K. Suzuki

J. Risteli, E. Gabazza, Koji Suzuki, 2000, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

Activation of Protein C Pathway in the Airways

E. Gabazza, Koji Suzuki, H. Fujimoto, 2002, Lung.

Protein C inhibitor regulates hepatocyte growth factor activator-mediated liver regeneration in mice

S. Uemoto, T. Hamada, Tatsuya Hayashi, 2007, Gut.

Protective role of protein C inhibitor in monocrotaline‐induced pulmonary hypertension

N. Bruno, Tatsuya Hayashi, E. Gabazza, 2006, Journal of thrombosis and haemostasis : JTH.

Characterization of a novel human protein C inhibitor (PCI) gene transgenic mouse useful for studying the role of PCI in physiological and pathological conditions

Tatsuya Hayashi, J. Nishioka, K. Asanuma, 2004, Journal of thrombosis and haemostasis : JTH.

Measurement of protein C inhibitor in seminal plasma is useful for detecting agenesis of seminal vesicles or the vas deferens.

J. Nishioka, J. Kawamura, K. Suzuki, 2000, Journal of andrology.

Molecular cloning, tissue distribution and androgen regulation of rat protein C inhibitor

T. Wakita, Tatsuya Hayashi, J. Nishioka, 1998, FEBS letters.

Protein C Inhibitor Secreted from Activated Platelets Efficiently Inhibits Activated Protein C on Phosphatidylethanolamine of Platelet Membrane and Microvesicles*

Tatsuya Hayashi, J. Nishioka, Koji Suzuki, 1998, The Journal of Biological Chemistry.

Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor.

J. Nishioka, J. Kawamura, K. Suzuki, 1996, European journal of biochemistry.

Protein S Deficiency: A Database of Mutations – Summary of the First Update

P. Reitsma, D. Cooper, F. Bernardi, 2000, Thrombosis and Haemostasis.

The last three consecutive epidermal growth factor-like structures of human thrombomodulin comprise the minimum functional domain for protein C-activating cofactor activity and anticoagulant activity.

S. Yamamoto, I. Maruyama, T. Hayashi, 1989, The Journal of biological chemistry.

Antithrombin and mortality in severe pneumonia patients with sepsis‐associated disseminated intravascular coagulation: an observational nationwide study: comment

H. Wada, K. Suzuki, H. Imai, 2015, Journal of thrombosis and haemostasis : JTH.

Thrombin-catalyzed activation of human coagulation factor V.

B. Dahlbäck, J. Stenflo, K. Suzuki, 1982, The Journal of biological chemistry.

Antithrombotic effect of recombinant human thrombomodulin on thrombin-induced thromboembolism in mice.

S. Yamamoto, I. Maruyama, O. Matsuzaki, 1990, Blood.

Mechanism of inhibition of activated protein C by protein C inhibitor.

J. Nishioka, K. Suzuki, S. Hashimoto, 1984, Journal of biochemistry.

Phenotypic consequence of the gene abnormality in the platelet glycoprotein IX gene observed in a patient with Bernard-Soulier syndrome through mammalian cell expression system.

T. Hayashi, K. Suzuki, T. Kato, 1999, Thrombosis research.

Cleavage site of calcium-dependent protease in human platelet membrane glycoprotein Ib.

K. Suzuki, G. Kōsaki, H. Yamazaki, 1986, Thrombosis research.

Adenosine regulates tissue factor expression on endothelial cells.

E. Gabazza, H. Deguchi, K. Suzuki, 1998, Thrombosis research.

Thrombin in the Airways of Asthmatic Patients

E. Gabazza, Koji Suzuki, Tetsu Kobayashi, 1999, Lung.

Thrombin stimulates the expression of PDGF in lung epithelial cells.

Tatsuya Hayashi, E. Gabazza, M. Ido, 2000, American journal of physiology. Lung cellular and molecular physiology.

Anti‐inflammatory effect of activated protein C in gastric epithelial cells

E. Gabazza, K. Fukudome, O. Taguchi, 2005, Journal of thrombosis and haemostasis : JTH.

Long-term inhalation of high-dose nitric oxide increases intraalveolar activation of coagulation system in mice.

E. Gabazza, O. Taguchi, Y. Adachi, 2001, American journal of respiratory and critical care medicine.

Protein C anticoagulant system in patients with interstitial lung disease.

J. Nishioka, E. Gabazza, H. Wada, 1998, American journal of respiratory and critical care medicine.

Molecular cloning, expression and tissue distribution of canine lipopolysaccharide (LPS)-binding protein.

T. Hayashi, K. Suzuki, N. Hanamura, 1998, Biochimica et biophysica acta.

Expression and Cytoprotective Effect of Protease-activated Receptor-1 in Gastric Epithelial Cells

H. Inoue, E. Gabazza, O. Taguchi, 2003, Scandinavian journal of gastroenterology.

Primary structure of vitamin K-dependent human protein Z.

J. Nishioka, Y. Deyashiki, T. Hayashi, 1990, Biochemical and biophysical research communications.

Protein S Deficiency: A Database of Mutations

P. Reitsma, D. Cooper, F. Bernardi, 1997, Thrombosis and Haemostasis.

Successful treatment of deep vein thrombosis in homozygous protein C deficiency with activated protein C

H. Wada, K. Suzuki, S. Shirakawa, 1993, American journal of hematology.

Dilazep, an antiplatelet agent, inhibits tissue factor expression in endothelial cells and monocytes.

E. Gabazza, Koji Suzuki, H. Wada, 1997, Blood.

Protein S is essential for the activated protein C-catalyzed inactivation of platelet-associated factor Va.

J. Nishioka, M. Matsuda, K. Suzuki, 1984, Journal of biochemistry.

Anti-beta2-glycoprotein I (beta2GPI) monoclonal antibodies with lupus anticoagulant-like activity enhance the beta2GPI binding to phospholipids.

T. Koike, E. Gabazza, E. Matsuura, 1997, The Journal of clinical investigation.

A re‐evaluation of the D‐dimer cut‐off value for making a diagnosis according to the ISTH overt‐DIC diagnostic criteria: communication from the SSC of the ISTH

J. Thachil, T. Iba, H. Wada, 2018, Journal of thrombosis and haemostasis : JTH.

β2-Glycoprotein I Modulates the Anticoagulant Activity of Activated Protein C on the Phospholipid Surface

J. Nishioka, E. Gabazza, Koji Suzuki, 1996, Thrombosis and Haemostasis.

Increased vascular endothelial cell markers in patients with chronic renal failure on maintenance haemodialysis

H. Wada, K. Suzuki, M. Takagi, 1994, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

A thrombin-based peptide corresponding to the sequence of the thrombomodulin-binding site blocks the procoagulant activities of thrombin.

J. Nishioka, K. Suzuki, 1991, The Journal of biological chemistry.

Localization of thrombomodulin-binding site within human thrombin.

J. Nishioka, T. Hayashi, K. Suzuki, 1990, The Journal of biological chemistry.

Gene organization of human protein C inhibitor, a member of SERPIN family proteins encoded in five exons.

T. Hayashi, K. Suzuki, 1993, International journal of hematology.

Renal blood flow, fibrinolysis, and platelet aggregation following tacrolimus (FK 506) treatment in rats.

J. Małyszko, T. Urano, Y. Takada, 1995, Thrombosis research.

Identical binding site on human platelets for von Willebrand factor and bovine platelet aggregating factor.

J. Nishioka, K. Suzuki, S. Hashimoto, 1980, Thrombosis research.

Enzyme immunoassay of human protein C by using monoclonal antibodies.

K. Suzuki, S. Mutoh, A. Nagayoshi, 1985, Thrombosis research.

Protein C Inhibitor: Structure and Function

J. Nishioka, Koji Suzuki, K. Toma, 1989, Thrombosis and Haemostasis.

Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation.

S. Yamamoto, I. Maruyama, J. Nishioka, 1987, The EMBO journal.

Fibrinolysis and serotonin under cyclosporine A treatment in renal transplant recipients.

J. Małyszko, Y. Takada, A. Takada, 1994, Thrombosis research.

[Scrotum exfoliative dermatitis with ulcers associated with treatment of acute promyelocytic leukemia with all-trans retinoic acid].

K. Tajima, T. Hayashi, K. Suzuki, 1998, [Rinsho ketsueki] The Japanese journal of clinical hematology.

Serotonergic measures in cyclosporine A treated rats.

J. Małyszko, Y. Takada, A. Takada, 1994, Thrombosis research.

Severe Bleeding Tendency in a Patient With Bernard‐Soulier Syndrome Associated With a Homozygous Single Base Pair Deletion in the Gene Coding for the Human Platelet Glycoprotein Ibα

Tomohiro Hayashi, K. Hayasaka, T. Hayashi, 1998, Journal of pediatric hematology/oncology.

Functional characterization of the 5'-regulatory region of the human thrombomodulin gene.

S. Hirosawa, K. Suzuki, K. Hirokawa, 1993, Journal of biochemistry.

Monoclonal antibodies for human thrombomodulin which recognize binding sites for thrombin and protein C.

T. Hayashi, K. Suzuki, 1990, Journal of biochemistry.

Regulation of activated protein C by thrombin-modified protein S.

J. Nishioka, K. Suzuki, S. Hashimoto, 1983, Journal of biochemistry.

Activated protein C attenuates coagulation‐associated over‐expression of fibrinolytic activity by suppressing the thrombin‐dependent inactivation of PAI‐1

F. Castellino, H. Mogami, T. Urano, 2003, Journal of thrombosis and haemostasis : JTH.

Characterization of the binding of factor Xa to fibrinogen/fibrin derivatives and localization of the factor Xa binding site on fibrinogen.

E. Gabazza, T. Nakagaki, K. Suzuki, 1995, European journal of biochemistry.

Vancomycin as well as ristocetin facilitates von Willebrand factor binding to platelets.

J. Nishioka, K. Suzuki, S. Hashimoto, 1980, Thrombosis research.

The influence of 2-mercaptoethanol on von Willebrand factor and bovine platelet aggregating factor.

J. Nishioka, K. Suzuki, S. Hashimoto, 1980, Thrombosis research.

Mapping active sites of blood coagulation serine proteases--activated protein C and thrombin--on simple graphics models.

K. Toma, K. Suzuki, 1989, Journal of molecular graphics.

Response of protein C and protein C inhibitor to warfarin therapy in patient with combined deficiency of Factors V and VIII.

C. Arkin, L. Hoyer, K. Suzuki, 1984, Thrombosis research.

Receptor-mediated endocytosis of thrombin-antithrombin III complex by the human monocytoid cell line U937.

T. Hamada, K. Suzuki, H. Takeya, 1994, Biochemical and biophysical research communications.

Differential regulation of protein S expression in hepatocytes and sinusoidal endothelial cells in rats with cirrhosis

S. Uemoto, Tatsuya Hayashi, J. Nishioka, 2006, Journal of thrombosis and haemostasis : JTH.

Isolation and characterisation of Kasumi-1 human myeloid leukaemia cell line resistant to tumour necrosis factor alpha-induced apoptosis.

M. Ido, Y. Komada, K. Suzuki, 1996, British Journal of Cancer.

Molecular mechanism of the dysfunction of protein S(Tokushima) (Lys155-->Glu) for the regulation of the blood coagulation system.

J. Nishioka, T. Hayashi, K. Suzuki, 1995, Biochimica et biophysica acta.

Protein S Tokushima: abnormal molecule with a substitution of Glu for Lys-155 in the second epidermal growth factor-like domain of protein S.

Tatsuya Hayashi, J. Nishioka, T. Hayashi, 1994, Blood.

Functional thrombomodulin expression on epithelial skin tumours as a differentiation marker for suprabasal keratinocytes

S. Ohyanagi, T. Hayashi, K. Suzuki, 1996, The British journal of dermatology.

Protease activated receptor 1 activation of platelet is associated with an increase in protein kinase CK2 activity

M. Ido, T. Hayashi, K. Suzuki, 2008, Journal of thrombosis and haemostasis : JTH.

Inhibition of cofactor activity of protein S by a complex of protein S and C4b-binding protein. Evidence for inactive ternary complex formation between protein S, C4b-binding protein, and activated protein C.

J. Nishioka, K. Suzuki, 1990, The Journal of biological chemistry.

Regulatory mechanisms of C4b‐binding protein (C4BP)α and β expression in rat hepatocytes by lipopolysaccharide and interleukin‐6

J. Nishioka, N. Akita, E. Gabazza, 2008, Journal of thrombosis and haemostasis : JTH.

Lipopolysaccharide‐induced decreased protein S expression in liver cells is mediated by MEK/ERK signaling and NFκB activation: involvement of membrane‐bound CD14 and toll‐like receptor‐4

Tatsuya Hayashi, J. Nishioka, E. Gabazza, 2006, Journal of thrombosis and haemostasis : JTH.

One-step sandwich enzyme immunoassays for human C4b-binding protein (C4BP) and protein S-C4BP complex using monoclonal antibodies.

S. Yoshida, K. Iwata, T. Hoshino, 1995, Clinica chimica acta; international journal of clinical chemistry.

Plasma protein S activity measured using Protac, a snake venom derived activator of protein C.

J. Nishioka, K. Suzuki, 1988, Thrombosis research.

Protein C activation in NIDDM patients

M. Sata, K. Murata, J. Nishioka, 1996, Diabetologia.

Hemostatic abnormalities in patients with pulmonary embolism compared with that in deep vein thrombosis

T. Nakano, H. Shiku, H. Wada, 1995, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Inhibition of factor VIII-associated platelet aggregation by heparin and dextran sulfate, and its mechanism.

J. Nishioka, K. Suzuki, S. Hashimoto, 1979, Biochimica et biophysica acta.

Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C.

S. Yamamoto, I. Maruyama, T. Shirai, 1988, Journal of biochemistry.

Organization and chromosomal localization of the human endothelial protein C receptor gene.

T. Wakita, Tatsuya Hayashi, Koji Suzuki, 1999, Gene.

Aspartic acid 349 in the fourth epidermal growth factor-like structure of human thrombomodulin plays a role in its Ca(2+)-mediated binding to protein C.

S. Yamamoto, T. Hayashi, G. Honda, 1991, The Journal of biological chemistry.

Efficacy and safety of anticoagulant therapy in three specific populations with sepsis: a meta‐analysis of randomized controlled trials: comment

H. Wada, K. Suzuki, H. Imai, 2016, Journal of Thrombosis and Haemostasis.

Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse.

E. Gabazza, Tetsu Kobayashi, O. Taguchi, 2001, American journal of respiratory and critical care medicine.

Increased endothelial and epidermal thrombomodulin expression and plasma thrombomodulin level in progressive systemic sclerosis.

H. Mizutani, T. Hayashi, K. Suzuki, 1996, Acta medica Okayama.

The role of human factor X activation peptide in activation of factor X by factor IXa.

J. Nishioka, T. Nakagaki, K. Suzuki, 1994, Journal of biochemistry.

Protein C inhibitor directly and potently inhibits activated hepatocyte growth factor activator

Tatsuya Hayashi, J. Nishioka, E. Gabazza, 2007, Journal of thrombosis and haemostasis : JTH.

[Factor V].

J. Nishioka, K. Suzuki, 1987, Rinsho byori. The Japanese journal of clinical pathology.

The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin.

E. Gabazza, M. Ido, Y. Adachi, 1999, International journal of oncology.

Characterization of functionally important regions of tissue factor by using monoclonal antibodies.

J. Nishioka, T. Ito, K. Suzuki, 1993, Journal of biochemistry.

Protein S Tokushima: An Abnormal Protein S Found in a Japanese Family with Thrombosis

J. Nishioka, T. Hayashi, K. Suzuki, 1993, Thrombosis and Haemostasis.

Binding site for vitamin K-dependent protein S on complement C4b-binding protein.

J. Nishioka, K. Suzuki, 1988, The Journal of biological chemistry.

Successful intravenous interferon-beta treatment of chronic hepatitis C in a patient with Bernard-Soulier syndrome.

K. Tajima, T. Hayashi, K. Suzuki, 2000, Thrombosis research.

Increased activated protein C‐protein C inhibitor complex level in patients positive for lupus anticoagulant

H. Wada, T. Hayashi, K. Suzuki, 1994, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Coagulation and fibrinolytic activities in 2 siblings with beta(2)-glycoprotein I deficiency.

A. Tsutsumi, T. Koike, S. Yasuda, 2000, Blood.

Blood coagulation factor Xa interacts with a linear sequence of the kringle 2 domain of prothrombin.

J. Nishioka, K. Suzuki, H. Takeya, 1994, Journal of Biochemistry (Tokyo).

Early detection of AML1/MTG8 fusion mRNA by RT-PCR in the bone marrow cells from a patient with isolated granulocytic sarcoma

K. Tajima, T. Hayashi, K. Suzuki, 1998, Leukemia.

Antithrombin or thrombomodulin administration in severe pneumonia patients with sepsis and disseminated intravascular coagulation: comment on two papers

H. Wada, K. Suzuki, H. Imai, 2015, Journal of thrombosis and haemostasis : JTH.

Prothrombin kringle 1 domain interacts with factor Va during the assembly of prothrombinase complex.

J. Nishioka, E. Gabazza, H. Deguchi, 1997, The Biochemical journal.

Inherited deficiency of functional and free form protein S.

J. Nishioka, K. Nakamura, T. Mori, 1989, Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society.

Plasminogen activators and plasminogen activator inhibitor 1 in urinary tract cancer.

T. Urano, Y. Takada, A. Takada, 1994, Urologia internationalis.