Yuxiang Dong

发表

Design of Hedgehog pathway inhibitors for cancer treatment

R. Mahato, Virender Kumar, J. Bariwal, 2018, Medicinal research reviews.

Antiprotozoal Selectivity of Diimidazoline N-Phenylbenzamides.

M. Kaiser, Yuxiang Dong, Xiaofang Wang, 2015, ACS infectious diseases.

Activity of diimidazoline amides against African trypanosomiasis.

M. Kaiser, Yuxiang Dong, Xiaofang Wang, 2014, Bioorganic & medicinal chemistry letters.

Effect of ozonide OZ418 against Schistosoma japonicum harbored in mice

S. Xiao, J. Xue, Yuxiang Dong, 2014, Parasitology Research.

Praziquantel analogs with activity against juvenile Schistosoma mansoni.

J. Keiser, J. Chollet, Y. Alnouti, 2010, Bioorganic & medicinal chemistry letters.

In Vitro and In Vivo Activities of Synthetic Trioxolanes against Major Human Schistosome Species

M. Tanner, J. Utzinger, J. Keiser, 2007, Antimicrobial Agents and Chemotherapy.

Immune responses to methamphetamine by active immunization with peptide-based, molecular adjuvant-containing vaccines.

R. Bevins, G. Thiele, Yuxiang Dong, 2009, Vaccine.

Targeted Amino Acid Substitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67.

Nicholas Y. Palermo, D. Ronning, Joseph A. Vetro, 2020, ACS infectious diseases.

In Vivo Activity of Aryl Ozonides against Schistosoma Species

J. Keiser, J. Chollet, Yuxiang Dong, 2011, Antimicrobial Agents and Chemotherapy.

Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513

S. Joshi, D. Coulter, J. Sharp, 2016, BMC Cancer.

Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials

R. Prankerd, S. Charman, W. Charman, 2008, Antimicrobial Agents and Chemotherapy.

Running Title : Heme alkylation by trioxolane antimalarials 4 5

R. Prankerd, S. Charman, W. Charman, 2008 .

Polyfluorinated Bis-styrylbenzene β-Amyloid Plaque Binding Ligands

Shannon M Walsh, T. Kiyota, T. Ikezu, 2007 .

Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides.

J. Karle, J. Chollet, S. Charman, 2007, Bioorganic & medicinal chemistry letters.

Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).

David M. Shackleford, J. Chollet, S. Charman, 2017, Journal of medicinal chemistry.

The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone.

J. Chollet, Yuxiang Dong, J. Vennerstrom, 2010, Bioorganic & medicinal chemistry letters.

Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.

J. K. Wood, J. Chollet, S. Charman, 2009, Bioorganic & medicinal chemistry letters.

Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978.

J. Keiser, R. Guy, Jaeki Min, 2014, The American journal of tropical medicine and hygiene.

Peripherally Cross-Linking the Shell of Core-Shell Polymer Micelles Decreases Premature Release of Physically Loaded Combretastatin A4 in Whole Blood and Increases its Mean Residence Time and Subsequent Potency Against Primary Murine Breast Tumors After IV Administration

Rajesh R Wakaskar, Vishakha V. Ambardekar, Rakesh K. Singh, 2014, Pharmaceutical Research.

Pharmacophore refinement guides the design of nanomolar-range botulinum neurotoxin serotype a light chain inhibitors

G. Ruthel, P. Wipf, R. Gussio, 2010 .

Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer

A. Chaudhary, R. Mahato, Virender Kumar, 2017, Scientific Reports.

Single-step conjugation of bioactive peptides to proteins via a self-contained succinimidyl bis-arylhydrazone.

G. Cole, C. Hung, C. McMahan, 2009, Bioconjugate chemistry.

Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides.

J. Chollet, S. Charman, D. Creek, 2007, Journal of medicinal chemistry.

Dispiro-1,2,4-trioxane analogues of a prototype dispiro-1,2,4-trioxolane: mechanistic comparators for artemisinin in the context of reaction pathways with iron(II).

J. K. Wood, James K. Wood, Yuxiang Dong, 2005, The Journal of organic chemistry.

Synthetic peroxides as antimalarials

Yuxiang Dong, J. Vennerstrom, Yuanqing Tang, 2004, Medicinal research reviews.

Peroxidic antimalarials

Yuxiang Dong, J. Vennerstrom, 2001 .

The activity of dispiro peroxides against Fasciola hepatica.

J. Keiser, Qingjie Zhao, Yuxiang Dong, 2011, Bioorganic & medicinal chemistry letters.

Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials.

R. Prankerd, S. Charman, W. Charman, 2007, Journal of pharmaceutical sciences.

Synthesis and Characterization of a Novel Mycophenolic Acid-Quinic Acid Conjugate Serving as Immunosuppressant with Decreased Toxicity.

R. Mahato, Yuxiang Dong, Yang Peng, 2015, Molecular pharmaceutics.

Synthesis of tetrasubstituted ozonides by the Griesbaum coozonolysis reaction: diastereoselectivity and functional group transformations by post-ozonolysis reactions.

J. Karle, Yuxiang Dong, J. Vennerstrom, 2004, The Journal of organic chemistry.

Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone.

J. Keiser, D. Siegel, C. Caffrey, 2020, The Journal of antimicrobial chemotherapy.

Progress in antischistosomal N,N'-diaryl urea SAR.

David M. Shackleford, J. Keiser, S. Charman, 2017, Bioorganic & medicinal chemistry letters.

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.

J. Karle, J. Chollet, S. Charman, 2005, Journal of medicinal chemistry.

Synthesis of 2-Azaadamantan-6-one: A Missing Isomer

Yuxiang Dong, Xiaofang Wang, J. Vennerstrom, 2018, ACS omega.

Differentiation between 1,2,4,5-tetraoxanes and 1,2,4,5,7,8-hexaoxonanes using 1H and 13C NMR analyses

Yuxiang Dong, J. Vennerstrom, 2001 .

The structure-activity relationship of the antimalarial ozonide arterolane (OZ277).

J. Chollet, S. Charman, W. Charman, 2010, Journal of medicinal chemistry.

One-Pot, Metal-Free Conversion of Anilines to Aryl Bromides and Iodides.

Yuxiang Dong, J. Vennerstrom, D. Stack, 2017, Organic letters.

Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12)

D. Kyle, S. Charman, C. Kocken, 2022, ACS omega.

Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.

J. Chollet, S. Charman, E. Ryan, 2013, Journal of medicinal chemistry.

Tricyclic Imidazolidin-4-ones by Witkop Oxidation of Tetrahydro-β-carbolines.

J. Garrison, Yuxiang Dong, Xiaofang Wang, 2020, The Journal of organic chemistry.

A one-pot synthesis of unsymmetrical bis-styrylbenzenes

Yuxiang Dong, J. Vennerstrom, D. P. Flaherty, 2009 .

Antischistosomal Tetrahydro-γ-carboline Sulfonamides.

J. Keiser, M. Kaiser, Yuxiang Dong, 2022, Bioorganic & medicinal chemistry letters.

Differentiation Between 1,2,4,5-Tetraoxanes and 1,2,4,5,7,8-Hexaoxonanes Using 1H and 13C NMR Analyses.

Yuxiang Dong, J. Vennerstrom, 2001 .

Structure-activity relationship of an ozonide carboxylic acid (OZ78) against Fasciola hepatica.

J. Keiser, Qingjie Zhao, Yuxiang Dong, 2010, Journal of medicinal chemistry.

Diozonides from coozonolyses of suitable O-methyl oximes and ketones

K. Griesbaum, Yuxiang Dong, Xuejun Liu, 1997 .

Identification of an antimalarial synthetic trioxolane drug development candidate

Christian Scheurer, Jonathan L. Vennerstrom, Susan A. Charman, 2004, Nature.

Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni.

J. Keiser, O. Braissant, Xiaofang Wang, 2011, Acta tropica.

Semipinacol and protoadamantane-adamantane rearrangements of 5,6-dibromoadamantan-2-one and -2-ol

J. K. Wood, James K. Wood, J. Garrison, 2017 .

Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160)

R. Brun, H. Matile, M. Kaiser, 2007, Antimicrobial Agents and Chemotherapy.

Effect of ozonide OZ418 against Schistosoma japonicum harbored in mice

S. Xiao, J. Xue, Yuxiang Dong, 2014, Parasitology Research.

Amino ozonides exhibit in vitro activity against Echinococcus multilocularis metacestodes.

J. Keiser, A. Hemphill, Yuxiang Dong, 2014, International journal of antimicrobial agents.

The synthetic peroxide OZ78 is effective against Echinostoma caproni and Fasciola hepatica.

M. Tanner, J. Utzinger, J. Keiser, 2006, The Journal of antimicrobial chemotherapy.

Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica.

J. Utzinger, J. Keiser, I. Fairweather, 2007, Transactions of the Royal Society of Tropical Medicine and Hygiene.

CLONORCHICIDAL PROPERTIES OF THE SYNTHETIC TRIOXOLANE OZ78

J. Utzinger, J. Keiser, S. Xiao, 2007, The Journal of parasitology.

Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep.

J. Keiser, R. Kaminsky, J. Huwyler, 2010, Veterinary parasitology.

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Christian Scheurer, Lukas Stingelin, David M. Shackleford, 2011, Proceedings of the National Academy of Sciences.

Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer

A. Chaudhary, R. Mahato, Virender Kumar, 2017, Scientific Reports.

Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials.

R. Prankerd, S. Charman, W. Charman, 2006, Journal of pharmaceutical sciences.

Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978)

David M. Shackleford, J. Keiser, Jeremy O. Jones, 2016, Journal of medicinal chemistry.

Polymeric Micellar Delivery of Novel Microtubule Destabilizer and Hedgehog Signaling Inhibitor for Treating Chemoresistant Prostate Cancer

Duane D. Miller, R. Mahato, Wei Li, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Special Section on Drug Delivery Technologies Polymeric Micellar Delivery of Novel Microtubule Destabilizer and Hedgehog Signaling Inhibitor for Treating Chemoresistant Prostate Cancer s

Duane D. Miller, R. Mahato, Yuxiang Dong, 2019 .

Peroxide Antimalarial Drugs Target Redox Homeostasis in Plasmodium falciparum Infected Red Blood Cells

D. Creek, Dovile Anderson, G. Siddiqui, 2021, bioRxiv.

N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα).

M. Brattain, Yuxiang Dong, J. Vennerstrom, 2012, Bioorganic & medicinal chemistry.

Comparative Antimalarial Activities of Six Pairs of 1,2,4,5-Tetraoxanes (Peroxide Dimers) and 1,2,4,5,7,8-Hexaoxonanes (Peroxide Trimers)

J. K. Wood, James K. Wood, J. Chollet, 2007, Antimicrobial Agents and Chemotherapy.

Dispiro‐1,2,4,5‐tetraoxanes via Ozonolysis of Cycloalkanone O‐Methyl Oximes: A Comparison with the Peroxidation of Cycloalkanones in Acetonitrile—Sulfuric Acid Media.

Yuxiang Dong, J. Vennerstrom, 1999 .

Dispiro-1,2,4,5-tetraoxanes via Ozonolysis of Cycloalkanone O-Methyl Oximes: A Comparison with the Peroxidation of Cycloalkanones in Acetonitrile−Sulfuric Acid Media

Yuxiang Dong, J. Vennerstrom, 1998 .

Small molecule mimics of DFTamP1, a database designed anti-Staphylococcal peptide.

Guangshun Wang, T. Lushnikova, Yuxiang Dong, 2017, Bioorganic & medicinal chemistry.

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine.

J. Chollet, S. Charman, W. Charman, 2006, Bioorganic & medicinal chemistry letters.

Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel)

O. Biehlmaier, P. Mäser, H. Matile, 2015, ACS infectious diseases.

Probing the Antimalarial Mechanism of Artemisinin and OZ277 (Arterolane) with Nonperoxidic Isosteres and Nitroxyl Radicals

Yuxiang Dong, J. Vennerstrom, S. Wittlin, 2009, Antimicrobial Agents and Chemotherapy.

Structure-Activity Relationship of Antischistosomal Ozonide Carboxylic Acids.

David M. Shackleford, J. Keiser, S. Charman, 2020, Journal of medicinal chemistry.

Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal.

J. Keiser, G. Panic, N. Gautam, 2015, The Journal of antimicrobial chemotherapy.

Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439.

David M. Shackleford, S. Charman, Qingjie Zhao, 2021, ACS infectious diseases.

Stochastic protein alkylation by antimalarial peroxides.

Remo S. Schmidt, P. Mäser, H. Matile, 2019, ACS infectious diseases.

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.

A. Ruf, S. Charman, W. Charman, 2008, Bioorganic & medicinal chemistry letters.

The comparative antimalarial properties of weak base and neutral synthetic ozonides.

J. Chollet, S. Charman, W. Charman, 2010, Bioorganic & medicinal chemistry letters.

Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes.

J. Chollet, S. Charman, W. Charman, 2006, Bioorganic & medicinal chemistry.

Synthesis and antimalarial activity of 1,2,4,5-tetraoxanes.

Yuxiang Dong, 2002, Mini reviews in medicinal chemistry.

Mechanisms of in situ activation for peroxidic antimalarials

Yuxiang Dong, J. Vennerstrom, 2003, Redox report : communications in free radical research.

Polyfluorinated bis-styrylbenzene beta-amyloid plaque binding ligands.

Shannon M Walsh, T. Kiyota, T. Ikezu, 2007, Journal of medicinal chemistry.

Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers.

T. Kiyota, T. Ikezu, Yuxiang Dong, 2010, Journal of medicinal chemistry.

Tetrasubstituted pyrazinones derived from the reaction of praziquantel with N-bromosuccinimide.

Qingjie Zhao, Yuxiang Dong, J. Vennerstrom, 2014, Tetrahedron letters.

Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes.

J. K. Wood, S. M. Walters, James K. Wood, 2000, Journal of medicinal chemistry.

Methyl-substituted dispiro-1,2,4,5-tetraoxanes: correlations of structural studies with antimalarial activity.

J. K. Wood, James K. Wood, D. Kyle, 2000, Journal of medicinal chemistry.

Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.

J. K. Wood, James K. Wood, R. Kaminsky, 1999, Journal of medicinal chemistry.

Targeting BRD4 and PI3K signaling pathways for the treatment of medulloblastoma.

D. Ronning, D. Coulter, R. Mahato, 2023, Journal of controlled release : official journal of the Controlled Release Society.

SAR of a new antischistosomal urea carboxylic acid.

David M. Shackleford, J. Keiser, S. Charman, 2018, Bioorganic & medicinal chemistry letters.

Praziquantel analogs with activity against juvenile Schistosoma mansoni.

J. Keiser, J. Chollet, Y. Alnouti, 2010, Bioorganic & medicinal chemistry letters.

Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978.

J. Keiser, Jaeki Min, Qingjie Zhao, 2014, The American journal of tropical medicine and hygiene.

SHORT PATH SYNTHESES OF ALPHA -DIOZONIDES BY SEQUENTIAL OZONOLYSES OF ACETYLENES AND O-METHYL OXIMES

K. Griesbaum, Yuxiang Dong, K. J. Mccullough, 1997 .

Probing the Antimalarial Mechanism of Artemisinin and OZ277 (Arterolane) with Nonperoxidic Isosteres and Nitroxyl Radicals

Yuxiang Dong, J. Vennerstrom, S. Wittlin, 2009, Antimicrobial Agents and Chemotherapy.

Immune responses to methamphetamine by active immunization with peptide-based, molecular adjuvant-containing vaccines.

R. Bevins, G. Thiele, Yuxiang Dong, 2009, Vaccine.