Michał Romański

发表

A novel open source tool for ELISA result analysis.

M. Zielińska, G. Garbacz, D. Danielak, 2020, Journal of pharmaceutical and biomedical analysis.

The Influence of Paracetamol on the Penetration of Sorafenib and Sorafenib N-Oxide Through the Blood–Brain Barrier in Rats

A. Stachowiak, E. Grześkowiak, Michał Romański, 2020, European Journal of Drug Metabolism and Pharmacokinetics.

Disposition of treosulfan and its active monoepoxide in a bone marrow, liver, lungs, brain, and muscle: Studies in a rat model with clinical relevance

A. Ziółkowska, F. Główka, Michał Romański, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Determination of prodrug treosulfan and its biologically active monoepoxide in rat plasma, liver, lungs, kidneys, muscle, and brain by HPLC–ESI–MS/MS method

F. Główka, C. Żaba, Michał Romański, 2017, Journal of pharmaceutical and biomedical analysis.

Penetration of Treosulfan and its Active Monoepoxide Transformation Product into Central Nervous System of Juvenile and Young Adult Rats

F. Główka, Michał Romański, J. Baumgart, 2015, Drug Metabolism and Disposition.

Effect of Temperature on the Kinetics of the Activation of Treosulfan and Hydrolytic Decomposition of Its Active Epoxy Derivatives.

F. Główka, Michał Romański, J. Mikołajewski, 2017, Journal of pharmaceutical sciences.

Dissolution of a Biopharmaceutics Classification System Class II Free Acid from Immediate Release Tablets Containing a Microenvironmental pH Modulator: Comparison of a Biorelevant Bicarbonate Buffering System with Phosphate Buffers

G. Garbacz, Michał Romański, Dagmara Hoc, 2022, AAPS PharmSciTech.

Ocular disposition of treosulfan and its active epoxy-transformers following intravenous administration in rabbits.

F. Główka, Michał Romański, A. Karbownik, 2016, Drug metabolism and pharmacokinetics.

Treosulfan Pharmacokinetics and its Variability in Pediatric and Adult Patients Undergoing Conditioning Prior to Hematopoietic Stem Cell Transplantation: Current State of the Art, In-Depth Analysis, and Perspectives

J. Wachowiak, F. Główka, Michał Romański, 2018, Clinical Pharmacokinetics.

Kinetic and Mechanistic Study of the pH-Dependent Activation (Epoxidation) of Prodrug Treosulfan Including the Reaction Inhibition in a Borate Buffer.

F. Główka, Michał Romański, Whitney Ratajczak, 2017, Journal of pharmaceutical sciences.

High-dose treosulfan in conditioning prior to hematopoietic stem cell transplantation

J. Wachowiak, F. Główka, Michał Romański, 2010, Expert opinion on investigational drugs.

Clinical bioanalysis of treosulfan and its epoxides: The importance of collected blood processing for valid pharmacokinetic results

F. Główka, Michał Romański, 2018, Journal of pharmaceutical and biomedical analysis.

Population pharmacokinetic approach for evaluation of treosulfan and its active monoepoxide disposition in plasma and brain on the basis of a rat model

D. Danielak, F. Główka, Michał Romański, 2020, Pharmacological Reports.

N-7-Guanine Adduct of the Active Monoepoxide of Prodrug Treosulfan: First Synthesis, Characterization, and Decomposition Profile Under Physiological Conditions.

F. Główka, Michał Romański, U. Girreser, 2018, Journal of pharmaceutical sciences.

Formation Rate-Limited Pharmacokinetics of Biologically Active Epoxy Transformers of Prodrug Treosulfan.

F. Główka, Michał Romański, A. Karbownik, 2016, Journal of pharmaceutical sciences.

Activation of Prodrug Treosulfan at pH 7.4 and 37°C Accompanied by Hydrolysis of Its Active Epoxides: Kinetic Studies with Clinical Relevance.

B. Urbaniak, Z. Kokot, F. Główka, 2015, Journal of pharmaceutical sciences.

Pharmacokinetics of treosulfan and its active monoepoxide in pediatric patients after intravenous infusion of high-dose treosulfan prior to HSCT.

J. Wachowiak, A. Wiela-Hojeńska, F. Główka, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Rapid and sensitive liquid chromatography-tandem mass spectrometry method for determination of protein-free pro-drug treosulfan and its biologically active monoepoxy-transformer in plasma and brain tissue.

F. Główka, C. Żaba, Michał Romański, 2014, Talanta.

Determination of partition coefficients n-octanol/water for treosulfan and its epoxy-transformers: an example of a negative correlation between lipophilicity of unionized compounds and their retention in reversed-phase chromatography.

F. Główka, Anna Siemiątkowska, Michał Romański, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

HPLC method for determination of biologically active epoxy-transformers of treosulfan in human plasma: pharmacokinetic application.

F. Główka, C. Żaba, Michał Romański, 2012, Journal of pharmaceutical and biomedical analysis.

In Vitro Study of the Enzymatic and Nonenzymatic Conjugation of Treosulfan with Glutathione

F. Główka, Michał Romański, 2019, European Journal of Drug Metabolism and Pharmacokinetics.

Liquid chromatography-tandem mass spectrometry method for simultaneous determination of three N-7-guanine adducts of the active epoxides of prodrug treosulfan in DNA in vitro.

F. Główka, Michał Romański, A. Tężyk, 2019, Talanta.

Direct high-performance liquid chromatography method with refractometric detection designed for stability studies of treosulfan and its biologically active epoxy-transformers.

F. Główka, C. Żaba, Michał Romański, 2012, Journal of pharmaceutical and biomedical analysis.

Kinetics of in Vitro Guanine- N7-Alkylation in Calf Thymus DNA by (2 S,3 S)-1,2-Epoxybutane-3,4-diol 4-methanesulfonate and (2 S,3 S)-1,2:3,4-Diepoxybutane: Revision of the Mechanism of DNA Cross-Linking by the Prodrug Treosulfan.

F. Główka, Michał Romański, A. Pogorzelska, 2019, Molecular pharmaceutics.

Application of a novel PhysioCell apparatus for biopredictive dissolution tests of oral immediate release formulations - a case study workflow for in vitro-in vivo predictions.

G. Garbacz, J. Dobosz, D. Danielak, 2023, International journal of pharmaceutics.

Conjunction of semi-mechanistic in vitro-in vivo modeling and population pharmacokinetics as a tool for virtual bioequivalence analysis - a case study for a BCS class II drug.

G. Garbacz, D. Danielak, Michał Romański, 2023, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

PhysioCell^®; — a Novel, Bio-relevant Dissolution Apparatus: Hydrodynamic Conditions and Factors Influencing the Dissolution Dynamics

G. Garbacz, J. Dobosz, D. Danielak, 2023, AAPS PharmSciTech.

A Rational Approach to Predicting Immediate Release Formulation Behavior in Multiple Gastric Motility Patterns: A Combination of a Biorelevant Apparatus, Design of Experiments, and Machine Learning

S. Polak, G. Garbacz, J. Dobosz, 2023, Pharmaceutics.

More Than a Gut Feeling—A Combination of Physiologically Driven Dissolution and Pharmacokinetic Modeling as a Tool for Understanding Human Gastric Motility

D. Danielak, Grzegorz Banach, Michał Romański, 2024, Molecular pharmaceutics.

Drug dissolution and transit in a heterogenous gastric chyme after fed administration: Semi-mechanistic modeling and simulations for an immediate-release and orodispersible tablets containing a poorly soluble drug.

D. Danielak, M. Gajda, Michał Romański, 2024, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

An extension of biorelevant fed-state dissolution tests to clinical pharmacokinetics - a study on gastrointestinal factors influencing rivaroxaban exposure and efficacy in atrial fibrillation patients.

G. Garbacz, D. Danielak, Michał Romański, 2023, International journal of pharmaceutics.

High-dose treosulfan in conditioning prior to hematopoietic stem cell transplantation

J. Wachowiak, F. Główka, Michał Romański, 2010, Expert opinion on investigational drugs.

In Vitro Simulation of the Fasted Gastric Conditions and Their Variability to Elucidate Contrasting Properties of the Marketed Dabigatran Etexilate Pellet-Filled Capsules and Loose Pellets.

D. Danielak, Michał Romański, J. Paszkowska, 2024, Molecular pharmaceutics.