I. Kathmann

发表

Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells.

Y. Assaraf, J. Schornagel, D. Priest, 1997, Advances in enzyme regulation.

Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1)

Rob Pieters, Gerrit Jansen, Godefridus J. Peters, 2014, Cancer Chemotherapy and Pharmacology.

Folate homeostasis of cancer cells affects sensitivity to not only antifolates but also other non-folate drugs: effect of MRP expression

G. Peters, G. Jansen, I. Kathmann, 2013 .

Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1).

G. Peters, R. Pieters, Y. Assaraf, 2004, Biochemical pharmacology.

A Structurally Altered Human Reduced Folate Carrier with Increased Folic Acid Transport Mediates a Novel Mechanism of Antifolate Resistance*

G. Peters, Y. Assaraf, J. Schornagel, 1998, The Journal of Biological Chemistry.

Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of reduced folates.

J. Schornagel, G. Jansen, G. Rijksen, 1990, The Journal of biological chemistry.

Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360)

G. Peters, L. Jeong, Dzjemma Sarkisjan, 2013, Investigational New Drugs.

Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco‐2 cells

E. Giovannetti, G. Peters, G. Jansen, 2008, International journal of cancer.

Cellular folate status modulates the expression of BCRP and MRP multidrug transporters in cancer cell lines from different origins

E. Giovannetti, G. Peters, J. Beliën, 2009, Molecular Cancer Therapeutics.

Lipoamino acid conjugates of methotrexate with antitumor activity.

G. Jansen, I. Toth, R. Pignatello, 1998, Journal of pharmaceutical sciences.

Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo

G. Peters, G. Jansen, H. Pinedo, 2008, Cancer Chemotherapy and Pharmacology.

Functional aspects of membrane folate receptors in human breast cancer cells with transport-related resistance to methotrexate

J. Schornagel, G. Jansen, C. Molthoff, 1996, Cancer Chemotherapy and Pharmacology.

Impact of cellular folate status and epidermal growth factor receptor expression on BCRP/ABCG2-mediated resistance to gefitinib and erlotinib

E. Giovannetti, G. Jansen, C. Calhau, 2009, British Journal of Cancer.

Epithelial Transfer of the Tyrosine Kinase Inhibitors Erlotinib, Gefitinib, Afatinib, Crizotinib, Sorafenib, Sunitinib, and Dasatinib: Implications for Clinical Resistance

E. Giovannetti, G. Peters, C. Tibaldi, 2020, Cancers.

Nitric oxide releasing acridone carboxamide derivatives as reverters of doxorubicin resistance in MCF7/Dx cancer cells.

G. Peters, I. Kathmann, V. Rajendra Prasad, 2016, Bioorganic chemistry.

Oxaliplatin activity in selected and unselected human ovarian and colorectal cancer cell lines.

G. Peters, P. Noordhuis, I. Kathmann, 2008, Biochemical pharmacology.

Subcellular localization of several structurally different tyrosine kinase inhibitors

G. Peters, Sarina Hitzerd, I. Kathmann, 2018, ADMET and DMPK.

Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.

G. Peters, J. Schornagel, A. Jackman, 1995, Molecular pharmacology.

RX-3117 (Fluorocyclopentenyl-Cytosine)-Mediated Down-Regulation of DNA Methyltransferase 1 Leads to Protein Expression of Tumor-Suppressor Genes and Increased Functionality of the Proton-Coupled Folate Carrier

G. Peters, L. Matherly, Dzjemma Sarkisjan, 2020, International journal of molecular sciences.

Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: role of carrier- and receptor-mediated transport systems.

J. Schornagel, G. Jansen, A. Jackman, 1991, Cancer research.

Expression of a folate binding protein in L1210 cells grown in low folate medium.

J. Schornagel, G. Jansen, B. Braakhuis, 1989, Cancer research.

Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.

G. Peters, Y. Assaraf, J. Schornagel, 2002, Biochemical pharmacology.

Loss of Multidrug Resistance Protein 1 Expression and Folate Efflux Activity Results in a Highly Concentrative Folate Transport in Human Leukemia Cells*

G. Peters, B. Dijkmans, Y. Assaraf, 2003, The Journal of Biological Chemistry.

Identification of a membrane-associated folate-binding protein in human leukemic CCRF-CEM cells with transport-related methotrexate resistance.

J. Schornagel, G. Jansen, G. Rijksen, 1989, Cancer research.

Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA

G. Peters, Dzjemma Sarkisjan, I. Kathmann, 2016, Nucleosides, nucleotides & nucleic acids.

Mechanisms of acquired resistance to methotrexate in a human squamous carcinoma cell line of the head and neck, exposed to different treatment schedules.

J. Schornagel, G. Hordijk, G. Jansen, 1991, European journal of cancer.

Induction of Resistance to the Lipophilic Cytarabine Prodrug Elacytarabine (CP-4055) in CEM Leukemic Cells

G. Peters, I. Kathmann, N. Losekoot, 2010, Nucleosides, nucleotides & nucleic acids.

The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis.

G. Peters, Y. Assaraf, A. Veerman, 2003, Biochemical pharmacology.

ABCG2 harboring the Gly482 mutation confers high-level resistance to various hydrophilic antifolates.

G. Peters, S. Bates, Y. Assaraf, 2005, Cancer research.

Acquired resistance of human T cells to sulfasalazine: stability of the resistant phenotype and sensitivity to non-related DMARDs

Y. Assaraf, G. Jansen, G. Scheffer, 2004, Annals of the rheumatic diseases.

The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates.

G. Peters, J. Wijnholds, P. Wielinga, 2005, Cancer research.

Antifolates Folates and Can Mediate Cellular Resistance against The Human Multidrug Resistance Protein MRP 5 Transports

G. Peters, J. Wijnholds, P. Wielinga, 2005 .

Development of sulfasalazine resistance in human T cells induces expression of the multidrug resistance transporter ABCG2 (BCRP) and augmented production of TNFα

B. Dijkmans, W. Lems, C. Schalkwijk, 2004, Annals of the rheumatic diseases.

Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy.

G. Peters, Y. Assaraf, G. Jansen, 2004, Blood.

Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration.

G. Peters, Y. Assaraf, D. Priest, 1999, Molecular pharmacology.

Measurement of folylpolyglutamate synthetase activity in head and neck squamous carcinoma cell lines and clinical samples using a new rapid separation procedure.

J. Schornagel, G. Hordijk, G. Jansen, 1992, Oncology research.

cells: implications for efficacy of methotrexate therapy methotrexate and its metabolite 7-hydroxymethotrexate in leukemia Disparate mechanisms of antifolate resistance provoked by

G. Peters, Y. Assaraf, G. Jansen, 2013 .

Schedule-Dependent Synergy Between the Histone Deacetylase Inhibitor Belinostat and the Dihydrofolate Reductase Inhibitor Pralatrexate in T-and B-cell Lymphoma Cells in vitro

G. Peters, G. Jansen, I. Kathmann, 2020, Frontiers in Cell and Developmental Biology.

Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function

E. Giovannetti, G. Peters, P. Pauwels, 2020, Journal of cellular physiology.

Synthesis of 2‐Fluoro N10‐Substituted Acridones and Their Cytotoxicity Studies in Sensitive and Resistant Cancer Cell Lines and Their DNA Intercalation Studies

G. Peters, Y. C. Mayur, I. Kathmann, 2009, Archiv der Pharmazie.

Cytotoxicity studies of some novel fluoro acridone derivatives against sensitive and resistant cancer cell lines and their mechanistic studies.

G. Peters, I. Kathmann, C. Lemos, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Transport of six tyrosine kinase inhibitors: active or passive ?

G. Peters, I. Kathmann, R. Honeywell, 2016 .

Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco‐2 cells

E. Giovannetti, G. Peters, G. Jansen, 2008, International journal of cancer.

Cytotoxicity studies of some novel fluoro acridone derivatives against sensitive and resistant cancer cell lines and their mechanistic studies.

G. Peters, Y. C. Mayur, I. Kathmann, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Mechanisms of resistance against methotrexate and novel antifolates in human CCRF-CEM leukemia cells

G. Peters, J. Schornagel, G. Jansen, 1997 .