Xinxin Ding

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Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts.

Xinxin Ding, L. Kaminsky, Xinxin Ding, 2003, Annual review of pharmacology and toxicology.

Effects of 8-methoxypsoralen on cytochrome P450 2A13.

Qing-Yu Zhang, P. Hollenberg, Xinxin Ding, 2004, Carcinogenesis.

Preclinical experimental models of drug metabolism and disposition in drug discovery and development

Chuang Lu, Donglu Zhang, Xinxin Ding, 2012 .

Generation and Characterization of a Novel CYP2A13-Transgenic Mouse Model s

Zhihua Liu, Qing-Yu Zhang, Xinxin Ding, 2014 .

Generation and Characterization of a Novel CYP2A13-Transgenic Mouse Model

Zhihua Liu, Qing-Yu Zhang, Xinxin Ding, 2014, Drug Metabolism and Disposition.

In Vivo Mechanisms of Tissue-Selective Drug Toxicity: Effects of Liver-Specific Knockout of the NADPH-Cytochrome P450 Reductase Gene on Acetaminophen Toxicity in Kidney, Lung, and Nasal Mucosa

H. Cui, Qing-Yu Zhang, M. Behr, 2005, Molecular Pharmacology.

Deletion of the NADPH-Cytochrome P450 Reductase Gene in Cardiomyocytes Does Not Protect Mice against Doxorubicin-Mediated Acute Cardiac Toxicity

E. Abel, M. Behr, Xinxin Ding, 2008, Drug Metabolism and Disposition.

An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine

D. Dunbar, L. Kaminsky, Qing-Yu Zhang, 2009, Drug Metabolism and Disposition.

Generation and Characterization of a Cyp2f2-Null Mouse and Studies on the Role of CYP2F2 in Naphthalene-Induced Toxicity in the Lung and Nasal Olfactory Mucosa

Qing-Yu Zhang, Xinxin Ding, Jinping Hu, 2011, Journal of Pharmacology and Experimental Therapeutics.

Generation and Characterization of a CYP2A13/2B6/2F1-Transgenic Mouse Model

Zhihua Liu, Qing-Yu Zhang, Y. Weng, 2012, Drug Metabolism and Disposition.

A Novel Recombinant Human Granulocyte Colony-Stimulating Factor (G-CSFa) Enhances Peripheral Platelet Recovery in Mice Exposed to adiotherapy and Has No Immunogenicity in Rats

Qing-Yu Zhang, Xinxin Ding, Yongping Jiang, 2014 .

EXPRESSION OF CYTOCHROME P450 AND OTHER BIOTRANSFORMATION GENES IN FETAL AND ADULT HUMAN NASAL MUCOSA

Qing-Yu Zhang, Y. Weng, Dazhi Liu, 2005, Drug Metabolism and Disposition.

Large-scale ex vivo generation of human neutrophils from cord blood CD34+ cells

Chen Wang, Xinxin Ding, Yu Zhang, 2017, PloS one.

Large‐Scale Ex Vivo Generation of Human Red Blood Cells from Cord Blood CD34+ Cells

Yupo Ma, Chen Wang, Xinxin Ding, 2017, Stem cells translational medicine.

Toxicokinetic Interaction between Hepatic Disposition and Pulmonary Bioactivation of Inhaled Naphthalene Studied Using Cyp2abfgs-Null and CYP2A13/2F1-Humanized Mice with Deficient Hepatic Cytochrome P450 Activity

Qing-Yu Zhang, Xinxin Ding, L. V. Van Winkle, 2019, Drug Metabolism and Disposition.

Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice

P. Edwards, Qing-Yu Zhang, Xinxin Ding, 2017, Environmental health perspectives.

Suppression of Pulmonary CYP2A13 Expression by Carcinogen-Induced Lung Tumorigenesis in a CYP2A13-Humanized Mouse Model

Zhihua Liu, S. Sell, Xinxin Ding, 2015, Drug Metabolism and Disposition.

Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse.

Xinxin Ding, Yuan-an Wei, Lei Li, 2014, Carcinogenesis.

Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.

Zhihua Liu, Xinxin Ding, Weizhu Yang, 2014, Carcinogenesis.

Transcriptional suppression of CYP2A13 expression by lipopolysaccharide in cultured human lung cells and the lungs of a CYP2A13-humanized mouse model.

D. Lawrence, Zhihua Liu, Xinxin Ding, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Respective Roles of CYP2A5 and CYP2F2 in the Bioactivation of 3-Methylindole in Mouse Olfactory Mucosa and Lung: Studies Using Cyp2a5-Null and Cyp2f2-Null Mouse Models

Xinxin Ding, G. Yost, Lei Li, 2012, Drug Metabolism and Disposition.

Generation and Characterization of a CYP2A13/2B6/2F1-Transgenic Mouse Model

Zhihua Liu, Qing-Yu Zhang, Y. Weng, 2012, Drug Metabolism and Disposition.

Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.

K. Kannan, M. Behr, Xinxin Ding, 2010, Toxicology and applied pharmacology.

Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: a comparison to the prototype cigarette smoke mutagens B(a)P and NNK.

J. G. Lamb, Xinxin Ding, G. Yost, 2010, Chemical research in toxicology.

The Pneumotoxin 3-Methylindole Is a Substrate and a Mechanism-Based Inactivator of CYP2A13, a Human Cytochrome P450 Enzyme Preferentially Expressed in the Respiratory Tract

W. Humphreys, Y. Shu, D. G. Morgan, 2009, Drug Metabolism and Disposition.

Mechanisms of differential expression of the CYP2A13 7520C and 7520G alleles in human lung: allelic expression analysis for CYP2A13 heterogeneous nuclear RNA, and evidence for the involvement of multiple Cis-regulatory single nucleotide polymorphisms

Xinxin Ding, Hong Wu, Jaime D’Agostino, 2009, Pharmacogenetics and genomics.

Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.

L. Kaminsky, Y. Weng, M. Behr, 2007, Cancer research.

Transcriptional Regulation of Human CYP2A13 Expression in the Respiratory Tract by CCAAT/Enhancer Binding Protein and Epigenetic Modulation

Xinxin Ding, Yuan-an Wei, G. Ling, 2007, Molecular Pharmacology.

CYP2A13: Variable Expression and Role in Human Lung Microsomal Metabolic Activation of the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone

S. Murphy, Qing-Yu Zhang, Xinxin Ding, 2007, Journal of Pharmacology and Experimental Therapeutics.

Development of a Real-Time Polymerase Chain Reaction-Based Method for the Measurement of Relative Allelic Expression and Identification of CYP2A13 Alleles with Decreased Expression in Human Lung

M. Caggana, Xinxin Ding, Xiuling Zhang, 2004, Journal of Pharmacology and Experimental Therapeutics.

Inhibition by Allyl Sulfides and Phenethyl Isothiocyanate of Methyl-n-pentylnitrosamine Depentylation by Rat Esophageal Microsomes, Human and Rat CYP2E1, and Rat CYP2A3

L. Schopfer, Xinxin Ding, S. Mirvish, 2004, Nutrition and cancer.

Immunoblot analysis and immunohistochemical characterization of CYP2A expression in human olfactory mucosa.

Qing-Yu Zhang, Xinxin Ding, Jun Gu, 2003, Biochemical pharmacology.

Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.

S. Murphy, Xinxin Ding, J. Jalas, 2003, Drug metabolism and disposition: the biological fate of chemicals.

EXPRESSION OF THE RAT CYP 2 A 3 GENE IN TRANSGENIC MICE

P. Swiatek, Qing-Yu Zhang, S. Ting, 2002 .

Immunohistochemical Localization of a Cytochrome P-450 Isozyme in Human Nasal Mucosa: Age-Related Trends

D. Sparks, T. Getchell, Xinxin Ding, 1993, The Annals of otology, rhinology, and laryngology.

Molecular probes for human cytochrome P450 enzymes: Recent progress and future perspectives

Guangbo Ge, Ling Yang, Xinxin Ding, 2021 .

Metabolism and Lung Toxicity of Inhaled Naphthalene: Effects of Postnatal Age and Sex.

Xinxin Ding, L. V. Van Winkle, N. Kovalchuk, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Deficits in neuronal cytochrome P450 activity attenuate opioid analgesia but not opioid side effects.

Xinxin Ding, Weizhu Yang, C. Fang, 2014, European journal of pharmacology.

CYP 1 B 1 EXPRESSION IN HUMAN LUNG

A. A. Reilly, S. Spivack, L. Kaminsky, 2001 .

Mycobacterium tuberculosis Rv3586 (DacA) Is a Diadenylate Cyclase That Converts ATP or ADP into c-di-AMP

Xin Zhou, G. Bai, Xinxin Ding, 2012, PloS one.

Preferential expression of cytochrome CYP CYP2R1 but not CYP1B1 in human cord blood hematopoietic stem and progenitor cells

Xinxin Ding, Yongping Jiang, Zhihua Ren, 2014, Acta pharmaceutica Sinica. B.

Suppression of Cytochrome P450 Reductase Enhances Long-Term Hematopoietic Stem Cell Repopulation Efficiency in Mice

J. Xu, T. Cheng, Xiaoming Wang, 2013, PloS one.

Role of mammary epithelial and stromal P450 enzymes in the clearance and metabolic activation of 7,12-dimethylbenz(a)anthracene in mice.

Lihua Wang, B. Moorthy, Xinxin Ding, 2012, Toxicology letters.

Mechanism of chloroform-induced renal toxicity: non-involvement of hepatic cytochrome P450-dependent metabolism.

K. Aldous, M. Behr, Xinxin Ding, 2008, Toxicology and applied pharmacology.

Impact of Nicotine Metabolism on Nicotine’s Pharmacological Effects and Behavioral Responses: Insights from a Cyp2a(4/5)bgs-Null Mouse

S. McCallum, Xinxin Ding, Kunzhi Jia, 2013, The Journal of Pharmacology and Experimental Therapeutics.

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Xinxin Ding, Xin Zhou, 2011, IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans.

Metabolism of styrene to styrene oxide and vinylphenols in cytochrome P450 2F2- and P450 2E1-knockout mouse liver and lung microsomes.

Xinxin Ding, Jiang Zheng, Lei Li, 2014, Chemical research in toxicology.

The Role of Cytochrome P450–Dependent Metabolism in the Regulation of Mouse Hepatic Growth Hormone Signaling Components and Target Genes by 3-Methylcholanthrene

Xinxin Ding, Chunja Lee, D. S. Riddick, 2013, Drug Metabolism and Disposition.

A small-molecule/cytokine combination enhances hematopoietic stem cell proliferation via inhibition of cell differentiation

Y. Zhang, Yupo Ma, Xinxin Ding, 2017, Stem Cell Research & Therapy.

Hydroxyl and sulfate radical-based oxidation of RhB dye in UV/H2O2 and UV/persulfate systems: Kinetics, mechanisms, and comparison.

L. Gutierrez, Minrui Li, J. Croué, 2020, Chemosphere.

Generation and Characterization of a Novel Cyp2a(4/5)bgs-Null Mouse Model

Qing-Yu Zhang, Xinxin Ding, Yuan-an Wei, 2013, Drug Metabolism and Disposition.

Novel Transgenic Mouse Model for Studying Human Serum Albumin as a Biomarker of Carcinogenic Exposure.

Qing-Yu Zhang, R. Turesky, Xinxin Ding, 2016, Chemical research in toxicology.

Effect of Cytochrome P450 Reductase Deficiency on 2-Amino-9H-pyrido[2,3-b]indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice.

Qing-Yu Zhang, R. Turesky, Xinxin Ding, 2015, Chemical research in toxicology.

Contribution of Pulmonary CYP-mediated Bioactivation of Naphthalene to Airway Epithelial Injury in the Lung.

Qing-Yu Zhang, Xinxin Ding, L. V. Van Winkle, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene

Thomas J. Begley, T. Begley, J. Melendez, 2020, Epigenetics.

Essential Role of the Cytochrome P450 Enzyme CYP2A5 in Olfactory Mucosal Toxicity of Naphthalene

Yan Li, L. Sheng, Xinxin Ding, 2014, Drug Metabolism and Disposition.

An in vitro system for measuring genotoxicity mediated by human CYP3A4 in Saccharomyces cerevisiae

P. Egner, Xinxin Ding, C. Cera, 2017, Environmental and molecular mutagenesis.

Naphthalene DNA Adduct Formation and Tolerance in the Lung.

B. Buchholz, E. Kuhn, Xinxin Ding, 2019, Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms.

An update on the role of intestinal cytochrome P450 enzymes in drug disposition

Qing-Yu Zhang, Xinxin Ding, Fang Xie, 2016, Acta pharmaceutica Sinica. B.

Regulation of Intestinal Cytochrome P450 Expression by Hepatic Cytochrome P450: Possible Involvement of Fibroblast Growth Factor 15 and Impact on Systemic Drug Exposure

Qing-Yu Zhang, Xinxin Ding, C. Fang, 2014, Molecular Pharmacology.

Bioactivation of the nasal toxicant 2,6-dichlorobenzonitrile: an assessment of metabolic activity in human nasal mucosa and identification of indicators of exposure and potential toxicity.

Xinxin Ding, Fang Xie, Xin Zhou, 2013, Chemical research in toxicology.

A critical role of Fas-associated protein with death domain phosphorylation in intracellular reactive oxygen species homeostasis and aging.

Wei Cheng, Rong Zhang, Hongqin Zhuang, 2014, Antioxidants & redox signaling.

Dietary Regulation of Mouse Intestinal P450 Expression and Drug Metabolism

Qing-Yu Zhang, Xinxin Ding, Kunzhi Jia, 2013, Drug Metabolism and Disposition.

Downregulation of Mouse Hepatic CYP3A Protein by 3-Methylcholanthrene Does Not Require Cytochrome P450-Dependent Metabolism

Xinxin Ding, Chunja Lee, D. S. Riddick, 2013, Drug Metabolism and Disposition.

Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism

R. Parker, Xinxin Ding, Sabrina A. Bardowell, 2012, Journal of Lipid Research.

Identification of Cytochrome P450 Oxidoreductase Gene Variants That Are Significantly Associated with the Interindividual Variations in Warfarin Maintenance Dose

L. Kaminsky, Xinxin Ding, Lei Li, 2011, Drug Metabolism and Disposition.

Mice Deficient in Intestinal Epithelium Cytochrome P450 Reductase are Prone to Acute Toxin-induced Mucosal Damage

N. Mantis, Qing-Yu Zhang, Xinxin Ding, 2014, Scientific Reports.

Influence of IL-3 functional fragment on cord blood stem cell ex vivo expansion and differentiation.

Y. Zhang, Yu Zhang, Yanxi Zhang, 2016, Stem cell investigation.

Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo

Qing-Yu Zhang, Xinxin Ding, Lei Li, 2015, Drug Metabolism and Disposition.

Safety and efficacy of ex vivo expanded CD34+ stem cells in murine and primate models

Yupo Ma, Xinxin Ding, Yu Zhang, 2019, Stem Cell Research & Therapy.

TLR4 mediates high-fat diet induced physiological changes in mice via attenuating PPARγ/ABCG1 signaling pathway.

Jing-cheng Li, Xinxin Ding, Li-li Zhang, 2018, Biochemical and biophysical research communications.

A Novel Defensive Mechanism against Acetaminophen Toxicity in the Mouse Lateral Nasal Gland: Role of CYP2A5-Mediated Regulation of Testosterone Homeostasis and Salivary Androgen-Binding Protein Expression

R. C. Karn, Qing-Yu Zhang, Xinxin Ding, 2011, Molecular Pharmacology.

Metabolomics of lung microdissections reveals region- and sex-specific metabolic effects of acute naphthalene exposure in mice.

O. Fiehn, P. Edwards, Xinxin Ding, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Metabolomics of lung microdissections reveals region- and sex-specific metabolic effects of acute naphthalene exposure in mice

O. Fiehn, P. Edwards, Xinxin Ding, 2021, bioRxiv.

Nomenclature for alleles of the cytochrome P450 oxidoreductase gene.

M. Ingelman-Sundberg, T. Ogata, D. Nebert, 2009, Pharmacogenetics and genomics.

Significance of neuronal cytochrome P450 activity in opioid-mediated stress-induced analgesia

Xinxin Ding, Weizhu Yang, J. Nalwalk, 2014, Brain Research.

Lung injury induced by pyrrolizidine alkaloids depends on metabolism by hepatic cytochrome P450s and blood transport of reactive metabolites

G. Lin, Yisheng He, Jiang Ma, 2020, Archives of Toxicology.

Specificity of cytochrome P450 2A3-catalyzed α-hydroxylation of N'-nitrosonornicotine enantiomers

S. Murphy, Xinxin Ding, E. McIntee, 2000 .

Analysis of testosterone and dihydrotestosterone in mouse tissues by liquid chromatography-electrospray ionization-tandem mass spectrometry.

Y. Weng, D. Spink, Xinxin Ding, 2010, Analytical biochemistry.

The Tissue-Specific Toxicity of Methimazole in the Mouse Olfactory Mucosa Is Partly Mediated through Target-Tissue Metabolic Activation by CYP2A5

M. Behr, Xinxin Ding, M. Genter, 2011, Drug Metabolism and Disposition.

Role of Hepatic and Intestinal P450 Enzymes in the Metabolic Activation of the Colon Carcinogen Azoxymethane in Mice

Qing-Yu Zhang, Xinxin Ding, C. Fang, 2014, Chemical research in toxicology.

Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic

O. Zuiderveld, R. Leurs, J. Bidlack, 2011, PAIN®.

Regulation of cytochrome P450 gene expression in the olfactory mucosa.

Xinxin Ding, M. Genter, Jun Gu, 2004, Chemico-biological interactions.

Prenatal polycyclic aromatic hydrocarbon exposure leads to behavioral deficits and downregulation of receptor tyrosine kinase, MET.

Marcus C. Ferguson, P. Levitt, M. Aschner, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Generation of a Mouse Model with a Reversible Hypomorphic Cytochrome P450 Reductase Gene: Utility for Tissue-Specific Rescue of the Reductase Expression, and Insights from a Resultant Mouse Model with Global Suppression of P450 Reductase Expression in Extrahepatic Tissues

Qing-Yu Zhang, Xinxin Ding, Yuan-an Wei, 2010, Journal of Pharmacology and Experimental Therapeutics.

A Mouse Model with Liver-Specific Deletion and Global Suppression of the NADPH-Cytochrome P450 Reductase Gene: Characterization and Utility for in Vivo Studies of Cyclophosphamide Disposition

D. Waxman, K. Kannan, Xinxin Ding, 2007, Journal of Pharmacology and Experimental Therapeutics.

Transgenic Mice with a Hypomorphic NADPH-Cytochrome P450 Reductase Gene: Effects on Development, Reproduction, and Microsomal Cytochrome P450

P. Swiatek, L. Kaminsky, H. Cui, 2005, Journal of Pharmacology and Experimental Therapeutics.

cDNA and Derived Amino Acid Sequence of Rabbit Nasal Cytochrome P 450 NMb ( P 450 llGl ) , a Unique lsozyme Possibly Involved in Olfaction ’

M. J. Coon, Xinxin Ding, T. Porter, 2003 .

Defining a relationship between dietary fatty acids and the cytochrome P450 system in a mouse model of fatty liver disease.

I. Ladunga, M. Brosnan, P. Black, 2011, Physiological genomics.

In Vivo SELEX of an Inhibitory NSCLC-Specific RNA Aptamer from PEGylated RNA Library

Haiping Yang, Yibang Zhang, Xinxin Ding, 2017, Molecular therapy. Nucleic acids.

High abundance of testosterone and salivary androgen-binding protein in the lateral nasal gland of male mice

L. Kaminsky, Y. Weng, Xinxin Ding, 2009, The Journal of Steroid Biochemistry and Molecular Biology.

Proximal Tubular Vacuolization and Hypersensitivity to Drug-induced Nephrotoxicity in Male Mice with Decreased Expression of the NADPH-Cytochrome P450 Reductase.

S. Sell, C. Mei, K. Dickman, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

A small-molecule/cytokine combination enhances hematopoietic stem cell proliferation via inhibition of cell differentiation

Yupo Ma, Yu Zhang, Xinxin Ding, 2017, Stem Cell Research & Therapy.

Safety and Efficacy of Megakaryocytes Induced from Hematopoietic Stem Cells in Murine and Nonhuman Primate Models

Xinxin Ding, Yu Zhang, Yongping Jiang, 2016, Stem cells translational medicine.

Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant.

M. Caggana, Hongming Li, Qing-Yu Zhang, 2002, The Journal of pharmacology and experimental therapeutics.

Liver-specific Deletion of the NADPH-Cytochrome P450 Reductase Gene

H. Cui, Qing-Yu Zhang, Y. Weng, 2003, Journal of Biological Chemistry.

Impact of hepatic P450‐mediated biotransformation on the disposition and respiratory tract toxicity of inhaled naphthalene

P. Edwards, Qing-Yu Zhang, Xinxin Ding, 2017, Toxicology and applied pharmacology.

Epitranscriptomic regulation of the response to the air pollutant naphthalene in mouse lungs: from the perspectives of specialized translation and tolerance linked to the writer ALKBH8

T. Begley, J. Melendez, P. Dedon, 2019, bioRxiv.

Neuronal cytochrome P450 activity and opioid analgesia: relevant sites and mechanisms

Xinxin Ding, Weizhu Yang, J. Nalwalk, 2015, Brain Research.

Development of Oxidative Stress by Cytochrome P450 Induction in Rodents Is Selective for Barbiturates and Related to Loss of Pyridine Nucleotide-dependent Protective Systems*

J. Morrow, DelindaA . Johnson, Jeffrey A. Johnson, 2008, Journal of Biological Chemistry.

Role of mouse cytochrome P450 enzymes of the CYP2ABFGS subfamilies in the induction of lung inflammation by cigarette smoke exposure.

Qing-Yu Zhang, Xinxin Ding, Matthew A Hartog, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Role of CYP2A5 in the Clearance of Nicotine and Cotinine: Insights from Studies on a Cyp2a5-null Mouse Model

W. Humphreys, Y. Shu, Xinxin Ding, 2010, Journal of Pharmacology and Experimental Therapeutics.

Targeted Disruption of the Olfactory Mucosa-Specific Cyp2g1 Gene: Impact on Acetaminophen Toxicity in the Lateral Nasal Gland, and Tissue-Selective Effects on Cyp2a5 Expression

P. Swiatek, H. Cui, Qing-Yu Zhang, 2004, Journal of Pharmacology and Experimental Therapeutics.

Hepatic Gene Expression Changes in Mouse Models with Liver-specific Deletion or Global Suppression of the NADPH-Cytochrome P450 Reductase Gene

A. A. Reilly, P. Black, C. DiRusso, 2005, Journal of Biological Chemistry.

Intestinal Epithelium–Specific Knockout of the Cytochrome P450 Reductase Gene Exacerbates Dextran Sulfate Sodium–Induced Colitis

Qing-Yu Zhang, Xinxin Ding, Fang Xie, 2015, The Journal of Pharmacology and Experimental Therapeutics.

A CYP2B6-humanized mouse model and its potential applications.

Qing-Yu Zhang, Xinxin Ding, Lei Li, 2018, Drug metabolism and pharmacokinetics.

Role of CYP2B in Phenobarbital-Induced Hepatocyte Proliferation in Mice

M. Negishi, Qing-Yu Zhang, Xinxin Ding, 2017, Drug Metabolism and Disposition.

Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms

N. Scheer, Xinxin Ding, J. Nalwalk, 2015, Drug Metabolism and Disposition.

Role of Small Intestinal Cytochromes P450 in the Bioavailability of Oral Nifedipine

D. Dunbar, L. Kaminsky, Qing-Yu Zhang, 2007, Drug Metabolism and Disposition.

Potential Biological Functions of Cytochrome P450 Reductase-dependent Enzymes in Small Intestine

Qing-Yu Zhang, D. Spink, Xinxin Ding, 2012, The Journal of Biological Chemistry.

Metabolic activation of the tobacco carcinogen 4-(methylnitrosamino)-(3-pyridyl)-1-butanone by cytochrome P450 2A13 in human fetal nasal microsomes.

S. Hecht, S. Murphy, Qing-Yu Zhang, 2005, Chemical research in toxicology.

METABOLISM OF NICOTINE AND COTININE BY HUMAN CYTOCHROME P450 2A13

Jun-yan Hong, S. Prabhu, Z. Bao, 2005, Drug Metabolism and Disposition.

Analysis of the AHR gene proximal promoter GGGGC-repeat polymorphism in lung, breast, and colon cancer.

S. Sell, E. Schneider, D. Spink, 2015, Toxicology and applied pharmacology.

Role of Lung P450 Oxidoreductase in Paraquat-Induced Collagen Deposition in the Lung

N. Cherrington, Xinxin Ding, L. V. Van Winkle, 2022, Antioxidants.

The key role of gut–liver axis in pyrrolizidine alkaloid-induced hepatotoxicity and enterotoxicity

G. Lin, Yisheng He, Jiang Ma, 2021, Acta pharmaceutica Sinica. B.

Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model

Qing-Yu Zhang, Xinxin Ding, Xiaoyu Fan, 2019, Acta pharmaceutica Sinica. B.

Transcriptional Regulation of Rat CYP2A3 by Nuclear Factor 1

R. Gronostajski, C. Hauer, Xinxin Ding, 2004, Journal of Biological Chemistry.

NADPH- and hydroperoxide-supported 17β-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1

J. Gierthy, D. Spink, Xinxin Ding, 2000, The Journal of Steroid Biochemistry and Molecular Biology.

Role of CYP2A5 in the Clearance of Nicotine and Cotinine: Insights from Studies on a Cyp2a5 -null Mouse Model

W. Humphreys, Y. Shu, Xinxin Ding, 2009 .

Single nucleotide polymorphisms of the human cyp2a13 gene: evidence for a null allele.

M. Caggana, Qing-Yu Zhang, Xinxin Ding, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Opioids Activate Brain Analgesic Circuits Through Cytochrome P450/Epoxygenase Signaling

O. Zuiderveld, R. Leurs, J. Mazurkiewicz, 2010, Nature Neuroscience.

Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation.

A. Y. Lu, Jun-yan Hong, Xinxin Ding, 2004, Archives of biochemistry and biophysics.

Myocardial Functional Recovery and Metabolic Status in Isolated Reperfused Rabbit Heart: Effects of Glucose Concentration and Temperature on Cardioplegia

S. Bolling, Xinxin Ding, K. Childs, 1995 .

Role of CYP2A5 in the Bioactivation of the Lung Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in Mice

Xinxin Ding, Fang Xie, Xin Zhou, 2012, Journal of Pharmacology and Experimental Therapeutics.

Expression of the rat CYP2A3 gene in transgenic mice.

P. Swiatek, Qing-Yu Zhang, Xinxin Ding, 2002, Drug metabolism and disposition: the biological fate of chemicals.

IDENTIFICATION OF CRITICAL AMINO ACID RESIDUES OF HUMAN CYP2A13 FOR THE METABOLIC ACTIVATION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE, A TOBACCO-SPECIFIC CARCINOGEN

A. Y. Lu, Jun-yan Hong, Xinxin Ding, 2004, Drug Metabolism and Disposition.

Contributions of Hepatic and Intestinal Metabolism to the Disposition of Niclosamide, a Repurposed Drug with Poor Bioavailability

Hongmin Li, Qing-Yu Zhang, Xinxin Ding, 2019, Drug Metabolism and Disposition.

A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice.

P. Dennis, M. C. Hollander, A. Patterson, 2011, Carcinogenesis.

Characterization of CYP2A13*2, a Variant Cytochrome P450 Allele Previously Found to Be Associated with Decreased Incidences of Lung Adenocarcinoma in Smokers

Qing-Yu Zhang, Xinxin Ding, Hong Wu, 2008, Drug Metabolism and Disposition.

Characterization and quantitative analysis of DNA adducts formed from lower chlorinated PCB-derived quinones.

Xinxin Ding, G. Eadon, Shouxun Zhao, 2004, Chemical Research in Toxicology.

Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3

P. Dalton, M. Finel, Xinxin Ding, 2009, Pharmacogenetics and genomics.

Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6.

P. Swiatek, H. Cui, Qing-Yu Zhang, 2005, Biochemical and biophysical research communications.

RNA-seq reveals sub-zones in mouse adrenal zona fasciculata and the sexually dimorphic responses to thyroid hormone.

Hui Wang, Yuan Kang, Xinxin Ding, 2020, Endocrinology.

The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: utility of renal specific P450 reductase knockout mouse models.

C. Mei, K. Aldous, Xinxin Ding, 2013, Toxicology and applied pharmacology.

NADPH–Cytochrome P450 Oxidoreductase: Roles in Physiology, Pharmacology, and Toxicology

R. Finn, C. Wolf, C. Flück, 2013, Drug Metabolism and Disposition.

Conditional knockout of the mouse NADPH‐cytochrome p450 reductase gene

P. Swiatek, Qing-Yu Zhang, Y. Weng, 2003, Genesis.

Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues

Xinxin Ding, Moshe Finel, M. Finel, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

NADPH – Cytochrome P 450 Oxidoreductase : Roles in Physiology , Pharmacology , and Toxicology

R. Finn, C. Wolf, C. Flück, 2012 .

Generation and Characterization of a Cyp2f2 -null Mouse and Studies on the Role of CYP2F2 in Naphthalene-induced Toxicity in the Lung and Nasal Olfactory Mucosa

Qing-Yu Zhang, Xinxin Ding, Jinping Hu, 2011 .

Regulation of the cytochrome P450 2A genes.

Xinxin Ding, T. Su, Ting Su, 2004, Toxicology and applied pharmacology.

Naphthalene genotoxicity: DNA adducts in primate and mouse airway explants.

B. Buchholz, E. Kuhn, Xinxin Ding, 2019, Toxicology letters.

Vascular biotransformation of organic nitrates is independent of cytochrome P450 monooxygenases

R. Brandes, A. Daiber, S. Offermanns, 2021, British journal of pharmacology.

Characterization of CYP 2 B 6 in a CYP 2 B 6-Humanized Mouse Model : Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo s

Qing-Yu Zhang, Xinxin Ding, Lei Li, 2014 .

Identification and Functional Characterization of a Conserved, Nuclear Factor 1-like Element in the Proximal Promoter Region ofCYP1A2 Gene Specifically Expressed in the Liver and Olfactory Mucosa*

Qing-Yu Zhang, Jiancheng Guo, Xinxin Ding, 2000, The Journal of Biological Chemistry.

Suppression of cytochrome P450 reductase expression promotes astrocytosis in subventricular zone of adult mice

Yue Wang, W. Yuan, Xinxin Ding, 2013, Neuroscience Letters.

Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism

E. White, Donna D. Zhang, P. Kiela, 2021, Molecular metabolism.

Safety and efficacy of ex vivo expanded CD34+ stem cells in murine and primate models

Yupo Ma, Xinxin Ding, Yu Zhang, 2019, Stem Cell Research & Therapy.

Characterization of A Bifunctional Synthetic RNA Aptamer and A Truncated Form for Ability to Inhibit Growth of Non-Small Cell Lung Cancer

I. Chen, Xinxin Ding, Rihe Liu, 2019, Scientific Reports.

Residues 39-56 of Stem Cell Factor Protein Sequence Are Capable of Stimulating the Expansion of Cord Blood CD34+ Cells

Xinxin Ding, Yongping Jiang, Bin Shen, 2015, PloS one.

Possible genotoxic modes of action for naphthalene.

Jun Nakamura, David Brusick, Xinxin Ding, 2008, Regulatory toxicology and pharmacology : RTP.

Chapter 10:The CYP2F, CYP2G and CYP2J Subfamilies

Qing-Yu Zhang, Xinxin Ding, 2008 .