A. van den Bergh

发表

Assessment of strain and strain rate by two-dimensional speckle tracking in mice: comparison with tissue Doppler echocardiography and conductance catheter measurements.

F. Rademakers, P. Claus, J. D’hooge, 2013, European heart journal cardiovascular Imaging.

The relative value of strain and strain rate for defining intrinsic myocardial function.

J D'hooge, F Rademakers, F. Rademakers, 2012, American journal of physiology. Heart and circulatory physiology.

IMI – oral biopharmaceutics tools project – evaluation of bottom‐up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Xavier Pepin, Leon Aarons, Hans Lennernäs, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span.

P. Carmeliet, K. Sipido, E. Kranias, 2006, Journal of molecular and cellular cardiology.

NO-Dependent Endothelial Dysfunction in Type II Diabetes Is Aggravated by Dyslipidemia and Hypertension, but Can Be Restored by Angiotensin-Converting Enzyme Inhibition and Weight Loss

I. Nevelsteen, P. Herijgers, A. van den Bergh, 2013, Journal of Vascular Research.

Interleukin-6 Causes Myocardial Failure and Skeletal Muscle Atrophy in Rats

M. Decramer, E. Verbeken, K. Maes, 2005, Circulation.

Pharmacokinetic Drug–Drug Interaction of Apalutamide, Part 2: Investigating Interaction Potential Using a Physiologically Based Pharmacokinetic Model

M. Monshouwer, D. Ouellet, L. D. De Zwart, 2020, Clinical Pharmacokinetics.

ACE-inhibition, but not weight reduction restores cardiomyocyte response to β-adrenergic stimulation in the metabolic syndrome

K. Sipido, I. Nevelsteen, P. Herijgers, 2013, BMC Cardiovascular Disorders.

Type II diabetic mice exhibit contractile dysfunction but maintain cardiac output by favourable loading conditions

P. Herijgers, W. Flameng, A. van den Bergh, 2006, European journal of heart failure.

Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice

K. Sipido, P. Pokreisz, P. Vermeersch, 2009, Circulation.

JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.

D. Moechars, K. Kusakabe, L. Leclercq, 2021, Journal of medicinal chemistry.

Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice.

M. Freichel, V. Flockerzi, R. Vennekens, 2010, The Journal of clinical investigation.

In vivo Models and Decision Trees for Formulation Development in Early Drug Development: A Review of Current Practices and Recommendations for Biopharmaceutical Development.

P Zane, P Langguth, A Müllertz, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance

J. D’hooge, P. Barzaghi, E. Verbeken, 2008, European heart journal.

Dyslipidaemia in type II diabetic mice does not aggravate contractile impairment but increases ventricular stiffness.

J. Balligand, P. Vangheluwe, F. Wuytack, 2008, Cardiovascular research.

Food‐restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserve

P. Carmeliet, S. Janssens, P. Vangheluwe, 2009, European journal of heart failure.

Trifluoromethyl Dihydrothiazine‐Based β‐Secretase (BACE1) Inhibitors with Robust Central β‐Amyloid Reduction and Minimal Covalent Binding Burden

K. Kusakabe, Shinji Suzuki, Y. Kido, 2019, ChemMedChem.

PBPK Absorption Modeling: Establishing the In Vitro–In Vivo Link—Industry Perspective

Filippos Kesisoglou, Neil Parrott, Xavier Pepin, 2019, The AAPS Journal.

The effect of UGT2B7*2 polymorphism on the pharmacokinetics of OROS® hydromorphone in Taiwanese subjects

A. van den Bergh, Chih-Cherng Lu, H. Richards, 2014, Journal of clinical pharmacology.

A Symbolic Regression Model for the Prediction of Drug Binding to Human Liver Microsomes.

Dries Van Rompaey, A. van den Bergh, Denise Morrison, 2023, Molecular Pharmaceutics.

Discovery of an Extremely Potent Thiazine-Based β-Secretase (BACE1) Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose.

K. Kusakabe, Shinji Suzuki, N. Asada, 2019, Journal of medicinal chemistry.

Preclinical Bioavailability Strategy for Decisions on Clinical Drug Formulation Development: An In Depth Analysis.

M. Brewster, C. Mackie, E. Mannaert, 2018, Molecular pharmaceutics.