S. Cocklin

发表

Proteins, recognition networks and developing interfaces for macromolecular biosensing

I. Chaiken, M. Sergi, J. Zurawski, 2004, Journal of molecular recognition : JMR.

IgG Binding Characteristics of Rhesus Macaque FcγR

Adam R Miles, G. Alter, C. Linde, 2016, The Journal of Immunology.

Inhibiting Early-Stage Events in HIV-1 Replication by Small-Molecule Targeting of the HIV-1 Capsid

R. Ptak, J. Sodroski, F. Krebs, 2012, Journal of Virology.

PDZ Domains Facilitate Binding of High Temperature Requirement Protease A (HtrA) and Tail-specific Protease (Tsp) to Heterologous Substrates through Recognition of the Small Stable RNA A (ssrA)-encoded Peptide*

I. Charles, M. Pallen, D. Maskell, 2002, The Journal of Biological Chemistry.

Broad-Spectrum Anti-Human Immunodeficiency Virus (HIV) Potential of a Peptide HIV Type 1 Entry Inhibitor

I. Chaiken, C. Cicala, J. Arthos, 2007, Journal of Virology.

The spliceosomal proteins PPIH and PRPF4 exhibit bi-partite binding.

E. Eisenmesser, Caroline Rajiv, T. Davis, 2017, The Biochemical journal.

Conformational and structural features of HIV-1 gp120 underlying the dual receptor antagonism by cross-reactive neutralizing antibody m18.

D. Dimitrov, J. Gershoni, E. Freire, 2011, Biochemistry.

Clade-Specific Alterations within the HIV-1 Capsid Protein with Implications for Nuclear Translocation

Alexej Dick, S. Cocklin, Megan E. Meuser, 2022, Biomolecules.

Copper Modulates the Catalytic Activity of Protein Kinase CK2

Todd I. Strochlic, Alexej Dick, S. Cocklin, 2022, Frontiers in Molecular Biosciences.

Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities

P. Zhan, Xinyong Liu, Han Ju, 2020, Journal of medicinal chemistry.

Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement.

R. Ptak, N. Madani, Amy M. Princiotto, 2014, Bioorganic & medicinal chemistry letters.

Expression, purification and crystallization of Aspergillus nidulans NmrA, a negative regulatory protein involved in nitrogen-metabolite repression.

D. Stammers, A. Hawkins, C. Nichols, 2001, Acta crystallographica. Section D, Biological crystallography.

Modulation of the ligand binding properties of the transcription repressor NmrA by GATA‐containing DNA and site‐directed mutagenesis

D. Stammers, A. Hawkins, K. Leslie, 2004, Protein science : a publication of the Protein Society.

Broad-Spectrum Anti-Human Immunodeﬁciency Virus (HIV) Potential of a Peptide HIV Type 1 Entry Inhibitor (cid:1)

I. Chaiken, C. Cicala, J. Arthos, 2007 .

Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement.

M. Tuyishime, S. Cocklin, Rae Lawrence, 2016, Bioorganic & medicinal chemistry letters.

The discovery and design of novel HIV-1 capsid modulators and future perspectives

P. Zhan, Xinyong Liu, Xiangyi Jiang, 2022, Expert opinion on drug discovery.

Design, Synthesis, and Mechanism Study of Benzenesulfonamide-containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2020, Journal of medicinal chemistry.

Real‐time monitoring of the membrane‐binding and insertion properties of the cholesterol‐dependent cytolysin anthrolysin O from Bacillus anthracis

I. Chaiken, P. Loll, M. Jost, 2006, Journal of molecular recognition : JMR.

Structure–Activity Relationships of a Novel Capsid Targeted Inhibitor of HIV-1 Replication

Sandhya Kortagere, Roger G. Ptak, Jimmy P. Xu, 2014, J. Chem. Inf. Model..

Design, Synthesis and Structure—Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Molecules.

Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, European journal of medicinal chemistry.

Structure, Function, and Interactions of the HIV-1 Capsid Protein

S. Cocklin, Megan E. Meuser, E. Rossi, 2021, Life.

Recent Advances in HIV-1 Gag Inhibitor Design and Development

Alexej Dick, S. Cocklin, 2020, Molecules.

Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer.

Jimmy P. Xu, S. Cocklin, Rae Lawrence, 2016, Bioorganic & medicinal chemistry letters.

A carrier protein strategy yields the structure of dalbavancin.

P. Loll, S. Cocklin, Isaac Zentner, 2012, Journal of the American Chemical Society.

The high resolution structure of tyrocidine A reveals an amphipathic dimer.

P. Loll, S. Cocklin, V. Nahoum, 2014, Biochimica et biophysica acta.

Phosphorylation of the RNA-binding protein Dazl by MAPKAP kinase 2 regulates spermatogenesis

Todd I. Strochlic, Emily A. McMillan, T. Davis, 2016, Molecular biology of the cell.

Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.

S. Cocklin, Isaac Zentner, F. Huang, 2012, Journal of medicinal chemistry.

New RAD51 Inhibitors to Target Homologous Recombination in Human Cells

A. Gall, Alexej Dick, S. Cocklin, 2021, Genes.

Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors

T. Skorski, S. Cocklin, K. Sullivan, 2016, Nucleic acids research.

Solution structure studies of monomeric human TIP47/perilipin‐3 reveal a highly extended conformation

J. Trewhella, C. Jeffries, R. Hynson, 2012, Proteins.

High-resolution crystal structure reveals molecular details of target recognition by bacitracin

P. Loll, S. Cocklin, N. J. Economou, 2013, Proceedings of the National Academy of Sciences.

Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators

E. De Clercq, C. Pannecouque, P. Zhan, 2022, Molecules.

Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2021, European journal of medicinal chemistry.

From design to biological mechanism evaluation of phenylalanine-bearing HIV-1 capsid inhibitors targeting a vital assembly interface

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Chinese Chemical Letters.

Rapid Optimization of the Metabolic Stability of a Human Immunodeficiency Virus Type-1 Capsid Inhibitor Using a Multistep Computational Workflow.

J. Salvino, Alexej Dick, S. Cocklin, 2021, Journal of medicinal chemistry.

Composition and Orientation of the Core Region of Novel HIV-1 Entry Inhibitors Influences Metabolic Stability

S. Cocklin, Megan E. Meuser, Rama Karadsheh, 2020, Molecules.

Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities.

P. Zhan, Xinyong Liu, Chin-Ho Chen, 2020, European journal of medicinal chemistry.

Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action.

Jimmy P. Xu, R. Ptak, G. Melikyan, 2018, Journal of drug design and research.

The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors

S. Cocklin, S. Navas-Martín, Bianca J. Querido, 2008, Retrovirology.

Antibody Binding Is a Dominant Determinant of the Efficiency of Human Immunodeficiency Virus Type 1 Neutralization

J. Sodroski, I. Chaiken, Xinzhen Yang, 2006, Journal of Virology.

A recombinant allosteric lectin antagonist of HIV‐1 envelope gp120 interactions

I. Chaiken, R. Shattock, S. Cocklin, 2007, Proteins.

Alprazolam Prompts HIV-1 Transcriptional Reactivation and Enhances CTL Response Through RUNX1 Inhibition and STAT5 Activation

Z. Klase, R. Van Duyne, S. Cocklin, 2021, Frontiers in Neurology.

Identification of a Small‐Molecule Inhibitor of HIV‐1 Assembly that Targets the Phosphatidylinositol (4,5)‐bisphosphate Binding Site of the HIV‐1 Matrix Protein

R. Ptak, P. Fedichev, S. Cocklin, 2013, ChemMedChem.

Analysis of the Activities of RAD54, a SWI2/SNF2 Protein, Using a Specific Small-molecule Inhibitor*

N. Tolliday, J. Negri, S. Cocklin, 2013, The Journal of Biological Chemistry.

The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short‐chain dehydrogenase/reductases

D. Stammers, A. Hawkins, C. Nichols, 2001, The EMBO journal.

Pandemic’s silver lining

A. Bradbury, S. D'Angelo, F. Ferrara, 2022, mAbs.

An optimized, synthetic DNA vaccine encoding the toxin A and toxin B receptor binding domains of Clostridium difficile induces protective antibody responses in vivo (VAC7P.958)

N. Sardesai, D. Weiner, M. Kutzler, 2014, Journal of Immunology.

Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.

R. Ptak, P. Fedichev, S. Cocklin, 2013, Bioorganic & medicinal chemistry letters.

Subtype Differences in the Interaction of HIV-1 Matrix with Calmodulin: Implications for Biological Functions

Alexej Dick, S. Cocklin, 2021, Biomolecules.

Insertion of perilipin 3 into a glycero(phospho)lipid monolayer depends on lipid headgroup and acyl chain species[S]

E. Kooijman, E. Mann, Taylor Arhar, 2016, Journal of Lipid Research.

Introducing metallocene into a triazole peptide conjugate reduces its off‐rate and enhances its affinity and antiviral potency for HIV‐1 gp120

I. Chaiken, Ferit Tuzer, S. Cocklin, 2009, Journal of molecular recognition : JMR.

Enhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic MABS C225 and 425

I. Chaiken, U. Rodeck, C. Kari, 2008, Cancer biology & therapy.

Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors.

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Bioorganic & medicinal chemistry.

Discovery of novel 1,2,4‐triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein

E. De Clercq, Dongwei Kang, C. Pannecouque, 2022, Journal of medical virology.

Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors

T. Skorski, S. Cocklin, K. Sullivan, 2016, Nucleic acids research.

Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2019, RSC advances.

Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins.

J. Sodroski, E. Freire, I. Chaiken, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Bioisosteric Replacement as a Tool in Anti-HIV Drug Design

Alexej Dick, S. Cocklin, 2020, Pharmaceuticals.

Mode of action for linear peptide inhibitors of HIV-1 gp120 interactions.

J. Sodroski, D. Burton, E. Freire, 2004, Biochemistry.

Interaction with CD4 and Antibodies to CD4-Induced Epitopes of the Envelope gp120 from a Microglial Cell-Adapted Human Immunodeficiency Virus Type 1 Isolate

Simon Cocklin, I. Chaiken, Francisco González-Scarano, 2005, Journal of Virology.

Reevaluation of the Requirement for TIP47 in Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Incorporation

M. Summers, E. Freed, S. Cocklin, 2013, Journal of Virology.

Field-Based Affinity Optimization of a Novel Azabicyclohexane Scaffold HIV-1 Entry Inhibitor

A. Ward, G. Ozorowski, Adel A Rashad, 2019, Molecules.

Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency

Adel A Rashad, Michael B. Murphy, S. Cocklin, 2018, Molecules.

Structural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1.

J. Sodroski, F. Krebs, Judith M. LaLonde, 2008, Journal of medicinal chemistry.

Structure of the complex between teicoplanin and a bacterial cell-wall peptide: use of a carrier-protein approach.

V. Stojanoff, P. Loll, J. Jakoncic, 2013, Acta crystallographica. Section D, Biological crystallography.

Interaction between the AAA+ ATPase p97 and its cofactor ataxin3 in health and disease: Nucleotide-induced conformational changes regulate cofactor binding

P. Loll, S. Cocklin, Dewight R Williams, 2017, The Journal of Biological Chemistry.

Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library.

Fangfang Zhang, Peng Zhan, Ye Tian, 2018, European journal of medicinal chemistry.

Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators.

E. De Clercq, Dongwei Kang, C. Pannecouque, 2023, RSC medicinal chemistry.

Rapid optimization of the metabolic stability of an HIV-1 capsid inhibitor using a multistep computational workflow

J. Salvino, Alexej Dick, S. Cocklin, 2021 .

Reevaluation of the Requirement for TIP47 in Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Incorporation

M. Summers, E. Freed, S. Cocklin, 2013, Journal of Virology.