Zofia Tylutki

发表

Mechanistic Physiologically Based Pharmacokinetic (PBPK) Model of the Heart Accounting for Inter-Individual Variability: Development and Performance Verification.

S. Polak, A. Mendyk, Zofia Tylutki, 2017, Journal of pharmaceutical sciences.

A four-compartment PBPK heart model accounting for cardiac metabolism - model development and application

Sebastian Polak, Zofia Tylutki, S. Polak, 2017, Scientific reports.

Model of the Distribution of Diastolic Left Ventricular Posterior Wall Thickness in Healthy Adults and Its Impact on the Behavior of a String of Virtual Cardiomyocytes

S. Polak, K. Stolarz-Skrzypek, K. Kawecka-Jaszcz, 2014, Journal of Cardiovascular Translational Research.

Thorough QT (TQT) studies: concordance with torsadogenesis and an evolving cardiac safety testing paradigm.

S. Polak, B. Wiśniowska, Zofia Tylutki, 2017, Drug discovery today.

Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals

S. Polak, A. Mendyk, Zofia Tylutki, 2018, Journal of Pharmacokinetics and Pharmacodynamics.

Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials

S. Polak, B. Wiśniowska, Zofia Tylutki, 2016, BMC Pharmacology and Toxicology.

Plasma vs heart tissue concentration in humans - literature data analysis of drugs distribution.

Sebastian Polak, Zofia Tylutki, S. Polak, 2015, Biopharmaceutics & drug disposition.

Abnormal olanzapine toxicokinetic profiles – population pharmacokinetic analysis

J. S. Anand, Zofia Tylutki, J. Wilimowska, 2015, Toxicology mechanisms and methods.

Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials

S. Polak, B. Wiśniowska, Zofia Tylutki, 2016, BMC Pharmacology and Toxicology.

The effect of increasing amitriptyline doses on cardiomyocytes’ electrophysiology – simulation study

Sebastian Polak, Zofia Tylutki, Jakob Jornil, 2016, Bio Algorithms Med Syst..

Humans Vary, So Cardiac Models Should Account for That Too!

Barbara Wiśniowska, Sebastian Polak, Zofia Tylutki, 2017, Front. Physiol..

Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations

S. Polak, B. Wiśniowska, Zofia Tylutki, 2016, Current Pharmacology Reports.

CardiacPBPK: A tool for the prediction and visualization of time-concentration profiles of drugs in heart tissue

Sebastian Polak, Zofia Tylutki, Jakub Szlęk, 2019, Comput. Biol. Medicine.

Better prediction of the local concentration-effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the evolution of model-informed drug discovery and development.

Sebastian Polak, Barbara Wiśniowska, Zofia Tylutki, 2019, Drug discovery today.

Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations

Sebastian Polak, Barbara Wiśniowska, Zofia Tylutki, 2016, Current Pharmacology Reports.