V. Leaner

发表

AP-1 complexes containing cJun and JunB cause cellular transformation of Rat1a fibroblasts and share transcriptional targets

M. Birrer, I. Kinoshita, V. Leaner, 2003, Oncogene.

Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer

M. Birrer, Wei Wei, V. Leaner, 2021, BMC cancer.

Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer Therapeutic

M. Birrer, J. Trent, Wei Wei, 2016, Molecular Cancer Therapeutics.

Tumour cells down-regulate CCN2 gene expression in co-cultured fibroblasts in a Smad7- and ERK-dependent manner

Beverley van Rooyen, Georgia Schäfer, V. Leaner, 2013, Cell Communication and Signaling.

Photolon, a chlorin e6 derivative, triggers ROS production and light-dependent cell death via necrosis.

K. Wirtz, V. Leaner, M. Parker, 2008, The international journal of biochemistry & cell biology.

Inhibition of the nuclear transporter, Kpnβ1, results in prolonged mitotic arrest and activation of the intrinsic apoptotic pathway in cervical cancer cells.

V. Leaner, Pauline J van der Watt, L. Angus, 2014, Carcinogenesis.

Reactive oxygen species mediated apoptosis of esophageal cancer cells induced by marine triprenyl toluquinones and toluhydroquinones

Robert A. Keyzers, M. Birrer, C. Whibley, 2007, Molecular Cancer Therapeutics.

Thymosin B 4 Is a Determinant of the Transformed Phenotype and Invasiveness of S-Adenosylmethionine Decarboxylase – Transfected Fibroblasts

M. Birrer, E. Hölttä, M. Yin, 2006 .

Circadian Oscillations Persist in Cervical and Esophageal Cancer Cells Displaying Decreased Expression of Tumor-Suppressing Circadian Clock Genes

L. Roden, V. Leaner, M. Parker, 2020, Molecular Cancer Research.

Dominant-Negative Mutants of c-Jun Ornithine Decarboxylase-and Ras-Overexpressing Cells by Reversible Regulation of the Transformed Phenotype of Updated

M. Birrer, E. Hölttä, P. Nummela, 2004 .

Reversible Regulation of the Transformed Phenotype of Ornithine Decarboxylase- and Ras-Overexpressing Cells by Dominant-Negative Mutants of c-Jun

M. Birrer, E. Hölttä, P. Nummela, 2004, Cancer Research.

A tight balance of Karyopherin β1 expression is required in cervical cancer cells

Sarah Carden, V. Leaner, Pauline J van der Watt, 2018, BMC Cancer.

Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer

M. Birrer, Wei Wei, V. Leaner, 2020, BMC cancer.

Overexpression of Kpnβ1 and Kpnα2 Importin Proteins in Cancer Derives from Deregulated E2F Activity

V. Leaner, Pauline J van der Watt, Ellen Ngarande, 2011, PloS one.

Transfected Fibroblasts −-Adenosylmethionine Decarboxylase S and Invasiveness of 4 Is a Determinant of the Transformed Phenotype β Thymosin

M. Birrer, E. Hölttä, M. Yin, 2006 .

HMG-I/Y is a c-Jun/activator protein-1 target gene and is necessary for c-Jun-induced anchorage-independent growth in Rat1a cells.

H. Donninger, M. Birrer, M. Katabami, 2004, Molecular cancer research : MCR.

NORE1A tumor suppressor candidate modulates p21CIP1 via p53.

D. Calvisi, H. Donninger, M. Birrer, 2009, Cancer research.

Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth

A. Sabichi, P. Dent, M. Birrer, 2003, Oncogene.

Cyclin A Is a c-Jun Target Gene and Is Necessary for c-Jun-induced Anchorage-independent Growth in RAT1a Cells*

H. Donninger, M. Birrer, M. Katabami, 2005, Journal of Biological Chemistry.

A mass spectrometry-based approach for the identification of Kpnβ1 binding partners in cancer cells

J. Blackburn, C. Hermann, Shaun Garnett, 2022, Scientific Reports.

Species‐Specific Regulation of the α‐2(I) Procollagen Gene by Proximal Promoter Elements

V. Leaner, I. Parker, Agatha M. Masemola, 2005 .

PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration.

C. Goding, S. Prince, S. Mowla, 2011, The Biochemical journal.

Nuclear transport proteins are secreted by cancer cells and identified as potential novel cancer biomarkers

N. Soares, J. Blackburn, V. Leaner, 2021, International journal of cancer.

The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation

M. Birrer, D. Govender, V. Leaner, 2009, International journal of cancer.

KPNB1-mediated nuclear import is required for motility and inflammatory transcription factor activity in cervical cancer cells

V. Leaner, T. Stelma, 2017, Oncotarget.

The nuclear exporter, Crm1, is regulated by NFY and Sp1 in cancer cells and repressed by p53 in response to DNA damage.

V. Leaner, Virna D Leaner, Pauline J van der Watt, 2011, Biochimica et biophysica acta.

Deregulated LAP2α expression in cervical cancer associates with aberrant E2F and p53 activities

Michelle C. Ward, V. Leaner, Pauline J van der Watt, 2011, IUBMB life.

p75-Ras-GRF1 Is a c-Jun/AP-1 Target Protein: Its Up Regulation Results in Increased Ras Activity and Is Necessary for c-Jun-Induced Nonadherent Growth of Rat1a Cells

H. Donninger, M. Birrer, G. Clark, 2005, Molecular and Cellular Biology.

Absence of feedback regulation in the synthesis of COL1A1.

V. Leaner, M. I. Parker, K. Dzobo, 2014, Life sciences.

Cross-talk between JNK/SAPK and ERK/MAPK Pathways

P. Sathyanarayana, M. Birrer, Jun Zhu, 2003, Journal of Biological Chemistry.

Novel small molecule inhibitor of Kpnβ1 induces cell cycle arrest and apoptosis in cancer cells.

J. Trent, Nonkululeko Mkwanazi, Sarah Carden, 2021, Experimental cell research.

Inhibition of AP-1 suppresses cervical cancer cell proliferation and is associated with p21 expression

M. Birrer, V. Leaner, Pauline J van der Watt, 2011, Biological chemistry.

Transcription Factors as Targets for Cancer Therapy: AP-1 a Potential Therapeutic Target

H. Donninger, M. Birrer, V. Leaner, 2007 .

The nuclear exporter , Crm 1 , is regulated by NFY and Sp 1 in cancer cells and repressed by p 53 in response to DNA damage

V. Leaner, Pauline J. van der Watt, Virna D. Leaner, 2011 .

Regulation of the human alpha 2(1) procollagen gene by sequences adjacent to the CCAAT box.

M. Parker, M. Collins, V. Leaner, 1997, The Biochemical journal.

Methylation of the α2(I) procollagen proximal promoter inhibits gene expression in SV40-transformed fibroblasts : research letter

M. Parker, V. Leaner, M. Ndlovu, 2005 .

Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma.

H. Donninger, M. Birrer, C. Khanna, 2009, The American journal of pathology.

Elevated expression of the nuclear export protein, Crm1 (exportin 1), associates with human oesophageal squamous cell carcinoma.

D. Govender, W. Zemanay, V. Leaner, 2014, Oncology reports.

The tumour suppressing role of the circadian clock

L. Roden, V. Leaner, Laura C Roden, 2019, IUBMB life.

p21-Activated Kinase 3 (PAK3) Is an AP-1 Regulated Gene Contributing to Actin Organisation and Migration of Transformed Fibroblasts

H. Donninger, M. Birrer, V. Leaner, 2013, PloS one.

A tight balance of Karyopherin β1 expression is required in cervical cancer cells

Sarah Carden, V. Leaner, Pauline J van der Watt, 2018, BMC Cancer.

The nuclear import receptor Kpnβ1 and its potential as an anticancer therapeutic target.

V. Leaner, Pauline J van der Watt, C. Stowell, 2013, Critical reviews in eukaryotic gene expression.

Interfering with Nuclear Transport as a Means of Interrupting Transcription Factor Activity in Cancer.

V. Leaner, Pauline J van der Watt, Aderonke Ajayi-Smith, 2019, Critical reviews in eukaryotic gene expression.

Therapeutic targeting of nuclear export and import receptors in cancer and their potential in combination chemotherapy

V. Leaner, Pauline J van der Watt, Stella Newell, 2023, IUBMB life.

Feedback regulation of the α2(1) collagen gene via the Mek–Erk signaling pathway

V. Leaner, M. Parker, Kevin Dzobo, 2012, IUBMB life.

Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential

P. Lavia, A. Verrico, V. Leaner, 2016, IUBMB life.

Elevated expression of the nuclear export protein, Crm1 (exportin 1), associates with human oesophageal squamous cell carcinoma.

D. Govender, V. Leaner, M. Parker, 2014, Oncology reports.