J. Hume

发表

Sodium current depression by lidocaine and quinidine in isolated ventricular cells

A. Brown, W. Giles, K. S. Lee, 1981, Nature.

Block by 4‐aminopyridine of a Kv1.2 delayed rectifier K+ current expressed in Xenopus oocytes.

K. Sanders, N. Publicover, B. Horowitz, 1994, The Journal of physiology.

Hypotonic Activation of Volume-sensitive Outwardly Rectifying Anion Channels (VSOACs) Requires Coordinated Remodeling of Subcortical and Perinuclear Actin Filaments

W. Hatton, J. Hume, G.-X. Wang, 2005, The Journal of Membrane Biology.

TRPC1 and Orai1 interact with STIM1 and mediate capacitative Ca(2+) entry caused by acute hypoxia in mouse pulmonary arterial smooth muscle cells.

H. Tian, C. Singer, Kathryn O’Neill, 2012, American journal of physiology. Cell physiology.

Properties of "creep currents" in single frog atrial cells

J. Hume, A. Uehara, 1986, The Journal of general physiology.

[Ca2+]i inhibition of K+ channels in canine pulmonary artery. Novel mechanism for hypoxia-induced membrane depolarization.

J. Hume, C. Gelband, J. M. Post, 1995, Circulation research.

Redox Regulation of K+ Channels and Hypoxic Pulmonary Vasoconstriction

S. Archer, E. K. Weir, J. Hume, 1993 .

Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction.

S. Archer, E. K. Weir, J. Hume, 1992, The American journal of physiology.

TRPC 1 and Orai 1 interact with STIM 1 and mediate capacitative Ca 2 entry caused by acute hypoxia in mouse pulmonary arterial smooth muscle cells

H. Tian, C. Singer, J. Hume, 2012 .

Orai1 interacts with STIM1 and mediates capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells.

H. Tian, C. Singer, J. Hume, 2010, American journal of physiology. Cell physiology.

Orai 1 interacts with STIM 1 and mediates capacitative Ca 2 entry in mouse pulmonary arterial smooth muscle cells

H. Tian, C. Singer, J. Hume, 2010 .

The contribution of TRPC1 and STIM1 to capacitative Ca(2+) entry in pulmonary artery.

J. Hume, J. Airey, L. Ng, 2010, Advances in experimental medicine and biology.

TRPC1 and STIM1 mediate capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells

C. Singer, J. Hume, J. Airey, 2009, The Journal of physiology.

Comparative interactions of organic Ca++ channel antagonists with myocardial Ca++ and K+ channels.

J. Hume, 1985, The Journal of pharmacology and experimental therapeutics.

Actions of phencyclidine on the action potential and membrane currents of single guinea-pig myocytes.

J. Hume, R. Hadley, 1986, The Journal of pharmacology and experimental therapeutics.

Intracellular divalent cations block smooth muscle K+ channels.

T. Ishikawa, J. Hume, K. Keef, 1993, Circulation research.

Modulation of K+ and Ca2+ channels by histamine H1‐receptor stimulation in rabbit coronary artery cells.

T. Ishikawa, J. Hume, K. Keef, 1993, The Journal of physiology.

Electrophysiological Mechanisms of Minoxidil Sulfate-Induced Vasodilation of Rabbit Portal Vein

N. Leblanc, J. Hume, K. Keef, 1989, Circulation research.

Comparative Capacitative Calcium Entry Mechanisms in Canine Pulmonary and Renal Arterial Smooth Muscle Cells

G. Smith, J. Hume, L. Johnston, 2002, The Journal of physiology.

Functional inhibition of native volume‐sensitive outwardly rectifying anion channels in muscle cells and Xenopus oocytes by anti‐ClC‐3 antibody

D. Duan, W. Hatton, B. Horowitz, 2001, The Journal of physiology.

Functional and molecular expression of volume‐regulated chloride channels in canine vascular smooth muscle cells

D. Duan, B. Horowitz, J. Hume, 1998, The Journal of physiology.

Functional and molecular identification of a novel chloride conductance in canine colonic smooth muscle.

K. Sanders, B. Horowitz, J. Hume, 1998, The American journal of physiology.

Dihydropyridine-sensitive calcium channels expressed in canine colonic smooth muscle cells.

K. Sanders, A. Rich, B. Horowitz, 1993, The American journal of physiology.

Calcium Channel Antagonist Properties of Bay K 8644 in Single Guinea Pig Ventricular Cells

J. Hume, R. Hadley, 1988, Circulation research.

Regulation of recombinant cardiac cystic fibrosis transmembrane conductance regulator chloride channels by protein kinase C.

B. Horowitz, F. Britton, J. Hume, 1999, Biophysical journal.

Propertiesof"CreepCurrents" inSingleFrog AtrialCells

J. Hume, A. Uehara, 1986 .

Anchoring protein is required for cAMP-dependent stimulation of L-type Ca(2+) channels in rabbit portal vein.

J. Hume, J. Zhong, K. Keef, 1999, The American journal of physiology.

Anchoring protein is required for cAMP-dependent stimulation of L-type Ca2+ channels in rabbit portal vein.

J. Hume, J. Zhong, K. Keef, 1999, American journal of physiology. Cell physiology.

Differential expression and alternative splicing of TRP channel genes in smooth muscles.

R. Walker, B. Horowitz, J. Hume, 2001, American journal of physiology. Cell physiology.

NO and the regulation of VSOACs

D. Duan, J. Hume, 2000, The Journal of physiology.

CFTR chloride channels in human and simian heart.

B. Horowitz, J. Hume, P. Hart, 1996, Cardiovascular research.

Prominent role of intracellular Ca2+ release in hypoxic vasoconstriction of canine pulmonary artery

R. Jabr, J. Hume, C. Gelband, 1997, British journal of pharmacology.

Cell culture alters Ca2+ entry pathways activated by store-depletion or hypoxia in canine pulmonary arterial smooth muscle cells.

W. Hatton, J. Hume, B. Kyle, 2008, American journal of physiology. Cell physiology.

A novel anionic inward rectifier in native cardiac myocytes.

D. Duan, B. Horowitz, F. Britton, 2000, Circulation research.

Membrane Electrical Properties of Vesicular Na‐Ca Exchange Inhibitors in Single Atrial Myocytes

P. Vassilev, J. Hume, D. Bielefeld, 1986, Circulation research.

Histamine Activates the Chloride Current in Cardiac Ventricular Myocytes

R. Harvey, J. Hume, 1990 .

Autonomic regulation of delayed rectifier K+ current in mammalian heart involves G proteins.

R. Harvey, J. Hume, 1989, The American journal of physiology.

ClC‐3 chloride channel is upregulated by hypertrophy and inflammation in rat and canine pulmonary artery

W. Hatton, J. Hume, Yan-ping Dai, 2005, British journal of pharmacology.

Hypotonic Activation of Short ClC3 Isoform Is Modulated by Direct Interaction between Its Cytosolic C-terminal Tail and Subcortical Actin Filaments*

J. Hume, L. Miller, Yan-ping Dai, 2007, Journal of Biological Chemistry.

ClC-3 Is a Fundamental Molecular Component of Volume-sensitive Outwardly Rectifying Cl− Channels and Volume Regulation in HeLa Cells and Xenopus laevis Oocytes*

B. Horowitz, J. Hume, M. Hermoso, 2002, The Journal of Biological Chemistry.

Novel Mechanism for Autonomic Regulation of Action Potential Duration and Resting Mem2vrane Potential

R. Harvey, J. Hume, C. D. Clark, 1990 .

Comparison of K+ channels in mammalian atrial and ventricular myocytes.

R. Harvey, J. Hume, A. Uehara, 1990, Progress in clinical and biological research.

Component of whole cell Ca current due to electrogenic Na-Ca-exchange in cardiac myocytes.

J. Hume, 1987, The American journal of physiology.

A time- and voltage-dependent K+ current in single cardiac cells from bullfrog atrium

W. Giles, R. Rasmusson, J. Hume, 1986, The Journal of general physiology.

D 600 block of L-type Ca2+ channel in vascular smooth muscle cells: comparison with permanently charged derivative, D 890.

N. Leblanc, J. Hume, 1989, The American journal of physiology.

A whole-cell patch clamp technique which minimizes cell dialysis

J. Hume, R. N. Leblanc, 1989, Molecular and Cellular Biochemistry.

Intracellular Na+ modulates the cAMP-dependent regulation of ion channels in the heart.

R. Harvey, J. Hume, J. Jurevičius, 1991, Proceedings of the National Academy of Sciences of the United States of America.

A Plethora of Cardiac Chloride Conductances: Molecular Diversity or a Related Gene Family

B. Horowitz, J. Hume, 1995, Journal of cardiovascular electrophysiology.

rapid communication Anchoring protein is required for cAMP-dependent stimulation of L-type Ca 2 1 channels in rabbit portal vein

J. Hume, J. Zhong, K. Keef, 1999 .

Mobilization of sarcoplasmic reticulum stores by hypoxia leads to consequent activation of capacitative Ca2+ entry in isolated canine pulmonary arterial smooth muscle cells

J. Hume, L. Ng, S. Wilson, 2005, The Journal of physiology.

Role of InsP3 and ryanodine receptors in the activation of capacitative Ca2+ entry by store depletion or hypoxia in canine pulmonary arterial smooth muscle cells

J. Hume, L. Ng, S. Wilson, 2007, British journal of pharmacology.

Alternative splicing of CFTR Cl- channels in heart.

B. Horowitz, P. Levesque, J. Hume, 1993, The American journal of physiology.

Ionic currents in single isolated bullfrog atrial cells

W. Giles, J. Hume, 1983, The Journal of general physiology.

Active and passive electrical properties of single bullfrog atrial cells

W. Giles, J. Hume, 1981, The Journal of general physiology.

Regulation of L‐type Ca2+ channels in rabbit portal vein by G protein αs and βγ subunits

C. Dessauer, J. Hume, J. Zhong, 1999 .

Anion transport in heart.

D. Duan, B. Horowitz, J. Hume, 2000, Physiological reviews.

Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.

J. Hume, J. Zhong, K. Keef, 2001, American journal of physiology. Cell physiology.

β‐Adrenergic receptor stimulation of L‐type Ca2+ channels in rabbit portal vein myocytes involves both αs and βγ G protein subunits

J. Hume, J. Zhong, K. Keef, 2001 .

Modulation of Ca2+ channels by cyclic nucleotide cross activation of opposing protein kinases in rabbit portal vein.

J R Hume, K D Keef, V. Ruiz-Velasco, 1998, Circulation research.

Regulation of Ca2+ channels by cAMP and cGMP in vascular smooth muscle cells.

T. Ishikawa, J. Hume, K. Keef, 1993, Circulation research.

cellsin canine pulmonary arterial smooth muscle Heterogeneity of calcium stores and elementary release

J. Wess, S. Wray, S. Fleischer, 2011 .

Caffeine inhibits InsP3 responses and capacitative calcium entry in canine pulmonary arterial smooth muscle cells.

J. Hume, S. Wilson, C. McAllister, 2009, Vascular pharmacology.

Inhibition of Ryanodine Receptors by 4-(2-Aminopropyl)-3,5-dichloro-N,N-dimethylaniline (FLA 365) in Canine Pulmonary Arterial Smooth Muscle Cells

I. Pessah, J. Hume, R. Goyal, 2007, Journal of Pharmacology and Experimental Therapeutics.

Role of basal extracellular Ca2+ entry during 5‐HT‐induced vasoconstriction of canine pulmonary arteries

J. Hume, L. Johnston, L. Ng, 2005, British journal of pharmacology.

Anion and cation modulation of the guinea-pig ventricular action potential during β-adrenoceptor stimulation

P. Levesque, L. Rosenshtraukh, J. Hume, 1993, Pflügers Archiv.

Inhibitory effects of glibenclamide on cystic fibrosis transmembrane regulator, swelling-activated, and Ca(2+)-activated Cl- channels in mammalian cardiac myocytes.

J. Hume, J. Yamazaki, 1997, Circulation research.

Hypotonic activation of volume-sensitive outwardly rectifying chloride channels in cultured PASMCs is modulated by SGK.

B. Horowitz, J. Hume, Yan-ping Dai, 2004, American journal of physiology. Heart and circulatory physiology.

Cardiac-specific, inducible ClC-3 gene deletion eliminates native volume-sensitive chloride channels and produces myocardial hypertrophy in adult mice.

H. Tian, C. Singer, Mi Zhang, 2010, Journal of molecular and cellular cardiology.

Molecular identification of a volume-regulated chloride channel

D. Duan, B. Horowitz, J. Hume, 1997, Nature.

Functional effects of novel anti-ClC-3 antibodies on native volume-sensitive osmolyte and anion channels in cardiac and smooth muscle cells.

D. Duan, W. Hatton, J. Hume, 2003, American journal of physiology. Heart and circulatory physiology.

A Serine Residue in ClC-3 Links Phosphorylation–Dephosphorylation to Chloride Channel Regulation by Cell Volume

D. Duan, B. Horowitz, J. Hume, 1999, The Journal of general physiology.

Ionic basis for spontaneous depolarizations in isolated smooth muscle cells of canine colon.

J. Hume, J. M. Post, 1992, The American journal of physiology.

Do catecholamines directly modulate the delayed plateau potassium current in frog atrium?

J. Hume, 1985, Journal of molecular and cellular cardiology.

Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum.

N. Leblanc, N Leblanc, J R Hume, 1990, Science.

Macroscopic K+ currents in single smooth muscle cells of the rabbit portal vein.

N. Leblanc, J. Hume, 1989, The Journal of physiology.

Physiological role of endogenous amines in the modulation of ventricular automaticity in the guinea‐pig.

B. Katzung, J. Hume, 1980, The Journal of physiology.

TREK‐1 Currents in Smooth Muscle Cells From Pregnant Human Myometrium

N. Leblanc, C. Singer, S. Barnett, 2011, American journal of physiology. Cell physiology.

Functional and molecular identification of a novel chloride conductance in canine colonic smooth muscle.

K. Sanders, B. Horowitz, J. Hume, 1998, American journal of physiology. Cell physiology.

"Creep currents" in single frog atrial cells may be generated by electrogenic Na/Ca exchange

J R Hume, J. Hume, A. Uehara, 1986, The Journal of general physiology.

pH regulation of voltage-dependent K+ channels in canine pulmonary arterial smooth muscle cells

J. Hume, D. Ahn, 1997, Pflügers Archiv.

Unitary chloride channels activated by protein kinase C in guinea pig ventricular myocytes.

J. Hume, M. Collier, 1995, Circulation research.

Inactivation of calcium current in bull‐frog atrial myocytes.

W. Giles, J. Hume, E. Shibata, 1988, The Journal of physiology.

Altered properties of volume‐sensitive osmolyte and anion channels (VSOACs) and membrane protein expression in cardiac and smooth muscle myocytes from Clcn3‐/‐ mice

D. Duan, W. Hatton, B. Horowitz, 2004, The Journal of physiology.

Molecular distribution of volume-regulated chloride channels (ClC-2 and ClC-3) in cardiac tissues.

D. Duan, W. Hatton, B. Horowitz, 2000, American journal of physiology. Heart and circulatory physiology.

Cloning and characterization of a Kv1.5 delayed rectifier K+ channel from vascular and visceral smooth muscles.

K. Sanders, B. Horowitz, P. Hart, 1994, The American journal of physiology.

Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells

J. Hume, A. Uehara, 1985, The Journal of general physiology.

Ionic basis of the different action potential configurations of single guinea‐pig atrial and ventricular myocytes.

J. Hume, A. Uehara, 1985, The Journal of physiology.

Functional role of anion channels in cardiac diseases

L. Ye, J. Hume, Z. M. Huang, 2005, Acta Pharmacologica Sinica.

Low osmolarity transforms ventricular fibrillation from complex to highly organized, with a dominant high-frequency source.

G. Salama, W. Hatton, J. Hume, 2006, Heart rhythm.

Role of Reverse‐Mode Na+‐Ca2+ Exchange in Excitation‐Contraction Coupling in the Heart a

J. Hume, P. Levesque, Normand Leblanc, 1991, Annals of the New York Academy of Sciences.

Autonomic regulation of a chloride current in heart.

R. Harvey, J. Hume, Robert D. Harvey, 1989, Science.

Relationship between calcium current and cytosolic calcium in canine gastric smooth muscle cells.

K. Sanders, N. Publicover, J. Hume, 1991, The American journal of physiology.

Regulation of Ca 2 + Channels by cAMP and cGMP in Vascular Smooth Muscle Cells

T. Ishikawa, J. Hume, K. Keef, 2005 .

Expression of cystic fibrosis transmembrane regulator Cl- channels in heart.

B. Horowitz, P. Levesque, J. Hume, 1992, Circulation research.

[Ca2+]i inhibition of K+ channels in canine renal artery. Novel mechanism for agonist-induced membrane depolarization.

J. Hume, C. Gelband, 1995, Circulation research.

Intracellular cyclic AMP inhibits native and recombinant volume‐regulated chloride channels from mammalian heart

D. Duan, B. Horowitz, J. Hume, 2000, The Journal of physiology.

P2Y purinergic receptor regulation of CFTR chloride channels in mouse cardiac myocytes

J. Hume, Ge‐Xin Wang, Shintaro Yamamoto-Mizuma, 2004, The Journal of physiology.

Purinoceptor‐coupled Cl− channels in mouse heart: a novel, alternative pathway for CFTR regulation

D. Duan, B. Horowitz, F. Britton, 1999, The Journal of physiology.

Evidence that outwardly rectifying Cl- channels underlie volume-regulated Cl- currents in heart.

S. Nattel, J. Hume, D. Duan, 1997, Circulation research.

Unitary Cl- channels activated by cytoplasmic Ca2+ in canine ventricular myocytes.

P. Levesque, J R Hume, J L Kenyon, 1996, Circulation research.

ATPo but not cAMPi activates a chloride conductance in mouse ventricular myocytes.

P. Levesque, J. Hume, 1995, Cardiovascular research.

Chloride current in mammalian cardiac myocytes. Novel mechanism for autonomic regulation of action potential duration and resting membrane potential

R. Harvey, J. Hume, C. D. Clark, 1990, The Journal of general physiology.

Chloride conductance pathways in heart.

R. Harvey, J. Hume, 1991, The American journal of physiology.

Re-examination of Na+-dependent regulation of cAMP-dependent Cl–currents in the heart

J. Hume, J. Warth, 1997, Pflügers Archiv.

Heterogeneity of calcium stores and elementary release events in canine pulmonary arterial smooth muscle cells.

S. Wilson, J. Hume, S. Wilson, 2001, American journal of physiology. Cell physiology.

Ionic currents in single smooth muscle cells of the canine renal artery.

J. Hume, C. Gelband, 1992, Circulation research.

Functional role of amino terminus in ClC‐3 chloride channel regulation by phosphorylation and cell volume

W. Hatton, B. Horowitz, F. Britton, 2006, Acta physiologica.

Regulation of volume-sensitive outwardly rectifying anion channels in pulmonary arterial smooth muscle cells by PKC.

W. Hatton, M. Walsh, J. Hume, 2002, American journal of physiology. Cell physiology.

Reversal potential of the calcium current in bull‐frog atrial myocytes.

D. Noble, J. Hume, E. Shibata, 1988, The Journal of physiology.

Cromakalim and lemakalim activate Ca2+-dependent K+ channels in canine colon

K. Sanders, J. Hume, A. Carl, 1992, Pflügers Archiv.

Cystic fibrosis gene encodes a cAMP-dependent chloride channel in heart.

B. Horowitz, P. Levesque, J. Hume, 1996, Proceedings of the National Academy of Sciences of the United States of America.

TRPC1, STIM1 and Orai1 Mediate Capacitative Calcium Entry Activated by Acute Hypoxia in Mouse Pulmonary Arterial Smooth Muscle Cells

J. Hume, J. Airey, L. Ng, 2011 .

Molecular mechanisms of regulation of fast‐inactivating voltage‐dependent transient outward K+ current in mouse heart by cell volume changes

D. Duan, L. Ye, J. Hume, 2005, The Journal of physiology.

Chloride channels in heart

B. Horowitz, P. Levesque, J. Hume, 1996 .

An intrinsic potential‐dependent inactivation mechanism associated with calcium channels in guinea‐pig myocytes.

J. Hume, R. Hadley, 1987, The Journal of physiology.

A . PCR Ampilfied Rglon BD 2 1 st Nucleotide Binding Domain B . Human CFTR NGDDSLFFSNFSLLGTPVLKDINFKIERGOLLAVAGSTGAGKYSLLMMIMGELEPSE 479 Rabbit Heart

B. Horowitz, P. Levesque, J. Hume, 2005 .

Functional Characterization of Novel Alternatively Spliced ClC-2 Chloride Channel Variants in the Heart*

D. Duan, L. Ye, B. Horowitz, 2005, Journal of Biological Chemistry.

Cloning and expression of a Kv1.2 class delayed rectifier K+ channel from canine colonic smooth muscle.

K. Sanders, K. Overturf, B. Horowitz, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Release of calcium from guinea pig cardiac sarcoplasmic reticulum induced by sodium-calcium exchange.

N. Leblanc, P. Levesque, J. Hume, 1994, Cardiovascular research.

CARDIAC‐SPECIFIC OVEREXPRESSION OF THE HUMAN SHORT CLC‐3 CHLORIDE CHANNEL ISOFORM IN MICE

P. Scowen, H. Tian, C. Singer, 2009, Clinical and experimental pharmacology & physiology.

CLC-3 chloride channels in the pulmonary vasculature.

D. Duan, J. Hume, J. Yamazaki, 2010, Advances in experimental medicine and biology.

Functional and molecular identification of a novel chloride conductance in canine colonic smooth muscle.

K. Sanders, B. Horowitz, J. Hume, 1998, American Journal of Physiology - Cell Physiology.

Voltage-dependent action of tetrodotoxin in mammalian cardiac myocytes.

K. S. Lee, P. Vassilev, J. Hume, 1986, The American journal of physiology.

Properties of "creep currents" in single frog atrial cells

J. Hume, A. Uehara, 1986, The Journal of general physiology.

Voltage clamp comparison of the organic calcium channel blockers D-600 and nisoldipine.

J. Hume, A. Uehara, 1984, Proceedings of the Western Pharmacology Society.

Effect of cromakalim and lemakalim on slow waves and membrane currents in colonic smooth muscle.

K. Sanders, J. Hume, R. Stevens, 1991, The American journal of physiology.

Action potentials and membrane currents of isolated single smooth muscle cells of cat and rabbit colon

J. Hume, D. Bielefeld, J. Krier, 1990, Pflügers Archiv.

Effects of autonomic neurotransmitters on automaticity in ventricular myocardium.

B. Katzung, J. Hume, 1977, Proceedings of the Western Pharmacology Society.