W. Larochelle

发表

Platelet-derived growth factor is an autocrine growth stimulator in retinal pigmented epithelial cells.

P. Campochiaro, I. Rodriguez, M. Johnson, 1994, Journal of cell science.

Biological responses to PDGF-BB versus PDGF-DD in human mesangial cells.

I. Behrmann, J. Floege, F. Strutz, 2006, Kidney international.

Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer.

M. Jeffers, H. Lichenstein, Frank Wu, 2002, Cancer research.

Determination of the tissue distributions and relative concentrations of the postsynaptic 43-kDa protein and the acetylcholine receptor in Torpedo.

W. Larochelle, S. Froehner, 1986, The Journal of biological chemistry.

PDGF-D inhibition by CR002 ameliorates tubulointerstitial fibrosis following experimental glomerulonephritis.

P. Boor, J. Floege, L. Villa, 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Treatment parameters modulating regression of human melanoma xenografts by an antibody–drug conjugate (CR011-vcMMAE) targeting GPNMB

M. Jeffers, H. Lichenstein, M. Torgov, 2007, Cancer Chemotherapy and Pharmacology.

Ulcerative Proctitis, Rectal Prolapse, and Intestinal Pseudo-Obstruction in Transgenic Mice Overexpressing Hepatocyte Growth Factor/Scatter Factor

G. Merlino, R. Kapur, H. Takagi, 2001, Laboratory Investigation.

The Oncogenomics Handbook

R. Shimkets, W. Larochelle, 2005 .

Photoreceptor-specific expression of platelet-derived growth factor-B results in traction retinal detachment.

P. Campochiaro, D. Zack, S. Hackett, 2000, The American journal of pathology.

Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers.

J. Rubin, R. Sharp, G. Merlino, 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Isoforms of platelet-derived growth factor and its receptors in epiretinal membranes: immunolocalization to retinal pigmented epithelial cells.

P. Campochiaro, J. Henderer, C. Csáky, 1995, Experimental eye research.

Platelet-derived growth factor AB heterodimer interchain interactions influence secretion as well as receptor binding and activation.

S. Aaronson, W. Larochelle, M. May, 1993, Biochemistry.

Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways.

T. Fleming, T. Matsui, M. Ruggiero, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Disassociation of Met-Mediated Biological Responses In Vivo: the Natural Hepatocyte Growth Factor/Scatter Factor Splice Variant NK2 Antagonizes Growth but Facilitates Metastasis

G. Merlino, T. Otsuka, J. Jakubczak, 2000, Molecular and Cellular Biology.

NK1, a Natural Splice Variant of Hepatocyte Growth Factor/Scatter Factor, Is a Partial Agonist In Vivo

G. Merlino, J. Jakubczak, W. Larochelle, 1998, Molecular and Cellular Biology.

A small v-sis/platelet-derived growth factor (PDGF) B-protein domain in which subtle conformational changes abrogate PDGF receptor interaction and transforming activity

S. Aaronson, K. Robbins, N. Giese, 1990, Molecular and cellular biology.

Renal tubular hyperplasia, polycystic disease, and glomerulosclerosis in transgenic mice overexpressing hepatocyte growth factor/scatter factor.

G. Merlino, T. Otsuka, W. Larochelle, 1997, Laboratory investigation; a journal of technical methods and pathology.

Cloning and characterization of the mouse homolog of the human A6 gene.

J. Beeler, W. Larochelle, M. Chedid, 1997, Gene.

Homology-Based Genomic Mining of Growth Factors Implicated in Neoplasia and Nephritides

G. Starling, G. Ara, W. Larochelle, 2005 .

A fully human monoclonal antibody (CR002) identifies PDGF-D as a novel mediator of mesangioproliferative glomerulonephritis.

B. Keyt, J. Peterson, F. Eitner, 2003, Journal of the American Society of Nephrology : JASN.

Jak1 Expression Is Required for Mediating Interleukin-4-induced Tyrosine Phosphorylation of Insulin Receptor Substrate and Stat6 Signaling Molecules*

R. Flavell, Ling-mei Wang, J. Pierce, 1997, The Journal of Biological Chemistry.

Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin

O. Dirsch, K. Csaky, S. Aaronson, 1995, The Journal of experimental medicine.

Consequences of Stat6 deletion on Sis/PDGF- and IL-4-induced proliferation and transcriptional activation in murine fibroblasts

P. Kriebel, M. Grusby, W. Larochelle, 1999, Oncogene.

Immunochemical detection of proteins biotinylated on nitrocellulose replicas.

W. Larochelle, S. Froehner, 1986, Journal of immunological methods.

Preclinical characterization of CG53135 (FGF-20) in radiation and concomitant chemotherapy/radiation-induced oral mucositis.

J. Peterson, M. Jeffers, S. Sonis, 2003, Clinical Cancer Research.

Preclinical Characterization of CG 53135 ( FGF-20 ) in Radiation and Concomitant Chemotherapy / Radiation-induced Oral Mucositis

J. Peterson, M. Jeffers, S. Sonis, 2003 .

Characterization of baculovirus-expressed human alpha and beta platelet-derived growth factor receptors.

M. Heidaran, J. Beeler, W. Larochelle, 1992, Biochemistry.

Molecular localization of the transforming and secretory properties of PDGF A and PDGF B.

S. Aaronson, K. Robbins, N. Giese, 1990, Science.

Chimeric molecules map and dissociate the potent transforming and secretory properties of PDGF A and PDGF B

S. Aaronson, K. Robbins, N. Giese, 1990, Journal of Cell Science.

Expression and purification of biologically active v-sis/platelet-derived growth factor B protein by using a baculovirus vector system

S. Aaronson, N. Giese, W. Larochelle, 1989, Journal of virology.

Structural coincidence of alpha PDGFR epitopes binding to platelet-derived growth factor-AA and a potent neutralizing monoclonal antibody.

J. Pierce, D. Mahadevan, M. Heidaran, 1994, The Journal of biological chemistry.

Differences in substrate specificities of alpha and beta platelet-derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming functions.

S. Aaronson, J. Pierce, M. Heidaran, 1993, The Journal of biological chemistry.

Five PDGF B amino acid substitutions convert PDGF A to a PDGF B-like transforming molecule.

S. Aaronson, J. Pierce, N. Giese, 1992, The Journal of biological chemistry.

Platelet-derived growth factor-A-induced retinal gliosis protects against ischemic retinopathy.

P. Campochiaro, D. Zack, N. Esumi, 2000, The American journal of pathology.

Transgenic MicewithIncreased Expression of Vascular Endothelial GrowthFactor intheRetina

W. Larochelle, H. Ozaki, N. Okamoto, 1997 .

Immunochemical localization of the epitope for a monoclonal antibody that neutralizes human platelet-derived growth factor mitogenic activity

S. Aaronson, K. Robbins, W. Larochelle, 1989, Molecular and cellular biology.

INSULIN-INDUCED PHOSPHORYLATION OF INSULIN RECEPTORS AND INSULIN RECEPTOR SUBSTRATE-1 DISPLACES PHOSPHORYLATED PLATELET-DERIVED GROWTH FACTOR RECEPTORS FROM BINDING SITES ON PI 3-KINASE*

Simeon I. Taylor, R. Levy-Toledano, W. Larochelle, 1995 .

Upregulation of vascular endothelial growth factor in ischemic and non-ischemic human and experimental retinal disease.

P. Campochiaro, W. Green, C. Chan, 1997, Histology and histopathology.

β PDGFR‐IgG chimera demonstrates that human β PDGFR Ig‐like domains 1 to 3 are sufficient for high affinity PDGF BB binding

D. Mahadevan, M. Heidaran, W. Larochelle, 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype.

R. Sharp, G. Merlino, T. Otsuka, 1998, Cancer research.

Keratinocyte growth factor

J. Rubin, P. Finch, D. Ron, 1995, Cell biology international.

Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor.

R. Sharp, G. Merlino, P. Kriebel, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization.

P. Campochiaro, D. Zack, S. Hackett, 1997, The American journal of pathology.

Heparan sulfate proteoglycan modulates keratinocyte growth factor signaling through interaction with both ligand and receptor.

K. Sakaguchi, Y. Takagi, R. Day, 1999, Biochemistry.

PDGF-D, a new protease-activated growth factor

J. Rothberg, Meijia Yang, R. Shimkets, 2001, Nature Cell Biology.

Isolation and characterization of a novel PDGF-induced human gene.

W. Larochelle, K. Santora, S. Nelson, 2000, Gene.

Soluble dominant‐negative receptor uncovers essential roles for fibroblast growth factors in multi‐organ induction and patterning

S. Mackem, R. Sharp, G. Merlino, 1998, The EMBO journal.

Angioarrestin: an antiangiogenic protein with tumor-inhibiting properties.

Meijia Yang, R. Shimkets, M. Jeffers, 2002, Cancer research.

Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis.

R. Shimkets, M. Jeffers, M. Yang, 2001, Cancer research.

Activity of the histone deacetylase inhibitor belinostat (PXD101) in preclinical models of prostate cancer

M. Jeffers, Xiaozhong Qian, E. Mills, 2008, International journal of cancer.

Fibroblast growth factors in cancer: therapeutic possibilities

M. Jeffers, H. Lichenstein, W. Larochelle, 2002, Expert opinion on therapeutic targets.

Velafermin (rhFGF-20) reduces the severity and duration of hamster cheek pouch mucositis induced by fractionated radiation

S. Sonis, B. Watkins, G. Ara, 2008, International journal of radiation biology.

FGFR2IIIb signaling regulates thymic epithelial differentiation

G. Gillard, A. Farr, W. Larochelle, 2007, Developmental dynamics : an official publication of the American Association of Anatomists.

Pharmacologically enhanced expression of GPNMB increases the sensitivity of melanoma cells to the CR011‐vcMMAE antibody‐drug conjugate

M. Jeffers, Xiaozhong Qian, E. Mills, 2008, Molecular oncology.

Comparison of the postsynaptic 43-kDa protein from muscle cells that differ in acetylcholine receptor clustering activity.

W. Larochelle, S. Froehner, 1987, The Journal of biological chemistry.

CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma.

Damon L. Meyer, M. Jeffers, B. Kuang, 2006, Clinical cancer research : an official journal of the American Association for Cancer Research.

Immunochemical demonstration that amino acids 360-377 of the acetylcholine receptor gamma-subunit are cytoplasmic

S. Froehner, R. Sealock, W. Larochelle, 1985, The Journal of cell biology.

Stat6 and Jak1 Are Common Elements in Platelet-derived Growth Factor and Interleukin-4 Signal Transduction Pathways in NIH 3T3 Fibroblasts*

Ling-mei Wang, J. Pierce, W. Larochelle, 1996, The Journal of Biological Chemistry.

Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6.

J. Pierce, W. Larochelle, B. K. Patel, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Specific receptor detection by a functional keratinocyte growth factor- immunoglobulin chimera

O. Dirsch, S. Aaronson, P. Finch, 1995, The Journal of cell biology.

Activity of PXD101, a histone deacetylase inhibitor, in preclinical ovarian cancer studies

M. Sehested, M. Jeffers, Xiaozhong Qian, 2006, Molecular Cancer Therapeutics.

Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties.

M. Jeffers, H. Lichenstein, W. Larochelle, 2005, Biochemical and biophysical research communications.

Decreased expression of keratinocyte growth factor receptor in a subset of human transitional cell bladder carcinomas

A. Hoznek, D. Chopin, J. Thiery, 1997, Oncogene.

Structural Role of Extracellular Domain 1 of α-Platelet-derived Growth Factor (PDGF) Receptor for PDGF-AA and PDGF-BB Binding (*)

N. Thanki, J. Saldanha, D. Mahadevan, 1995, The Journal of Biological Chemistry.

Multiple Growth Factor Induction of a Murine Early Response Gene That Complements a Lethal Defect in Yeast Ribosome Biogenesis*

J. Aris, W. Larochelle, B. K. Patel, 2000, The Journal of Biological Chemistry.

Prokaryotic expression cloning of a novel human tyrosine kinase

S. Aaronson, J. Beeler, S. Tronick, 1994, Molecular and cellular biology.

Recombinant semaphorin 6A-1 ectodomain inhibits in vivo growth factor and tumor cell line-induced angiogenesis

Enrique Alvarez, M. Jeffers, F. Boldog, 2005, Cancer biology & therapy.

Inhibition of platelet-derived growth factor autocrine growth stimulation by a monoclonal antibody to the human alpha platelet-derived growth factor receptor.

S. Aaronson, L. M. Wang, J. Pierce, 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Localization of the human stat6 gene to chromosome 12q13.3-q14.1, a region implicated in multiple solid tumors.

C. Keck, W. Larochelle, B. K. Patel, 1998, Genomics.

Interleukin-15 Induces Rapid Tyrosine Phosphorylation of STAT6 and the Expression of Interleukin-4 in Mouse Mast Cells*

M. Kubo, T. Matsuguchi, Y. Yoshikai, 2000, The Journal of Biological Chemistry.

A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain.

S. Aaronson, K. Robbins, W. Larochelle, 1991, Genes & development.

Homodimerization Controls the Fibroblast Growth Factor 9 Subfamily's Receptor Binding and Heparan Sulfate-Dependent Diffusion in the Extracellular Matrix

P. Pollock, S. Byron, M. Mohammadi, 2009, Molecular and Cellular Biology.

Staining of proteins on nitrocellulose replicas.

W. Larochelle, S. Froehner, 1990, Methods in enzymology.

Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor.

L. Fretto, J. Seroogy, J. Tomlinson, 1993, Journal of Biological Chemistry.