial Cells of the Thymic Medulla

A. Farr, F. Cuttitta, A. Treston, 1998, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Distribution of peptidyl-glycine alpha-amidating mono-oxygenase (PAM) enzymes in normal human lung and in lung epithelial tumors.

J. Polak, L. Montuenga, D. Springall, 1996, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Autocrine growth loops dependent on peptidyl alpha-amidating enzyme as targets for novel tumor cell growth inhibitors.

J. Mulshine, M. Miller, A. Treston, 1999, Lung cancer.

Purification and Characterization of a Protein That Permits Early Detection of Lung Cancer IDENTIFICATION OF HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-A2/B1 AS THE ANTIGEN FOR MONOCLONAL ANTIBODY 703D4*

A. Treston, E. Unsworth, F. Scott, 1996 .

Identification and synthesis of O-methylcatechol metabolites of phenobarbital and some N-alkyl derivatives.

M. Eadie, A. Treston, W. Hooper, 1987, Journal of pharmaceutical sciences.

Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects

K. Spurgers, A. Sampath, U. Ramstedt, 2022, PLoS neglected tropical diseases.

Effect of gastrin‐releasing peptide on the pancreatic tumor cell line (capan)

J. Mulshine, I. Avis, M. Jett, 1993, Molecular carcinogenesis.

A mitogenic peptide amide encoded within the E peptide domain of the insulin-like growth factor IB prohormone.

J. Siegfried, J. Mulshine, F. Cuttitta, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Alpha-amidation of peptide hormones in lung cancer.

J. Siegfried, J. Mulshine, I. Avis, 1991, Cancer cells.

Nickel(II)-promoted ethanolysis and hydrolysis of N-(2-pyridylmethyl)urea. A model for urease

A. Treston, R. Andrews, B. Zerner, 1982 .

N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum α-Glucosidases I and II with Antiviral Activity.

R. Mariuzza, S. S. Karade, N. Zitzmann, 2021, Journal of medicinal chemistry.

Structure elucidation by synthesis of four metabolites of the antitumor drug ENMD-1198 detected in human plasma samples

M. Cushman, A. Treston, G. Agoston, 2009 .

Synthesis and enantiomeric separation of 2-phthalimidino-glutaric acid analogues: potent inhibitors of tumor metastasis.

J H Shah, G M Swartz, A E Papathanassiu, 1999, Journal of medicinal chemistry.

The regulatory roles of liver and kidney in cobalamin (vitamin B12) metabolism in the rat: the uptake and intracellular binding of cobalamin and the activity of the cobalamin-dependent enzymes in response to varying cobalamin supply.

J. Owens, A. Treston, E. Bowman, 1984, Clinical science.

Investigational New Drug Enabling Nonclinical Safety Pharmacology Assessment of the Iminosugar UV-4, a Broad-Spectrum Host-Targeted Antiviral Agent

A. Sampath, U. Ramstedt, Kelly L. Warfield, 2022, International journal of toxicology.

Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer

G. Sledge, A. Storniolo, D. Murry, 2006, Investigational New Drugs.

A Phase II Multicenter, Randomized, Double-Blind, Safety Trial Assessing the Pharmacokinetics, Pharmacodynamics, and Efficacy of Oral 2-Methoxyestradiol Capsules in Hormone-Refractory Prostate Cancer

C. Yiannoutsos, G. Wilding, J. Kolesar, 2005, Clinical Cancer Research.

High-performance liquid chromatography with thermospray mass spectrometric detection of α-carboxyamido aminoacids

A. Yergey, A. Treston, D. Vicchio, 1989 .

Iminosugars: A host-targeted approach to combat Flaviviridae infections

T. Butters, Kelly L. Warfield, A. Treston, 2020, Antiviral Research.

Urinary metabolites of phenobarbitone, primidone, and their N-methyl and N-ethyl derivatives in humans.

A. Treston, W. Hooper, Wayne D. Hooper, 1992, Xenobiotica; the fate of foreign compounds in biological systems.

Metabolic studies with phenobarbitone, primidone and their N-alkyl derivatives: quantification of substrates and metabolites using chemical ionization gas chromatography-mass spectrometry.

A. Treston, W. Hooper, 1990, Journal of chromatography.

Identification of p-hydroxyprimidone as a minor metabolite of primidone in rat and man.

M. Eadie, A. Treston, W. Hooper, 1983, Drug metabolism and disposition: the biological fate of chemicals.

A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate

G. Wilding, M. Carducci, J. Eickhoff, 2012, Investigational New Drugs.

Insulin-like Growth Factor Expression in Human Cancer Cell Lines (*)

J. Battey, C. Grimley, F. Cuttitta, 1996, The Journal of Biological Chemistry.

Initiators and promoters of lung cancer.

J. Mulshine, M. Birrer, A. Treston, 1993, Chest.

Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors.

J. Mulshine, A. Treston, I. Avis, 1999, Cancer research.

Beyond transcriptional events

J. Mulshine, A. Treston, 1989, Nature.

Synthesis and antitumor activities of 3-modified 2-methoxyestradiol analogs.

A. Treston, T. Lavallee, G. Agoston, 2009, Bioorganic & medicinal chemistry letters.

Synthesis of 2- and 17-substituted estrone analogs and their antiproliferative structure-activity relationships compared to 2-methoxyestradiol.

A. Treston, G. Swartz, T. Lavallee, 2009, Bioorganic & medicinal chemistry.

S-3-Amino-phthalimido-glutarimide inhibits angiogenesis and growth of B-cell neoplasias in mice.

R. D'Amato, M. S. Rogers, R. LeBlanc, 2002, Cancer research.

Iminosugars: A host-targeted approach to combat Flaviviridae infections

T. Butters, Kelly L. Warfield, A. Treston, 2020, Antiviral Research.

Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4

R. Dwek, E. Harris, M. Buck, 2016, Antiviral research.

Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum α-Glucosidase I with Anti-SARS-CoV-2 Activity.

Alexander D. MacKerell, R. Mariuzza, S. S. Karade, 2023, Journal of medicinal chemistry.

Assessment of the potential for host‐targeted iminosugars UV‐4 and UV‐5 activity against filovirus infections in vitro and in vivo

X. Qiu, G. Wong, U. Ramstedt, 2017, Antiviral research.

Differential Expression of the Early Lung Cancer Detection Marker, Heterogeneous Nuclear Ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in Normal Breast and Neoplastic Breast Cancer

J. Mulshine, D. Allred, Jun Zhou, 2001, Breast Cancer Research and Treatment.

Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling.

T. Moody, J. Mulshine, M. Jett, 1996, The Journal of clinical investigation.

Expression in human lung cancer cell lines of genes of prohormone processing and the neuroendocine phenotype

A M Treston, A. Treston, F. Scott, 1996, Journal of cellular biochemistry. Supplement.

Autocrine growth factors as therapeutic targets in lung cancer.

J. Mulshine, I. Avis, Y. Nakanishi, 1989, Chest.

Effect of growth factors on the in vitro growth of small cell lung cancer as determined in a colorimetric assay

J. Minna, J. Mulshine, H. Kleinman, 1988 .

Isolation and Functional Expression of Human Pancreatic Peptidylglycine α-Amidating Monooxygenase

Y. Misumi, A. Treston, F. Arakawa, 1994 .

Control of tumor cell biology through regulation of peptide hormone processing.

J. Mulshine, F. Cuttitta, A. Treston, 1992, Journal of the National Cancer Institute. Monographs.

Human peptidylglycine alpha-amidating monooxygenase transcripts derived by alternative mRNA splicing of an unreported exon.

A. Treston, M. Vos, J. Jones, 1995, Gene.

Agents anti-angiogeniques

A. Treston, T. Lavallee, G. Agoston, 2005 .

Synthesis and in vivo antitumor evaluation of 2-methoxyestradiol 3-phosphate, 17-phosphate, and 3,17-diphosphate.

M. Cushman, Wei Song, A. Treston, 2007, Journal of medicinal chemistry.

Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes with critical stages of mammalian lung development.

A. Treston, I. Avis, J. L. Mulshine, 1998, American journal of respiratory cell and molecular biology.