D. Dartt

发表

Direct evidence of cytoplasmic delivery of PKC-alpha, -epsilon and -zeta pseudosubstrate lipopeptides: study of their implication in the induction of apoptosis.

C. Sergheraert, C. Auriault, H. Gras-masse, 1999, FEBS letters.

TFOS DEWS II pain and sensation report.

Nancy A McNamara, Pedram Hamrah, James S Wolffsohn, 2017, The ocular surface.

Protein kinase C regulation of corneal endothelial cell proliferation and cell cycle.

N. Joyce, D. Dartt, M. Graham, 2000, Investigative ophthalmology & visual science.

Presence and localization of neurotrophins and neurotrophin receptors in rat lacrimal gland.

Lili Chen, D. Zoukhri, R. Hodges, 2003, Investigative ophthalmology & visual science.

Effect of Overexpression of Protein Kinase Cα on Rat Lacrimal Gland Protein Secretion

A. Toker, A. Kazlauskas, R. Hodges, 2002 .

Pro-Resolving Mediator Annexin A1 Regulates Intracellular Ca2+ and Mucin Secretion in Cultured Goblet Cells Suggesting a New Use in Inflammatory Conjunctival Diseases

Jeffrey A. Bair, C. Serhan, T. Utheim, 2021, Frontiers in Immunology.

Conjunctival Goblet Cells

R. Hodges, D. Dartt, 2010 .

Effect of phorbol esters on rat lacrimal gland protein secretion.

L. Ronco, D. Dartt, S. A. Murphy, 1988, Investigative ophthalmology & visual science.

Control of mucin production by ocular surface epithelial cells.

D. Dartt, 2004, Experimental eye research.

Neither non-toxigenic Staphylococcus aureus nor commensal S. epidermidi activates NLRP3 inflammasomes in human conjunctival goblet cells

M. Gilmore, P. Bispo, Dayu Li, 2017, BMJ Open Ophthalmology.

The Impact of Storage Temperature on the Morphology, Viability, Cell Number and Metabolism of Cultured Human Conjunctival Epithelium

T. Lyberg, R. Islam, T. Utheim, 2015, Current eye research.

Differential effects of the EGF family of growth factors on protein secretion, MAPK activation, and intracellular calcium concentration in rat lacrimal gland.

L. L. Chen, D. Zoukhri, R. Hodges, 2005, Experimental eye research.

Identification of the Raf-1 signaling pathway used by cAMP to inhibit p42/p44 MAPK in rat lacrimal gland acini: role in potentiation of protein secretion.

R. Hodges, D. Dartt, Chika Funaki, 2010, Investigative ophthalmology & visual science.

Complexity of the tear film: importance in homeostasis and dysfunction during disease.

D. Dartt, M. Willcox, Darlene A. Dartt, 2013, Experimental eye research.

Effect of tear hyperosmolarity and signs of clinical ocular surface pathology upon conjunctival goblet cell function in the human ocular surface.

Jonathan E. Moore, D. Frazer, V. Mcgilligan, 2011, Investigative ophthalmology & visual science.

Interaction of IFN-γ with Cholinergic Agonists to Modulate Rat and Human Goblet Cell Function

D. Dartt, Y. Diebold, L. García-Posadas, 2015, Mucosal Immunology.

Tear film mucins: front line defenders of the ocular surface; comparison with airway and gastrointestinal tract mucins.

R. Hodges, D. Dartt, 2013, Experimental eye research.

Isolation, characterization, and propagation of rat conjunctival goblet cells in vitro.

R. Hodges, D. Dartt, V. Tepavčević, 2001, Investigative ophthalmology & visual science.

Preoperative characteristics and a potential mechanism of chronic dry eye after LASIK.

D. Azar, D. Schaumberg, Lili Chen, 2008, Investigative ophthalmology & visual science.

Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK activity, and secretion in conjunctival goblet cells.

D. Dartt, H. Urashima, J. Ríos, 2008, Experimental eye research.

Changes in rabbit lacrimal gland fluid osmolarity with flow rate.

D. Dartt, J. P. Gilbard, 1982, Investigative ophthalmology & visual science.

Identification of Objective Morphometric Markers of Xerostomia in the Oral Mucosa Epithelium with In Vivo Confocal Microscopy

N. Lagali, T. Utheim, D. Dartt, 2017, Microscopy and Microanalysis.

Differential regulation by Ca(2+) of calmodulin- and PKC-dependent contractile pathways in cat lower oesophageal sphincter.

J. H. Park, U. Sohn, H. Je, 2003, Autonomic & autacoid pharmacology.

Diagnostic Test Efficacy of Meibomian Gland Morphology and Function

N. Lagali, T. Utheim, D. Dartt, 2019, Scientific Reports.

Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland.

R. Hodges, D. Dartt, Chika Funaki, 2007, American journal of physiology. Cell physiology.

Resolvin E1 Reduces Leukotriene B4-Induced Intracellular Calcium Increase and Mucin Secretion in Rat Conjunctival Goblet Cells.

Jeffrey A. Bair, C. Serhan, R. Hodges, 2020, The American journal of pathology.

Meibomian Gland Morphology Is a Sensitive Early Indicator of Meibomian Gland Dysfunction.

N. Lagali, T. Utheim, D. Dartt, 2019, American journal of ophthalmology.

Functional and Morphological Evaluation of Meibomian Glands in the Assessment of Meibomian Gland Dysfunction Subtype and Severity.

N. Lagali, K. Tønseth, T. Utheim, 2019, American journal of ophthalmology.

Dry Eye Disease Patients with Xerostomia Report Higher Symptom Load and Have Poorer Meibum Expressibility

N. Lagali, T. Utheim, D. Dartt, 2016, PloS one.

Lipoxin A4 Counter-regulates Histamine-stimulated Glycoconjugate Secretion in Conjunctival Goblet Cells

C. Serhan, Dayu Li, R. Hodges, 2016, Scientific Reports.

of Inflammation Resolvins D1 and E1 To Promote Resolution Stimulated by Leukotrienes Is Reduced by Conjunctival Goblet Cell Secretion

C. Serhan, K. Lashkari, Dayu Li, 2011 .

Conjunctival Goblet Cell Secretion Stimulated by Leukotrienes Is Reduced by Resolvins D1 and E1 To Promote Resolution of Inflammation

C. Serhan, K. Lashkari, Dayu Li, 2011, The Journal of Immunology.

Chapter 14 – The lacrimal gland and dry-eye disease

D. Dartt, 2010 .

The aging lacrimal gland: changes in structure and function.

Darlene, E. Rocha, M. Alves, 2008, The ocular surface.

A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells.

C. Sergheraert, E. Loing, D. Zoukhri, 2001, American journal of physiology. Cell physiology.

Lacrimal Gland Myoepithelial Cells Are Altered in a Mouse Model of Dry Eye Disease.

O. K. Olstad, T. Utheim, H. Makarenkova, 2020, The American journal of pathology.

The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases

D. Zeldin, C. Serhan, K. Honn, 2019, Advances in Experimental Medicine and Biology.

VEGF-dependent conjunctivalization of the corneal surface.

N. Mitsiades, B. Kirchhof, G. Yancopoulos, 2003, Investigative ophthalmology & visual science.

Role of the Phospholipase C Pathway and Calcium Mobilization in Oxytocin-Induced Contraction of Lacrimal Gland Myoepithelial Cells.

Jeffrey A. Bair, P. Hamrah, J. Morokuma, 2021, Investigative ophthalmology & visual science.

Storage Temperature Alters the Expression of Differentiation-Related Genes in Cultured Oral Keratinocytes

O. K. Olstad, R. Islam, M. Griffith, 2016, PloS one.

Effect of histamine on Ca(2+)-dependent signaling pathways in rat conjunctival goblet cells.

Dayu Li, R. Hodges, D. Dartt, 2012, Investigative ophthalmology & visual science.

Effect of biopsy location and size on proliferative capacity of ex vivo expanded conjunctival tissue.

T. Utheim, D. Dartt, S. Raeder, 2012, Investigative ophthalmology & visual science.

Resolvin D1 and Aspirin-Triggered Resolvin D1 Regulate Histamine-stimulated Conjunctival Goblet Cell Secretion

C. Serhan, N. Chiang, Jianwei Jiao, 2013, Mucosal Immunology.

of Inflammation Resolvins D1 and E1 To Promote Resolution Stimulated by Leukotrienes Is Reduced by Conjunctival Goblet Cell Secretion

C. Serhan, K. Lashkari, Dayu Li, 2011 .

Mouse Models of Sjögren’s Syndrome with Ocular Surface Disease

D. Dartt, S. Masli, 2020, International journal of molecular sciences.

Immunopathology and Infectious Diseases Sjögren ’ s Syndrome-Like Ocular Surface Disease in Thrombospondin-1 Deficient Mice

Takeru Yoshimura, A. Gulati, D. Dartt, 2010 .

Signaling Pathways Used by the Specialized Pro-Resolving Mediator Maresin 2 Regulate Goblet Cell Function: Comparison with Maresin 1

Jeffrey A. Bair, C. Serhan, T. Utheim, 2022, International journal of molecular sciences.

RvE1 uses the LTB4 receptor BLT1 to increase [Ca2+]i and stimulate mucin secretion in cultured rat and human conjunctival goblet cells.

C. Serhan, T. Utheim, R. Hodges, 2020, The ocular surface.

Signaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca2+ in cultured rat conjunctival goblet cells

C. Serhan, T. Utheim, R. Hodges, 2018, Experimental eye research.

Resolvin D2 elevates cAMP to increase intracellular [Ca2+] and stimulate secretion from conjunctival goblet cells

Jeffrey A. Bair, C. Serhan, T. Utheim, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways

C. Serhan, T. Utheim, R. Hodges, 2017, Investigative ophthalmology & visual science.

Cornea Resolvin D 1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways

C. Serhan, T. Utheim, R. Hodges, 2017 .

Lipoxin A4 activates ALX/FPR2 Receptor to Regulate Conjunctival Goblet Cell Secretion

Jeffrey A. Bair, C. Serhan, Dayu Li, 2016, Mucosal Immunology.

Immunoresolvent Resolvin D1 Maintains the Health of the Ocular Surface.

C. Serhan, R. Hodges, D. Dartt, 2019, Advances in experimental medicine and biology.

Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics.

C. Serhan, P. Norris, R. Hodges, 2017, Prostaglandins, leukotrienes, and essential fatty acids.

Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2

D. Dartt, S. Gorini, Lacrimal Gland, 1998, Advances in Experimental Medicine and Biology.

Resolvin D2 and Resolvin D1 Differentially Activate Protein Kinases to Counter-Regulate Histamine-Induced [Ca2+]i Increase and Mucin Secretion in Conjunctival Goblet Cells

Jeffrey A. Bair, C. Serhan, T. Utheim, 2021, International journal of molecular sciences.

Maresin 1, a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion in conjunctival goblet cells

Jeffrey A. Bair, C. Serhan, T. Utheim, 2020, Journal of cellular physiology.

Resolvin D1 Treatment on Goblet Cell Mucin and Immune Responses in the Chronic Allergic Eye Disease (AED) Model

C. Serhan, D. Saban, R. Mathew, 2018, Mucosal Immunology.

Conjunctival epithelial and goblet cell function in chronic inflammation and ocular allergic inflammation

D. Dartt, S. Masli, 2014, Current opinion in allergy and clinical immunology.

Isolation and characterization of cultured human conjunctival goblet cells.

R. Hodges, D. Dartt, J. Ríos, 2003, Investigative ophthalmology & visual science.

Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion.

Dayu Li, R. Hodges, D. Dartt, 2012, Investigative ophthalmology & visual science.

Immunolocalization of muscarinic and VIP receptor subtypes and their role in stimulating goblet cell secretion.

D. Zoukhri, R. Hodges, D. Dartt, 1999, Investigative ophthalmology & visual science.

Effect of VIP on intracellular [Ca2+], extracellular regulated kinase 1/2, and secretion in cultured rat conjunctival goblet cells.

Jianwei Jiao, Dayu Li, R. Hodges, 2013, Investigative ophthalmology & visual science.

Role of cPKCalpha and nPKCepsilon in EGF-stimulated goblet cell proliferation.

Jeffrey A. Bair, C. Kublin, K. Lashkari, 2009, Investigative ophthalmology & visual science.

Vasoactive intestinal peptide-stimulated glycoconjugate secretion from conjunctival goblet cells.

D. Dartt, J. D. Zieske, T. L. Kessler, 1996, Experimental eye research.

Stimulatory role of PKCalpha in extracellular regulated kinase 1/2 pathway in conjunctival goblet cell proliferation.

Jeffrey A. Bair, K. Lashkari, R. Hodges, 2009, Investigative ophthalmology & visual science.

Role of neurotrophins and neurotrophin receptors in rat conjunctival goblet cell secretion and proliferation.

J. Gu, J. Gu, R. Hodges, 2007, Investigative ophthalmology & visual science.

Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells.

D. Zoukhri, R. Hodges, D. Dartt, 2003, Investigative ophthalmology & visual science.

Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion.

D. Zoukhri, R. Hodges, D. Dartt, 2003, American journal of physiology. Cell physiology.

Development of conjunctival goblet cells and their neuroreceptor subtype expression.

D. Dartt, Y. Diebold, J. Ríos, 2000, Investigative ophthalmology & visual science.

Regulation of conjunctival goblet cell secretion by Ca(2+)and protein kinase C.

D. Zoukhri, R. Hodges, D. Dartt, 2000, Experimental eye research.

Localization of nerves adjacent to goblet cells in rat conjunctiva.

D. Dartt, J. D. Zieske, T. L. Kessler, 1995, Current eye research.

Stimulation of goblet cell mucous secretion by activation of nerves in rat conjunctiva.

D. Dartt, J. D. Zieske, T. L. Kessler, 1995, Current eye research.

Regulation of mucin and fluid secretion by conjunctival epithelial cells

D. Dartt, 2002, Progress in Retinal and Eye Research.

Protein kinase C isoforms differentially control lacrimal gland functions.

C. Sergheraert, D. Zoukhri, R. Hodges, 1998, Advances in experimental medicine and biology.

Alpha 1-adrenergic and cholinergic agonists activate MAPK by separate mechanisms to inhibit secretion in lacrimal gland.

D. Zoukhri, R. Hodges, D. Dartt, 2003, American journal of physiology. Cell physiology.

Molecular layer deposition builds biocompatible substrates for epithelial cells.

O. Nilsen, D. Dartt, J. Eidet, 2018, Journal of biomedical materials research. Part A.

New Twists to an Old Story: Novel Concepts in the Pathogenesis of Allergic Eye Disease

Santa Jeremy Ono, D. Saban, J. Niederkorn, 2013, Current eye research.

Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland.

T. Salt, V. Trinkaus-Randall, E. Fletcher, 2014, Experimental eye research.

Role of Mitogen-Activated Protein Kinase in Cholinergic Stimulation of Conjunctival Goblet Cell Secretion

D. Zoukhri, D. Dartt, J. Ríos, 2002 .

Characterisation of Gel-Forming Mucins Produced In Vivo and In Ex Vivo Conjunctival Explant Cultures

I. Pintelon, M. Haagdorens, S. Ní Dhubhghaill, 2021, International journal of molecular sciences.

Cornea Effect of VIP on Intracellular [ Ca 2 þ ] , Extracellular Regulated Kinase 1 / 2 , and Secretion in Cultured Rat Conjunctival Goblet Cells

Jianwei Jiao, Dayu Li, R. Hodges, 2013 .

Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells.

Dayu Li, R. Hodges, D. Dartt, 2011, Investigative ophthalmology & visual science.

Phospholipase D1, but not D2, regulates protein secretion via Rho/ROCK in a Ras/Raf-independent, MEK-dependent manner in rat lacrimal gland.

V. Natarajan, R. Hodges, D. Dartt, 2011, Investigative ophthalmology & visual science.

Cholinergic activation of phospholipase D in lacrimal gland acini is independent of protein kinase C and calcium.

D. Zoukhri, D. Dartt, 1995, The American journal of physiology.

Resolvin D2 uses multiple Ca2+‐dependent signaling pathways to stimulate mucin secretion in rat and human conjunctival goblet cells

Jeffrey A. Bair, C. Serhan, T. Utheim, 2022, Journal of cellular physiology.

TheraPearl Eye Mask and Blephasteam for the treatment of meibomian gland dysfunction: a randomized, comparative clinical trial

Xiaoran Lai, S. Olafsson, N. Lagali, 2021, Scientific Reports.

Cholinergic-induced Ca2+ elevation in rat lacrimal gland acini is negatively modulated by PKCdelta and PKCepsilon.

C. Sergheraert, D. Zoukhri, R. Hodges, 2000, Investigative ophthalmology & visual science.

Sex-based differences in conjunctival goblet cell responses to pro-inflammatory and pro-resolving mediators

C. Serhan, T. Utheim, D. Dartt, 2022, Scientific Reports.

Printed in Great Britain CYCLIC NUCLEOTIDE-DEPENDENT ENZYME SECRETION IN THE RAT LACRIMAL GLAND BY D. A. DARTT*, M. DONOWITZ, V. J. JOSHI, R. S. MATHIEU AND G. W. G. SHARPt

M. Donowitz, D. Dartt, G. Sharp, 2005 .

Signal transduction pathways activated by cholinergic and alpha 1-adrenergic agonists in the lacrimal gland.

D. Zoukhri, R. Hodges, D. Dartt, 1998, Advances in experimental medicine and biology.

Lacrimal gland PKC isoforms are differentially involved in agonist-induced protein secretion.

A. Toker, C. Sergheraert, D. Zoukhri, 1997, The American journal of physiology.

Lacrimal gland electrolyte and water secretion in the rabbit: localization and role of (Na+ + K+)‐activated ATPase.

D. Dartt, J. H. Poulsen, M. Møller, 1981, The Journal of physiology.

Effect of protein kinase C and Ca(2+) on p42/p44 MAPK, Pyk2, and Src activation in rat conjunctival goblet cells.

R. Hodges, D. Dartt, J. Ríos, 2007, Experimental eye research.

Ca2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes.

M. Donowitz, K. Kawano, D. Zoukhri, 2003, American journal of physiology. Cell physiology.

Optimization of Storage Temperature for Retention of Undifferentiated Cell Character of Cultured Human Epidermal Cell Sheets

S. Reppe, L. Bergersen, M. Griffith, 2017, Scientific Reports.

Alteration in cellular turnover and progenitor cell population in lacrimal glands from thrombospondin 1-/- mice, a model of dry eye.

R. Islam, T. Utheim, H. Makarenkova, 2016, Experimental eye research.

Myoepithelial Cells: Their Origin and Function in Lacrimal Gland Morphogenesis, Homeostasis, and Repair

H. Makarenkova, D. Dartt, 2015, Current Molecular Biology Reports.

Spatial transcriptomics of the lacrimal gland features macrophage activity and epithelium metabolism as key alterations during chronic inflammation

H. Makarenkova, D. Dartt, C. D. de Paiva, 2022, Frontiers in Immunology.

Signaling Pathways of Purinergic Receptors and Their Interactions with Cholinergic and Adrenergic Pathways in the Lacrimal Gland.

R. Hodges, D. Dartt, 2016, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Stimulation of tear secretion by topical agents that increase cyclic nucleotide levels.

D. Dartt, J. P. Gilbard, S. R. Rossi, 1990, Investigative ophthalmology & visual science.

Presence of nerves and their receptors in mouse and human conjunctival goblet cells.

R. Hodges, D. Dartt, Y. Diebold, 2001, Investigative ophthalmology & visual science.

Hot towels: The bedrock of Meibomian gland dysfunction treatment - A review.

J. Wolffsohn, J. Craig, J. Vehof, 2022, Contact lens & anterior eye : the journal of the British Contact Lens Association.

Nitric oxide and cGMP mediate alpha1D-adrenergic receptor-Stimulated protein secretion and p42/p44 MAPK activation in rat lacrimal gland.

J. Gu, J. Gu, R. Hodges, 2005, Investigative ophthalmology & visual science.

Regulation of tear secretion.

D. Dartt, 1994, Advances in experimental medicine and biology.

Signal transduction and control of lacrimal gland protein secretion: a review.

D. Dartt, 1989, Current eye research.

Role of cyclic AMP and Ca2+ in potentiation of rat lacrimal gland protein secretion.

P. Rose, L. Ronco, D. Dartt, 1988, Investigative ophthalmology & visual science.

Role of calcium in cholinergic stimulation of lacrimal gland protein secretion.

M. Donowitz, P. Rose, D. Dartt, 1985, Current eye research.

Vasoactive intestinal polypeptide stimulation of protein secretion from rat lacrimal gland acini.

P. Rose, D. Dartt, C. Vaillant, 1984, The American journal of physiology.

Physiology of Tear Production

D. Dartt, 1992 .

Author ' s personal copy Vitreous Anatomy , Aging , and Anomalous Posterior Vitreous Detachment

J. Sebag, D. Dartt, 2010 .

Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland.

D. Zoukhri, R. Hodges, D. Dartt, 2003, Investigative ophthalmology & visual science.

Regulatory pathways in lacrimal gland epithelium.

R. Hodges, D. Dartt, 2003, International review of cytology.

Stimulation of tear secretion and treatment of dry-eye disease with 3-isobutyl-1-methylxanthine.

D. Dartt, J. P. Gilbard, S. R. Rossi, 1991, Archives of ophthalmology.

Comparison of proteins in lacrimal gland fluid secreted in response to different stimuli.

C. Matkin, D. Dartt, K. Gray, 1988, Investigative ophthalmology & visual science.

Research in dry eye: report of the Research Subcommittee of the International Dry Eye WorkShop (2007).

Friedrich Paulsen, Stefano Bonini, Michael E. Stern, 2007, The ocular surface.

Age-dependent alterations in mouse exorbital lacrimal gland structure, innervation and secretory response.

C. Kublin, Lili Chen, D. Zoukhri, 2005, Experimental eye research.

Proteins in fluids from individual orbital glands and in tears.

D. Dartt, S. Botelho, I. Knox, 1980, Investigative ophthalmology & visual science.

Interaction of EGF family growth factors and neurotransmitters in regulating lacrimal gland secretion.

D. Dartt, 2004, Experimental eye research.

Regulation of lacrimal gland secretion by neurotransmitters and the EGF family of growth factors.

D. Dartt, 2001, Experimental eye research.

Alpha 1-adrenergic and cholinergic agonists use separate signal transduction pathways in lacrimal gland.

P. Rose, R. Hodges, D. Dartt, 1992, The American journal of physiology.

Lacrimal gland inositol trisphosphate isomer and inositol tetrakisphosphate production.

L. Ronco, R. Hodges, D. Dartt, 1990, The American journal of physiology.

Formation and Function of the Tear Film

D. Dartt, 2011 .

Characterization of P2X7 purinergic receptors and their function in rat lacrimal gland.

R. Hodges, D. Dartt, M. Shatos, 2009, Investigative ophthalmology & visual science.

Neural regulation of lacrimal gland secretory processes: Relevance in dry eye diseases

Darlene A. Dartt, D. Dartt, 2009, Progress in Retinal and Eye Research.

Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK.

D. Zoukhri, R. Hodges, D. Dartt, 2006, Investigative ophthalmology & visual science.

Effects of α1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells

D. Perez, R. Gaivin, D. Zoukhri, 2006 .

THE EFFECTS OF 1D-ADRENERGIC RECEPTORS ON SHEDDING OF BIOLOGICALLY ACTIVE EGF IN FRESHLY ISOLATED LACRIMAL GLAND

D. Perez, R. Gaivin, D. Zoukhri, 2006 .

Effects of α1D-adrenergic receptors on shedding of biologically active EGF in freshly isolated lacrimal gland epithelial cells

Lili Chen, D. Perez, R. Gaivin, 2006 .

Dysfunctional neural regulation of lacrimal gland secretion and its role in the pathogenesis of dry eye syndromes.

D. Dartt, 2004, The ocular surface.

Regulation of inositol phosphates, calcium and protein kinase C in the lacrimal gland

D. Dartt, 1994, Progress in Retinal and Eye Research.

The TFOS International Workshop on Contact Lens Discomfort: report of the subcommittee on neurobiology.

C. Belmonte, J. Gallar, P. Hamrah, 2013, Investigative ophthalmology & visual science.

Biopsy harvesting site and distance from the explant affect conjunctival epithelial phenotype ex vivo.

T. Utheim, D. Dartt, S. Raeder, 2012, Experimental eye research.

The conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restoration.

S. Rauz, Rachel L. Williams, L. Bosworth, 2021, The ocular surface.

Chronic dry eye in photorefractive keratectomy and laser in situ keratomileusis: Manifestations, incidence, and predictive factors

Rose K Sia, Michael J. Mines, K. Bower, 2015, Journal of cataract and refractive surgery.

Goblet cell response after photorefractive keratectomy and laser in situ keratomileusis

Rose K Sia, Michael J. Mines, K. Bower, 2016, Journal of cataract and refractive surgery.

Dry eye after refractive surgery

K. Tsubota, D. Dartt, R. T. Ang, 2001, Current opinion in ophthalmology.

Polymorphism in THBS1 gene is associated with post-refractive surgery chronic ocular surface inflammation.

Rose K Sia, K. Bower, D. Dartt, 2014, Ophthalmology.

Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion.

A. Toker, A. Kazlauskas, D. Zoukhri, 2004, Investigative ophthalmology & visual science.

Ocular pathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes.

Jonathan E. Moore, J. Dooley, J. Moore, 2007, Investigative ophthalmology & visual science.

Mist delivery of eye medication to the anterior segment.

R. Dana, D. Dartt, J. Collins, 2007, American journal of ophthalmology.

Tears and Their Secretion

D. Zoukhri, R. Hodges, D. Dartt, 2005 .

Povidone iodine treatment is deleterious to human ocular surface conjunctival cells in culture

Jeffrey A. Bair, T. Utheim, Dayu Li, 2020, BMJ open ophthalmology.

Resolvin D1, but not resolvin E1, transactivates the epidermal growth factor receptor to increase intracellular calcium and glycoconjugate secretion in rat and human conjunctival goblet cells

C. Serhan, T. Utheim, Dayu Li, 2019, Experimental eye research.

Context-Dependent Regulation of Conjunctival Goblet Cell Function by Allergic Mediators

R. Hodges, D. Dartt, Y. Diebold, 2018, Scientific Reports.

Activation of the EGF Receptor by Histamine Receptor Subtypes Stimulates Mucin Secretion in Conjunctival Goblet Cells

T. Utheim, Dayu Li, R. Hodges, 2018, Investigative ophthalmology & visual science.

Role of PKCα activation of Src, PI-3K/AKT, and ERK in EGF-stimulated proliferation of rat and human conjunctival goblet cells.

Dayu Li, R. Hodges, D. Dartt, 2013, Investigative ophthalmology & visual science.

Simple limbal epithelial transplantation: Current status and future perspectives

K. Tønseth, C. Jackson, T. Utheim, 2019, Stem cells translational medicine.

OPC-12759 Increases Proliferation of Cultured Rat Conjunctival Goblet Cells

D. Dartt, H. Urashima, J. Ríos, 2006, Cornea.

Hyaluronic acid in the treatment of dry eye disease

J. Vehof, K. Tønseth, T. Utheim, 2022, Acta ophthalmologica.

Effect of Storage Temperature on Structure and Function of Cultured Human Oral Keratinocytes

T. Lyberg, R. Islam, M. Griffith, 2015, PloS one.

Effects of serum-free storage on morphology, phenotype, and viability of ex vivo cultured human conjunctival epithelium.

B. Roald, T. Lyberg, W. Louch, 2012, Experimental eye research.

VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2.

Susumu Ishida, David T. Shima, Yuichi Kaji, 2004, Investigative ophthalmology & visual science.

Isolation and characterization of progenitor cells in uninjured, adult rat lacrimal gland.

R. Hodges, D. Dartt, M. Shatos, 2012, Investigative ophthalmology & visual science.

miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium.

O. K. Olstad, T. Lyberg, A. Trøseid, 2013, Experimental eye research.

Tissue Harvesting Site and Culture Medium Affect Attachment, Growth, and Phenotype of Ex Vivo Expanded Oral Mucosal Epithelial Cells

R. Islam, M. Griffith, T. Utheim, 2017, Scientific Reports.

EGF-induced ERK phosphorylation independent of PKC isozymes in human corneal epithelial cells.

D. Dartt, Keping Xu, Fushin Yu, 2002, Investigative ophthalmology & visual science.

Role of mitogen-activated protein kinase in cholinergic stimulation of conjunctival goblet cell secretion.

D. Zoukhri, D. Dartt, J. Ríos, 2000, Advances in experimental medicine and biology.

Artificial Polymeric Scaffolds as Extracellular Matrix Substitutes for Autologous Conjunctival Goblet Cell Expansion

G. Wnek, D. Kaplan, C. Ghezzi, 2016, Investigative ophthalmology & visual science.

Antibiotic treatment for dry eye disease related to meibomian gland dysfunction and blepharitis - A review.

J. Vehof, N. Lagali, T. Utheim, 2022, The ocular surface.

Staphylococcus aureus Activates the NLRP3 Inflammasome in Human and Rat Conjunctival Goblet Cells

Jonathan E. Moore, M. Gilmore, V. Mcgilligan, 2013, PloS one.

Effect of Transportation on Cultured Limbal Epithelial Sheets for Worldwide Treatment of Limbal Stem Cell Deficiency

B. Roald, T. Lyberg, T. Utheim, 2018, Scientific Reports.

Concise Review: Comparison of Culture Membranes Used for Tissue Engineered Conjunctival Epithelial Equivalents

T. Utheim, D. Dartt, J. Eidet, 2015, Journal of functional biomaterials.

Process-Induced Chemical Changes in Food

A. Privat, D. Sullivan, D. Dartt, 1998, Advances in Experimental Medicine and Biology.

Biological tissues and components, and synthetic substrates for conjunctival cell transplantation.

S. Rauz, Rachel L. Williams, L. Bosworth, 2021, The ocular surface.

Flavonoids in the Living System

D. Sullivan, D. Dartt, R. Huxtable, 1998, Advances in Experimental Medicine and Biology.

Conjunctival Goblet Cell Function: Effect of Contact Lens Wear and Cytokines

D. Dartt, L. Contreras-Ruiz, Y. Diebold, 2016, Eye & contact lens.

Modulation of Conjunctival Goblet Cell Function by Inflammatory Cytokines

D. Dartt, L. Contreras-Ruiz, L. Contreras-Ruiz, 2013, Mediators of inflammation.

Presence of EGF growth factor ligands and their effects on cultured rat conjunctival goblet cell proliferation.

J. Gu, J. Gu, Lili Chen, 2008, Experimental eye research.

Effect of calcium antagonism or chelation on rabbit lacrimal gland secretion and membrane potentials

D. Dartt, S. Botelho, 1980, The Journal of physiology.

Protein phosphorylation in Golgi, endosomal, and endoplasmic reticulum membrane fractions of lacrimal gland.

D. Zoukhri, R. Hodges, D. Dartt, 1996, Current eye research.

Tissue-Specific Progenitor and Stem Cells Lacrimal Gland Repair Using Progenitor Cells

R. Meech, H. Makarenkova, D. Dartt, 2017 .

Lacrimal Gland Repair Using Progenitor Cells

R. Meech, H. Makarenkova, D. Dartt, 2016, Stem cells translational medicine.

Lacrimal gland innervation is not altered with the onset and progression of disease in a murine model of Sjögren's syndrome.

D. Zoukhri, R. Hodges, D. Dartt, 1998, Clinical immunology and immunopathology.

Alpha 1-adrenergic agonist-stimulated protein secretion in rat exorbital lacrimal gland acini.

P. Rose, L. Ronco, R. Hodges, 1994, Experimental eye research.

Eledoisin and lacrimal secretion in the rabbit.

D. Dartt, J. P. Gilbard, S. R. Rossi, 1990, Current eye research.

Cyclic nucleotide‐dependent enzyme secretion in the rat lacrimal gland.

M. Donowitz, D. Dartt, G. Sharp, 1984, The Journal of physiology.

Ca2+- and calmodulin-dependent protein phosphorylation in rat lacrimal gland.

M. Donowitz, D. Dartt, G. Sharp, 1982, The Biochemical journal.

The association between visual display terminal use and dry eye: a review

J. Vehof, T. Utheim, D. Dartt, 2021, Acta ophthalmologica.

Novel engineered, membrane-localized variants of vascular endothelial growth factor (VEGF) protect retinal ganglion cells: a proof-of-concept study

Jeffrey A. Bair, Ru Xiao, L. Vandenberghe, 2018, Cell Death & Disease.

ERK/p44p42 mitogen-activated protein kinase mediates EGF-stimulated proliferation of conjunctival goblet cells in culture.

J. Gu, J. Gu, K. Lashkari, 2008, Investigative ophthalmology & visual science.

Advances in Lactoferrin Research

D. Sullivan, D. Legrand, A. Pierce, 1998, Advances in Experimental Medicine and Biology.

Different protein kinase C isozymes mediate lower esophageal sphincter tone and phasic contraction of esophageal circular smooth muscle.

C. Sergheraert, U. Sohn, K. Harnett, 1997, Molecular pharmacology.

Vasoactive intestinal peptide activates Ca2+ -dependent K+ channels through a cAMP pathway in mouse lacrimal cells

P. Brehm, J. Lechleiter, D. Dartt, 1988, Neuron.

Thrombospondin-1 Is Necessary for the Development and Repair of Corneal Nerves

Jeffrey A. Bair, R. Hodges, D. Dartt, 2018, International journal of molecular sciences.

Alteration in Nerves and Neurotransmitter Stimulation of Lacrimal Gland Secretion in the TSP-1−/− Mouse Model of Aqueous Deficiency Dry Eye

H. Makarenkova, R. Hodges, D. Dartt, 2018, Mucosal Immunology.

Effects of explant size on epithelial outgrowth, thickness, stratification, ultrastructure and phenotype of cultured limbal epithelial cells

B. Roald, T. Lyberg, T. Utheim, 2019, PloS one.

Role of Ca2+ and protein kinase C in cholinergic, and alpha1-adrenergic agonists and EGF stimulated mitogen-activated protein kinase activity in lacrimal gland.

D. Zoukhri, R. Hodges, D. Dartt, 2002, Advances in experimental medicine and biology.

Isolation and characterization of secretory vesicles from bovine neurohypophyses.

C. Torp-Pedersen, N. Thorn, M. Gratzl, 1980, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

Military Vision Research Program

D. Dartt, 2011 .

Review on the possible pathophysiological mechanisms underlying visual display terminal‐associated dry eye disease

J. Vehof, T. Utheim, D. Dartt, 2022, Acta ophthalmologica.

Isolation and characterization of human goblet cells in vitro: regulation of proliferation and activation of mitogen-activated protein kinase by EGF and carbachol.

D. Dartt, M. Shatos, H. Kano, 2000, Advances in experimental medicine and biology.

Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini.

C. Okamoto, S. Hamm-Alvarez, C. Rhodes, 2005, American journal of physiology. Cell physiology.

Immunolocalization of Lacrimal Gland PKC Isoforms. Effect of Phorbol Esters and Cholinergic Agonists on Their Cellular Distribution

D. Zoukhri, R. Hodges, D. Dartt, 1997, The Journal of Membrane Biology.

Role of protein kinase C in cholinergic stimulation of lacrimal gland protein secretion

D. Zoukhri, R. Hodges, D. Dartt, 1994, FEBS letters.

Role of Protein Kinase C in α1-Adrenergic and Cholinergic Agonist Stimulated Protein Secretion

R. Hodges, D. Dartt, D. Dicker, 1994 .

Role of protein kinase C in alpha 1-adrenergic and cholinergic agonist stimulated protein secretion.

R. Hodges, D. Dartt, D. Dicker, 1994, Advances in experimental medicine and biology.

Ca2+ signaling by cholinergic and alpha1-adrenergic agonists is up-regulated in lacrimal and submandibular glands in a murine model of Sjögren's syndrome.

D. Zoukhri, R. Hodges, D. Dartt, 1998, Clinical immunology and immunopathology.

Lymphocytic infiltration and goblet cell marker alteration in the conjunctiva of the MRL/MpJ-Fas(lpr) mouse model of Sjögren's syndrome.

Lili Chen, R. Hodges, D. Dartt, 2007, Experimental eye research.

Effects of Ca2+ and calmodulin on cyclic nucleotide metabolism in neurosecretosomes isolated from ox neurohypophyses

C. Torp-Pedersen, N. Thorn, D. Dartt, 1981, Brain Research.

Chambered warm moist air eyelid warming devices – a review

J. Wolffsohn, J. Craig, J. Vehof, 2021, Acta ophthalmologica.

Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3

Michael E. Stern, Kazuo Tsubota, K. Tsubota, 2002, Advances in Experimental Medicine and Biology.

Bcl‐2 enhances Ca2+ signaling to support the intrinsic regenerative capacity of CNS axons

R. Neve, D. Chen, W. Snider, 2005, The EMBO journal.

The Level of Inflammatory Tear Cytokines is Elevated in Congenital Aniridia and Associated with Meibomian Gland Dysfunction.

H. Aass, R. Baraas, N. Lagali, 2018, Investigative ophthalmology & visual science.

Tear lipocalin: structure and function.

D. Dartt, Darlene A Dartt, 2011, The ocular surface.

Concordance between common dry eye diagnostic tests

Jonathan E. Moore, V. Mcgilligan, J. Moore, 2008, British Journal of Ophthalmology.

Evaluation of the Ocular Surface Disease Index Questionnaire as a Discriminative Test for Clinical Findings in Dry Eye Disease Patients

T. Utheim, M. Yazdani, D. Dartt, 2019, Current eye research.

Tear Production Levels and Dry Eye Disease Severity in a Large Norwegian Cohort

N. Lagali, T. Utheim, M. Yazdani, 2018, Current eye research.

Benzalkonium Chloride-Preserved Anti-Glaucomatous Eye Drops and Their Effect on Human Conjunctival Goblet Cells in vitro

Jeffrey A. Bair, G. Petrovski, S. Heegaard, 2021, Biomedicine Hub.

Impact of benzalkonium chloride-preserved and preservative-free latanoprost eye drops on cultured human conjunctival goblet cells upon acute exposure and differences in physicochemical properties of the eye drops

Jeffrey A. Bair, G. Petrovski, S. Heegaard, 2021, BMJ Open Ophthalmology.

Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment

G. Petrovski, S. Heegaard, T. Utheim, 2019, Journal of glaucoma.

In-office thermal systems for the treatment of dry eye disease.

J. Vehof, D. Dartt, J. Olafsson, 2022, Survey of ophthalmology.

Encyclopedia of the eye

Joseph C. Besharse, R. Dana, J. Besharse, 2010 .

Increased tear secretion in pancreatic cholera: a newly recognized symptom in an experiment of nature.

M. Donowitz, D. Dartt, J. P. Gilbard, 1988, The American journal of medicine.

Interaction of alpha1D-adrenergic and P2X(7) receptors in the rat lacrimal gland and the effect on intracellular [Ca2+] and protein secretion.

R. Hodges, D. Dartt, 2011, Investigative Ophthalmology and Visual Science.

Cholinergic agonists activate P2X7 receptors to stimulate protein secretion by the rat lacrimal gland.

R. Hodges, D. Dartt, 2011, Investigative ophthalmology & visual science.

Identification of vasoactive intestinal peptide receptor subtypes in the lacrimal gland and their signal-transducing components.

C. Sergheraert, D. Zoukhri, R. Hodges, 1997, Investigative ophthalmology & visual science.

Bioactive titaminates from molecular layer deposition

O. Nilsen, D. Dartt, J. Eidet, 2017 .

Lacrimal Gland Epithelial Cells Shape Immune Responses through the Modulation of Inflammasomes and Lipid Metabolism

V. Shestopalov, H. Makarenkova, D. Dartt, 2023, International journal of molecular sciences.

Myoepithelial Cells: Their Origin and Function in Lacrimal Gland Morphogenesis, Homeostasis, and Repair

H. Makarenkova, D. Dartt, 2015, Current Molecular Biology Reports.

The First Transcriptomic Atlas of the Adult Lacrimal Gland Reveals Epithelial Complexity and Identifies Novel Progenitor Cells in Mice

H. Makarenkova, D. Dartt, C. D. de Paiva, 2023, Cells.

Sex and age differences in symptoms and signs of dry eye disease in a Norwegian cohort of patients.

T. Utheim, D. Dartt, R. Badian, 2020, The ocular surface.

Serum-Free and Xenobiotic-Free Preservation of Cultured Human Limbal Epithelial Cells

B. Roald, T. Lyberg, R. Islam, 2015, PloS one.

Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease

V. Vitelli, N. Lagali, T. Utheim, 2020, Scientific Reports.

Signaling pathways used by EGF to stimulate conjunctival goblet cell secretion.

Jeffrey A. Bair, Dayu Li, R. Hodges, 2012, Experimental eye research.

Role of cPKC α and nPKC ε in EGF-Stimulated Goblet Cell Proliferation

Jeffrey A. Bair, K. Lashkari, D. Zoukhri, 2009 .

Identification and cellular localization of the components of the VIP signaling pathway in the lacrimal gland.

D. Zoukhri, R. Hodges, D. Dartt, 1998, Advances in experimental medicine and biology.

Context-Dependent Regulation of Conjunctival Goblet Cell Function by Allergic Mediators

R. Hodges, D. Dartt, Y. Diebold, 2018, Scientific Reports.

Anti-Inflammatory and Pro-resolving Actions of the N-Terminal Peptides Ac2-26, Ac2-12 and Ac9-25 of Annexin A1 on Conjunctival Goblet Cell Function.

Jeffrey A. Bair, C. Serhan, T. Utheim, 2023, The American journal of pathology.

Protein in rabbit lacrimal gland fluid.

D. Dartt, S. Botelho, 1979, Investigative ophthalmology & visual science.

Cholinergic-Induced Ca2+ Elevation in Rat Lacrimal Gland Acini Is Negatively Modulated by PKCδ and PKCε

C. Sergheraert, D. Zoukhri, R. Hodges, 2000 .

Transcorneal but not transpalpebral electrical stimulation disrupts mucin homeostasis of the ocular surface

D. Chen, T. Utheim, Kin-Sang Cho, 2022, BMC ophthalmology.

Novel engineered, membrane-localized variants of vascular endothelial growth factor (VEGF) protect retinal ganglion cells: a proof-of-concept study

Jeffrey A. Bair, Ru Xiao, L. Vandenberghe, 2018, Cell Death & Disease.

Comprar Immunology, inflammation and diseases of the eye | Darlene A. Dartt | 9780123819741 | Academic Press

R. Dana, J. Niederkorn, D. Dartt, 2011 .

Meibomian gland dysfunction and keratopathy are associated with dry eye disease in aniridia

R. Baraas, N. Lagali, T. Utheim, 2018, British Journal of Ophthalmology.

Purinergic 2X 4 (P2X4), but not P2X7, receptors increase cytosolic [Ca2+] and stimulate mucin secretion in rat conjunctival goblet cells to maintain ocular surface health.

Jeffrey A. Bair, T. Utheim, D. Dartt, 2023, Experimental eye research.