R. Colombo

发表

Omics and Clinical Data Integration

C. Damiani, E. Sacco, M. Vanoni, 2018 .

A mechanism for inhibiting the SUMO pathway.

R. Hay, G. Draetta, S. Chiocca, 2004, Molecular cell.

Target Identification and Validation in Drug Discovery

J. Moll, R. Colombo, 2013, Methods in Molecular Biology.

Identification of thyroid tumor cell vulnerabilities through a siRNA-based functional screening

A. Neri, M. Pierotti, F. Gasparri, 2015 .

Accelerating the computational analysis of biological systems by means of Graphics Processing Units

Giancarlo Mauri, Marco S. Nobile, Paolo Cazzaniga, 2013, ICONS 2013.

Histone Deacetylase 1 Inactivation by an Adenovirus Early Gene Product

M. Cotten, G. Draetta, S. Chiocca, 2002, Current Biology.

Emerging ensembles of kinetic parameters to identify experimentally observed phenotypes

G. Mauri, D. Pescini, C. Damiani, 2018 .

Targeted inhibition of the gatekeeper mutant T315I of Bcr-Abl by an Aurora kinase inhibitor

M. Modugno, A. Isacchi, E. Casale, 2007 .

Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein

G. Draetta, S. Chiocca, R. Colombo, 2003, Oncogene.

Computational Strategies for a System-Level Understanding of Metabolism

Marco S. Nobile, Riccardo Colombo, Dario Pescini, 2014, Metabolites.

Synthesis and SAR of new pyrazolo[4,3-h]quinazoline-3-carboxamide derivatives as potent and selective MPS1 kinase inhibitors.

Riccardo Colombo, M. Angiolini, Daniele Donati, 2011, Bioorganic & medicinal chemistry letters.

An ensemble evolutionary constraint-based approach to understand the emergence of metabolic phenotypes

Giancarlo Mauri, Riccardo Colombo, Dario Pescini, 2014, Natural Computing.

Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase.

Antonella Isacchi, Riccardo Colombo, Enrico Pesenti, 2010, Cancer research.

Target Validation to Biomarker Development

J. Moll, R. Colombo, 2012, Molecular Diagnosis & Therapy.

An inhibitor of the mitotic kinase, MPS1, is selective towards pancreatic cancer cells

M. Korc, B. Herbert, Jae-Hoon Jeong, 2014 .

Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I.

C. Bokemeyer, T. Brümmendorf, S. Balabanov, 2008, Blood.

Targeting aneuploid cancer cells

J. Moll, R. Colombo, 2011, Expert opinion on therapeutic targets.

The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1

G. Draetta, S. Chiocca, C. Seiser, 2002, EMBO reports.

Crystal structure of the T315I Abl mutant in complex with the aurora kinases inhibitor PHA-739358.

Antonella Isacchi, Riccardo Colombo, Michele Modugno, 2007, Cancer research.

Target Validation and Biomarker Identification in Oncology

J. Moll, R. Colombo, 2012, Molecular Diagnosis & Therapy.

A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect

Giancarlo Mauri, Riccardo Colombo, Hans V. Westerhoff, 2017, PLoS Comput. Biol..

Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins

K. Camphausen, N. Caplen, U. Shankavaram, 2014, Molecular Cancer Research.

Fuzzy Self-Tuning PSO: A settings-free algorithm for global optimization

Giancarlo Mauri, Marco S. Nobile, Paolo Cazzaniga, 2017, Swarm Evol. Comput..

Integration of single-cell RNA-seq data into metabolic models to characterize tumour cell populations

Giancarlo Mauri, Davide Maspero, Marzia Di Filippo, 2018, bioRxiv.

Selective Inhibition of Pancreatic Ductal Adenocarcinoma Cell Growth by the Mitotic MPS1 Kinase Inhibitor NMS-P715

M. Korc, B. Herbert, Jae-Hoon Jeong, 2013, Molecular Cancer Therapeutics.

Small Molecule Therapeutics Selective Inhibition of Pancreatic Ductal Adenocarcinoma Cell Growth by the Mitotic MPS 1 Kinase Inhibitor NMSP 715

M. Korc, B. Herbert, Jae-Hoon Jeong, 2014 .

In vivo and in silico analysis of PCNA ubiquitylation in the activation of the Post Replication Repair pathway in S. cerevisiae

Attila Csikász-Nagy, Dario Pescini, Paolo Plevani, 2013, BMC Systems Biology.

Integration of single-cell RNA-seq data into population models to characterize cancer metabolism

Giancarlo Mauri, Hans V. Westerhoff, Chiara Damiani, 2019, PLoS Comput. Biol..

Identification of Myb-binding Protein 1A (MYBBP1A) as a Novel Substrate for Aurora B Kinase

M. Modugno, A. Isacchi, P. Cappella, 2010, The Journal of Biological Chemistry.

Constraining Mechanism Based Simulations to Identify Ensembles of Parametrizations to Characterize Metabolic Features

Giancarlo Mauri, Riccardo Colombo, Dario Pescini, 2016, CIBB.

An ensemble evolutionary constraint-based approach to understand the emergence of metabolic phenotypes

L. Alberghina, G. Mauri, D. Pescini, 2014, Natural Computing.

SupraBiology 2014: Promoting UK-China collaboration on Systems Biology and High Performance Computing

Xiangke Liao, Riccardo Colombo, Hans V. Westerhoff, 2015, Quantitative Biology.

Emerging ensembles of kinetic parameters to characterize observed metabolic phenotypes

G. Mauri, D. Pescini, C. Damiani, 2018, BMC Bioinformatics.

Constraint-Based Modeling and Simulation of Cell Populations

Giancarlo Mauri, Riccardo Colombo, Dario Pescini, 2016, WIVACE.

COSYS: A Computational Infrastructure for Systems Biology

Giancarlo Mauri, Marco S. Nobile, Paolo Cazzaniga, 2016, CIBB.

A Computational Approach for Multi-Level Biological Complex Systems Analysis

Colombo, R. Colombo, Colombo, 2015 .

An ensemble approach to the study of the emergence of metabolic and proliferative disorders via Flux Balance Analysis

Giancarlo Mauri, Riccardo Colombo, Dario Pescini, 2013, WIVACE.

Zooming-in on cancer metabolic rewiring with tissue specific constraint-based models

Giancarlo Mauri, Riccardo Colombo, Chiara Damiani, 2016, Comput. Biol. Chem..

Destabilizing aneuploidy by targeting cell cycle and mitotic checkpoint proteins in cancer cells.

J. Moll, R. Colombo, 2010, Current drug targets.

Proactive Particles in Swarm Optimization: A self-tuning algorithm based on Fuzzy Logic

Giancarlo Mauri, Marco S. Nobile, Paolo Cazzaniga, 2015, 2015 IEEE International Conference on Fuzzy Systems (FUZZ-IEEE).

Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase.

A. Isacchi, S. R. Depaolini, F. Colotta, 2010, Cancer research.

Emerging ensembles of kinetic parameters to characterize observed metabolic phenotypes

Giancarlo Mauri, Monika Heiner, David R. Gilbert, 2018, BMC Bioinformatics.