V. Zannis

发表

Role of Esrrg in the fibrate-mediated regulation of lipid metabolism genes in human ApoA-I transgenic mice

D. Sanoudou, K. Drosatos, K. Hayes, 2009, The Pharmacogenomics Journal.

Transcriptional regulatory mechanisms of the human apolipoprotein genes in vitro and in vivo

D. Kardassis, A. Kritis, V. Zannis, 2001, Current opinion in lipidology.

Structure, evolution, and tissue-specific synthesis of human apolipoprotein AIV.

S. Karathanasis, V. Zannis, I. Yunis, 1986, Biochemistry.

Reconstituted HDL-apoE3 promotes endothelial cell migration through ID1 and its downstream kinases ERK1/2, AKT and p38 MAPK.

C. Mantzoros, D. Kardassis, D. Sanoudou, 2021, Metabolism: clinical and experimental.

Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake.

A. Rigotti, M. Krieger, S. Xu, 1997, Journal of lipid research.

Pleiotropic Functions of HDL Lead to Protection from Atherosclerosis and Other Diseases

D. Kardassis, Panagiotis Fotakis, V. Zannis, 2012 .

Pharmacodynamic and pharmacokinetic analysis of apoE4 [L261A, W264A, F265A, L268A, V269A], a recombinant apolipoprotein E variant with improved biological properties.

V. Zannis, Kyriakos E Kypreos, A. Lampropoulou, 2012, Biochemical pharmacology.

Analysis of the structure and function relationship of human apolipoprotein E in vivo, using adenovirus‐mediated gene transfer

B. Teusink, L. Havekes, V. Zannis, 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux Published, JLR Papers in Press, November 16, 2003. DOI 10.1194/jlr.M300355-JLR200

M. Freeman, A. Mendez, A. L. Morris, 2004, Journal of Lipid Research.

Probing the pathways of chylomicron and HDL metabolism using adenovirus-mediated gene transfer

D. Kardassis, V. Zannis, H. Kan, 2004, Current opinion in lipidology.

SR-BI mediates cholesterol efflux via its interactions with lipid-bound ApoE. Structural mutations in SR-BI diminish cholesterol efflux.

M. Krieger, T. Nieland, V. Zannis, 2005, Biochemistry.

LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice s⃞

V. Zannis, Kyriakos E Kypreos, 2006, Journal of Lipid Research.

Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT.

V. Zannis, Kyriakos E Kypreos, 2007, The Biochemical journal.

Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity.

Jared T. Shaw, T. Kirchhausen, M. Krieger, 2008, Biochemistry.

An indirect negative autoregulatory mechanism involved in hepatocyte nuclear factor-1 gene expression.

I. Talianidis, V. Zannis, A. Kritis, 1993, Nucleic acids research.

Purification and characterization of human erythrocyte purine nucleoside phosphorylase and its subunits.

D. Martin, V. Zannis, D. Doyle, 1978, The Journal of biological chemistry.

Characterization of mutant subunits of human purine nucleoside phosphorylase.

D. Martin, A. Ammann, L. Gudas, 1978, The Journal of biological chemistry.

The complete sequence and structural analysis of human apolipoprotein B‐100: relationship between apoB‐100 and apoB‐48 forms.

D. Atkinson, R. Nolte, C. Cladaras, 1986, The EMBO journal.

Binding specificity and modulation of the human ApoCIII promoter activity by heterodimers of ligand-dependent nuclear receptors.

D. Kardassis, S. Lavrentiadou, M. Hadzopoulou-Cladaras, 1999, Biochemistry.

Functional specificity of two hormone response elements present on the human apoA-II promoter that bind retinoid X receptor alpha/thyroid receptor beta heterodimers for retinoids and thyroids: synergistic interactions between thyroid receptor beta and upstream stimulatory factor 2a.

D. Kardassis, E. Hatzivassiliou, V. Zannis, 2003, The Biochemical journal.

Role of ABCA 1 and ABCG 1 in Atherogenesis

A. Tall, E. Schaefer, M. Diffenderfer, 2010 .

Molecular biology of human apolipoprotein B and related diseases.

D. Kardassis, M. Hussain, C. Cladaras, 1988, Advances in experimental medicine and biology.

An inherited polymorphism in the human apolipoprotein A-I gene locus related to the development of atherosclerosis

R. Norum, J. Breslow, S. Karathanasis, 1983, Nature.

Natural human apoA-I mutations L141RPisa and L159RFIN alter HDL structure and functionality and promote atherosclerosis development in mice.

D. Kardassis, S. Georgopoulos, Panagiotis Fotakis, 2015, Atherosclerosis.

Apolipoprotein gene expression in the rabbit: abundance, size, and distribution of apolipoprotein mRNA species in different tissues.

A. Chobanian, P. Brecher, V. Zannis, 1988, Journal of lipid research.

Complementary DNA derived structure of the amino-terminal domain of human apolipoprotein B and size of its messenger RNA transcript.

R. Nicolosi, A. Nussbaum, C. Cladaras, 1986, Biochemistry.

Regulatory Gene Mutations Affecting Apolipoprotein Gene Expression: Functions and Regulatory Behavior of Known Genes May Guide Future Pharmacogenomic Approaches to Therapy

D. Kardassis, Tong Liu, V. Zannis, 2003, Clinical chemistry and laboratory medicine.

A DNA insertion in the apolipoprotein A-I gene of patients with premature atherosclerosis

J. Breslow, S. Karathanasis, V. Zannis, 1983, Nature.

Regulation of ApoA-I Gene Expression and Prospects to Increase Plasma ApoA-I and HDL Levels

D. Kardassis, D. Sanoudou, K. Drosatos, 2010 .

Promoter elements and factors involved in hepatic transcription of the human ApoA-I gene positive and negative regulators bind to overlapping sites.

P. Monaci, A. Nicosia, D. Ramji, 1991, The Journal of biological chemistry.

Linkage of human apolipoproteins A-I and C-III genes

J. Breslow, S. Karathanasis, V. Zannis, 1983, Nature.

Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease.

C. Abraham, S. Aleshkov, V. Zannis, 1997, Biochemistry.

Old and new players in the lipoprotein system.

V. Zannis, J. Cohen, 2000, Current opinion in lipidology.

LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux.

D. Golenbock, Min Hi Park, M. Fitzgerald, 2015, Biochemistry.

Effect of dietary cholesterol and alloxan-diabetes on tissue cholesterol and apolipoprotein E mRNA levels in the rabbit.

A. Chobanian, P. Brecher, V. Zannis, 1991, Journal of Lipid Research.

The Effect of Natural LCAT Mutations on the Biogenesis of HDL.

D. Kardassis, J. Kuivenhoven, Panagiotis Fotakis, 2015, Biochemistry.

Role of apolipoproteins, ABCA1 and LCAT in the biogenesis of normal and aberrant high density lipoproteins

Panagiotis Fotakis, V. Zannis, Shi Su, 2017, Journal of biomedical research.

ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT[S]

D. Kardassis, E. Stratikos, Panagiotis Fotakis, 2013, Journal of Lipid Research.

Apolipoprotein AIV promotes the biogenesis of apoA-IV containing HDL particles with the participation of ABCA 1 and LCAT

D. Kardassis, E. Stratikos, Panagiotis Fotakis, 2012 .

[40] Intra- and extracellular modifications of apolipoproteins

J. Breslow, S. Karathanasis, V. Zannis, 1986 .

Generation of a Recombinant Apolipoprotein E Variant with Improved Biological Functions

K. V. van Dijk, L. Havekes, V. Zannis, 2005, Journal of Biological Chemistry.

ApoA‐I Functions and Synthesis of HDL: Insights from Mouse Models of Human HDL Metabolism

D. Kardassis, C. Fielding, V. Zannis, 2008 .

Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels

L. Køber, D. Kardassis, R. Frikke-Schmidt, 2011, Journal of internal medicine.

Regulation of Renin Gene Expression in Hypertensive Rats

H. Gavras, V. Zannis, S. Makrides, 1988, Hypertension.

Discrete roles of apoA‐I and apoE in the biogenesis of HDL species: Lessons learned from gene transfer studies in different mouse models

K. Drosatos, V. Zannis, G. Koukos, 2008, Annals of medicine.

The Carboxy-Terminal Region of apoA-I is Required for the ABCA1-Dependent Formation of α-HDL but not preβ-HDL Particles In Vivo

V. Zannis, G. Koukos, A. Chroni, 2007 .

Point mutations in apolipoprotein A-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase deficiency.

Tong Liu, A. Duka, V. Zannis, 2005, Biochemistry.

Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide Published, JLR Papers in Press, April 21, 2004. DOI 10.1194/jlr.M300358-JLR200

T. Kirchhausen, M. Krieger, T. Nieland, 2004, Journal of Lipid Research.

Reconstituted Discoidal ApoE-Phospholipid Particles Are Ligands for the Scavenger Receptor BI

M. Krieger, S. Lavrentiadou, V. Zannis, 2002, The Journal of Biological Chemistry.

SREBP-1 binds to multiple sites and transactivates the human ApoA-II promoter in vitro : SREBP-1 mutants defective in DNA binding or transcriptional activation repress ApoA-II promoter activity.

P. Pissios, V. Zannis, H. Kan, 1999, Arteriosclerosis, thrombosis, and vascular biology.

Tissue-specific posttranslational modification of rat apoE. Synthesis of sialated apoE forms by neonatal rat aortic smooth muscle cells.

N. Bucher, M. Hussain, C. Franzblau, 1988, Journal of lipid research.

8 Lipoproteins and atherogenesis

D. Kardassis, V. Zannis, E. Zanni, 2004 .

[49] Genetic polymorphism in human apolipoprotein E

V. Zannis, 1986 .

Distribution of apolipoprotein A-I, C-II, C-III, and E mRNA in fetal human tissues. Time-dependent induction of apolipoprotein E mRNA by cultures of human monocyte-macrophages.

C. L. Jackson, F. S. Cole, S. Karathanasis, 1985, Biochemistry.

Activation of CAAT Enhancer-binding Protein δ (C/EBPδ) by Interleukin-1 Negatively Influences Apolipoprotein C-III Expression*

I. Talianidis, A. Beigneux, J. Chambaz, 1997, The Journal of Biological Chemistry.

Abstract 584: ApoE3[K146N/R147W] Acts as a Dominant Negative ApoE Form that Prevents Remnant Clearance and Inhibits the Biogenesis of HDL

D. Kardassis, Panagiotis Fotakis, V. Zannis, 2014 .

apoE3[K146N/R147W] acts as a dominant negative apoE form that prevents remnant clearance and inhibits the biogenesis of HDL[S]

D. Kardassis, Panagiotis Fotakis, V. Zannis, 2014, Journal of Lipid Research.

AN APOLIPOPROTEIN E4 FRAGMENT AFFECTS MMP9, TIMP1 AND CYTOKINE LEVELS IN BRAIN CELL LINES

E. Tsilibary, A. Tzinia, V. Zannis, 2012 .

Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4[S]

K. Drosatos, V. Zannis, A. Vezeridis, 2011, Journal of Lipid Research.

Biophysical properties of apolipoprotein E4 variants: implications in molecular mechanisms of correction of hypertriglyceridemia.

D. Gantz, D. Atkinson, V. Zannis, 2008, Biochemistry.

Carboxyl Terminus of Apolipoprotein A-I (ApoA-I) Is Necessary for the Transport of Lipid-free ApoA-I but Not Prelipidated ApoA-I Particles through Aortic Endothelial Cells*

A. von Eckardstein, L. Rohrer, D. Kardassis, 2011, The Journal of Biological Chemistry.

Ultraspiracle, a Drosophila retinoic X receptor alpha homologue, can mobilize the human thyroid hormone receptor to transactivate a human promoter.

E. Hatzivassiliou, P. Cardot, V. Zannis, 1997, Biochemistry.

Promoter elements and factors required for hepatic and intestinal transcription of the human ApoCIII gene.

C. Cladaras, M. Hadzopoulou-Cladaras, V. Zannis, 1990, The Journal of biological chemistry.

Regulation of the human ApoA-II gene by the synergistic action of factors binding to the proximal and distal regulatory elements.

C. Cladaras, J. Chambaz, P. Cardot, 1991, The Journal of biological chemistry.

Promoter elements and factors required for hepatic transcription of the human ApoA-II gene.

C. Cladaras, J. Chambaz, P. Cardot, 1991, The Journal of biological chemistry.

The molecular basis of a familial apoE deficiency. An acceptor splice site mutation in the third intron of the deficient apoE gene.

G. Pavlakis, B. Felber, C. Cladaras, 1987, The Journal of biological chemistry.

High level of expression of functional human platelet alpha 2-adrenergic receptors in a stable mouse C127 cell line.

H. Gavras, D. Vassilatis, C. Flordellis, 1990, Biochimica et biophysica acta.

Alterations of the glutamine residues of human apolipoprotein AI propeptide by in vitro mutagenesis. Characterization of the normal and mutant protein forms.

V. Zannis, A. Roghani, 1988, Biochemistry.

Isolation and characterization of a third isoform of human hepatocyte nuclear factor 4.

I. Talianidis, N. Moschonas, S. Cereghini, 1996, Gene.

Complex interactions between SP1 bound to multiple distal regulatory sites and HNF-4 bound to the proximal promoter lead to transcriptional activation of liver-specific human APOCIII gene.

I. Talianidis, V. Zannis, A. Tambakaki, 1995, Biochemistry.

Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux

V. Zannis, A. Chroni, G. Daniil, 2013, PloS one.

Isolation and characterization of cDNA clones encoding human liver glutamate dehydrogenase: evidence for a small gene family.

J. Papamatheakis, G. Mavrothalassitis, A. Mitsialis, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1.

M. Freeman, Tong Liu, M. Fitzgerald, 2004, Biochemistry.

Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids.

D. Kardassis, I. Talianidis, P. Papakosta, 2003, The Biochemical journal.

The –700/–310 Fragment of the Apolipoprotein A-IV Gene Combined with the –890/–500 Apolipoprotein C-III Enhancer Is Sufficient to Direct a Pattern of Gene Expression Similar to That for the Endogenous Apolipoprotein A-IV Gene*

J. Chambaz, P. Cardot, V. Zannis, 1999, The Journal of Biological Chemistry.

Characterization of the promoter elements required for hepatic and intestinal transcription of the human apoB gene: definition of the DNA-binding site of a tissue-specific transcriptional factor

R. Cortese, D. Kardassis, D. Ramji, 1990, Molecular and cellular biology.

Domains of Apolipoprotein E Contributing to Triglyceride and Cholesterol Homeostasis in Vivo

K. V. van Dijk, L. Havekes, V. Zannis, 2001, The Journal of Biological Chemistry.

Contribution of cysteine 158, the glycosylation site threonine 194, the amino- and carboxy-terminal domains of apolipoprotein E in the binding to amyloid peptide beta (1-40).

S. Lavrentiadou, S. Aleshkov, V. Zannis, 1999, Biochemistry.

HDL-apoA-I induces the expression of angiopoietin like 4 (ANGPTL4) in endothelial cells via a PI3K/AKT/FOXO1 signaling pathway.

D. Kardassis, D. Sanoudou, Panagiotis Fotakis, 2018, Metabolism: clinical and experimental.

Genetic polymorphism in human apolipoprotein E.

V. Zannis, 1986, Methods in enzymology.

Mutagenesis of the glycosylation site of human ApoCIII. O-linked glycosylation is not required for ApoCIII secretion and lipid binding.

V. Zannis, A. Roghani, 1988, The Journal of biological chemistry.

Synthesis, modification, and flotation properties of rat hepatocyte apolipoproteins.

M. Hussain, V. Zannis, E. Zanni, 1989, Biochimica et biophysica acta.

Expression of Multiple α2‐Adrenergic Receptor Messenger RNA Species in Rat Tissues

H. Gavras, M. Castellano, V. Zannis, 1990, Hypertension.

Purification and characterization of a heat stable nuclear factor CIIIB1 involved in the regulation of the human ApoC-III gene.

D. Kardassis, C. Cladaras, V. Zannis, 1991, The Journal of biological chemistry.

Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain Published, JLR Papers in Press, October 16, 2002. DOI 10.1194/jlr.M200313-JLR200

B. Teusink, K. V. van Dijk, L. Havekes, 2003, Journal of Lipid Research.

Genetic mutations affecting human lipoproteins, their receptors, and their enzymes.

D. Kardassis, V. Zannis, E. Zanni, 1993, Advances in human genetics.

Effects of substituents on the rates of deacylation of substituted benzoyl papains. Role of a carboxylate residue in the catalytic mechanism.

J. Kirsch, V. Zannis, 1978, Biochemistry.

Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3.

D. Kardassis, C. Cladaras, P. Cardot, 1992, The Journal of biological chemistry.

Intracellular early and late modifications of human apolipoprotein A-II. Effect of glutamine- +1 to leucine substitution.

J. Chambaz, V. Zannis, E. Zanni, 1994, Biochemistry.

Transcriptional regulation of the human apolipoprotein genes.

D. Kardassis, C. Cladaras, M. Hadzopoulou-Cladaras, 1991, Advances in experimental medicine and biology.

Molecular biology of human apolipoproteins B and E and associated diseases of lipoprotein metabolism.

V. Zannis, 1989, Advances in lipid research.

Organization of the regulatory elements and nuclear activities participating in the transcription of the human apolipoprotein B gene.

D. Kardassis, C. Cladaras, V. Zannis, 1992, The Journal of biological chemistry.

Purification and characterization of the nuclear factor BA1. A transcriptional activator of the human apoB gene.

D. Kardassis, C. Cladaras, V. Zannis, 1990, The Journal of biological chemistry.

Regulation of HDL genes: transcriptional, posttranscriptional, and posttranslational.

A. Dávalos, D. Kardassis, V. Zannis, 2015, Handbook of experimental pharmacology.

Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL

M. Krieger, V. Zannis, A. Chroni, 2006, Journal of Molecular Medicine.

The SP1 sites of the human apoCIII enhancer are essential for the expression of the apoCIII gene and contribute to the hepatic and intestinal expression of the apoA-I gene in transgenic mice.

S. Georgopoulos, V. Zannis, H. Kan, 2000, Nucleic acids research.

High-Density Lipoprotein Attenuates Th1 and Th17 Autoimmune Responses by Modulating Dendritic Cell Maturation and Function

D. Kardassis, E. Drakos, D. Boumpas, 2015, The Journal of Immunology.

Transcriptional regulation of the apolipoprotein A-IV gene involves synergism between a proximal orphan receptor response element and a distant enhancer located in the upstream promoter region of the apolipoprotein C-III gene.

I. Talianidis, V. Zannis, J. Lacorte, 1994, Nucleic acids research.

A Short Proximal Promoter and the Distal Hepatic Control Region-1 (HCR-1) Contribute to the Liver Specificity of the Human Apolipoprotein C-II Gene

D. Kardassis, P. Vorgia, V. Zannis, 1998, The Journal of Biological Chemistry.

The Carboxyl-terminal Hydrophobic Residues of Apolipoprotein A-I Affect Its Rate of Phospholipid Binding and Its Association with High Density Lipoprotein*

A. Jonas, V. Zannis, S. Makrides, 1997, The Journal of Biological Chemistry.

Distal apolipoprotein C-III regulatory elements F to J act as a general modular enhancer for proximal promoters that contain hormone response elements. Synergism between hepatic nuclear factor-4 molecules bound to the proximal promoter and distal enhancer sites.

D. Kardassis, I. Talianidis, M. Hadzopoulou-Cladaras, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Purification and characterization of nuclear factors binding to the negative regulatory element D of human apolipoprotein A-II promoter: a negative regulatory effect is reversed by GABP, an Ets-related protein.

J. Chambaz, P. Cardot, V. Zannis, 1994, Biochemistry.

Factors participating in the liver-specific expression of the human apolipoprotein A-II gene and their significance for transcription.

D. Kardassis, C. Cladaras, J. Chambaz, 1993, Biochemistry.

Secretion of lipid‐poor nascent human apolopoprotein apoAI, apoCIII, and apoE by cell clones expressing the corresponding genes

M. Hussain, C. Cladaras, V. Zannis, 1991, Electrophoresis.

Site-directed mutagenesis and structure-function analysis of the human apolipoprotein A-I. Relation between lecithin-cholesterol acyltransferase activation and lipid binding.

C. Fielding, C. Cladaras, V. Zannis, 1992, The Journal of biological chemistry.

Lipid-free structure and stability of apolipoprotein A-I: probing the central region by mutation.

D. Atkinson, Tong Liu, V. Zannis, 2002, Biochemistry.

Transcriptional regulation of the human apolipoprotein genes.

D. Kardassis, A. Kritis, V. Zannis, 2001, Frontiers in bioscience : a journal and virtual library.

Intracellular modification of human apolipoprotein AII (apoAII) and sites of apoAII mRNA synthesis: comparison of apoAII with apoCII and apoCIII isoproteins.

M. Hussain, V. Zannis, 1990, Biochemistry.

Apolipoprotein A-I Exerts Bactericidal Activity against Yersinia enterocolitica Serotype O:3*

T. Meri, M. Biedzka-Sarek, M. Skurnik, 2011, The Journal of Biological Chemistry.

Cloning and expression of a rat brain alpha 2B-adrenergic receptor.

H. Gavras, D. Handy, C. Flordellis, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Specific Mutations in ABCA1 Have Discrete Effects on ABCA1 Function and Lipid Phenotypes Both In Vivo and In Vitro

M. Hayden, G. Chimini, R. Singaraja, 2006, Circulation research.

Detailed molecular model of apolipoprotein A-I on the surface of high-density lipoproteins and its functional implications.

S. Harvey, J. Segrest, V. Zannis, 2000, Trends in cardiovascular medicine.

Binding of High Density Lipoprotein (HDL) and Discoidal Reconstituted HDL to the HDL Receptor Scavenger Receptor Class B Type I*

M. Krieger, J. Kane, Tong Liu, 2000, Journal of Biological Chemistry.

Inflammatory Signaling Pathways Regulating ApoE Gene Expression in Macrophages*

M. Simionescu, D. Kardassis, V. Zannis, 2007, Journal of Biological Chemistry.

Mechanism of a transcriptional cross talk between transforming growth factor-beta-regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4.

A. Moustakas, D. Kardassis, Aristidis Moustakas, 2003, Molecular biology of the cell.

Direct physical interactions between HNF-4 and Sp1 mediate synergistic transactivation of the apolipoprotein CIII promoter.

D. Kardassis, E. Falvey, M. Hadzopoulou-Cladaras, 2002, Biochemistry.

A Hormone Response Element in the Human Apolipoprotein CIII (ApoCIII) Enhancer Is Essential for Intestinal Expression of the ApoA-I and ApoCIII Genes and Contributes to the Hepatic Expression of the Two Linked Genes in Transgenic Mice*

S. Georgopoulos, V. Zannis, H. Kan, 2000, The Journal of Biological Chemistry.

ApoE isoforms and carboxyl-terminal-truncated apoE4 forms affect neuronal BACE1 levels and Aβ production independently of their cholesterol efflux capacity.

V. Zannis, Christina Raftopoulou, A. Chroni, 2018, The Biochemical journal.

MicroRNA-370 controls the expression of MicroRNA-122 and Cpt1α and affects lipid metabolism[S]

D. Iliopoulos, K. Drosatos, I. Goldberg, 2010, Journal of Lipid Research.

HDL biogenesis, remodeling, and catabolism.

D. Kardassis, M. Jauhiainen, C. Ehnholm, 2015, Handbook of experimental pharmacology.

Characterization of the subunit composition of HGPRTase from human erythrocytes and cultured fibroblasts

L. Gudas, V. Zannis, D. Martin, 1980, Biochemical Genetics.

An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42

E. Tsilibary, E. Stratikos, A. Tzinia, 2010, Journal of neurochemistry.

Role of Apolipoprotein E in Alzheimer’s Disease

D. Kardassis, S. Aleshkov, V. Zannis, 1998 .

Genetic Factors Contributing to Cardiovascular Disease that may affect Endothelial Structure and Function: The Role of Proteins involved in Lipoprotein Transport

D. Kardassis, V. Zannis, E. Zanni, 1996 .

DNA binding specificity and transactivation properties of SREBP-2 bound to multiple sites on the human apoA-II promoter.

J. Chambaz, P. Pissios, V. Zannis, 1999, Nucleic acids research.

A2b Adenosine Receptor Regulates Hyperlipidemia and Atherosclerosis

M. Koupenova, H. Gavras, Dan Yang, 2012, Circulation.

Vascular Medicine A 2 b Adenosine Receptor Regulates Hyperlipidemia and Atherosclerosis

M. Koupenova, H. Gavras, Dan Yang, 2012 .

Biophysical Analysis of Apolipoprotein E3 Variants Linked with Development of Type III Hyperlipoproteinemia

E. Stratikos, V. Zannis, A. Chroni, 2011, PloS one.

Domains of apoE4 required for the biogenesis of apoE-containing HDL

V. Zannis, A. Chroni, A. Vezeridis, 2011, Annals of medicine.

The A 2 b Adenosine Receptor Regulates Hyperlipidemia and Atherosclerosis

M. Koupenova, H. Gavras, Dan Yang, 2011 .

Residues Leu261, Trp264, and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of apolipoprotein E-containing high-density lipoprotein.

K. Drosatos, V. Zannis, Kyriakos E Kypreos, 2007, Biochemistry.

Apolipoprotein A-I of primates.

R. Nicolosi, V. Zannis, 1984, Journal of lipid research.

Binding Specificity and Modulation of the ApoA-I Promoter Activity by Homo- and Heterodimers of Nuclear Receptors (*)

V. Zannis, Iphigenia Tzameli, 1996, The Journal of Biological Chemistry.

Regulation of Human Apolipoprotein M Gene Expression by Orphan and Ligand-dependent Nuclear Receptors*

D. Kardassis, V. Zannis, I. Mosialou, 2010, The Journal of Biological Chemistry.

A Dominant Negative Form of the Transcription Factor c-Jun Affects Genes That Have Opposing Effects on Lipid Homeostasis in Mice*

D. Kardassis, D. Sanoudou, K. Drosatos, 2007, Journal of Biological Chemistry.

Apolipoprotein A 4 of primates

V. Zannis, J. Nicolosi, 2002 .

Apolipoprotein A4 of primates

R. Nicolosi, V. Zannis, 1984 .

Transcriptional regulation of the genes involved in lipoprotein transport. The role of proximal promoters and long-range regulatory elements and factors in apolipoprotein gene regulation.

D. Kardassis, I. Talianidis, V. Zannis, 1996, Hypertension.

Tissue Uptake Mechanisms Involved in the Clearance of Non-Protein Nanoparticles that Mimic LDL Composition: A Study with Knockout and Transgenic Mice

R. Maranhão, C. Mesquita, Panagiotis Fotakis, 2017, Lipids.

mRNA and apolipoprotein E synthesis abnormalities in peripheral blood monocyte macrophages in familial apolipoprotein E deficiency.

J. Ordovás, E. Schaefer, F. S. Cole, 1985, The Journal of biological chemistry.

Murine mammary-derived cells secrete the N-terminal 41% of human apolipoprotein B on high density lipoprotein-sized lipoproteins containing a triacylglycerol-rich core.

I. Talianidis, D. Small, A. Kritis, 1995, Proceedings of the National Academy of Sciences of the United States of America.

The N-terminal 17% of apoB binds tightly and irreversibly to emulsions modeling nascent very low density lipoproteins.

D. Gantz, C. McKnight, D. Small, 2001, Journal of lipid research.

The Central Helices of ApoA-I Can Promote ATP-binding Cassette Transporter A1 (ABCA1)-mediated Lipid Efflux

A. von Eckardstein, Y. Uehara, Tong Liu, 2003, The Journal of Biological Chemistry.

Expression of human apolipoprotein E but not that of apolipoprotein A-I by mouse C127 cells is associated with increased secretion of lipids in the form of vesicles and discs.

A. Tercyak, D. Gantz, D. Small, 1992, Journal of lipid research.

Inhibition of c-Jun-N-terminal Kinase Increases Cardiac Peroxisome Proliferator-activated Receptor α Expression and Fatty Acid Oxidation and Prevents Lipopolysaccharide-induced Heart Dysfunction*

S. Homma, K. Drosatos, P. Schulze, 2011, The Journal of Biological Chemistry.

Substitutions of glutamate 110 and 111 in the middle helix 4 of human apolipoprotein A-I (apoA-I) by alanine affect the structure and in vitro functions of apoA-I and induce severe hypertriglyceridemia in apoA-I-deficient mice.

V. Zannis, H. Kan, A. Chroni, 2004, Biochemistry.

Significance of the hydrophobic residues 225–230 of apoA-I for the biogenesis of HDL1[S]

D. Kardassis, E. Stratikos, Panagiotis Fotakis, 2013, Journal of Lipid Research.

Alteration of negatively charged residues in the 89 to 99 domain of apoA-I affects lipid homeostasis and maturation of HDL[S]

D. Kardassis, A. Duka, V. Zannis, 2011, Journal of Lipid Research.

Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: the abnormal HDL phenotypes can be corrected by treatment with LCAT.

D. Kardassis, A. Duka, V. Zannis, 2007, The Biochemical journal.

Influence of Isoforms and Carboxyl-Terminal Truncations on the Capacity of Apolipoprotein E To Associate with and Activate Phospholipid Transfer Protein.

M. Jauhiainen, J. Metso, V. Zannis, 2015, Biochemistry.

Specific Mutations in ABCA 1 Have Discrete Effects on ABCA 1 Function and Lipid Phenotypes Both In Vivo and In Vitro

M. Hayden, G. Chimini, R. Singaraja, 2006 .

Expression, secretion, and lipid-binding characterization of the N-terminal 17% of apolipoprotein B.

D. Small, C. Cladaras, M. Hadzopoulou-Cladaras, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of glutamate dehydrogenase isoproteins purified from the cerebellum of normal subjects and patients with degenerative neurological disorders, and from human neoplastic cell lines.

M. Hussain, A. Plaitakis, V. Zannis, 1989, The Journal of biological chemistry.

Physical and functional interactions between liver X receptor/retinoid X receptor and Sp1 modulate the transcriptional induction of the human ATP binding cassette transporter A1 gene by oxysterols and retinoids.

D. Kardassis, V. Zannis, E. Thymiakou, 2007, Biochemistry.

Expression of ApoE gene in Chinese hamster cells with a reversible defect in O-glycosylation. Glycosylation is not required for apoE secretion.

M. Krieger, M. Hadzopoulou-Cladaras, V. Zannis, 1989, The Journal of biological chemistry.

Intracellular modifications of human apolipoprotein E.

V. Zannis, D. Silverman, J. vanderSpek, 1986, The Journal of biological chemistry.

Biophysical analysis of progressive C-terminal truncations of human apolipoprotein E4: insights into secondary structure and unfolding properties.

E. Stratikos, V. Zannis, G. Nounesis, 2008, Biochemistry.

Inhibition of hepatocyte nuclear factor 4 transcriptional activity by the nuclear factor kappaB pathway.

D. Kardassis, V. Zannis, Varvara Nikolaidou-Neokosmidou, 2006, The Biochemical journal.

An apolipoprotein E4 fragment affects matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 1 and cytokine levels in brain cell lines

E. Tsilibary, A. Tzinia, V. Zannis, 2012, Neuroscience.

Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain.

V. Zannis, E. Zanni, Kyriakos E Kypreos, 2003, Biochemistry.

ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression Published, JLR Papers in Press, May 1, 2005. DOI 10.1194/jlr.M400479-JLR200

L. Havekes, P. Rensen, K. Willems van Dijk, 2005, Journal of Lipid Research.

Structure and function of apolipoprotein A-I and high-density lipoprotein

S. Harvey, G. Anantharamaiah, J. Segrest, 2000, Current opinion in lipidology.

Allele-dependent thermodynamic and structural perturbations in ApoE variants associated with the correction of dyslipidemia and formation of spherical ApoE-containing HDL particles.

K. Drosatos, E. Stratikos, V. Zannis, 2013, Atherosclerosis.

Structure and stability of apolipoprotein a-I in solution and in discoidal high-density lipoprotein probed by double charge ablation and deletion mutation.

Tong Liu, D. Atkinson, Tong Liu, 2006, Biochemistry.

Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype.

K. V. van Dijk, L. Havekes, V. Zannis, 2003, Biochemistry.

SMAD Proteins Transactivate the Human ApoCIII Promoter by Interacting Physically and Functionally with Hepatocyte Nuclear Factor 4*

D. Kardassis, V. Zannis, Katerina Pardali, 2000, The Journal of Biological Chemistry.

Transactivation of the Human Apolipoprotein CII Promoter by Orphan and Ligand-dependent Nuclear Receptors

D. Kardassis, V. Zannis, Vassilis I. Zannis, 1998, The Journal of Biological Chemistry.

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes.

R J Havel, R. Mahley, R. Havel, 1982, Journal of lipid research.

Characterization of the subunits of purine nucleoside phosphorylase from cultured normal human fibroblasts

L. Gudas, V. Zannis, D. Martin, 1979, Biochemical Genetics.

Role of the hydrophobic and charged residues in the 218–226 region of apoA-I in the biogenesis of HDL1[S]

D. Kardassis, Melissa Beck, E. Stratikos, 2013, Journal of Lipid Research.

apoE3[K146N/R147W] acts as a dominant negative apoE form that prevents remnant clearance and inhibits the biogenesis of HDL[S]

D. Kardassis, Panagiotis Fotakis, V. Zannis, 2014, Journal of Lipid Research.

Abstract 584: ApoE3[K146N/R147W] Acts as a Dominant Negative ApoE Form that Prevents Remnant Clearance and Inhibits the Biogenesis of HDL

D. Kardassis, Panagiotis Fotakis, V. Zannis, 2014 .

LCAT can rescue the abnormal phenotype produced by the natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FIN.

D. Kardassis, A. Duka, V. Zannis, 2007, Biochemistry.

The amino-terminal 1-185 domain of apoE promotes the clearance of lipoprotein remnants in vivo. The carboxy-terminal domain is required for induction of hyperlipidemia in normal and apoE-deficient mice.

L. Havekes, V. Zannis, Kyriakos E Kypreos, 2001, Biochemistry.

ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT[S]

D. Kardassis, E. Stratikos, Panagiotis Fotakis, 2013, Journal of Lipid Research.

Carboxyl Terminus of Apolipoprotein A-I (ApoA-I) Is Necessary for the Transport of Lipid-free ApoA-I but Not Prelipidated ApoA-I Particles through Aortic Endothelial Cells*

A. von Eckardstein, L. Rohrer, D. Kardassis, 2011, The Journal of Biological Chemistry.

Isolation and characterization of cDNA clones corresponding to two different human apoC-l I I alleles

J. Breslow, S. Karathanasis, V. Zannis, 2002 .

Apolipoprotein E

J. Breslow, V. Zannis, 2004, Molecular and Cellular Biochemistry.

Tissue Uptake Mechanisms Involved in the Clearance of Non-Protein Nanoparticles that Mimic LDL Composition: A Study with Knockout and Transgenic Mice

R. Maranhão, C. Mesquita, Panagiotis Fotakis, 2017, Lipids.

Genetic mutations affecting human lipoprotein metabolism.

J. Breslow, V. Zannis, V. I. Zannis, 1985, Advances in human genetics.

Isoproteins of human apolipoprotein A-I demonstrated in plasma and intestinal organ culture.

A. Katz, J. Breslow, V. Zannis, 1980, The Journal of biological chemistry.

Transactivation of the ApoCIII promoter by ATF-2 and repression by members of the Jun family.

D. Kardassis, S. Lavrentiadou, M. Hadzopoulou-Cladaras, 1998, Biochemistry.

Regulation of Human Apolipoprotein M Gene Expression by Orphan and Ligand-dependent Nuclear Receptors*

D. Kardassis, V. Zannis, I. Mosialou, 2010, The Journal of Biological Chemistry.