J. Fenton

G. Shen, F. Ofosu, J. Fenton, 2000, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

Role of external Na+ and cytosolic pH in agonist-evoked cytosolic Ca2+ response in human platelets.

A. Aviv, T. Andersen, J. Fenton, 1994, The American journal of physiology.

Activation of cyclic nucleotide formation in murine neuroblastoma N1E-115 cells by modified human thrombins.

E. Richelson, J. Fenton, M. Mckinney, 1984, The Journal of biological chemistry.

Catalysis of Thrombin Inhibition Provides an Index for Estimating the Antithrombotic Potential of Glycosaminoglycans in Rabbits

J. Hirsh, F. Ofosu, J. Fenton, 1987, Thrombosis and Haemostasis.

6 – Structural Regions and Bioregulatory Functions of Thrombin

J. Fenton, 1987 .

Thrombin stimulation of matrix fibronectin

P. Armstrong, T. Andersen, J. Fenton, 1996, Journal of cellular physiology.

Human prothrombin fragments FI(αβ) and F2: Preparation and characterization of structural and biological properties☆

J. Fenton, T. Hugli, D. Aronson, 1980 .

Thrombin induces IL-6 production in fibroblasts and epithelial cells. Evidence for the involvement of the seven-transmembrane domain (STD) receptor for alpha-thrombin.

L. Sower, J. Fenton, G. Klimpel, 1995, Journal of immunology.

Platelet thrombin receptors. Binding of alpha-thrombin is coupled to signal generation by a chymotrypsin-sensitive mechanism.

T. Detwiler, J. Fenton, S. W. Tam, 1980, The Journal of biological chemistry.

Thrombin inhibition by hirudin: how hirudin inhibits thrombin.

J. Maraganore, F. Ofosu, J. Fenton, 1991, Haemostasis.

Rat Platelets Adhere to Human Thrombin-Treated Rat Lungs under Flow Conditions

C. Venturini, J. Fenton, F. Minnear, 1989, Thrombosis and Haemostasis.

Thrombin‐induced thromboxane generation by neutrophils and lymphocytes: Dependence on enzymic site

R. Bizios, A. Malik, L. Lai, 1987, Journal of cellular physiology.

Passive Participation of Fixed Platelets in Aggregation Facilitated by Covalently Bound Fibrinogen

J. Fenton, 2005 .

Thrombin effects on osteoblastic cells. II. Structure-function relationships.

C. Dolce, R. Dziak, D. Tatakis, 1991, Biochemical and biophysical research communications.

Second messengers in thrombin‐stimulated bone resorption

P. Stern, J. Fenton, V. Stathopoulos, 1990, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Protease mitogenic response of chick embryo fibroblasts and receptor binding/processing of human alpha-thrombin.

J. Fenton, J. Perdue, S. A. Sonder, 1981, The Journal of biological chemistry.

Thrombin Prevents the Expression of Inducible Nitric Oxide Synthase in Vascular Smooth Muscle Cells by a Proteolytically-Activated Thrombin Receptor

R. Busse, V. Schini-Kerth, B. Fisslthaler, 1995, Thrombosis and Haemostasis.

Human thrombin receptor‐activating peptide‐induced proliferation of cultured vascular smooth muscle cells exhibits species specificity

G. Owens, I. Sarembock, C. McNamara, 1995 .

Thrombin inhibition with dipeptidyl argininals.

J. Fareed, J. Fenton, J. Catalfamo, 1988, Thrombosis research.

Thrombin‐induced prostacyclin biosynthesis in human endothelium: Role of guanine nucleotide regulatory proteins in stimulus/coupling responses

Joe G. N. Garcia, J. Fenton, J. Garcia, 1990, Journal of cellular physiology.

Affinity labeling of antibodies to the p-azophenyltrimethylammonium hapten, and a comparison of affinity-labeled antibodies of two different specificities.

J. Fenton, S. J. Singer, 1971, Biochemistry.

Thrombin specificity with tripeptide chromogenic substrates: comparison of human and bovine thrombins with and without fibrinogen clotting activities.

J. Fenton, S. A. Sonder, 1986, Clinical chemistry.

Modulation of thrombin-hirudin interaction by specific ion effects.

E. Di Cera, R. De Cristofaro, J. Fenton, 1992, Journal of molecular biology.

Human thrombins. Group IA and IIA salt-dependent properties of alpha-thrombin.

K. Koehler, J. Fenton, B. Landis, 1981, The Journal of biological chemistry.

Exo-site affinity labeling of human thrombins. Similar labeling on the A chain and B chain/fragments of clotting alpha- and nonclotting gamma/beta-thrombins.

D. Bing, J. Fenton, M. Cory, 1977, The Journal of biological chemistry.

Opposing Actions of Thrombin and Protease Nexin‐1 on Amyloid β‐Peptide Toxicity and on Accumulation of Peroxides and Calcium in Hippocampal Neurons

M. Mattson, S. Zimmer, J. Fenton, 1995, Journal of neurochemistry.

ENDOTHELIAL CELL AND PLATELET BINDING SITES FOR THROMBIN

J. Isaacs, D. Gospodarowicz, K. Glenn, 1981, Annals of the New York Academy of Sciences.

Thrombin and Antithrombotics

F. Ofosu, J. Fenton, H. Hassouna, 1998, Seminars in thrombosis and hemostasis.

Thrombin-stimulated events in cultured vascular smooth-muscle cells.

K. Griendling, B. Berk, J. Fenton, 1991, The Biochemical journal.

Endothelin-like pulmonary vasoconstrictor peptide release by alpha-thrombin.

A. Malik, T. Andersen, J. Fenton, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Thrombin binding to platelets and their activation in plasma

J. Freedman, F. Ofosu, J. Fenton, 1994, British journal of haematology.

Catalytic competence of human alpha- and gamma-thrombin in the activation of fibrinogen and factor XIII.

L. Lorand, J. Shafer, S. D. Lewis, 1987, Biochemistry.

Inhibition of thrombin and SFLLR-peptide stimulation of platelet aggregation, phospholipase A2 and Na+/H+ exchange by a thrombin receptor antagonist.

S. Natarajan, J. Fenton, M. Peluso, 1995, Biochemical pharmacology.

Thrombin-induced platelet secretion. Further evidence for a specific pathway.

M. Shuman, J. Fenton, M. Botney, 1979, The Journal of clinical investigation.

Thrombin Interactions with Hirudin

J. Fenton, 1989, Seminars in thrombosis and hemostasis.

Thrombin-Elicited Contractile Responses of Aortic Smooth Muscle

J. Fenton, D. Walz, M. Aiken, 1985, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Human alpha- to zeta-thrombin cleavage occurs with neutrophil cathepsin G or chymotrypsin while fibrinogen clotting activity is retained.

J. Fenton, D. Walz, M. Brower, 1990, Biochemistry.

Thrombin a

J. Fenton, 1986 .

Specificity of thrombin: evidence for selectivity in acylation rather than binding for p-nitrophenyl alpha-amino-p-toluate.

R. Feinman, J. Fenton, T. Ryan, 1976, Biochemistry.

Specificity of thrombin: I. Esterolytic properties of thrombin, plasma, trypsin, and chymotrypsin with Nβ-substituted guanidino derivatives of p-nitrophenyl-p′-guanidinobenzoate☆

J. Fenton, M. Fasco, 1973 .

Specificity of the Thrombin-Induced Release of Tissue Plasminogen Activator from Cultured Human Endothelial Cells

R. Marlar, D. Stern, P. Nawroth, 1986, Thrombosis and Haemostasis.

Understanding thrombin and hemostasis.

F. Ofosu, J. Fenton, H. Hassouna, 1993, Hematology/Oncology Clinics of North America.

Platelet aggregation abnormalities after cardiopulmonary bypass.

M. Huang, T. Andersen, J. Bennett, 1994, Blood.

Thrombin‐induced chemotaxis and aggregation of neutrophils

R. Bizios, A. Malik, L. Lai, 1986, Journal of cellular physiology.

Proteolysis of Human α‐Thrombin by Human Neutrophil Elastase Results in Decreased Fibrinogen Clotting and Platelet‐Stimulatory Activity

J. Fenton, M. Brower, K. Garry, 1986 .

Human thrombins. Production, evaluation, and properties of alpha-thrombin.

J. Fenton, M. Fasco, A. B. Stackrow, 1977, The Journal of biological chemistry.

Human α-Thrombin Preparations

M. Zabinski, J. Finlayson, J. Fenton, 1977 .

Inhibition of fibrinolytic enzymes by thrombin inhibitors.

J. Fenton, N. Gilboa, G. B. Villannueva, 1988, Enzyme.

Thrombin upregulates interleukin-8 in lung fibroblasts via cleavage of proteolytically activated receptor-I and protein kinase C-gamma activation.

S. Hoffman, R. Silver, J. Fenton, 2000, American journal of respiratory cell and molecular biology.

Comparison of alpha- and gamma-thrombin on lung fluid balance in anesthetized sheep.

R. Bizios, A. Malik, J. Fenton, 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

Thrombin after clot formation

F. Ofosu, J. Fenton, 1990 .

Leeches to hirulogs and other thrombin-directed antithrombotics.

J. Fenton, 1992, Hematology/oncology clinics of North America.

Warfarin-stereochemical aspects of its metabolism by rat liver microsomes.

W. Trager, L. Pohl, S. Nelson, 1976, Biochemical pharmacology.

Diagnostic mycoserology by immunoelectroosmophoresis: a general, rapid, and sensitive microtechnic.

M. Gordon, J. Fenton, R. Almy, 1971, American journal of clinical pathology.

Bioregulatory functions of thrombin

M. Shuman, J. Fenton, D. Walz, 1986 .

Double-Signal Hypothesis for Thrombin Initiation of Cell Proliferation

J. S. Bergmann, J. Fenton, D. Carney, 1986, Seminars in thrombosis and hemostasis.

Isolation and Fluorescent Labeling of Ulex europaeus Anti‐H Lectin *

J. Fenton, C. Otten, C. R. Duggleby, 1965, Vox Sanguinis.

Thrombin receptor activation peptide induces pulmonary vasoconstriction.

A. Malik, H. Lum, T. Andersen, 1994, The American journal of physiology.

Responses of Aortic Smooth Muscle to Thrombin and Thrombin Analogues a

G F Anderson, J W Fenton, J. Fenton, 1986, Annals of the New York Academy of Sciences.

Human d-Phe-Pro-Arg-CH2-α-thrombin crystallization and diffraction data

K. Mann, A. Tulinsky, E. Skrzypczak‐Jankun, 1989 .

Proflavin binding within the fibrinopeptide groove adjacent to the catalytic site of human alpha-thrombin.

J. Fenton, S. A. Sonder, 1984, Biochemistry.

Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion

A. Malik, C. Tiruppathì, T. Andersen, 1992, The Journal of cell biology.

Binding of Thrombin to the G-protein-linked Receptor, and Not to Glycoprotein Ib, Precedes Thrombin-mediated Platelet Activation*

J. Freedman, F. Ofosu, Longbin Liu, 1997, The Journal of Biological Chemistry.

Monocyte chemotaxis: stimulation by specific exosite region in thrombin.

R. Bar-Shavit, G. Wilner, J. Fenton, 1983, Science.

High-affinity alpha-thrombin binding to platelet glycoprotein Ib alpha: identification of two binding domains.

H. Gralnick, H. Krutzsch, S. Williams, 1994, Proceedings of the National Academy of Sciences of the United States of America.

High-affinity a-thrombin binding to platelet glycoprotein Iba : Identification of two binding domains ( hombods / bood cgt )

H. Gralnick, J. Fenton, L. McKeown, 2022 .

Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.

C W Turck, C. Turck, J. Chen, 1994, Biochemistry.

Equilibrium binding of thrombin to platelets.

J. Fenton, T. Detwiler, B. M. Martin, 1976, Biochemistry.

Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin.

J. Maraganore, J. Jablonski, K. Ramachandran, 1990, Biochemistry.

Human alpha-thrombin binding to nonpolymerized fibrin-Sepharose: evidence for an anionic binding region.

L. Berliner, J. Fenton, Y. Sugawara, 1985, Biochemistry.

Selective immobilization of alpha-thrombin by surface-bound fibrin.

J. Fenton, M. Mudd, M. Danitz, 1981, The Journal of laboratory and clinical medicine.

Polyethylene glycol 6,000 enhancement of the clotting of fibrinogen solutions in visual and mechanical assays.

J. Fenton, M. Fasco, 1974, Thrombosis research.

Thrombin's enzymatic activity increases permeability of endothelial cell monolayers.

J. Fenton, F. Minnear, M. Demichele, 1990, Journal of applied physiology.

Inhibition of Thrombin by Antithrombin III and Heparin Cofactor II In Vivo

Long-bin Liu, F. Ofosu, M. Andrew, 1995, Thrombosis and Haemostasis.

Thrombin adsorption to surfaces and prevention with polyethylene glycol 6,000.

J W Fenton, M J Fasco, J. Fenton, 1976, Thrombosis research.

Human α- and γ-thrombin specificity with tripeptide p-nitroanalide substrates under physiologically relevant conditions

J. Fenton, J. Witting, T. Miller, 1987 .

The action of thrombin on peptide p-nitroanilide substrates: Hydrolysis of Tos-Gly-Pro-Arg-pNA and D-Phe-Pip-Arg-pNA by human α and γ and bovine α and β-thrombins

J. Fenton, C. Jackson, R. Lottenberg, 1982 .

Thrombin clotting activity measurement and standardization with lyophilized plasma.

B. Evatt, J. Fenton, C. Wideman, 1986, Clinical chemistry.

The rational design of thrombin-directed antithrombotics.

A. Malik, T. Andersen, J. Fenton, 1993, Advances in experimental medicine and biology.

Affinity labeling of lysine-149 in the anion-binding exosite of human alpha-thrombin with an N alpha-(dinitrofluorobenzyl)hirudin C-terminal peptide.

J. Maraganore, J. Fenton, P. Bourdon, 1990, Biochemistry.

Thrombin inhibition by synthetic hirudin peptides.

J. Maraganore, J. Fenton, 1990, Advances in experimental medicine and biology.

alpha-thrombin bound to extracellular endothelial matrix induces pronounced fibrin deposition and platelet thrombus growth in flowing non-anticoagulated human blood.

K. Sakariassen, J. Fenton, J. A. Salatti, 1994, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Thrombin potently stimulates cytokine production in human vascular smooth muscle cells but not in mononuclear phagocytes.

P. Libby, S. Coughlin, S. Clinton, 1996, Circulation research.

Photoaffinity labeling of a single receptor for alpha-thrombin on mouse embryo cells.

K. Glenn, J. Fenton, D. Carney, 1979, The Journal of biological chemistry.

Two distinct elastases from different strains of Pseudomonas aeruginosa.

J. Fenton, K. Miller, T. Muraschi, 1969, Biochimica et biophysica acta.

G proteins and phospholipase C mediate thrombin-induced generation of plasminogen activator inhibitor-1 from vascular smooth muscle cells.

K. Cockell, J. Fenton, S. Ren, 1997, Journal of Vascular Research.

Regulation of Thrombin Generation and Functions

J W Fenton, J. Fenton, 1988, Seminars in thrombosis and hemostasis.

ThrombinSpecificitywithTripeptideChromogenicSubstrates:Comparisonof Humanand BovineThrombinswithand withoutFibrinogenClottingActivities

J. Fenton, 2004 .

Thrombin-platelet interactions: an assessment of the roles of saturable and nonsaturable binding in platelet activation.

R. J. Alexander, T. Detwiler, J. Fenton, 1983, Archives of biochemistry and biophysics.

Photoaffinity labeling of specific alpha-thrombin binding sites on Chinese hamster lung cells.

H. Wiley, J. Fenton, D. Cunningham, 1983, The Journal of biological chemistry.

Haemoglobin inhibition of fibrin polymerization and clotting.

J. Fenton, D. Moon, D. V. Brezniak, 1994, Blood Coagulation and Fibrinolysis.

Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization

M. Goligorsky, A. Malik, H. Lum, 1993, The Journal of cell biology.

Regulation by Phospholipase C , Protein Kinase C , and Cyclic Adenosine 3 ’ 5 ’-Monophosphate

V. Natarajan, J. Fenton, 2003 .

Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3'5'-monophosphate.

V. Natarajan, J. Fenton, J. Garcia, 1992, Blood.

Catalytically competent human and bovine ζ‐thrombin and chimeras generated from unfolded polypeptide chains

J. Shafer, J. Fenton, D. V. Brezniak, 1992, Protein science : a publication of the Protein Society.

Thrombin Anion‐binding Exosite Interactions with Heparin and Various Polyanions a

J. Fareed, J. Fenton, C. Pouliott, 1989, Annals of the New York Academy of Sciences.

Thrombin-specific inhibition by and slow cleavage of hirulog-1.

J. Maraganore, J. Fenton, P. Bourdon, 1992, The Biochemical journal.

Differential inactivation of human and bovine α-thrombins by exosite affinity-labeling reagents

J. Fenton, S. A. Sonder, 1983 .

Active-site topography of human coagulant (alpha) and noncoagulant (beta) thrombins.

L. Berliner, J. Fenton, R. Bauer, 1981, Biochemistry.

Fibronectin fragments in lung lymph after thrombin-induced lung vascular injury.

A. Malik, F. Blumenstock, J. Fenton, 1989, Laboratory investigation; a journal of technical methods and pathology.

Large-scale preparation and preliminary characterization of human thrombin.

J. Harrington, J. Fenton, K. Miller, 1971, Biochimica et biophysica acta.

Transcellular signaling and pharmacological modulation of thrombin-induced production of plasminogen activator inhibitor-1 in vascular smooth muscle cells.

G. Shen, J. Fenton, S. Ren, 1998, Seminars in thrombosis and hemostasis.

Thrombin functions and antithrombotic intervention.

J. Fenton, 1995, Thrombosis and haemostasis.

Affinity labeling of antibodies to the p-azophenyltrimethylammonium hapten and a structural relationship among antibody active sites of different specificities.

J. Fenton, S. J. Singer, 1965, Biochemical and biophysical research communications.

Initiation of DNA synthesis by human thrombin: Relationships between receptor binding, enzymic activity, and stimulation of 86Rb + influx

J. Fenton, D. Carney, J. Stiernberg, 1984, Journal of cellular physiology.

Receptor-mediated chemotactic response of a macrophage cell line (J774) to thrombin.

R. Bar-Shavit, G. Wilner, J. Fenton, 1983, Laboratory investigation; a journal of technical methods and pathology.

Anion-binding exosite of human alpha-thrombin and fibrin(ogen) recognition.

M. Zabinski, G. Wilner, J. Fenton, 1988, Biochemistry.

Platelets adhere to thrombin-treated endothelial cells in vitro.

P. del Vecchio, J. Fenton, F. Minnear, 1989, The American journal of physiology.

Depletion of protein kinase Cepsilon in normal and scleroderma lung fibroblasts has opposite effects on tenascin expression.

S. Lipsitz, S. Hoffman, R. Silver, 2001, Arthritis and rheumatism.

Endogenous platelet fibrinogen surface expression on activated platelets.

H. Gralnick, S. Williams, J. Fenton, 1991, The Journal of laboratory and clinical medicine.

Thrombin Noncovalent-Protein Binding And Fibrin(Ogen) Recognition

M. Zabinski, G. Wilner, J. Fenton, 1981, Thrombosis and Haemostasis.

Thrombin Active-Site Regions

D. Bing, J. Fenton, 1986, Seminars in thrombosis and hemostasis.

Thrombin-induced aggregation of lymphocytes: non-enzymic induction by an hirudin-blocked thrombin exosite.

R. Bizios, A. Malik, L. Lai, 1985, Thrombosis research.

Human alpha- and gamma-thrombin specificity with tripeptide p-nitroanalide substrates under physiologically relevant conditions.

J. Fenton, J. Witting, T. Miller, 1987, Thrombosis research.

FURTHER EVIDENCE FOR A SPECIFIC PATHWAY

M. Shuman, J. Fenton, M. Botney, 1979 .

Purification and Characterization of Activation Fragments F1 and F2 from Human Prothrombin

A. P. Ball, J. Fenton, D. Aronson, 1975, Thrombosis and Haemostasis.

Linkage between proton binding and amidase activity in human alpha-thrombin: effect of ions and temperature.

D. J. Albright, E. Di Cera, R. De Cristofaro, 1991, Biochemistry.

Linkage between proton binding and amidase activity in human gamma-thrombin.

E. Di Cera, R. De Cristofaro, J. Fenton, 1992, Biochemistry.

Human α- and ζ-thrombin inhibition by recombinant HV1 and HV2k47 hirudins

J. Fenton, D. V. Brezniak, J. R. Hayes, 1991 .

Duality of plasmin effect on cytosolic free calcium in human platelets.

A. Aviv, T. Andersen, J. Fenton, 1995, The American journal of physiology.

Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors.

A. Tulinsky, J. Maraganore, J W Fenton, 1994, Biochemistry.

Introduction

M. Shuman, J. Fenton, D. Walz, 1986 .

Human thrombin: partial primary structure.

A. Thompson, J. Fenton, M. Legaz, 1977, Archives of biochemistry and biophysics.

Thrombospondin fragmentation by alpha-thrombin and resistance to gamma-thrombin.

K. Takahashi, J. Fenton, D. Walz, 1984, Biochemical Journal.

Thrombin Receptor-Related Hemostatic Defect After Cardiopulmonary Bypass

Atul Gupta, J. Fenton, S. Ferraris, 1996, Seminars in thrombosis and hemostasis.

Chemotactic response of monocytes to thrombin

R. Bar-Shavit, G. Wilner, J. Fenton, 1983, The Journal of cell biology.

Thrombospondin fragmentation by α-thrombin and resistance to γ-thrombin

J. Fenton, D. Walz, M. Aiken, 1984 .

Thrombin-induced leukopenia and thrombocytopenia are attenuated by PAF antagonist WEB 2086.

J. Fenton, J. Kaplan, P. Gudewicz, 1991, The Journal of laboratory and clinical medicine.

Enzymatic activity is necessary for thrombin-mediated increase in endothelial permeability.

M. Aschner, J. Aschner, A. Malik, 1990, The American journal of physiology.

Evaluation of Thrombin Activity by Immunoquantitation of Fibrinopeptide A Generation

D. Hoppensteadt, J. Fareed, J. Fenton, 1986, Seminars in thrombosis and hemostasis.