W. Mourad

J. Tanguay, G. Ducrocq, R. Schaub, 2011, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

Expression of functional major histocompatility complex class II molecules on HMC‐1 human mast cells

M. Koutsilieris, R. Al-Daccak, W. Mourad, 1998, Journal of leukocyte biology.

ZINC INDUCES DIMERIZATION OF THE CLASS II MHC MOLECULE THAT LEADS TO COOPERATIVE BINDING TO A SUPERANTIGEN

Yi Guo, Zhong Li, Hongmin Li, 2006 .

Beta1 integrin blockade overcomes doxorubicin resistance in human T-cell acute lymphoblastic leukemia

F. Aoudjit, F. Barabé, R. Al-Daccak, 2019, Cell Death & Disease.

The Interaction of CD154 with the α5β1 Integrin Inhibits Fas-Induced T Cell Death

F. Aoudjit, Ghada S. Hassan, N. Alaaeddine, 2016, PloS one.

Original Research: Focus on Platelets Enhanced Levels of Soluble CD40 Ligand Exacerbate Platelet Aggregation and Thrombus Formation Through a CD40-Dependent Tumor Necrosis Factor Receptor-Associated Factor-2/Rac1/p38 Mitogen-Activated Protein Kinase Signaling Pathway*

Y. Merhi, W. Mourad, J. Théorêt, 2010 .

Enhanced Levels of Soluble CD40 Ligand Exacerbate Platelet Aggregation and Thrombus Formation Through a CD40-Dependent Tumor Necrosis Factor Receptor–Associated Factor-2/Rac1/p38 Mitogen-Activated Protein Kinase Signaling Pathway*

Y. Merhi, W. Mourad, J. Théorêt, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Crystal structure of the Mycoplasma arthritidis-derived mitogen in apo form reveals a 3D domain-swapped dimer.

Yi Guo, Zhong Li, Hongmin Li, 2010, Journal of molecular biology.

CD154 from the Cell Surface Inhibits CD40-Dependent and -Independent Cleavage of Monoclonal Antibody Targeting the CD154 Cleavage Site

Ghada S. Hassan, W. Mourad, Y. Darif, 2021 .

A natural mutation of the amino acid residue at position 60 destroys staphylococcal enterotoxin A murine T-cell mitogenicity

M. Ouellette, J. Hébert, W. Mahana, 1995, Infection and immunity.

Novel Functions of Integrins as Receptors of CD154: Their Role in Inflammation and Apoptosis

Ghada S. Hassan, W. Mourad, S. Salti, 2022, Cells.

CD40 associates with the MHC class II molecules on human B cells

F. Chandad, R. Al-Daccak, W. Mourad, 1999, European journal of immunology.

CD20 is physically and functionally coupled to MHC class II and CD40 on human B cell lines

R. Al-Daccak, W. Mourad, C. Léveillé, 1999, European journal of immunology.

B cells and autoimmunity 2004: new concepts and therapeutic perspectives

P. Lipsky, W. Mourad, M. Zouali, 2005, Expert opinion on therapeutic targets.

Induction of chemokine gene expression by major histocompatibility complex class II ligands in human fibroblast-like synoviocytes. Differential regulation by interleukin-4 and dexamethasone.

T. Schall, R. Al-Daccak, W. Mourad, 1994, The Journal of biological chemistry.

Engagement of MHC-class II molecules by staphylococcal exotoxins delivers a comitogenic signal to human B cells.

R. Geha, T. Chatila, R. Fuleihan, 1991, Journal of immunology.

The staphylococcal toxic shock syndrome toxin 1 triggers B cell proliferation and differentiation via major histocompatibility complex- unrestricted cognate T/B cell interaction

R. Geha, T. Chatila, W. Mourad, 1989, The Journal of experimental medicine.

HLA-DO increases bacterial superantigen binding to human MHC molecules by inhibiting dissociation of class II-associated invariant chain peptides.

J. Routy, A. Pezeshki, J. Thibodeau, 2013, Human immunology.

Cross-linking of major histocompatibility complex class II molecules by staphylococcal enterotoxin A superantigen is a requirement for inflammatory cytokine gene expression

R. Sékaly, T. Kalland, M. Dohlsten, 1995, The Journal of experimental medicine.

CD40L Priming of Platelets via NF‐κB Activation is CD40‐ and TAK1‐Dependent

Souhad El Akoum, Y. Merhi, W. Mourad, 2018, Journal of the American Heart Association.

Peripherally Generated Foxp3+ Regulatory T Cells Mediate the Immunomodulatory Effects of IVIg in Allergic Airways Disease

C. Piccirillo, A. Massoud, B. Mazer, 2017, The Journal of Immunology.

Study of the epitope structure of purified Dac G I and Lol p I, the major allergens of Dactylis glomerata and Lolium perenne pollens, using monoclonal antibodies.

J. Hébert, W. Mourad, G. Peltre, 1988, Journal of immunology.

Allergenicity and cross‐reactivity of cat and dog allergenic extracts

W. Mourad, Y. Boutin, E. Vrancken, 1988, Clinical allergy.

Involvement of nuclear factor κB in platelet CD40 signaling.

Y. Merhi, W. Mourad, Y. Zaid, 2012, Biochemical and biophysical research communications.

Evaluation of Nonspecific Nasal Reactivity to Histamine during and after Natural Ragweed Pollen Exposure

J. Hébert, W. Mourad, P. Bédard, 1989 .

The Journal of Toxicological Sciences

M. Oudghiri, W. Mourad, Y. Darif, 2015 .

Crosstalk between T cells and bronchial fibroblasts obtained from asthmatic subjects involves CD40L/alpha 5 beta 1 interaction.

F. Aoudjit, A. Semlali, J. Chakir, 2010, Molecular immunology.

Involvement of zinc in the binding of Mycoplasma arthritidis‐derived mitogen to the proximity of the HLA‐DR binding groove regardless of histidine 81 of the β chain

M. Ouellette, Hongmin Li, R. Al-Daccak, 2002, European journal of immunology.

Incidence and distribution of immunocytes in the murine oral mucosa.

W. Mourad, M. Lacasse, A. Collet, 1987, Advances in experimental medicine and biology.

Ligation of MHC class II molecules differentially upregulates TNF beta gene expression in B cell lines of different MHC class II haplotypes.

D. Charron, R. Al-Daccak, W. Mourad, 1999, Human immunology.

Staphylococcal enterotoxin D is a promiscuous superantigen offering multiple modes of interactions with the MHC class II receptors.

R. Sékaly, M. Sundström, P. Antonsson, 1998, Journal of immunology.

Functional analysis of Mycoplasma arthritidis-derived mitogen interactions with class II molecules

L. Rink, C. Bernatchez, R. Al-Daccak, 1997, Infection and immunity.

Synergistic effect between CD40 and class II signals overcome the requirement for class II dimerization in superantigen‐induced cytokine gene expression

R. Al-Daccak, W. Mourad, K. Mehindate, 1996, European journal of immunology.

CD40- and HLA-DR-mediated cell death pathways share a lot of similarities but differ in their use of ADP-ribosyltransferase activities.

R. Al-Daccak, W. Mourad, C. Léveillé, 1999, International immunology.

CD154 inhibits death of T cells via a Cis interaction with the α5β1 integrin

F. Aoudjit, Ghada S. Hassan, W. Mourad, 2020, PloS one.

Interaction of CD154 with different receptors and its role in bidirectional signals

Souhad El Akoum, Y. Merhi, M. Oudghiri, 2015, European journal of immunology.

CD40 Ligand Binds to α5β1 Integrin and Triggers Cell Signaling*

J. Wilkins, Y. Merhi, R. Lapointe, 2007, Journal of Biological Chemistry.

Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC

Yi Guo, D. Kranz, Zhong Li, 2007, Nature Structural &Molecular Biology.

Role of CD154 in cancer pathogenesis and immunotherapy.

Ghada S. Hassan, W. Mourad, J. Stagg, 2015, Cancer treatment reviews.

CD40/CD40 Homodimers Are Required for CD40-induced Phosphatidylinositol 3-Kinase-dependent Expression of B7.2 by Human B Lymphocytes*

R. Lapointe, W. Mourad, C. Reyes-Moreno, 2004, Journal of Biological Chemistry.

Requirement of Transmembrane Domain for CD154 Association to Lipid Rafts and Subsequent Biological Events

Ghada S. Hassan, W. Mourad, Daniel Yacoub, 2012, PloS one.

Superantigens initiate cognate CD4+ T cell/ B cell interactions leading to early activation and proliferation of B cells

R. Al-Daccak, P. Naccache, W. Mourad, 1995, European journal of immunology.

Requirement of the extracellular cysteine at position six for CD40/CD40 dimer formation and CD40-induced IL-8 expression.

W. Mourad, A. Akoum, C. Reyes-Moreno, 2005, Molecular immunology.

An indirect quantitative method for the assessment of angiogenesis in human tissues.

A. Lemay, W. Mourad, A. Akoum, 2005, Fertility and sterility.

Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules.

R. Geha, T. Chatila, J. Parsonnet, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Involvement of the cytoplasmic cysteine-238 of CD40 in its up-regulation of CD23 expression and its enhancement of TLR4-triggered responses.

Ghada S. Hassan, W. Mourad, Daniel Yacoub, 2015, International immunology.

IL‐4 mRNA transcription is induced in mouse bone marrow‐derived mast cells through an MHC class II‐dependent signaling pathway

M. Singer, C. Tkaczyk, W. Mourad, 1998, European journal of immunology.

Essential Role of Protein Kinase Cδ in Platelet Signaling, αIIbβ3 Activation, and Thromboxane A2 Release*

Y. Merhi, L. Villeneuve, W. Mourad, 2006, Journal of Biological Chemistry.

Mek 2 Is Dispensable for Mouse Growth and Development

M. Tremblay, J. Charron, R. Erikson, 2003 .

Superantigen-induced collagenase gene expression in human IFN-gamma-treated fibroblast-like synoviocytes involves prostaglandin E2. Evidence for a role of cyclooxygenase-2 and cytosolic phospholipase A2.

B. Kennedy, J. Dayer, J. Dayer, 1995, Journal of immunology.

Intravenous immunoglobulin attenuates airway hyperresponsiveness in a murine model of allergic asthma

C. Piccirillo, A. Massoud, B. Mazer, 2011, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Engagement of major histocompatibility complex class II molecules induces sustained, lymphocyte function-associated molecule 1-dependent cell adhesion

R. Geha, T. Chatila, W. Mourad, 1990, The Journal of experimental medicine.

Enhancement of Rituximab-induced cell death by the physical association of CD20 with CD40 molecules on the cell surface.

Ghada S. Hassan, H. El-Gabalawy, W. Mourad, 2014, International immunology.

CD154 Is Released from T-cells by a Disintegrin and Metalloproteinase Domain-containing Protein 10 (ADAM10) and ADAM17 in a CD40 Protein-dependent Manner*

Ghada S. Hassan, W. Mourad, Daniel Yacoub, 2013, The Journal of Biological Chemistry.

CD40 ligand binds to alpha5beta1 integrin and triggers cell signaling.

J. Wilkins, Y. Merhi, R. Lapointe, 2007, The Journal of biological chemistry.

Polyester arterial grafts impregnated with cross-linked albumin: the rate of degradation of the coating in vivo.

R. Guidoin, M. King, W. Mourad, 1988, European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.

Coexpression of TLR2 or TLR4 with HLA-DR Potentiates the Superantigenic Activities of Mycoplasma arthritidis–Derived Mitogen

Ghada S. Hassan, W. Mourad, Y. El Fakhry, 2014, The Journal of Immunology.

Mycoplasma arthritidis Activities of HLA-DR Potentiates the Superantigenic Coexpression of TLR2 or TLR4 with

Ghada S. Hassan, W. Mourad, M. Shio, 2014 .

Signalling via MHC class II molecules selectively induces IL-1 beta over IL-1 receptor antagonist gene expression.

R. Al-Daccak, P. Poubelle, W. Mourad, 1994, Biochemical and biophysical research communications.

CD40-mediated cell death requires TRAF6 recruitment.

Ghada S. Hassan, W. Mourad, A. Nadiri, 2012, Immunobiology.

Mimicry of a neutralizing epitope of the major outer membrane protein of Chlamydia trachomatis by anti-idiotypic antibodies

G. Paradis, J. Hébert, W. Mourad, 1994, Infection and immunity.

Subsets of HLA-DR1 molecules defined by SEB and TSST-1 binding.

R. Sékaly, T. Jardetzky, I. Cloutier, 1994, Science.

Staphylococcal superantigens as inducers of signal transduction in MHC class II-positive cells.

R. Geha, T. Chatila, R. Al-Daccak, 1993, Seminars in immunology.

Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex.

Yi Guo, Zhong Li, Hongmin Li, 2004, Structure.

Delineation of the HLA-DR Region and the Residues Involved in the Association with the Cytoskeleton*

H. Khalil, J. Thibodeau, A. Brunet, 2004, Journal of Biological Chemistry.

Modulation of Mycoplasma arthritidis-derived superantigen-induced cytokine gene expression by dexamethasone and interleukin-4

L. Rink, J. Hébert, R. Al-Daccak, 1994, Infection and immunity.

Interleukin-4, transforming growth factor beta 1, and dexamethasone inhibit superantigen-induced prostaglandin E2-dependent collagenase gene expression through their action on cyclooxygenase-2 and cytosolic phospholipase A2.

F. Aoudjit, R. Al-Daccak, W. Mourad, 1996, Laboratory investigation; a journal of technical methods and pathology.

CD154 Resistant to Cleavage from Intracellular Milieu and Cell Surface Induces More Potent CD40-Mediated Responses

Ghada S. Hassan, W. Mourad, Y. Darif, 2021, The Journal of Immunology.

Cellular reactions to polyester arterial prostheses impregnated with cross-linked albumin: in vivo studies in mice.

R. Guidoin, R. Roy, Y. Merhi, 1989, Biomaterials.

Detection of auto‐anti‐idiotypic antibodies to Lol p I(rye I) IgE antibodies in human sera by the use of murine idiotypes: levels in atopic and non‐atopic subjects and effects of immunotherapy

J. Hébert, W. Mourad, D. Bernier, 1990, Clinical and experimental immunology.

Aspirin Reduces the Potentiating Effect of CD40L on Platelet Aggregation via Inhibition of Myosin Light Chain

Y. Merhi, W. Mourad, K. Kojok, 2020, Journal of the American Heart Association.

Mycoplasma arthritidis-derived superantigen induces proinflammatory monokine gene expression in the THP-1 human monocytic cell line

L. Rink, J. Hébert, R. Al-Daccak, 1994, Infection and immunity.

Zinc Induces Dimerization of the Class II Major Histocompatibility Complex Molecule That Leads to Cooperative Binding to a Superantigen*

Yi Guo, Hongmin Li, Yi Guo, 2007, Journal of Biological Chemistry.

Engagement of major histocompatibility complex class II molecules by superantigen induces inflammatory cytokine gene expression in human rheumatoid fibroblast-like synoviocytes

S. McColl, T. Schall, W. Mourad, 1992, The Journal of experimental medicine.

CD40 Ligand and Its Receptors in Atherothrombosis

Ghada S. Hassan, Y. Merhi, W. Mourad, 2012 .

CD154 and its receptors in inflammatory vascular pathologies.

Ghada S. Hassan, Y. Merhi, W. Mourad, 2009, Trends in immunology.

Beta1 integrin blockade overcomes doxorubicin resistance in human T-cell acute lymphoblastic leukemia

F. Aoudjit, F. Barabé, R. Al-Daccak, 2019, Cell Death & Disease.

Lipid Raft-dependent and -independent Signaling through HLA-DR Molecules*

H. Khalil, J. Thibodeau, W. Mourad, 2003, The Journal of Biological Chemistry.

Leishmania donovani‐induced macrophages cyclooxygenase‐2 and prostaglandin E2 synthesis

M. Olivier, W. Mourad, C. Matte, 2001, Parasite immunology.

Amyloid heart disease. New frontiers and insights in pathophysiology, diagnosis, and management.

Walid M. Hassan, W. Mourad, Walid Hassan, 2005, Texas Heart Institute journal.

Critical role of lipid rafts in CD154‐mediated T cell signaling

W. Mourad, H. Alturaihi, Y. El Fakhry, 2010, European journal of immunology.

Constitutively active Stat5b signaling confers tolerogenic functions to dendritic cells of NOD mice and halts diabetes progression.

Denis Gris, J. Stankova, M. Rola-Pleszczynski, 2017, Journal of autoimmunity.

An unexpected role for MHC class II

Ghada S. Hassan, W. Mourad, 2011, Nature Immunology.

Triggering HLA-DR molecules on human peripheral monocytes induces their death.

D. Charron, R. Al-Daccak, W. Mourad, 1999, Cellular immunology.

Semaphorin 4C: A Novel Component of B-Cell Polarization in Th2-Driven Immune Responses

R. Friedel, B. Mazer, W. Mourad, 2016, Frontiers in immunology.

Semaphorin 4C: A Novel Component of B-Cell Polarization in Th2-Driven Immune Responses

R. Friedel, B. Mazer, W. Mourad, 2016, Front. Immunol..

T cell receptor-major histocompatibility complex class II interaction is required for the T cell response to bacterial superantigens

R. Sékaly, N. Labrecque, J. Thibodeau, 1994, The Journal of experimental medicine.

Characterization of anti-idiotypic antibodies and their use as probes for determination of shared idiotopes expressed on murine and human IgE anti-rye I antibodies.

J. Hébert, W. Mourad, G. Pelletier, 1988, Immunology.

Anti-idiotypic antibodies as probes for the determination of idiotopes shared by human and monoclonal murine antibodies.

J. Hébert, W. Mourad, G. Pelletier, 1988, Molecular immunology.

Generation of anti-idiotypic and anti-anti-idiotypic monoclonal antibodies in the same fusion. Support of Jerne's Network Theory.

J. Hébert, W. Mourad, Y. Boutin, 1990, Journal of immunology.

Mapping of Lol p I allergenic epitopes by using murine monoclonal antibodies.

J. Hébert, W. Mourad, D. Bernier, 1989, Molecular immunology.

Demonstration of idiotypes expressed on basophil-bound IgE antibodies by using anti-idiotype-induced histamine release in grass pollen-allergic patients.

J. Hébert, W. Mourad, S. Mécheri, 1988, Immunology.

Allergenicity and cross-reactivity of rye grass pollen extracts revealed by monoclonal antibodies.

J. Hébert, W. Mourad, G. Pelletier, 1986, Journal of immunological methods.

Isolation and characterization of Poa p I allergens of Kentucky bluegrass pollen with a murine monoclonal anti-Lol p I antibody.

J. Hébert, A. Ekramoddoullah, W. Mourad, 1988, International archives of allergy and applied immunology.

A conserved polylysine motif in CD86 cytoplasmic tail is necessary for cytoskeletal association and effective co-stimulation.

R. Sékaly, O. Acuto, F. Michel, 2012, Biochemical and biophysical research communications.

Essential role of protein kinase C delta in platelet signaling, alpha IIb beta 3 activation, and thromboxane A2 release.

Y. Merhi, L. Villeneuve, W. Mourad, 2006, The Journal of biological chemistry.

The crystal structure of staphylococcal enterotoxin type D reveals Zn2+‐mediated homodimerization.

L. Abrahmsén, M. Sundström, P. Antonsson, 1996, The EMBO journal.

Mutagenesis, biochemical, and biophysical characterization of Mycoplasma arthritidis-derived mitogen.

Yi Guo, Zhong Li, Hongmin Li, 2007, Molecular immunology.

CD40 associates with the MHC class II molecules on human B cells

F. Chandad, R. Al-Daccak, W. Mourad, 1999, European journal of immunology.

CD20 is physically and functionally coupled to MHC class II and CD40 on human B cell lines

R. Al-Daccak, W. Mourad, C. Léveillé, 1999, European journal of immunology.

Immunogenicity and Allergenicity of Whey Protein Hydrolysates

J. Hébert, W. Mourad, S. Gauthier, 1988 .

CD40 translocation to lipid rafts: Signaling requirements and downstream biological events

Ghada S. Hassan, M. Polyak, Maria J Polyak, 2011, European journal of immunology.

Zinc-binding Sites in the N Terminus of Mycoplasma arthritidis-derived Mitogen Permit the Dimer Formation Required for High Affinity Binding to HLA-DR and for T Cell Activation*

W. Mourad, Marc-André Langlois, Youssef El Fakhry, 2003, Journal of Biological Chemistry.

Binding of Mycoplasma arthritidis‐derived mitogen to human MHC class II molecules via its N terminus is modulated by invariant chain expression and its C terminus is required for T cell activation

M. Ouellette, W. Mourad, Marc-André Langlois, 2000, European Journal of Immunology.

MAM dimers bind to HLA-DR and activate T cells Zinc-binding sites in the N-terminus of Mycoplasma arthritidis -derived mitogen permit the dimer formation required for high affinity binding to HLA-DR and for T-cell activation*

W. Mourad, Marc-André Langlois, Youssef El Fakhry, 2003 .

Soluble CD40 ligand impairs the anti-platelet function of peripheral blood angiogenic outgrowth cells via increased production of reactive oxygen species

Y. Merhi, W. Mourad, Y. Zaid, 2013, Thrombosis and Haemostasis.

Soluble CD 40 ligand impairs the anti-platelet function of peripheral blood angiogenic outgrowth cells via increased production of reactive oxygen species

Y. Merhi, W. Mourad, Y. Zaid, 2018 .

Involvement of nuclear factor κB in platelet CD40 signaling.

Y. Merhi, W. Mourad, Y. Zaid, 2012, Biochemical and biophysical research communications.

Molecular characterization and role in T cell activation of staphylococcal enterotoxin A binding to the HLA-DR alpha-chain.

R. Sékaly, T. Kalland, I. Cloutier, 1997, Journal of immunology.

IL‐4 mRNA transcription is induced in mouse bone marrow‐derived mast cells through an MHC class II‐dependent signaling pathway

M. Singer, C. Tkaczyk, W. Mourad, 1998, European Journal of Immunology.

Suppression byrelevant allergen ofthespontaneous invitro production ofryeGroup Ispecific IgE antibodies byhumanperipheral blood lymphocytes

W. Mourad, 1987 .

Immunobiology of the oral mucosa in the mouse.

S. Néron, W. Mourad, N. Deslauriers, 1985, Immunology.