P. Mollat

发表

Functional studies of membrane-bound and purified human Hedgehog receptor Patched expressed in yeast.

A. Polidori, B. Pucci, D. Fleury, 2009, Biochimica et biophysica acta.

The Hedgehog Receptor Patched Is Involved in Cholesterol Transport

B. Lacombe, L. Bretillon, R. Bittman, 2011, PloS one.

Species specificity and organ, cellular and subcellular localization of the 100 kDa Ras GTPase activating protein.

J. Grassi, C. Yang, D. Evain-Brion, 1994, Journal of cell science.

Crystallization and preliminary X-ray analysis of the human androgen receptor ligand-binding domain with a coactivator-like peptide and selective androgen receptor modulators.

T. Prangé, D. Fleury, P. Mollat, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.

J. Steyaert, N. Triballeau, K. Conrath, 2017, Journal of medicinal chemistry.

Combined administration of a small-molecule inhibitor of TRAF6 and Docetaxel reduces breast cancer skeletal metastasis and osteolysis.

A. Sparatore, M. Capulli, A. Sims, 2020, Cancer letters.

Regulation of breast cancer induced bone disease by cancer-specific IKKβ

S. Ralston, M. Capulli, A. Sims, 2018, Oncotarget.

Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation.

R. Baron, G. Adelmant, S. Roman-Roman, 2001, Journal of cell science.

Pharmacological Inhibition of the Skeletal IKKβ Reduces Breast Cancer-Induced Osteolysis

S. Marino, P. Mollat, A. Idris, 2018, Calcified Tissue International.

Expression, purification, characterization and crystallization of a recombinant human cytosolic beta-glucosidase produced in insect cells.

D. Fleury, P. Mollat, R. Touitou, 2007, Protein expression and purification.

Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysis

A. Sparatore, S. Vukicevic, A. Bozec, 2021, Biochemical Pharmacology.

Discovery of diarylhydantoins as new selective androgen receptor modulators.

T. Prangé, N. Triballeau, D. Guédin, 2012, Journal of medicinal chemistry.

Comparison of the biochemical properties of unprocessed and processed forms of the small GTP-binding protein, rab6p.

A. Chaffotte, B. Goud, C. Yang, 1993, European journal of biochemistry.

The Hedgehog Receptor Patched Functions in Multidrug Transport and Chemotherapy Resistance

M. Bidet, P. Mollat, I. Mus-Veteau, 2012, Molecular Cancer Research.

Identification of small molecule inhibitors of RANKL and TNF signalling as anti-inflammatory and antiresorptive agents in mice

S. Ralston, P. Mollat, Mohini Gray, 2013, Annals of the rheumatic diseases.

Bone Cell-autonomous Contribution of Type 2 Cannabinoid Receptor to Breast Cancer-induced Osteolysis*

S. Ralston, J. Logan, S. Marino, 2015, The Journal of Biological Chemistry.

Small molecule inhibitors of IκB kinase signaling inhibit osteoclast formation in vitro and prevent ovariectomy‐induced bone loss in vivo

S. Vukicevic, S. Ralston, P. Mollat, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Non–Neutralizing Monoclonal Antibodies Against RAS GTPase–Activating Protein: Production, Characterization and Use in an Enzyme Immunometric Assay

J. Grassi, Y. Frobert, P. Mollat, 1992, Bio/Technology.

Pharmacological characterization of GLPG1972/S201086, a potent and selective small molecule inhibitor of ADAMTS5.

Margaret M. Smith, C. Little, F. De Ceuninck, 2021, Osteoarthritis and cartilage.

Hydrogen sulphide‐releasing diclofenac derivatives inhibit breast cancer‐induced osteoclastogenesis in vitro and prevent osteolysis ex vivo

A. Sparatore, S. Ralston, J. Logan, 2012, British journal of pharmacology.

Endogenous glutathione-binding proteins of insect cell lines: characterization and removal from glutathione S-transferase (GST) fusion proteins.

P. Mollat, C. Capdevila, E. Sarubbi, 2000, Protein expression and purification.

Pharmacological evidence for the bone-autonomous contribution of the NFκB/β-catenin axis to breast cancer related osteolysis.

J. Logan, S. Marino, P. Mollat, 2017, Cancer letters.

A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss.

Akira Yamaguchi, Kazuhiro Aoki, Roland Baron, 2006, The Journal of clinical investigation.

Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fib

N. Triballeau, M. Lamers, B. Hrvačić, 2017, Journal of medicinal chemistry.

Differential roles of JNK and Smad2 signaling pathways in the inhibition of c-Myc-induced cell death by TGF-β

C. Tournigand, A. Atfi, M. Bourgeade, 2000, Oncogene.

Expression, purification and functional characterization of Wnt signaling co-receptors LRP5 and LRP6.

D. Fleury, G. Rawadi, P. Mollat, 2010, Protein expression and purification.

IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line

F. Gouilleux, V. Gouilleux-Gruart, P. Mollat, 1999, Oncogene.

Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass

R. Baron, C. Niehrs, F. Morvan, 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Pharmacological Inhibition of the Skeletal IKKβ Reduces Breast Cancer-Induced Osteolysis

S. Marino, P. Mollat, A. Idris, 2018, Calcified Tissue International.

Purification, characterization, and cellular localization of the 100-kDa human placental GTPase-activating protein.

C. Carles, W. Rostène, M. Riva, 1993, The Journal of biological chemistry.

Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis.

N. Triballeau, E. M. van der Aar, T. Christophe, 2021, Journal of medicinal chemistry.

GLPG1972: a potent, selective, orally available adamts-5 inhibitor for the treatment of OA

C. Little, T. Christophe, P. Mollat, 2017 .

Expression, purification and characterization of murine Dkk1 protein.

D. Fleury, G. Rawadi, P. Mollat, 2008, Protein expression and purification.

Identi ﬁ cation of small molecule inhibitors of RANKL and TNF signalling as anti-in ﬂ ammatory and antiresorptive agents in mice

P. Mollat, I. Greig, E. Coste, 2022 .

Hydrogen sulphide‐releasing diclofenac derivatives inhibit breast cancer‐induced osteoclastogenesis in vitro and prevent osteolysis ex vivo

P. Mollat, P. Soldato, A. Idris, 2012, British journal of pharmacology.