K. Flurkey

发表

Preparation and characterization of antisera and monoclonal antibodies to serotonergic and dopaminergic ligands

M. Bolger, D. Linthicum, K. Flurkey, 1985, Journal of Neuroimmunology.

Low Utilization of Circulating Glucose after Food Withdrawal in Snell Dwarf Mice*

L. Kupper, J. Swenberg, D. Carling, 2007, Journal of Biological Chemistry.

Pitfalls of animal model systems in ageing research.

K. Flurkey, Joanne M Currer, 2004, Best practice & research. Clinical endocrinology & metabolism.

Glycine supplementation extends lifespan of male and female mice

M. Bogue, D. Vaughan, A. Ryazanov, 2019, Aging cell.

The Diabetes-Prone NZO/HlLt Strain. I. Immunophenotypic Comparison to the Related NZB/BlNJ and NZW/LacJ Strains

E. Leiter, K. Flurkey, E. Sargent, 2002, Laboratory Investigation.

Altered oxidative stress response of the long-lived Snell dwarf mouse.

C. Hsieh, J. Papaconstantinou, D. Harrison, 2004, Biochemical and biophysical research communications.

Physiologic and endocrinologic characterization of male sex-biased diabetes in C57BLKS/J mice congenic for the fat mutation at the carboxypeptidease E locus

J. Naggert, E. Leiter, W. Beamer, 1999, Endocrine.

Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice.

K. Flurkey, C. M. Astle, D. Harrison, 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

ImperialCollegeofLondon,LondonW120NN,UnitedKingdom

L. Kupper, J. Swenberg, D. Carling, 2007 .

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

N. Rosenthal, L. Leng, R. Bucala, 2021, Aging cell.

Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J‐Leprdb mice

D. Harrison, Sergey Ryzhov, R. Koza, 2018, Annals of the New York Academy of Sciences.

MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice

D. Melzer, L. Harries, G. Kuchel, 2017, Scientific Reports.

Rapamycin/metformin co‐treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice

N. Calcutt, R. Koza, K. Flurkey, 2022, Aging cell.

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Marco Pahor, Christy S. Carter, Randy Strong, 2009, Nature.

Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes

D. Harrison, K. Flurkey, P. Reifsnyder, 2016, Aging.

Graafian follicle growth and replacement in anovulatory ovaries of ageing C57BL/6J mice.

C. Finch, R. Gosden, K. Flurkey, 1983, Journal of reproduction and fertility.

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Z. D. Sharp, S. Pletcher, A. Salmon, 2014, Aging cell.

The Snell dwarf mutation Pit1 dw can increase life span in mice

J. Papaconstantinou, D. Harrison, K. Flurkey, 2002, Mechanisms of Ageing and Development.

Use of genetic models to investigate the hypophyseal regulation of senescence.

D. Harrison, K. Flurkey, 1990 .

Pituitary removal in adult mice increases life span

D. Harrison, K. Flurkey, R. Powers, 2006, Mechanisms of Ageing and Development.

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

B. Ames, D. Allison, J. Simpkins, 2013, Aging cell.

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.

R. de Cabo, D. Sinclair, J. Baur, 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.

Effects of the Pit1 mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse

C. Hsieh, J. Papaconstantinou, D. Harrison, 2002, Mechanisms of Ageing and Development.

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

Richard A. Miller, J. Papaconstantinou, R A Miller, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

Kenneth L. Hensley, E. Ongini, R. Floyd, 2008, Aging cell.

PohnB6F1: a cross of wild and domestic mice that is a new model of extended female reproductive life span.

Y. Brandvain, S. Austad, Richard A. Miller, 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

Transient shortening of estrous cycles in aging C57BL/6J mice: effects of spontaneous pseudopregnancy, progesterone, L-dihydroxyphenylalanine, and hydergine.

C. Finch, P. Randall, Y. Sinha, 1987, Biology of reproduction.

Supernumerary ovarian grafts in aging C57BL/6J mice reveal complexities in the neuroendocrine impairments of acyclic mice.

C. Finch, P. May, K. Flurkey, 1987, Biology of reproduction.

The regulation of luteinizing hormone and prolactin in C57BL/6J mice: effects of estradiol implant size, duration of ovariectomy, and aging.

C. Finch, C. Mobbs, Y. Sinha, 1984, Endocrinology.

Age effects on luteinizing hormone, progesterone and prolactin in proestrous and acyclic C57BL/6j mice.

C. Finch, Y. Sinha, K. Flurkey, 1982, Biology of reproduction.

Estradiol regulates cell surface immunoglobulin in old mice.

C. Finch, K. Flurkey, D. Eskinazi, 1986, Developmental and comparative immunology.

Aging and the regulation of luteinizing hormone in C57BL/6J mice: impaired elevations after ovariectomy and spontaneous elevations at advanced ages.

C. Finch, K Flurkey, K. Flurkey, 1983, Biology of reproduction.

How the evolutionary theory of aging can guide us in the search for aging genes

Rong Yuan, K. Flurkey, 2012, Aging.

Preparation and characterization of antisera and monoclonal antibodies to haloperdol

M. Bolger, D. Linthicum, P. Laduron, 1985 .

Mouse models in aging research.

D. Harrison, David E. Harrison, Kevin Flurkey, 2007 .

Studies on ovarian-hypothalamic-pituitary interactions during reproductive aging in C57BL/6J mice

C. Finch, L. S. Felicio, J. Nelson, 1980, Peptides.

Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains

Qingying Meng, S. Tsaih, B. Paigen, 2012, Proceedings of the National Academy of Sciences.

NIDDM Genes in Mice: Deleterious Synergism by Both Parental Genomes Contributes to Diabetogenic Thresholds

E. Leiter, K. Flurkey, P. Reifsnyder, 1998, Diabetes.

Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm

C. Hsieh, J. Papaconstantinou, D. Harrison, 2002, Mechanisms of Ageing and Development.

Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans

D. Melzer, L. Pilling, L. Ferrucci, 2016, Aging cell.

Contributions of dysregulated energy metabolism to type 2 diabetes development in NZO/H1Lt mice with polygenic obesity.

H. Pan, E. Leiter, L. Kozak, 2004, Metabolism: clinical and experimental.

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer

Dudley Lamming, D. Sabatini, J. de Magalhães, 2016, Aging cell.

Neuroendocrine inhibition of glucose production and resistance to cancer in dwarf mice

J. Swenberg, M. Stridsberg, D. Harrison, 2009, Experimental Gerontology.

Elevated circulating glucose increases the risk of cancer and reduces the effectiveness of medical treatment in cancer patients

J. Swenberg, M. Stridsberg, D. Harrison, 2008 .

mouse insulin-like growth factor-I Three-locus and four-locus QTL interactions influence

G. Churchill, P. Hanlon, A. Galecki, 2006 .

Mice severely deficient in growth hormone have normal hematopoiesis.

Y. Sharma, D. Harrison, K. Flurkey, 2005, Experimental hematology.

Acarbose improves health and lifespan in aging HET3 mice

T. Slaga, J. Wilkinson, G. Lithgow, 2019, Aging cell.

Genetic regulation of life span, metabolism, and body weight in Pohn, a new wild-derived mouse strain.

Qingying Meng, Rong Yuan, D. Harrison, 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.

A reduced peripheral blood CD4+ lymphocyte proportion is a consistent ageing phenotype

Jichun Chen, D. Harrison, K. Flurkey, 2002, Mechanisms of Ageing and Development.

Altered growth characteristics of skin fibroblasts from wild‐derived mice, and genetic loci regulating fibroblast clone size

S. Austad, B. King, Rong Yuan, 2006, Aging cell.

Altered cholesterologenic and lipogenic transcriptional profile in livers of aging Snell dwarf (Pit1dw/dwJ) mice

J. Papaconstantinou, Kevin Flurkey, K. Flurkey, 2004, Aging cell.

An aging Interventions Testing Program: study design and interim report

Kenneth L. Hensley, Randy Strong, E. Ongini, 2007, Aging cell.

Estradiol-induced adult anovulatory syndrome in female C57BL/6J mice: age-like neuroendocrine, but not ovarian, impairments.

C. Finch, C. Mobbs, Y. Sinha, 1984, Biology of reproduction.

Maximum Life Spans in Mice are Extended by Wild Strain Alleles

T. Roderick, Jichun Chen, K. Flurkey, 2001, Experimental biology and medicine.

Differential sensitivity of virgin and memory T lymphocytes to calcium ionophores suggests a buoyant density separation method and a model for memory cell hyporesponsiveness to Con A.

R. Miller, M. Stadecker, K. Flurkey, 1991, Journal of Immunology.

Memory T lymphocyte hyporesponsiveness to non‐cognate stimuli: a key factor in age‐related immunodeficiency

Richard A. Miller, M. Stadecker, K. Flurkey, 1992, European journal of immunology.

Anti-Insulin Receptor Autoantibodies Are Not Required for Type 2 Diabetes Pathogenesis in NZL/Lt Mice, a New Zealand Obese (NZO)-Derived Mouse Strain

S. Najjar, Deanna R. Brickley, S. Pietropaolo, 2004, Experimental diabesity research.

Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice

C. Hsieh, J. Papaconstantinou, D. Harrison, 2005, Mechanisms of Ageing and Development.

Heritability of life span in mice and its implication for direct and indirect selection for longevity

T. Roderick, D. Harrison, K. Flurkey, 2004, Genetica.

Handbook of physiology, section 11: Aging by E.J. Masoro (Ed.), Oxford University Press, Oxford, 1995. ISBN 0-19-507722-9, $165.00, 681 pp

Kevin Flurkey, K. Flurkey, 1996, Experimental Gerontology.

Genetic regulation of life span, metabolism, and body weight in Pohn, a new wild-derived mouse strain.

Qingying Meng, Rong Yuan, D. Harrison, 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.

Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes

D. Harrison, K. Flurkey, P. Reifsnyder, 2016, Aging.

Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used

R. Korstanje, G. Cortopassi, R. Allsopp, 2023, GeroScience.