S. Wring

发表

Screen‐printed voltammetric and amperometric electrochemical sensors for decentralized testing

John P. Hart, Stephen A. Wring, J. Hart, 1994 .

Predicting P-glycoprotein substrates by a quantitative structure-activity relationship model.

Vijay K Gombar, Joseph W Polli, J. Polli, 2004, Journal of pharmaceutical sciences.

Rational use of in vitro P-glycoprotein assays in drug discovery.

J. Polli, L. Huang, J. Humphreys, 2001, The Journal of pharmacology and experimental therapeutics.

Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate

S. Rannard, A. Owen, Seonghee Park, 2017, Antimicrobial Agents and Chemotherapy.

Enfuvirtide Cerebrospinal Fluid (CSF) Pharmacokinetics and Potential use in Defining CSF HIV-1 Origin

D. Kuritzkes, R. Price, S. Deeks, 2008, Antiviral therapy.

Chemically modified, carbon-based electrodes and their application as electrochemical sensors for the analysis of biologically important compounds. A review

John P. Hart, Stephen A. Wring, J. Hart, 1992 .

A reagentless, disposable biosensor for lactic acid based on a screen-printed carbon electrode containing Meldola's Blue and coated with lactate dehydrogenase, NAD+ and cellulose acetate

John P. Hart, Stephen A. Wring, J. Hart, 1995 .

Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis

B. Nare, N. Yarlett, C. Bacchi, 2013, Parasitology.

SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro

G. Fischer, S. Hopkins, M. Murray, 2009, Antimicrobial Agents and Chemotherapy.

Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay.

T. E. Richardson, M. Phillips, B. Posner, 2017, ACS infectious diseases.

Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.

M. Phillips, M. Peel, J. D. De Brabander, 2018, Journal of medicinal chemistry.

Enfuvirtide plasma levels and injection site reactions using a needle-free gas-powered injection system (Biojector)

J. Montaner, R. Joy, M. Harris, 2006, AIDS.

Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis

K. Jarnagin, B. Nare, R. Brun, 2010, Antimicrobial Agents and Chemotherapy.

Steady-State Brain Concentrations of Antihistamines in Rats

Kelly H. Jordan, Larry J. Shampine, J. Polli, 2004, Pharmacology.

Rationale for Targeting the Serotonin System as a Treatment of Pulmonary Hypertension

T. Pack, S. Wring, 2019 .

Development of a Novel Formulation That Improves Preclinical Bioavailability of Tenofovir Disoproxil Fumarate

R. Ramabhadran, P. Domanico, S. Wring, 2017, Journal of pharmaceutical sciences.

Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis

K. Borroto-Esoda, Seonghee Park, G. Garrett, 2017, Antimicrobial Agents and Chemotherapy.

A trial design to maximize knowledge of the effects of rodatristat ethyl in the treatment of pulmonary arterial hypertension (ELEVATE 2)

M. Palacios, Jill Denning, S. Wring, 2022, Pulmonary circulation.

Clinical Pharmacokinetics and Drug‐Drug Interaction Potential for Coadministered SCY‐078, an Oral Fungicidal Glucan Synthase Inhibitor, and Tacrolimus

S. Wring, G. Atiee, Christy Corr, 2018, Clinical pharmacology in drug development.

Lack of Impact by SCY‐078, a First‐in‐Class Oral Fungicidal Glucan Synthase Inhibitor, on the Pharmacokinetics of Rosiglitazone, a Substrate for CYP450 2C8, Supports the Low Risk for Clinically Relevant Metabolic Drug‐Drug Interactions

S. Wring, G. Atiee, Christy Corr, 2018, Journal of clinical pharmacology.

MSG-10: a Phase 2 study of oral ibrexafungerp (SCY-078) following initial echinocandin therapy in non-neutropenic patients with invasive candidiasis.

W. Powderly, J. Vazquez, P. Pappas, 2019, The Journal of antimicrobial chemotherapy.

SCY-078, a Novel Fungicidal Agent, Demonstrates Distribution to Tissues Associated with Fungal Infections during Mass Balance Studies with Intravenous and Oral [14C]SCY-078 in Albino and Pigmented Rats

K. Borroto-Esoda, S. Wring, E. Solon, 2018, Antimicrobial Agents and Chemotherapy.

SCY-078 Is Fungicidal against Candida Species in Time-Kill Studies

M. Ghannoum, K. Borroto-Esoda, M. Peel, 2017, Antimicrobial Agents and Chemotherapy.

Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus

T. Matthews, J. J. Dwyer, M. Greenberg, 2007, Proceedings of the National Academy of Sciences.

Determination of reduced glutathione in human whole blood by high-performance liquid chromatography with electrochemical detection by a graphite-epoxy resin electrode chemically modified with cobalt phthalocyanine.

J. Hart, B. Birch, S. Wring, 1991, Talanta.

Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles

V. Yardley, S. Croft, Seonghee Park, 2018, Antimicrobial Agents and Chemotherapy.

Method to Screen Substrates of Apical Sodium-Dependent Bile Acid Transporter

J. Polli, R. Rais, S. Wring, 2008, The AAPS Journal.

SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei.

B. Nare, N. Yarlett, C. Bacchi, 2011, Bioorganic & medicinal chemistry letters.

The electroanalysis of mannitol, xylose and lactulose at copper electrodes: voltammetric studies and bioanalysis in human urine by means of HPLC with electrochemical detection.

R. Causon, S. Wring, W. Jenner, 1998, Journal of pharmaceutical and biomedical analysis.

Automated quantitative and qualitative analysis of metabolic stability: a process for compound selection during drug discovery.

C. Serabjit-Singh, S. Wring, I. S. Silver, 2002, Methods in enzymology.

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

B. Nare, Jennifer L Owens, R. Brun, 2011, PLoS neglected tropical diseases.

Voltammetric behaviour of ascorbic acid at a graphite-epoxy composite electrode chemically modified with cobalt phthalocyanine and its amperometric determination in multivitamin preparations

J. Hart, B. Birch, S. Wring, 1990 .

Development of an amperometric assay for the determination of reduced glutathione, using glutathione peroxidase and screen‐printed carbon electrodes chemically modified with cobalt phthalocyanine

John P. Hart, Stephen A. Wring, Brian Jeffrey Birch, 1992 .

Chemically modified, screen-printed carbon electrodes

John P. Hart, Stephen A. Wring, J. Hart, 1992 .

Recent developments in the design and application of screen-printed electrochemical sensors for biomedical, environmental and industrial analyses

John P. Hart, Stephen A. Wring, J. Hart, 1997 .

Simultaneous determination of zidovudine and lamivudine in human serum using HPLC with tandem mass spectrometry.

J. Dunn, S. Wring, R. Carr, 2000, Journal of pharmaceutical and biomedical analysis.

The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation

M. Ghannoum, P. Mukherjee, M. Retuerto, 2017, Antimicrobial Agents and Chemotherapy.

Development of screen-printed carbon electrodes, chemically modified with cobalt phthalocyanine, for electrochemical sensor applications

Brian J. Birch, John P. Hart, Stephen A. Wring, 1990 .

Pre-concentration of vitamin K1 (phylloquinone) at carbon paste electrodes and its determination in plasma by adsorptive stripping voltammetry.

J. Hart, S. Wring, I. Morgan, 1989, The Analyst.

Development of an improved carbon electrode chemically modified with cobalt phthalocyanine as a re-usable sensor for glutathione

J. Hart, B. Birch, S. Wring, 1989 .

Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides

W. Denny, A. M. Thompson, E. Chatelain, 2018, Bioorganic & medicinal chemistry letters.

89 SAFETY, PLASMA PHARMACOKINETICS, AND ANTI-VIRAL ACTIVITY OF SCY-635 IN ADULT PATIENTS WITH CHRONIC HEPATITIS C VIRUS INFECTION

S. Hopkins, B. Dimassimo, J. Lalezari, 2009 .

Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors.

J. Polli, L. Huang, C. Serabjit-Singh, 2001, Drug metabolism and disposition: the biological fate of chemicals.

The production and evaluation of a radioligand and antiserum for the radioimmunoassay of subnanogram per millilitre concentrations of lamivudine.

J. J. Newman, S. Wring, J. Williams, 1994, Journal of pharmaceutical and biomedical analysis.

Rapid development of affinity matured monoclonal antibodies using RIMMS.

J. A. Payne, B. Champion, K. Kilpatrick, 1997, Hybridoma.

Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs

Stephen A. Wring, Joseph W. Polli, Kimberly K. Adkison, 2002, Journal of Pharmacology and Experimental Therapeutics.

Midazolam Exhibits Characteristics of a Highly Permeable P-Glycoprotein Substrate

J. Polli, J. Polli, J. Rautio, 2003, Pharmaceutical Research.

Interaction of Native Bile Acids with Human Apical Sodium-Dependent Bile Acid Transporter (hASBT): Influence of Steroidal Hydroxylation Pattern and C-24 Conjugation

J. Polli, Anand Balakrishnan, S. Wring, 2006, Pharmaceutical Research.

Influence of charge and steric bulk in the C-24 region on the interaction of bile acids with human apical sodium-dependent bile acid transporter.

J. Polli, A. Coop, Anand Balakrishnan, 2006, Molecular pharmaceutics.

Serotonin and Pulmonary Hypertension; Sex and Drugs and ROCK and Rho.

M. Palacios, B. Fanburg, T. Pack, 2022, Comprehensive Physiology.

Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis.

B. Nare, N. Yarlett, M. Orr, 2011, Future medicinal chemistry.

ELEVATE 2: A multicenter study of rodatristat ethyl in patients with WHO Group 1 pulmonary arterial hypertension (PAH)

M. Humbert, M. Palacios, S. Wring, 2021, Pulmonary hypertension.

A sensitive radioimmunoassay, combined with solid-phase extraction, for the sub-nanogram per ml determination of ondansetron in human plasma.

S. Wring, R. Rooney, C. P. Goddard, 1994, Journal of pharmaceutical and biomedical analysis.

A Novel 1,3-Beta-d-Glucan Inhibitor, Ibrexafungerp (Formerly SCY-078), Shows Potent Activity in the Lower pH Environment of Vulvovaginitis

M. Ghannoum, K. Borroto-Esoda, N. Isham, 2019, Antimicrobial Agents and Chemotherapy.

SCYX-7158 (AN5568): CNS Exposure Predicted from First-in-Human Clinical Studies Indicates a Single Oral Dose Treatment is Possible for Sterile Cures of Stage 2 Human African Trypanosomiasis

A. Tarral, C. Mowbray, S. Wring, 2013 .

Voltammetric behaviour of screen-printed carbon electrodes, chemically modified with selected mediators, and their application as sensors for the determination of reduced glutathione

Brian J. Birch, John P. Hart, Stephen A. Wring, 1991 .

Influence of Charge and Steric Bulk in C-24 Region on the Interaction of Bile Acids with Human Apical Sodium Dependent Bile Acid Transporter (hASBT)

J. Polli, A. Coop, Anand Balakrishnan, 2008 .

Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity.

T. E. Richardson, M. Phillips, M. Peel, 2017, Bioorganic & medicinal chemistry.

Development of a disposable amperometric sensor for reduced nicotinamide adenine dinucleotide based on a chemically modified screen-printed carbon electrode

John P. Hart, Stephen A. Wring, J. Hart, 1994 .

Influence of Passive Permeability on Apparent P-glycoprotein Kinetics

James E. Polli, Stephen A. Wring, Joseph W. Polli, 2000, Pharmaceutical Research.

Determination of glutathione in human plasma using high-performance liquid chromatography with electrochemical detection with a carbon-epoxy resin composite electrode chemically modified with cobalt phthalocyanine.

J. Hart, B. Birch, S. Wring, 1989, The Analyst.

SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro

G. Fischer, S. Hopkins, M. Murray, 2009, Antimicrobial Agents and Chemotherapy.

Radioimmunoassay for the determination of alosetron in human urine and saliva.

P. Andrew, S. Wring, C. P. Goddard, 1994, The Analyst.

Process Development of TRI-999, a Fatty-Acid-Modified HIV Fusion Inhibitory Peptide

S. Schneider, B. Bray, S. Wring, 2008 .

Development of a sensitive radioimmunoassay for the potential anti-migraine drug GR151004: including cross-validation to liquid chromatography—mass spectrometry—mass spectrometry and application to pharmacokinetic studies

G. Bowers, S. Wring, W. Jenner, 1996 .