H. Scholz

发表

Digitoxin intoxication during concomitant use of amiodarone

I. Buschmann, T. Meinertz, M. Thoenes, 1998, European Journal of Clinical Pharmacology.

STEERING COMMITTEE AND INVESTIGATORS OF THE LEVOSIMENDAN INFUSION VERSUS DOBUTAMINE (LIDO) STUDY. EFFICACY AND SAFETY OF INTRAVENOUS LEVOSIMENDAN COMPARED WITH DOBUTAMINE IN SEVERE LOWOUTPUT HEART FAILURE (THE LIDO STUDY): A RANDOMISED DOUBLEBLIND TRIAL

J. Papp, F. Follath, J. Cleland, 2002 .

Stimulatory effects of DB-c-AMP and adrenaline on myocardial contraction and 45Ca exchange. Experiments at reduced calcium concentration and low frequencies of stimulation

T. Meinertz, H. Nawrath, H. Scholz, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

The effect of the internal sodium concentration on calcium fluxes in isolated guinea‐pig auricles

H. Reuter, H. Glitsch, H. Scholz, 1970, The Journal of physiology.

Pharmacological aspects of calcium channel blockers

H. Scholz, 2004, Cardiovascular Drugs and Therapy.

Effects of caffeine, halothane, succinylcholine, phenylephrine and isoproterenol on myocardial force of contraction of malignant hyperthermia susceptible swine

J. Scholz, W. Schmitz, N. Roewer, 1991, Acta anaesthesiologica Scandinavica.

Receptor mechanisms involved in the 5‐HT‐induced inotropic action in the rat isolated atrium

S. Läer, H. Scholz, J. Neumann, 1998, British journal of pharmacology.

Enhanced pulmonary expression of the TrkB neurotrophin receptor in hypoxic rats is associated with increased acetylcholine‐induced airway contractility

H. Scholz, A. Paliege, H. Scholz, 2009, Acta physiologica.

Usefulness of increased myocardial cyclic adenosine 3',5'-monophosphate content as a sign of rejection after cardiac transplantation.

W. Schmitz, P. Lichtlen, H. E. von der Leyen, 1995, The American journal of cardiology.

Changes in cardiac beta 1- and beta 2-adrenoceptor densities after human cardiac transplantation: relation to transplant coronary vasculopathy and pretransplantation disease.

M. Steinfath, W. Schmitz, A. Haverich, 1992, American heart journal.

Increased myocardial cAMP in patients with transplant coronary vasculopathy

W. Schmitz, A. Haverich, P. Lichtlen, 1992, The Lancet.

Isoprenaline Stimulates Gene Transcription of the Inhibitory G Protein a-Subunit G . ia-2 in Rat Heart

K. Boheler, W. Schmitz, T. Eschenhagen, 2005 .

Isoprenaline-induced increase in the 40/41 kDa pertussis toxin substrates and functional consequences on contractile response in rat heart

M. Steinfath, J. Schulte am Esch, W. Schmitz, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Distinct down-regulation of cardiac β1- and β2-adrenoceptors in different human heart diseases

M. Steinfath, W. Schmitz, A. Haverich, 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

Isoprenaline-induced increase in mRNA levels of inhibitory G-protein α-subunits in rat heart

W. Schmitz, T. Eschenhagen, A. Warnholtz, 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effects of metoprolol on myocardial β-adrenoceptors and Giα-proteins in patients with congestive heart failure

M. Steinfath, W. Schmitz, P. Hanrath, 1996, European Journal of Clinical Pharmacology.

Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart.

K. Boheler, F. Müller, W. Schmitz, 1993, Circulation research.

Effect of captopril on myocardial β-adrenoceptor density and Giα-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy

M. Steinfath, J. Schulte am Esch, W. Schmitz, 2004, European Journal of Clinical Pharmacology.

Determination of carvedilol in human cardiac tissue by high-performance liquid chromatography.

S. Läer, H. Scholz, F. Behn, 2001, Journal of chromatographic science.

HPLC quantification of carvedilol in small plasma volumes from children

T. Mir, S. Läer, H. Scholz, 2001 .

Regulation of the human Giα-2 gene promotor activity in embryonic chicken cardiomyocytes

L. Weinstein, W. Schmitz, J. Weil, 2004, Basic Research in Cardiology.

Developmental changes of nitric oxide-sensitive guanylyl cyclase expression in pulmonary arteries.

J. Kempfert, R. Middendorff, M. Koglin, 2001, Biochemical and biophysical research communications.

Expression and tissue localization of soluble guanylyl cyclase in the human placenta using novel antibodies directed against the alpha(2) subunit.

J. Kempfert, T. Löning, A. Bamberger, 2001, The Journal of clinical endocrinology and metabolism.

Muscarinic and beta-adrenergic regulation of heart rate, force of contraction and calcium current is preserved in mice lacking endothelial nitric oxide synthase.

R. Fischmeister, G. Vandecasteele, T. Eschenhagen, 1999, Nature medicine.

Reduced α1‐ and β2‐adrenoceptor‐mediated positive inotropic effects in human end‐stage heart failure

M. Steinfath, W. Schmitz, A. Haverich, 1992 .

Phosphodiesterase inhibition and positive inotropic effects.

W. Schmitz, H. E. von der Leyen, H. Scholz, 1989, Journal of cardiovascular pharmacology.

INCREASE IN MYOCARDIAL Gi-PROTEINS IN HEART FAILURE

W. Schmitz, P. Kalmar, H. Scholz, 1988, The Lancet.

Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure.

W. Schmitz, A. Haverich, T. Eschenhagen, 1992, Circulation research.

Long term beta-adrenoceptor-mediated up-regulation of Gi alpha and G(o) alpha mRNA levels and pertussis toxin-sensitive guanine nucleotide-binding proteins in rat heart.

J. Schulte am Esch, W. Schmitz, M. Diederich, 1992, Molecular pharmacology.

Changes in cardiac β-Adrenoceptors in human heart diseases: Relationship to the degree of heart failure and further evidence for etiology-related regulation of β1 and β2 subtypes☆

M. Steinfath, W. Schmitz, P. Kalmar, 1993 .

Endotoxin and cytokines induce direct cardiodepressive effects in mammalian cardiomyocytes via induction of nitric oxide synthase.

W. Schmitz, H. Scholz, M. Thoenes, 1996, Journal of molecular and cellular cardiology.

Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations

W. Schmitz, A. Haverich, H. Leyen, 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

Phosphodiesterase inhibition and positive inotropy in failing human myocardium.

F. Müller, W. Schmitz, T. Eschenhagen, 1992, Basic Research in Cardiology.

Expression of inducible nitric oxide synthase in failing and non-failing human heart.

U. Förstermann, A. Nüssler, H. Scholz, 1996, Journal of molecular and cellular cardiology.

Bovine hereditary cardiomyopathy: an animal model of human dilated cardiomyopathy.

F. Müller, W. Schmitz, M. Diederich, 1995, Journal of molecular and cellular cardiology.

Evidence against a role of a pertussis toxin-sensitive guanine nucleotide-binding protein in the alpha1-adrenoceptor-mediated positive inotropic effect in the heart

M. Böhm, W. Schmitz, H. Scholz, 1987, Naunyn-Schmiedeberg's Archives of Pharmacology.

Evidence for the existence of inositol tetrakisphosphate in mammalian heart. Effect of alpha 1-adrenoceptor stimulation.

J. Scholz, W. Schmitz, H. Scholz, 1990, Circulation research.

Basal and isoprenaline-stimulated cAMP content in failing versus nonfailing human cardiac preparations.

W. Schmitz, P. Kalmar, H. Scholz, 1989, Journal of cardiovascular pharmacology.

Inactivation of GiαProteins Increases Arrhythmogenic Effects ofβ-Adrenergic Stimulation in the Heart

J. Weil, T. Eschenhagen, H. Scholz, 1998 .

Effects of metoprolol on myocardial beta-adrenoceptors and Gi alpha-proteins in patients with congestive heart failure.

M. Steinfath, W. Schmitz, P. Hanrath, 1996, European journal of clinical pharmacology.

Regional distribution of β1- and β2-adrenoceptors in the failing and nonfailing human heart

M. Steinfath, W. Schmitz, P. Kalmar, 2004, European Journal of Clinical Pharmacology.

Decrease in β1- and increase in β2-adrenoceptors in long-term follow-up after orthotopic cardiac transplantation

M. Steinfath, W. Schmitz, A. Haverich, 1992 .

Cardiac α1‐adrenoceptor densities in different mammalian species

M. Steinfath, W. Schmitz, H. Scholz, 1992 .

The role of alpha 1-adrenergic and muscarinic receptors in cardiac function.

F. Müller, W. Schmitz, T. Eschenhagen, 1991, European heart journal.

Increased expression of constitutive nitric oxide synthase III, but not inducible nitric oxide synthase II, in human heart failure.

U. Förstermann, T. Eschenhagen, H. Scholz, 1998, Journal of the American College of Cardiology.

Classification and mechanism of action of antiarrhythmic drugs *

H. Scholz, 1994, Fundamental & clinical pharmacology.

Localization of preproenkephalin mRNA in rat heart: selective gene expression in left ventricular myocardium.

J. Weil, T. Eschenhagen, H. Scholz, 1998, American journal of physiology. Heart and circulatory physiology.

Localization of preproenkephalin mRNA in rat heart: selective gene expression in left ventricular myocardium.

J. Weil, T. Eschenhagen, H. Scholz, 1998, The American journal of physiology.

Time course and extent of a 1-adrenoceptor density changes in rat heart after f-adrenoceptor blockade '

H. Scholz, M. Nose, Volker, 2006 .

Time course and extent of α1‐adrenoceptor density changes in rat heart after β‐adrenoceptor blockade

H. Scholz, M. Nose, V. Steinkraus, 1989 .

Effects of saterinone and its enantiomers R(+)-saterinone and S(−)-saterinone on the phosphodiesterase isoenzymes from ventricular tissue of failing human hearts and porcine hearts

A. Haverich, H. Scholz, C. Schumacher, 1994, Naunyn-Schmiedeberg's Archives of Pharmacology.

Mechanism of action and cardiotonic activity of a new phosphodiesterase inhibitor, the benzimidazole derivative adibendan (BM 14.478), in guinea-pig hearts

H. Leyen, H. Scholz, T. Bethke, 1988, Naunyn-Schmiedeberg's Archives of Pharmacology.

Phosphodiesterase inhibition in ventricular cardiomyocytes from guinea‐pig hearts

W. Schmitz, H. Scholz, B. Stein, 1992, British journal of pharmacology.

Alpha-adrenoceptor-mediated positive inotropic effect of phenylephrine in isolated human ventricular myocardium.

W. Schmitz, A. Mügge, H. Scholz, 1984, European journal of pharmacology.

Relation of positive inotropic and chronotropic effects of pimobendan, UD-CG 212 Cl, milrinone and other phosphodiesterase inhibitors to phosphodiesterase III inhibition in guinea-pig heart

H. Leyen, H. Scholz, W. Meyer, 1989, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effects of adenosine analogues on contractile response and CAMP content in guinea-pig isolated ventricular myocytes

W. Schmitz, H. Scholz, J. Neumann, 1989, Naunyn-Schmiedeberg's Archives of Pharmacology.

Characterization of biochemical effects of CGS 21680C, an A2-adenosine receptor agonist, in the mammalian ventricle.

W. Schmitz, H. Scholz, J. Neumann, 1997, Journal of cardiovascular pharmacology.

Effects of adenosine analogues on force and cAMP in the heart. Influence of adenosine deaminase.

W. Schmitz, H. Scholz, J. Neumann, 1989, European journal of pharmacology.

Mechanism of the "Antiadrenergic" Effects of Adenosine on Myocardial Force of Contraction

M. Böhm, W. Schmitz, H. Scholz, 1987 .

Regulation and possible functional implications of G-protein mRNA expression in nonfailing and failing ventricular myocardium.

J. Schulte am Esch, W. Schmitz, T. Eschenhagen, 1992, Basic research in cardiology.

Existence and functional role of alpha 1-adrenoceptors in the mammalian heart.

A. Mügge, H. Scholz, R. Brückner, 1985, Journal of molecular and cellular cardiology.

Reduction of myocardial myoglobin in bovine dilated cardiomyopathy.

J. Weil, T. Eschenhagen, H. Scholz, 1997, Journal of molecular and cellular cardiology.

Relation between contractile function and regulatory cardiac proteins in hypertrophied hearts.

E. Krause, W. Schmitz, H. Scholz, 1996, The American journal of physiology.

Effects of α- and β-adrenergic agonists, phosphodiesterase inhibitors and adenosine on isolated human heart muscle preparations

E. Erdmann, W. Schmitz, H. Scholz, 1987 .

Distinct down-regulation of cardiac beta 1- and beta 2-adrenoceptors in different human heart diseases.

M. Steinfath, W. Schmitz, A. Haverich, 1991, Naunyn-Schmiedeberg's archives of pharmacology.

Positive inotropic agents: Different mechanisms of action

H. Scholz, 1986 .

Pharmacological actions of various inotropic agents.

H. Scholz, 1983, European heart journal.

Muscarinic and β-adrenergic regulation of heart rate, force of contraction and calcium current is preserved in mice lacking endothelial nitric oxide synthase

R. Fischmeister, G. Vandecasteele, T. Eschenhagen, 1999, Nature Medicine.

Phosphodiesterase-inhibiting properties of newer inotropic agents.

H. Scholz, W. Meyer, 1986, Circulation.

Pharmacological characterization of A2-adenosine receptors in guinea-pig ventricular cardiomyocytes.

W. Schmitz, H. Scholz, B. Stein, 1994, Journal of molecular and cellular cardiology.

Reduced a1- and fl2-adrenoceptor-mediated positive inotropic effects in human end-stage heart failure

M. Steinfath, W. Schmitz, H. Scholz, 2006 .

Increased myocardial α1adrenoceptor density in rats chronically treated with propranolol

A. Mügge, H. Scholz, C. Reupcke, 1985 .

Increased myocardial alpha 1 adrenoceptor density in rats chronically treated with propranolol.

A. Mügge, H. Scholz, C. Reupcke, 1985, European journal of pharmacology.

Pharmacological profile of CGP 48506, a new positive inotropic agent

H. Scholz, J. Neumann, N. Zimmermann, 1997 .

Purified cardiac cell membranes with high (Na+ + K+) ATPase activity contain significant NADH-vanadate reductase activity

F. L. Crane, E. Erdmann, W. Schmitz, 1979, Nature.

Role of guanine nucleotide-binding protein in the regulation by adenosine of cardiac potassium conductance and force of contraction. Evaluation with pertussis toxin

M. Böhm, W. Schmitz, H. Scholz, 1986, Naunyn-Schmiedeberg's Archives of Pharmacology.

Pertussis toxin prevents adenosine receptor- and m-cholinoceptor-mediated sinus rate slowing and AV conduction block in the guinea-pig heart

M. Böhm, W. Schmitz, H. Scholz, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effect of DB-c-AMP on mechanical characteristics of ventricular and atrial preparations of several mammalian species

T. Meinertz, H. Nawrath, H. Scholz, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Influence of cyclization and acyl substitution on the inotropic effects of adenine nucleotides

T. Meinertz, H. Nawrath, H. Scholz, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Positive inotropic effect of bay K 8644: cAMP-independence and lack of inhibitory effect of adenosine

M. Böhm, W. Schmitz, H. Scholz, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

Cardiac glycoside receptor, (Na+ + K+)-ATPase activity and force of contraction in rat heart.

E. Erdmann, H. Scholz, G. Philipp, 1980, Biochemical pharmacology.

Functional evidence against the existence of β2-adrenoceptors mediating positive inotropic effects in guinea-pig right ventricular myocardium

W. Schmitz, A. Mügge, H. Scholz, 1996, Naunyn-Schmiedeberg's Archives of Pharmacology.

Pharmacological characterization of protein phosphatase activities in preparations from failing human hearts.

L. Jones, H. Scholz, J. Neumann, 1999, The Journal of pharmacology and experimental therapeutics.

The technique of endobronchial lidocaine administration does not influence plasma concentration profiles and pharmacokinetic parameters in humans.

J. Scholz, M. Steinfath, S. Läer, 1995, Resuscitation.

Receptor-Mediated Regulation of Cardiac Contractility: lnotropic Effects of Alpha-Adrenoceptor Stimulation with Phenylephrine and Noradrenaline in Failing Human Hearts

T. Eschenhagen, H. Scholz, J. Neumann, 1996 .

Expression of nitric oxide-sensitive guanylyl cyclase subunits in human corpus cavernosum.

H. Scholz, S. Behrends, A. Steenpass, 2000, Biochemical pharmacology.

Beta-adrenoceptor stimulation-induced increase in cardiac Gi-protein expression and in carbachol sensitivity.

J. Schulte am Esch, W. Schmitz, T. Eschenhagen, 1991, European heart journal.

Evidence for isoproterenol-induced phosphorylation of phosphatase inhibitor-1 in the intact heart.

A. Nairn, W. Schmitz, R. Gupta, 1991, Circulation research.

Functional evidence for the existence of adenosine receptors in the human heart.

M. Böhm, W. Schmitz, A. Mügge, 1985, European journal of pharmacology.

Differential regulation of mRNA specific for beta 1- and beta 2-adrenergic receptors in human failing hearts. Evaluation of the absolute cardiac mRNA levels by two independent methods.

W. Schmitz, W. Kübler, T. Eschenhagen, 1996, Journal of molecular and cellular cardiology.

Effects of the beta2-adrenoceptor agonists fenoterol and salbutamol on force of contraction in isolated human ventricular myocardium

W. Schmitz, A. Mügge, H. Scholz, 1985, Klinische Wochenschrift.

Effects on transmembrane action potential, slow inward current and force of contraction in ventricular cardiac muscle of BRL 31660, a new antiarrhythmic drug with class I and class IV activity

W. Schmitz, H. Scholz, R. Brückner, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

The positive inotropic effect of phenylephrine in the presence of propranolol. Increase in time to peak force and in relaxation time without increase in c-AMP

T. Meinertz, H. Scholz, R. Brückner, 1978, Naunyn-Schmiedeberg's Archives of Pharmacology.

Possible role of cyclic AMP in the relaxation process of mammalian heart: Effects of dibutyryl cyclic AMP and theophylline on potassium contractures in cat papillary muscles

T. Meinertz, H. Nawrath, H. Scholz, 1976, Naunyn-Schmiedeberg's Archives of Pharmacology.

Evidence for a dibutyryl-c-AMP increased 45Ca release from cardiac muscle.

S. Wellek, T. Meinertz, H. Nawrath, 1975, Research communications in chemical pathology and pharmacology.

Interaction between sotalol and an antacid preparation.

S. Läer, H. Scholz, J. Neumann, 1997, British journal of clinical pharmacology.

Effects of (−)-Phenylephrine on force of contraction in the presence of cocaine and hydrocortisone in cat papillary muscle

W. Schmitz, A. Mügge, H. Scholz, 1984, Naunyn-Schmiedeberg's Archives of Pharmacology.

Mechanisms of the contractile effects of flosequinoxan

E. Gams, L. Jones, G. Bodor, 1995, Naunyn-Schmiedeberg's Archives of Pharmacology.

Interaction of beta-adrenoceptor and adenosine receptor agonists on phosphorylation. Identification of target proteins in mammalian ventricles.

E. Krause, W. Schmitz, R. Gupta, 1995, Journal of molecular and cellular cardiology.

Stimulatory effect of vanadate on cyclic AMP levels in cat papillary muscle.

E. Erdmann, W. Schmitz, H. Scholz, 1980, Biochemical pharmacology.

Glyceryl trinitrate treatment up-regulates soluble guanylyl cyclase in rat dura mater

B. Csillik, J. Kempfert, L. Vécsei, 2001, Neuroreport.

Comparison of the Stereoselective Effects of a Thiadiazinone Derivative on Contractile Parameters and Protein Phosphorylation in the Mammalian Ventricle

W. Schmitz, H. Scholz, J. Neumann, 1995, Journal of cardiovascular pharmacology.

Increased sensitivity to α-adrenoceptor stimulation but intact purinergic and muscarinergic effects in prehypertensive cardiac hypertrophy of spontaneously hypertensive rats

M. Böhm, W. Schmitz, H. Scholz, 1986, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effects of the phosphatase inhibitor calyculin A on the phosphorylation of C-protein in mammalian ventricular cardiomyocytes.

E. Krause, W. Schmitz, H. Scholz, 1995, Biochemical pharmacology.

The Expression Pattern of Nitric Oxide-sensitive Guanylyl Cyclase in the Rat Heart Changes During Postnatal Development

J. Kempfert, R. Middendorff, M. Koglin, 2002, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Increased responsiveness to stimulation of alpha- but not beta-adrenoceptors in the hereditary cardiomyopathy of the Syrian hamster. Intact adenosine- and cholinoceptor-mediated isoprenaline antagonistic effect.

M. Böhm, W. Schmitz, H. Scholz, 1986, European journal of pharmacology.

DISSOCIATION OF THEOPHYLLINE UPTAKE AND INOTROPIC EFFECT IN MYOCARDIAL TISSUE: INFLUENCE OF TEMPERATURE, pH AND CALCIUM

H. Scholz, P. Bellemann, 1975, British journal of pharmacology.

Proceedings: Inability of propranolol to change the effects of theophylline on myocardial mechanics.

H. Scholz, W. Kasper, H. Greiner, 1975, Naunyn-Schmiedeberg's archives of pharmacology.

RELATIONSHIP BETWEEN THEOPHYLLINE UPTAKE AND INOTROPIC EFFECT IN THE GUINEA‐PIG HEART

H. Scholz, P. Bellemann, 1974, British journal of pharmacology.

Alpha-1 adrenoceptor-mediated positive inotropic effect and inositol trisphosphate increase in mammalian heart.

J. Scholz, M. Steinfath, M. Lohse, 1988, The Journal of pharmacology and experimental therapeutics.

Adenosine inhibits the positive inotropic effect of 3‐isobutyl‐1‐methylxanthine in papillary muscles without effect on cyclic AMP or cyclic GMP

M. Böhm, W. Schmitz, H. Scholz, 1988, British journal of pharmacology.

MECHANISMS OF ACTION

H. Scholz, W. Meyer, 2005 .

Negative inotropic effects of aldosterone antagonists in isolated human and guinea-pig ventricular heart muscle

W. Schmitz, A. Mügge, H. Scholz, 1984, Klinische Wochenschrift.

Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts.

W. Schmitz, H. Scholz, J. Neumann, 1999, Cardiovascular research.

The regulation of the calcium conductance of cardiac muscle by adrenaline.

H. Reuter, H. Scholz, 1977, The Journal of physiology.

Biochemical and electrophysiological mechanisms of the positive inotropic effect of calyculin A, a protein phosphatase inhibitor.

W. Schmitz, K. Wiechen, H. Scholz, 1994, The Journal of pharmacology and experimental therapeutics.

Vanadate and its significance in biochemistry and pharmacology.

E. Erdmann, K. Werdan, W. Schmitz, 1984, Biochemical pharmacology.

Effects of Beta- and Alpha-Adrenoceptor Activators and Adrenergic Transmitter Releasing Agents on the Mechanical Activity of the Heart

H. Scholz, 1980 .

No differences in benzo(a)pyrene hydroxylase activity in the human immature placenta and in the human fetal liver from cigarette smoking and nonsmoking women

H. Scholz, E. Schlede, 1974, Journal of perinatal medicine.

Effect of vanadium in the +5, +4 and +3 oxidation states on cardiac force of contraction, adenylate cyclase and (Na+ + K+)-ATPase activity.

E. Erdmann, K. Werdan, W. Schmitz, 1982, Biochemical pharmacology.

Molecular and Cellular Mechanisms of Cardiovascular Regulation

M. Morad, H. Scholz, M. Endoh, 1996, Springer Japan.

Dibutyryl cyclic AMP and adrenaline increase contractile force and 45Ca uptake in mammalian cardiac muscle

T. Meinertz, H. Nawrath, H. Scholz, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Myocardial alpha-adrenoceptors and positive inotropy.

A. Mügge, H. Scholz, C. Reupcke, 1986, Journal of molecular and cellular cardiology.

Effect of papaverine on cyclic AMP, calcium uptake and force of contraction in isolated guinea-pig auricles.

T. Meinertz, H. Nawrath, H. Scholz, 1977, Research communications in chemical pathology and pharmacology.

Positive inotropic but no relaxant effects of phenylephrine in cat papillary muscle.

T. Meinertz, H. Scholz, B. Schmelzle, 1978, Journal of cyclic nucleotide research.

Pertussis toxin unmasks stimulatory myocardial A2-adenosine receptors on ventricular cardiomyocytes.

W. Schmitz, H. Scholz, J. Neumann, 1993, Journal of molecular and cellular cardiology.

Cardiac effects of adenosine and adenosine analogs in guinea-pig atrial and ventricular preparations: evidence against a role of cyclic AMP and cyclic GMP.

W. Schmitz, H. Scholz, W. Meyer, 1985, The Journal of pharmacology and experimental therapeutics.

Effects of α‐adrenoceptor stimulation with phenylephrine in the presence of propranolol on force of contraction, slow inward current and cyclic AMP content in the bovine heart

H. Scholz, R. Brückner, 1984, British journal of pharmacology.

Effectiveness of theophylline to increase cyclic AMP levels and force of contraction in electrically paced guinea-pig auricles. Comparison with isoprenaline, calcium and ouabain

T. Meinertz, H. Scholz, B. Schmelzle, 1977, Naunyn-Schmiedeberg's Archives of Pharmacology.

A study of the ion selectivity and the kinetic properties of the calcium dependent slow inward current in mammalian cardiac muscle.

H. Reuter, H. Scholz, 1977, The Journal of physiology.

Carvedilol therapy in pediatric patients with congestive heart failure: a study investigating clinical and pharmacokinetic parameters.

B. Meibohm, T. Mir, S. Läer, 2002, American heart journal.

Small blood volumes from children for quantitative sotalol determination using high-performance liquid chromatography.

S. Läer, H. Scholz, I. Wauer, 2001, Journal of chromatography. B, Biomedical sciences and applications.

Quantitation of diltiazem in human cardiac tissue using high-performance liquid chromatography.

S. Läer, H. Scholz, J. Neumann, 1997, Journal of chromatographic science.

Response of isolated human ventricular myocardium to cyclic AMP and its dibutyryl derivative

T. Meinertz, H. Nawrath, H. Scholz, 1974, Klinische Wochenschrift.

Nitric Oxide Activates the β2 Subunit of Soluble Guanylyl Cyclase in the Absence of a Second Subunit*

M. Koglin, H. Scholz, L. Budaeus, 2001, The Journal of Biological Chemistry.

The Pharmacology of Propafenone

H. Scholz, 1983 .

Radioimmunochemical quantification of Gi alpha in right and left ventricles from patients with ischaemic and dilated cardiomyopathy and predominant left ventricular failure.

M. Steinfath, M. Böhm, P. Schnabel, 1994, Journal of molecular and cellular cardiology.

Cellular and molecular aspects of contractile dysfunction in heart failure.

T. Eschenhagen, H. Scholz, C. Mittmann, 1998, Cardiovascular research.

Inotropic Stimulation and Myocardial Energetics

H. Scholz, H. Just, C. Holubarsch, 1989, Steinkopff.

Enrichment of G protein α-subunit mRNAs in the AV-conducting system of the mammalian heart

U. Laufs, W. Schmitz, J. Weil, 1995 .

Inhibition of the effects of adenosine on force of contraction and the slow calcium inward current by pertussis toxin is associated with myocardial lesions.

M. Böhm, W. Schmitz, H. Scholz, 1988, Cardiovascular research.

Inotropic actions of adenosine derivatives in the mammalian heart

W. Schmitz, H. Scholz, J. Neumann, 1993 .

Dissociation of the effects of forskolin and dibutyryl cAMP on force of contraction and phospholamban phosphorylation in human heart failure.

P. Karczewski, E. Krause, W. Schmitz, 1999, Journal of cardiovascular pharmacology.

Differential antagonism by 1,3-dipropylxanthine-8-cyclopentylxanthine and 9-chloro-2-(2-furanyl)-5,6-dihydro-1,2,4-triazolo(1,5-c)quinazolin-5-im ine of the effects of adenosine derivatives in the presence of isoprenaline on contractile response and cyclic AMP content in cardiomyocytes. Evidence for

W. Schmitz, H. Scholz, J. Neumann, 1990, Journal of Pharmacology and Experimental Therapeutics.

Positive inotropic effect of carbachol and inositol phosphate levels in mammalian atria after pretreatment with pertussis toxin.

W. Schmitz, H. Scholz, C. Kohl, 1990, The Journal of pharmacology and experimental therapeutics.

Effects of adenosine receptor and muscarinic cholinergic receptor agonists on cardiac protein phosphorylation. Influence of pertussis toxin.

W. Schmitz, L. Jones, G. Bodor, 1994, Journal of Pharmacology and Experimental Therapeutics.

Adenosine inhibition of catecholamine-induced increase in force of contraction in guinea-pig atrial and ventricular heart preparations. Evidence against a cyclic AMP- and cyclic GMP-dependent effect.

B. Haubitz, M. Böhm, W. Schmitz, 1984, The Journal of pharmacology and experimental therapeutics.

Evidence for adenosine receptor-mediated isoprenaline-antagonistic effects of the adenosine analogs PIA and NECA on force of contraction in guinea-pig atrial and ventricular cardiac preparations

M. Böhm, W. Schmitz, H. Scholz, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effects of PIA and NECA on contractile behaviour and cAMP content in isolated cardiomyocytes in the presence of the A1-adenosine receptor antagonist DPCPX☆

W. Schmitz, H. Scholz, J. Neumann, 1989 .

Evidence for physiological functions of protein phosphatases in the heart: evaluation with okadaic acid.

W. Schmitz, R. Gupta, H. Scholz, 1993, The American journal of physiology.

Apparent up‐regulation of stimulatory G‐protein α subunits in the pregnant human myometrium is mimicked by elevated smoothelin expression 1

T. Wieland, T. Eschenhagen, H. Scholz, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Increased expression of cardiac phosphatases in patients with end-stage heart failure.

W. Schmitz, T. Eschenhagen, L. Jones, 1997, Journal of molecular and cellular cardiology.

In Vivo β-Adrenergic Stimulation Leads to Biphasic Regulation of Giα-2 Gene Transcriptional Activity in Rat Heart

F. Müller, W. Schmitz, T. Eschenhagen, 1994 .

Effect of theophylline on calcium exchangeability in ventricular myocardium

H. Scholz, P. Bellemann, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Adrenaline, DB-c-AMP and myocardial 45Ca exchange. Comparative studies in rat and guinea-pig auricles

T. Meinertz, H. Nawrath, H. Scholz, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Sodium fluoride attenuates the negative inotropic effects of muscarinic M2 and adenosine receptor agonists.

H. Scholz, J. Neumann, U. Kirchhefer, 1995, European journal of pharmacology.

Effects of carbachol and (−)‐N6‐phenylisopropyladenosine on myocardial inositol phosphate content and force of contraction

J. Scholz, W. Schmitz, H. Scholz, 1990, British journal of pharmacology.

Mechanisms of the contractile effects of 2,3-butanedione-monoxime in the mammalian heart

R. Maas, E. Gams, L. Jones, 1996, Naunyn-Schmiedeberg's Archives of Pharmacology.

Deferoxamine blocks interactions of fluoride and carbachol in isolated mammalian cardiac preparations.

H. Scholz, J. Neumann, 1998, European journal of pharmacology.

Calcium sensitization as new principle of inotropic therapy in end-stage heart failure?

E. Gams, H. Scholz, J. Neumann, 1998, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Positive inotropic effects of the calcium sensitizer CGP 48506 in guinea pig myocardium.

W. Schmitz, E. Gams, H. Scholz, 1996, The Journal of pharmacology and experimental therapeutics.

Positive inotropic effects of the calcium sensitizer CGP 48506 in failing human myocardium.

I. Grupp, W. Schmitz, A. Haverich, 1996, The Journal of pharmacology and experimental therapeutics.

Mechanisms of the contractile effects of levosimendan in the mammalian heart.

W. Schmitz, H. Scholz, J. Neumann, 1997, The Journal of pharmacology and experimental therapeutics.

Isoprenaline-like effects of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine on mechanical, biochemical and electrophysiological parameters in the mammalian heart

W. Schmitz, H. Scholz, M. Nose, 1985, Experientia.

Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations

J. Scholz, M. Lohse, W. Schmitz, 1989, Naunyn-Schmiedeberg's Archives of Pharmacology.

Adenosine and adenosine analogs inhibit phosphodiesterase activity in the heart

W. Schmitz, H. Scholz, M. Nose, 1984, Naunyn-Schmiedeberg's Archives of Pharmacology.

Increase in IP3 precedes alpha-adrenoceptor-induced increase in force of contraction in cardiac muscle.

J. Scholz, M. Steinfath, W. Schmitz, 1987, European journal of pharmacology.

ADRENALINE, ADENOSINE, AND FEEDBACK

M. Böhm, W. Schmitz, H. Scholz, 1985, The Lancet.

Three‐dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system

Thomas Eschenhagen, E. Elson, W. Zimmermann, 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[On the influence of the extracellular Ca concentration on membrane potential and contraction of isolated heart preparations during graded depolarization].

H. Reuter, H. Scholz, 1968, Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere.

Existence and alpha 1-adrenergic stimulation of inositol polyphosphates in mammalian heart.

J. Scholz, J. Schulte am Esch, W. Schmitz, 1992, Molecular pharmacology.

Ca(++)-dependent constitutive nitric oxide synthase is not involved in the cyclic GMP-increasing effects of carbachol in ventricular cardiomyocytes.

W. Schmitz, A. Mülsch, H. Scholz, 1993, The Journal of pharmacology and experimental therapeutics.

Introduction: Mechanisms of positive inotropic effects

H. Scholz, 1989, Basic Research in Cardiology.

Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts

P. Karczewski, E. Krause, W. Schmitz, 2004, Molecular and Cellular Biochemistry.

Stimulatory effect of vanadate on (Na+ + K+)-ATPase activity and on 3H-ouabain-binding in a cat heart cell membrane preparation

E. Erdmann, W. Schmitz, H. Scholz, 1979, Nature.

Positive inotropism of vanadate in cat papillary muscle

E. Erdmann, W. Schmitz, H. Scholz, 1978, Nature.

Long-term beta adrenoceptor-mediated alteration in contractility and expression of phospholamban and sarcoplasmic reticulum Ca(++)-ATPase in mammalian ventricle.

F. Müller, W. Schmitz, H. Baba, 1998, The Journal of pharmacology and experimental therapeutics.

Pertussis toxin does not inhibit the alpha 1-adrenoceptor-mediated effect on inositol phosphate production in the heart.

J. Scholz, M. Steinfath, M. Lohse, 1987, European journal of pharmacology.

On the mechanism of the cardiotonic and smooth muscle relaxing effects of the methylxanthines

H. Scholz, 1984 .

On the mechanism of action of theophylline on the heart and other organs

H. Scholz, 1982 .

Preserved Frank-Starling mechanism in human end stage heart failure.

J. Weil, T. Eschenhagen, U. Remmers, 1998, Cardiovascular research.

Does an impaired adenosine mediated feedback control play a role in the development of hereditary dystrophic cardiomyopathy?

M. Böhm, W. Schmitz, H. Scholz, 1986, Cardiovascular research.

Cardiac ai-adrenoceptor densities in different mammalian species

W. Schmitz, H. Scholz, M. Nose, 2006 .

Effects of Isomazole on Force of Contraction and Phosphodiesterase Isoenzymes I‐IV in Nonfailing and Failing Human Hearts

W. Schmitz, A. Haverich, H. E. von der Leyen, 1991, Journal of cardiovascular pharmacology.

Cardiac alpha 1-adrenoceptor densities in different mammalian species.

Y. Y. Chen, M. Steinfath, W. Schmitz, 1992, British Journal of Pharmacology.

Stimulatory (insulin-mimetic) and inhibitory (ouabain-like) action of vanadate on potassium uptake and cellular sodium and potassium in heart cells in culture.

E. Erdmann, K. Werdan, W. Schmitz, 1982, Biochimica et biophysica acta.

Chronic treatment with carbachol sensitizes the myocardium to cAMP-induced arrhythmia.

M. Steinfath, M. Böhm, W. Schmitz, 1996, Circulation.

Negative inotropic effect of vanadate in ventricular myocardium in the presence of 3-isobutyl-1-methylxanthine or isoprenaline

E. Erdmann, K. Werdan, W. Schmitz, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

On the cardiac contractile, biochemical and electrophysiological effects of cantharidin, a phosphatase inhibitor.

W. Schmitz, M. Apel, M. Tepel, 1995, The Journal of pharmacology and experimental therapeutics.

Reduced alpha 1- and beta 2-adrenoceptor-mediated positive inotropic effects in human end-stage heart failure.

M. Steinfath, W. Schmitz, H. E. von der Leyen, 1992, British journal of pharmacology.

Inotropic drugs and their mechanisms of action.

H. Scholz, 1984, Journal of the American College of Cardiology.

Evidence against a role of (Na++K+-ATPase in the alpha-adrenoceptor mediated positive inotropic effect of phenylephrine

E. Erdmann, K. Werdan, W. Schmitz, 1980, Experientia.

Messenger RNA expression and immunological quantification of phospholamban and SR-Ca(2+)-ATPase in failing and nonfailing human hearts.

F. Müller, W. Schmitz, T. Eschenhagen, 1996, Cardiovascular research.

Importance of cardiac cell membranes in vanadate-induced NADH oxidation

E. Erdmann, W. Schmitz, H. Scholz, 1981, Nature.

Adrenoceptors in the Myocardium: Mechanical and Biochemical Events Resulting from Their Stimulation

H. Scholz, 1986 .

Inotropic drugs in the treatment of heart failure.

H. Scholz, 1984, Hospital practice.

Regulation of the human Gi alpha-2 gene promotor activity in embryonic chicken cardiomyocytes.

L. Weinstein, W. Schmitz, J. Weil, 1996, Basic Research in Cardiology.

[The positive ionotropic effect of dibutyryl-3',5'-AMP on isolated rat atria].

T. Meinertz, H. Nawrath, H. Scholz, 1972, Pflügers Archiv: European Journal of Physiology.

On the mechanism of positive inotropic effects of alpha-adrenoceptor agonists

J. Scholz, W. Schmitz, H. Scholz, 2007, Basic Research in Cardiology.

Cardiac alpha-receptors and cardiac hypertrophy in genetic predisposition to hypertension.

M. Böhm, W. Schmitz, H. Scholz, 1986, American heart journal.

Increased sensitivity to alpha-adrenoceptor stimulation but intact purinergic and muscarinergic effects in prehypertensive cardiac hypertrophy of spontaneously hypertensive rats.

M. Böhm, W. Schmitz, H. Scholz, 1986, Naunyn-Schmiedeberg's archives of pharmacology.

Assignment of GUCY1B2, the gene coding for the beta2 subunit of human guanylyl cyclase to chromosomal band 13q14.3 between markers D13S168 and D13S155.

H. Eiberg, J. Bullerdiek, B. Kazmierczak, 1999, Genomics.

High Selectivity for Inhibition of Phosphodiesterase III and Positive Inotropic Effects of MCI‐154 in Guinea Pig Myocardium

W. Schmitz, H. Scholz, B. Armah, 1993, Journal of cardiovascular pharmacology.

Possible involvement of inositol-lipid metabolism in malignant hyperthermia.

J. Scholz, J. Schulte am Esch, W. Schmitz, 1991, British Journal of Anaesthesia.

Effects of Beta‐ and Alpha‐adrenergic Agonists, Adenosine, and Carbachol in Heart Muscle Isolated from Malignant Hyperthermia Susceptible Swine

M. Böhm, W. Schmitz, N. Roewer, 1988, Anesthesiology.

Effects of the benzimidazole derivatives pimobendan and 2-(4-hydroxy-phenyl)-5-(5-methyl-3-oxo-4,5-dihydro-2H-6- pyridazinyl) benzimidazole . HCl on phosphodiesterase activity and force of contraction in guinea-pig hearts.

C. Berger, H. Scholz, J. Starbatty, 1985, Arzneimittel-Forschung.

New positive inotropic agents acting by phosphodiesterase inhibition or alpha 1-adrenergic stimulation.

J. Scholz, W. Schmitz, H. E. von der Leyen, 1989, Pharmacological research.

The Influence of Intracellular Sodium Concentration on Calcium Influx in Isolated Guinea-Pig Auricles / Der Einfluß der intracellulären Natriumkonzentration auf den Calcium-influx in isolierte Meerschweinchenvorhöfe

H. Reuter, H. Glitsch, H. Scholz, 1969 .

The influence of intracellular sodium concentration on calcium influx in isolated guinea-pig auricles

H. Reuter, H. Glitsch, H. Scholz, 2006, Naunyn-Schmiedebergs Archiv für Pharmakologie.

Evidence for alpha 1-adrenoceptor-mediated increase of inositol trisphosphate in the human heart.

J. Scholz, W. Schmitz, P. Kalmar, 1989, Journal of cardiovascular pharmacology.

Inotropic response in CHF: myocarditis vs dilated cardiomyopathy.

W. Schmitz, J. Scholz, P. Kalmar, 1988, American Heart Journal.

Inotropic drugs and their mechanisms of action.

H. Scholz, 1984, Journal of the American College of Cardiology.

Enrichment of G protein alpha-subunit mRNAS in the AV-conducting system of the mammalian heart.

U. Laufs, W. Schmitz, J. Weil, 1995, Journal of molecular and cellular cardiology.

Assignment1 of GUCY1A3, a candidate gene for hypertension, to human chromosome bands 4q31.1→q31.2 by in situ hybridization

J. Bullerdiek, B. Kazmierczak, H. Scholz, 2000, Cytogenetic and Genome Research.

Effects of the Beta-Adrenoceptor Blocker Carvedilol in Children with Myocardial Failure

T. Mir, S. Läer, H. Scholz, 2003 .

The effect of calcium and sodium ions on the potassium contracture of mammalian cardiac muscle

H. Scholz, 1969 .

[Malignant hyperthermia and inositol phosphate metabolism in the heart and skeletal musculature].

J. Scholz, J. Schulte am Esch, W. Schmitz, 1991, Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS.

The β2 subunit of nitric oxide-sensitive guanylyl cyclase is developmentally regulated in rat kidney

J. Kempfert, H. Scholz, L. Budaeus, 2001, Naunyn-Schmiedeberg's Archives of Pharmacology.