G. Lalmanach

Pitter F. Huesgen, R. Hollingsworth, C. Overall, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cigarette smoke induces overexpression of active human cathepsin S in lungs from current smokers with or without COPD.

O. Eickelberg, Y. Courty, C. Staab-Weijnitz, 2019, American journal of physiology. Lung cellular and molecular physiology.

Regulation of TGF-β1-driven Differentiation of Human Lung Fibroblasts

S. Marchand-Adam, B. Gilmore, G. Lalmanach, 2014, The Journal of Biological Chemistry.

Therapeutic targeting of cathepsin C: from pathophysiology to treatment

N. Thakker, H. Roberts, I. Chapple, 2018, Pharmacology & therapeutics.

Cysteine Cathepsins S and L Modulate Anti-angiogenic Activities of Human Endostatin*

Ludovic C. Gillet, F. Veillard, L. Gillet, 2011, The Journal of Biological Chemistry.

Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells*

Ludovic C. Gillet, J. Le Guennec, L. Gillet, 2009, Journal of Biological Chemistry.

Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations.

A. Delmas, V. Aucagne, G. Lalmanach, 2012, Angewandte Chemie.

Protean proteases: at the cutting edge of lung diseases

C. Overall, K. Borensztajn, B. Turk, 2017, European Respiratory Journal.

Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants

G. Lalmanach, F. Lecaille, A. Saidi, 2020, International journal of molecular sciences.

Cysteine cathepsins and caspases in silicosis

G. Lalmanach, F. Lecaille, E. Diot, 2006, Biological chemistry.

Reversible inhibition of cathepsin L‐like proteases by 4‐mer pseudopeptides

J. McKerrow, F. Gauthier, G. Lalmanach, 2001, FEBS letters.

Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis

C. Czaplewski, A. Giełdoń, A. Lesner, 2019, International journal of molecular sciences.

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases*

M. Si-Tahar, N. Heuzé-Vourc’h, A. Lesner, 2016, The Journal of Biological Chemistry.

Lung cysteine cathepsins: intruders or unorthodox contributors to the kallikrein-kinin system?

F. Veillard, G. Lalmanach, F. Lecaille, 2008, The international journal of biochemistry & cell biology.

Imaging of extracellular cathepsin S activity by a selective near infrared fluorescence substrate-based probe.

A. Delmas, M. Galibert, V. Aucagne, 2019, Biochimie.

Specific cleavage of the lung surfactant protein A by human cathepsin S may impair its antibacterial properties.

R. Veldhuizen, J. Sage, G. Lalmanach, 2013, The international journal of biochemistry & cell biology.

Extracellular catalase activity protects cysteine cathepsins from inactivation by hydrogen peroxide

N. Heuzé-Vourc’h, F. Veillard, G. Lalmanach, 2008, FEBS letters.

Regulation of cathepsin K activity by hydrogen peroxide

D. Brömme, F. Veillard, M. Belghazi, 2008, Biological chemistry.

Active cathepsins B, H, K, L and S in human inflammatory bronchoalveolar lavage fluids

M. Martino, F. Gauthier, G. Lalmanach, 2006, Biology of the cell.

The abnormal accumulation of heparan sulfate in patients with mucopolysaccharidosis prevents the elastolytic activity of cathepsin V.

R. Linhardt, Fuming Zhang, S. Samsonov, 2021, Carbohydrate polymers.

Chicken cystatin stimulates nitric oxide release from interferon-gamma-activated mouse peritoneal macrophages via cytokine synthesis.

B. Vray, J. Hoebeke, F. Gauthier, 1999, European journal of biochemistry.

Pro-angiogenic effect of human kallikrein-related peptidase 12 (KLK12) in lung endothelial cells does not depend on kinin-mediated activation of B2 receptor

T. Kryza, N. Heuzé-Vourc’h, Y. Courty, 2013, Biological chemistry.

Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins

R. Gordon, D. Brömme, G. Lalmanach, 2006, Biological chemistry.

Evaluation of a peptide ELISA for the detection of rituximab in serum.

M. Maurel, M. Belghazi, G. Paintaud, 2007, Journal of immunological methods.

Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis

T. Reinheckel, S. Marchand-Adam, I. Couillin, 2016, Respiratory Research.

Conserved cystatin segments as models for designing specific substrates and inhibitors of cysteine proteinases

L. Juliano, R. Mayer, J. Chagas, 1995, Journal of protein chemistry.

Binding of heparan sulfate to human cystatin C modulates inhibition of cathepsin L: Putative consequences in mucopolysaccharidosis.

Fuming Zhang, S. Samsonov, F. Labarthe, 2022, Carbohydrate polymers.

Modulation of the expression and activity of cathepsin S in reconstructed human skin by neohesperidin dihydrochalcone.

S. Samsonov, J. Sage, C. Nizard, 2022, Matrix biology : journal of the International Society for Matrix Biology.

Discrimination between rat thiostatin (T-kininogen) and one of its cystatin-like inhibitory fragments by a monoclonal antibody, and localization of the epitope.

T. Moreau, F. Gauthier, G. Lalmanach, 1991, European journal of biochemistry.

Modulation of hypotensive effects of kinins by cathepsin K.

D. Brömme, G. Lalmanach, F. Lecaille, 2007, Archives of biochemistry and biophysics.

Cystatins Up-regulate Nitric Oxide Release from Interferon-γ- activated Mouse Peritoneal Macrophages*

R. Lucius, B. Vray, J. Hoebeke, 1996, The Journal of Biological Chemistry.

Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S.

A. Delmas, D. Brömme, B. Korkmaz, 2018, European journal of medicinal chemistry.

Procongopain from Trypanosoma congolense Is Processed at Basic pH: An Unusual Feature among Cathepsin L-Like Cysteine Proteases

F. Gauthier, G. Lalmanach, F. Lecaille, 2003, Biological chemistry.

Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors.

R. Ménard, T. Vernet, J. Scharfstein, 2001, Molecular and biochemical parasitology.

Discrimination of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, and mammalian cathepsins B and L, by a pH-inducible fluorogenic substrate of trypanosomal cysteine proteinases.

J. Scharfstein, M. Juliano, F. Gauthier, 1999, European journal of biochemistry.

Investigation of the substrate specificity of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, through the use of cystatin-derived substrates and inhibitors.

J. Scharfstein, L. Juliano, M. Juliano, 1996, The Biochemical journal.

Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases.

J. Scharfstein, L. Juliano, M. Vannier-Santos, 2000, Molecular and biochemical parasitology.

Rat cathepsin K: Enzymatic specificity and regulation of its collagenolytic activity.

S. Samsonov, K. Bojarski, G. Lalmanach, 2019, Biochimica et biophysica acta. Proteins and proteomics.

Assignment of proton NMR resonances and conformational analysis of the K13CK cystatin‐like peptide

G. Lalmanach, D. Davoust, E. Lebrun, 1992 .

Kininogens: More than cysteine protease inhibitors and kinin precursors.

G. Lalmanach, F. Lecaille, C. Naudin, 2010, Biochimie.

Cathepsin V: Molecular characteristics and significance in health and disease.

G. Lalmanach, F. Lecaille, A. Saidi, 2022, Molecular aspects of medicine.

Curcumin inhibits the TGF-β1-dependent differentiation of lung fibroblasts via PPARγ-driven upregulation of cathepsins B and L

G. Lalmanach, F. Lecaille, A. Saidi, 2019, Scientific Reports.

A Virus Essential for Insect Host-Parasite Interactions Encodes Cystatins

L. Cattolico, E. Huguet, J. Drezen, 2005, Journal of Virology.

Differential expression of cathepsins K, S and V between young and aged Caucasian women skin epidermis.

E. Perrier, R. Kurfurst, J. Sage, 2014, Matrix biology : journal of the International Society for Matrix Biology.

Binding of chondroitin 4-sulfate to cathepsin S regulates its enzymatic activity.

T. Livache, A. Roget, E. Perrier, 2013, Biochemistry.

Cysteine Cathepsins: Markers and Therapy Targets in Lung Disorders

J. Sage, G. Lalmanach, F. Lecaille, 2011 .

Cystatin M/E (Cystatin 6): A Janus-Faced Cysteine Protease Inhibitor with Both Tumor-Suppressing and Tumor-Promoting Functions

G. Lalmanach, F. Lecaille, A. Saidi, 2021, Cancers.

Pregnancy-Associated Plasma Protein-A Is Involved in Insulin-Like Growth Factor Binding Protein-2 (IGFBP-2) Proteolytic Degradation in Bovine and Porcine Preovulatory Follicles: Identification of Cleavage Site and Characterization of IGFBP-2 Degradation1

Philippe Monget, M. Overgaard, C. Oxvig, 2002, Biology of reproduction.

The occluding loop of cathepsin B prevents its effective inhibition by human kininogens.

C Naudin, E. Purisima, J. Krupa, 2010, Journal of molecular biology.

Cathepsin L, But Not Cathepsin B, Is a Potential Kininogenase

F. Gauthier, G. Lalmanach, C. Desmazes, 2001, Biological chemistry.

Cathepsin L, But Not Cathepsin B, Is a Potential Kininogenase

F. Gauthier, G. Lalmanach, C. Desmazes, 2001 .

Inhibition of cathepsin B by its propeptide: Use of overlapping peptides to identify a critical segment

M. Martino, J. Chagas, F. Gauthier, 1996, FEBS letters.

An immunochemical approach to investigating the mechanism of inhibition of cysteine proteinases by members of the cystatin superfamily.

J. Hoebeke, T. Moreau, F. Gauthier, 1992, Journal of immunological methods.

Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: targetting the disease rather than the parasite.

A. Musoke, F. Gauthier, G. Lalmanach, 2001, International journal for parasitology.

CA-074, But Not Its Methyl Ester CA-074Me, Is a Selective Inhibitor of Cathepsin B within Living Cells

G. Lalmanach, L. Mach, M. Montaser, 2002, Biological chemistry.

Aminopeptidase N1 (EtAPN1), an M1 Metalloprotease of the Apicomplexan Parasite Eimeria tenella, Participates in Parasite Development

S. McGowan, F. Brossier, G. Lalmanach, 2014, Eukaryotic Cell.

Eimeripain, a Cathepsin B-Like Cysteine Protease, Expressed throughout Sporulation of the Apicomplexan Parasite Eimeria tenella

M. Katrib, F. Brossier, G. Lalmanach, 2012, PloS one.

Selective Inhibition of the Collagenase Activity of Cathepsin K*

J. Selent, D. Brömme, G. Lalmanach, 2007, Journal of Biological Chemistry.

The Interplay of Glycosaminoglycans and Cysteine Cathepsins in Mucopolysaccharidosis

G. Lalmanach, F. Lecaille, A. Saidi, 2023, Biomedicines.

Biochemical properties and regulation of cathepsin K activity.

D. Brömme, G. Lalmanach, F. Lecaille, 2008, Biochimie.

Yin and Yang in the proteolytic landscape.

G. Lalmanach, 2010, Biochimie.

Interaction between cystatin-derived peptides and papain

J. Hoebeke, T. Moreau, F. Gauthier, 1993, Journal of protein chemistry.

Revisiting the S2 specificity of papain by structural analogs of Phe

F. Gauthier, G. Lalmanach, F. Lecaille, 1999, FEBS letters.

Oxidation of cathepsin S by major chemicals of cigarette smoke.

L. Nadal-Desbarats, G. Lalmanach, F. Lecaille, 2020, Free radical biology & medicine.

Human Cysteine Cathepsins Are Not Reliable Markers of Infection by Pseudomonas aeruginosa in Cystic Fibrosis

A. Szymańska, F. Kasprzykowski, F. Gauthier, 2011, PloS one.

Proteases in the limelight: Both ordinary digestive enzymes and smart signaling pathway regulators.

G. Lalmanach, 2016, Biochimie.

Antimicrobial Peptide LL-37 Is Both a Substrate of Cathepsins S and K and a Selective Inhibitor of Cathepsin L.

S. Samsonov, K. Nazmi, D. Brömme, 2015, Biochemistry.

The Unusual Resistance of Avian Defensin AvBD7 to Proteolytic Enzymes Preserves Its Antibacterial Activity

K. Loth, V. Labas, D. Brömme, 2016, PloS one.

A new, sensitive fluorogenic substrate for papain based on the sequence of the cystatin inhibitory site.

L. Juliano, T. Moreau, F. Gauthier, 1993, Archives of biochemistry and biophysics.

Cathepsin K: a cysteine protease with unique kinin-degrading properties.

P. Saftig, S. Duchêne, D. Brömme, 2004, The Biochemical journal.

Inhibition of a cathepsin L-like cysteine protease by a chimeric propeptide-derived inhibitor.

E. Purisima, M. Belghazi, G. Lalmanach, 2005, Biochemistry.

Human cystatin C: A new biomarker of idiopathic pulmonary fibrosis?

S. Marchand-Adam, G. Lalmanach, F. Lecaille, 2014, Proteomics. Clinical applications.

The S2 subsites of cathepsins K and L and their contribution to collagen degradation

E. Purisima, D. Brömme, Dieter Brömme, 2007, Protein science : a publication of the Protein Society.

Cleavage of Occludin by Cigarette Smoke-Elicited Cathepsin S Increases Permeability of Lung Epithelial Cells

Y. Courty, G. Lalmanach, F. Lecaille, 2022, Antioxidants.

Monitoring Human Neutrophil Activation by a Proteinase 3 Near-Infrared Fluorescence Substrate-Based Probe.

B. Korkmaz, J. Madinier, V. Aucagne, 2021, Bioconjugate chemistry.

Cysteine cathepsins in human silicotic bronchoalveolar lavage fluids.

M. Maurel, Marie-Christine Maurel, Gilles Lalmanach, 2006, Biochimica et biophysica acta.

Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of

Ludovic C. Gillet, G. Lalmanach, F. Lecaille, 2009 .

In silico and in vitro mapping of specificity patterns of glycosaminoglycans towards cysteine cathepsins B, L, K, S and V.

S. Samsonov, K. Bojarski, J. Sage, 2022, Journal of molecular graphics & modelling.

Labelling of four distinct trophozoite falcipains of Plasmodium falciparum by a cystatin-derived probe

I. Florent, F. Gauthier, G. Lalmanach, 2005, Biological chemistry.

Antimicrobial proteins and peptides in human lung diseases: A friend and foe partnership with host proteases.

G. Lalmanach, F. Lecaille, Pierre-Marie Andrault, 2016, Biochimie.

Selective inhibition of human cathepsin S by 2,4,6-trisubstituted 1,3,5-triazine analogs.

A. Bojarski, D. Warszycki, Vincent Roy, 2018, Bioorganic & medicinal chemistry.

Therapeutic targeting of cathepsin C: from pathophysiology to treatment

N. Thakker, H. Roberts, I. Chapple, 2018, Pharmacology & therapeutics.

Straightforward synthesis of 2,4,6-trisubstituted 1,3,5-triazine compounds targeting cysteine cathepsins K and S.

A. Bojarski, D. Warszycki, Vincent Roy, 2016, European journal of medicinal chemistry.

Substrate-derived triazolo- and azapeptides as inhibitors of cathepsins K and S.

A. Delmas, D. Brömme, B. Korkmaz, 2018, European journal of medicinal chemistry.

Antimicrobial Peptide LL-37 Is Both a Substrate of Cathepsins S and K and a Selective Inhibitor of Cathepsin L.

K. Nazmi, D. Brömme, M. T. Pisabarro, 2015, Biochemistry.

Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations.

A. Delmas, V. Aucagne, G. Lalmanach, 2012, Angewandte Chemie.

Kininogens: More than cysteine protease inhibitors and kinin precursors.

G. Lalmanach, F. Lecaille, C. Naudin, 2010, Biochimie.

Active site labeling of cysteine cathepsins by a straightforward diazomethylketone probe derived from the N-terminus of human cystatin C.

Vincent Roy, L. Agrofoglio, B. Gilmore, 2015, Biochemical and biophysical research communications.

Subsite specificity of trypanosomal cathepsin L-like cysteine proteases. Probing the S2 pocket with phenylalanine-derived amino acids.

T. Moreau, F. Gauthier, G. Lalmanach, 2001, European journal of biochemistry.

Short-term exposure to cigarette smoke upregulates cathepsin S and alters expression of tight junction ZO-1

G. Lalmanach, F. Lecaille, A. Saidi, 2024, Biochimie.

Exposure to cigarette smoke triggers proteolytic cleavage of occludin, a tight junction protein, by cathepsin S and impairs the pulmonary epithelial barrier during COPD

Y. Courty, G. Lalmanach, F. Lecaille, 2023, Revue des Maladies Respiratoires.

[Alteration of pulmonary epithelial permeability by cathepsin S in chronic obstructive pulmonary disease].

G. Lalmanach, F. Lecaille, A. Saidi, 2023, Revue des maladies respiratoires.

Extracellular catalase activity protects cysteine cathepsins from inactivation by hydrogen peroxide

N. Heuzé-Vourc’h, G. Lalmanach, F. Lecaille, 2008, FEBS Letters.