N. Almstead

发表

Identification of PTC725, an Orally Bioavailable Small Molecule That Selectively Targets the Hepatitis C Virus NS4B Protein

S. Peltz, X. Tong, Z. Gu, 2013, Antimicrobial Agents and Chemotherapy.

Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors.

A. Freemont, J. Woessner, J. Hoyland, 2001, Osteoarthritis and cartilage.

Safety, Tolerability, and Pharmacokinetics of PTC124, a Nonaminoglycoside Nonsense Mutation Suppressor, Following Single‐ and Multiple‐Dose Administration to Healthy Male and Female Adult Volunteers

S. Peltz, S. Paushkin, L. Miller, 2007, Journal of clinical pharmacology.

Comparison of the pharmacology of hydroxamate- and carboxylate-based matrix metalloproteinase inhibitors (MMPIs) for the treatment of osteoarthritis

Bo Peng, T. Baker, M. Natchus, 2006, Inflammation Research.

P3.12 Small molecule compounds that correct alternative splicing of the SMN2 gene and restore SMN protein expression and function

S. Peltz, D. Kobayashi, S. Paushkin, 2011, Neuromuscular Disorders.

Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B.

Z. Gu, A. Nomeir, F. Lahser, 2016, Bioorganic & medicinal chemistry letters.

Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B.

Z. Gu, C. Espiritu, H. Ren, 2013, Bioorganic & Medicinal Chemistry Letters.

Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties

S. Peltz, A. Jacobson, T. Davis, 2018, Molecular Cancer Therapeutics.

The Next Generation of MMP Inhibitors: Design and Synthesis

M. Dowty, M. Natchus, B. Barnett, 1999, Annals of the New York Academy of Sciences.

Phase 1 Study of Safety, Tolerability, and Pharmacokinetics of PTC299, an Inhibitor of Stress‐Regulated Protein Translation

S. Peltz, Thomas P. Davis, G. Elfring, 2016, Clinical pharmacology in drug development.

Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.

T. Baker, M. Natchus, D. Foltz, 2001, Journal of medicinal chemistry.

Ataluren Pharmacokinetics in Healthy Japanese and Caucasian Subjects

Ronald Kong, O. Laskin, J. Mcintosh, 2019, Clinical pharmacology in drug development.

4-Hydroxy-2-pyridones: Discovery and evaluation of a novel class of antibacterial agents targeting DNA synthesis.

J. Narasimhan, A. Branstrom, Josephine Sheedy, 2017, Bioorganic & medicinal chemistry letters.

Potent and selective carboxylic acid-based inhibitors of matrix metalloproteinases.

G. Ciszewski, M. Natchus, N. Almstead, 2001, Journal of medicinal chemistry.

Metabolism and Disposition of Ataluren after Oral Administration to Mice, Rats, Dogs, and Humans

Ronald Kong, Elizabeth Goodwin, J. Mcintosh, 2020, Drug Metabolism and Disposition.

On the stereochemical course of the addition of allylsilanes to aldehydes

S. Denmark, Larry M. Wolf, N. Almstead, 2012 .

Gas chromatographic-mass spectrometric analysis of hydroxylamine for monitoring the metabolic hydrolysis of metalloprotease inhibitors in rat and human liver microsomes.

J. K. Hu, B. Smith, K. Wehmeyer, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Discovery and Optimization of Small Molecule Splicing Modifiers of Survival Motor Neuron 2 as a Treatment for Spinal Muscular Atrophy.

J. Narasimhan, Song Huang, Josephine Sheedy, 2016, Journal of medicinal chemistry.

The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold.

T. Hudlický, M. Natchus, R. Bookland, 2001, Bioorganic & medicinal chemistry letters.

Ataluren metabolism: Ataluren-O-1β-acyl glucuronide is a stable circulating metabolite in mouse, rat, dog and human.

J. Colacino, Ronald Kong, M. Weetall, 2021, Drug metabolism and pharmacokinetics.

In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren

J. Colacino, Ronald Kong, Elizabeth Goodwin, 2020, Pharmacology research & perspectives.

6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B.

Z. Gu, H. Ren, A. Nomeir, 2015, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors.

M. Natchus, L. Williams, M G Natchus, 1999, Journal of medicinal chemistry.

Spectroscopic studies on the TiCl4-promoted reaction of allylsilanes with aldehydes and α,β-enones

S. Denmark, N. Almstead, 1992 .

Studies on the Mechanism and Origin of Stereoselective Opening of Chiral Dioxane Acetals

S. Denmark, N. Almstead, 1991 .

On the Stereoselective Opening of Chiral Dioxane Acetals. Nucleophile Dependence

S. Denmark, N. Almstead, 1991 .

On the Stereoselective Opening of Achiral Dioxane Acetals

S. Denmark, N. Almstead, 1991 .

The Origin of Stereoselective Opening of Chiral Dioxane and Dioxolane Acetals: Solution Structure of Their Lewis Acid Complexes+

T. Willson, S. Denmark, N. Almstead, 1989 .

Spectroscopic studies on the structure and conformation of Lewis acid-aldehyde complexes

S. Denmark, N. Almstead, 1993 .

Stereochemical studies on the addition of allylstannanes to aldehydes. The SE' component

S. Denmark, N. Almstead, 1994 .

Allylation of Carbonyls: Methodology and Stereochemistry

S. Denmark, N. Almstead, 2007 .

Stereochemical Studies on the Addition of Allylsilanes to Aldehydes. The SE' Component

S. Denmark, N. Almstead, 2019 .

Studies on the Mechanism and Origin of Stereoselective Opening of Chiral Dioxane Acetals.

S. Denmark, N. Almstead, 1992 .

On the Stereoselective Opening of Chiral Dioxane Acetals. Nucleophile Dependence.

S. Denmark, N. Almstead, 1992 .

The Origin of Stereoselective Opening of Chiral Dioxane and Dioxolane Acetals: Solution Structure of Their Lewis Acid Complexes.

T. Willson, S. Denmark, N. Almstead, 1990 .

On the Stereoselective Opening of Achiral Dioxane Acetals.

S. Denmark, N. Almstead, 1992 .

The Next Generation of MMP Inhibitors: Design and Synthesis

M. Dowty, M. Natchus, B. Barnett, 1999, Annals of the New York Academy of Sciences.

Design and synthesis of phosphinamide-based hydroxamic acids as inhibitors of matrix metalloproteinases.

M. Natchus, M G Natchus, N. Almstead, 1999, Journal of medicinal chemistry.

Structure-activity relationship (SAR) optimization of 6-(indol-2-yl)pyridine-3-sulfonamides: identification of potent, selective, and orally bioavailable small molecules targeting hepatitis C (HCV) NS4B.

Ramesh Kakarla, Guangming Chen, Song Huang, 2014, Journal of medicinal chemistry.

Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform

Jean Hedrick, S. Peltz, T. Davis, 2016, PloS one.

PTC124 targets genetic disorders caused by nonsense mutations

Meenal Patel, Feng He, Masataka Kawana, 2007, Nature.

SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy

Anirvan Ghosh, Roland Schmucki, Hasane Ratni, 2014, Science.

1,4-radical elimination in cyclohexene systems: A model for the chorismate synthase reaction

B. Giese, N. Almstead, 1994 .

THE DESIGN AND SYNTHESIS OF SULFUR CONTAINING BISPHOSPHONIC ACIDS FOR THE TREATMENT OF ARTHRITIS

M. Francis, F. H. Ebetino, N. Almstead, 1999 .

Discovery of N-(4'-(indol-2-yl)phenyl)sulfonamides as novel inhibitors of HCV replication.

Z. Gu, H. Ren, J. Colacino, 2013, Bioorganic & medicinal chemistry letters.

Selective synthesis of 1-substituted 4-chloropyrazolo[3,4-d]pyrimidines.

N. Almstead, Y. Moon, C. Morrill, 2013, Organic letters.

Design and synthesis of piperazine-based matrix metalloproteinase inhibitors.

M. Dowty, M. Natchus, M G Natchus, 2000, Journal of medicinal chemistry.

Following Single-and Multiple-Dose Administration to Healthy Male and Female Adult Safety , Tolerability , and Pharmacokinetics of PTC 124 , a Nonaminoglycoside Nonsense Mutation

S. Peltz, S. Paushkin, L. Miller, 2007 .

Design and synthesis of conformationally-constrained MMP inhibitors.

M. Natchus, B. Barnett, M G Natchus, 1998, Bioorganic & medicinal chemistry letters.

Heterocycle-based MMP inhibitors with P2' substituents.

M. Natchus, N. Almstead, M. J. Janusz, 2001, Bioorganic & medicinal chemistry letters.

Chemoselective Reactions of 4,6-Dichloro-2-(methylsulfonyl)pyrimidine and Related Electrophiles with Amines

N. Almstead, Y. Moon, Seongwoo Hwang, 2013, Synthesis.

Reading through premature stop codons with PTC1 24. Project Catalyst to find more Duchenne drugs. Interview by Guenter Scheuerbrandt.

N. Almstead, E. Welch, Diane Goetz, 2008, Acta myologica.

Development of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines.

T. Baker, M. Dowty, M. Natchus, 2000, Journal of medicinal chemistry.