A. Gangjee

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Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase.

V. Cody, J. Luft, W. Pangborn, 2002, Acta crystallographica. Section D, Biological crystallography.

Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents.

M. Ihnat, Sudhir Raghavan, A. Gangjee, 2010, Bioorganic & medicinal chemistry.

Dihydrofolate reductase as a target for chemotherapy in parasites.

S. Kurup, A. Gangjee, O. Namjoshi, 2007, Current pharmaceutical design.

CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified cross-validated r(2)-guided region selection (q(2)-GRS) routine and its initial application.

Xin Lin, S. Queener, A. Gangjee, 2010, Bioorganic & medicinal chemistry.

Antiangiogenic and antitumor agents. Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases.

M. Ihnat, A. Gangjee, Jie Yang, 2003, Bioorganic & medicinal chemistry.

Trimethoprim Resistance of Dihydrofolate Reductase Variants from Clinical Isolates of Pneumocystis jirovecii

V. Cody, S. Queener, A. Gangjee, 2013, Antimicrobial Agents and Chemotherapy.

Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents.

M. Ihnat, J. Thorpe, A. Gangjee, 2008, Bioorganic & medicinal chemistry.

Discovery of novel antitumor antimitotic agents that also reverse tumor resistance.

Charles D Smith, J. Yu, A. Gangjee, 2007, Journal of medicinal chemistry.

Therapeutic Targeting of a Novel 6-Substituted Pyrrolo [2,3-d]pyrimidine Thienoyl Antifolate to Human Solid Tumors Based on Selective Uptake by the Proton-Coupled Folate Transporter

Christina Cherian, L. Matherly, Z. Hou, 2011, Molecular Pharmacology.

Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolate Inhibitors of De Novo Purine Biosynthesis in the Chemotherapy of Solid Tumors

M. Romero, Christina Cherian, Jianmei Wu, 2010, Molecular Pharmacology.

Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity.

Christina Cherian, L. Matherly, Z. Hou, 2008, Journal of medicinal chemistry.

Microsoft Word-SHMT2 Pharmacodynamics Manuscript final 10-7-19 FINAL

L. Matherly, M. Hüttemann, Z. Hou, 2019 .

Discovery of Novel Antifolate Inhibitors of De Novo Purine Nucleotide Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter Over the Reduced Folate Carrier for Cellular Entry

L. Matherly, A. Gangjee, 2011 .

Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry.

Christina Cherian, Jianmei Wu, L. Matherly, 2009, Journal of medicinal chemistry.

2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance.

Charles D Smith, A. Gangjee, O. Namjoshi, 2011, Bioorganic & medicinal chemistry.

Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry.

Christina Cherian, Jianmei Wu, L. Matherly, 2010, Journal of medicinal chemistry.

Functional Loss of the Reduced Folate Carrier Enhances the Antitumor Activities of Novel Antifolates with Selective Uptake by the Proton-Coupled Folate Transporter

Christina Cherian, L. Matherly, Z. Hou, 2012, Molecular Pharmacology.

Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates

L. Matherly, Jenny Huang, Z. Hou, 2016, Molecular Pharmacology.

Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates.

Tina Talreja, Yibin Zeng, S. Queener, 2007, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents

Andrew J. Robles, F. Islam, E. Hamel, 2022, Molecules.

The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity.

M. Ihnat, E. Hamel, S. Mooberry, 2020, Bioorganic & medicinal chemistry.

Synthesis of 5,7-disubstituted-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amines as microtubule inhibitors.

Charles D Smith, S. Kurup, A. Gangjee, 2013, Bioorganic & medicinal chemistry.

Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implications of inhibiting 5-aminoimidazole-4-carbo

Christina Cherian, L. Matherly, Z. Hou, 2013, Journal of medicinal chemistry.

N⁴-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors.

M. Ihnat, J. Thorpe, S. Kurup, 2012, Bioorganic & medicinal chemistry.

The evolving biology of the proton‐coupled folate transporter: New insights into regulation, structure, and mechanism

L. Matherly, Z. Hou, A. Gangjee, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Abstract 5682: Design and preclinical evaluation of single agents with combination chemotherapy potential.

M. Ihnat, J. Thorpe, E. Hamel, 2013 .

Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase.

W. L. Jorgensen, K. Anderson, A. White, 2014, Bioorganic & medicinal chemistry letters.

Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase.

M. Romero, Christina Cherian, L. Matherly, 2011, Journal of medicinal chemistry.

Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis.

L. Matherly, Z. Hou, L. Polin, 2018, Journal of medicinal chemistry.

Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates

L. Matherly, Z. Hou, L. Polin, 2017, Molecular Cancer Therapeutics.

Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in Vitro and in Vivo evaluation as antitumor agents.

F. Islam, M. Ihnat, E. Hamel, 2021, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells.

E. Hamel, S. Mooberry, A. Gangjee, 2016, Journal of medicinal chemistry.

Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates.

A. Gangjee, J. McGuire, R. Kisliuk, 2006, Bioorganic & medicinal chemistry.

Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

L. Matherly, Z. Hou, L. Polin, 2022, Scientific Reports.

Role of Lysine 411 in Substrate Carboxyl Group Binding to the Human Reduced Folate Carrier, as Determined by Site-Directed Mutagenesis and Affinity Inhibition

Christina Cherian, Jianmei Wu, L. Matherly, 2008, Molecular Pharmacology.

Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.

L. Matherly, Z. Hou, L. Polin, 2018, Journal of medicinal chemistry.

Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.

C. Dann, H. Xu, L. Matherly, 2016, Journal of medicinal chemistry.

Novel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents.

L. Matherly, Z. Hou, Sudhir Raghavan, 2015, Journal of medicinal chemistry.

Structure–Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter

L. Matherly, Z. Hou, Sudhir Raghavan, 2014, Journal of medicinal chemistry.

Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.

Christina Cherian, L. Matherly, Z. Hou, 2013, Journal of medicinal chemistry.

Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier.

Christina Cherian, L. Matherly, Z. Hou, 2012, Journal of medicinal chemistry.

Biology and therapeutic applications of the proton-coupled folate transporter

L. Matherly, Z. Hou, A. Gangjee, 2022, Expert opinion on drug metabolism & toxicology.

2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pynmidines as potential inhibitors of thymidylate synthase

A. Gangjee, R. Kisliuk, Jianming Yu, 2002 .

Inhibition of insulin-like growth factor I receptor autophosphorylation by novel 6-5 ring-fused compounds.

W. Miller, W. Li, Yibin Zeng, 2004, Biochemical pharmacology.

Vasodilator activity of adenosine analogs.

A. Gangjee, J. Kitzen, H. P. Hogenkamp, 1978, Journal of pharmaceutical sciences.

Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I.

S. Kurup, A. Gangjee, H. D. Jain, 2007, Anti-cancer agents in medicinal chemistry.

Synthesis of classical and nonclassical, partially restricted, linear, tricyclic 5-deaza antifolates.

Yibin Zeng, A. Gangjee, J. McGuire, 2002, Journal of medicinal chemistry.

Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.

R. Devraj, A. Gangjee, J. McGuire, 1995, Journal of medicinal chemistry.

Synthesis and biological activities of tetrahydroquinazoline analogs of aminopterin and methotrexate

N. Zaveri, S. Queener, A. Gangjee, 1995 .

Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.

Satyendra Shenoy, M. Ihnat, Sudhir Raghavan, 2010, Journal of medicinal chemistry.

Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase inhibitors and antitumor agents: synthesis and biological activities of 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl] pyrido[2,3-d]pyrimidines.

S. Queener, A. Gangjee, O. Adair, 1999, Journal of medicinal chemistry.

Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3-d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents.

S. Queener, A. Gangjee, Jie Yang, 2006, Bioorganic & medicinal chemistry.

Synthesis of a series of diaminobenzo[f]- and diaminobenzo[h]pyrimido[4,5-b]quinolines as 5-deaza tetracyclic nonclassical antifolates

R. Devraj, L. Barrows, I. Donkor, 1996 .

Synthesis and biological activities of substituted dihydrobenzo[h]‐pyrimido[4,5‐b]quinolines as tetracyclic 5‐deaza nonclassical folates

I. Donkor, A. Gangjee, R. Kisliuk, 1991 .

Synthesis and biological activity of 5,11-methylenetetrahydro-5- deazahomofolic acid.

I. Donkor, A. Gangjee, R. Kisliuk, 1991, Journal of medicinal chemistry.

Synthesis of substituted dihydrobenzo[f]pyrimido[4,5-b]-quinolines as tetracyclic 5-deaza nonclassical folates

I. Donkor, A. Gangjee, F. Duah, 1990 .

Synthesis of substituted tetrahydropyrimido-[4,5-b][1,7]naphthyridines as potential antitumor agents

I. Donkor, A. Gangjee, 1987 .

Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.

M. Ihnat, E. Hamel, A. Gangjee, 2017, Bioorganic & medicinal chemistry.

6-substituted 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.

A. Vasudevan, S. Queener, A. Gangjee, 1995, Journal of medicinal chemistry.

Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1).

Xiaohong Song, Xin Lin, A. Gangjee, 2006, Journal of medicinal chemistry.

Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.

S. Queener, A. Gangjee, O. Adair, 2003, Journal of medicinal chemistry.

Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells.

E. Hamel, S. Mooberry, Sudhir Raghavan, 2013, Bioorganic & medicinal chemistry.

2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.

A. Vasudevan, S F Queener, S. Queener, 1996, Journal of medicinal chemistry.

Synthesis of classical and a nonclassical 2-amino-4-oxo-6-methyl-5-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of thymidylate synthase.

F. Mavandadi, S. Queener, A. Gangjee, 1999, Journal of medicinal chemistry.

Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.

E. Elzein, S. Queener, A. Gangjee, 2001, Journal of medicinal chemistry.

Synthesis, Antifolate, and Antitumor Activities of Classical and Nonclassical 2‐Amino‐4‐oxo‐5‐substituted‐pyrrolo[2,3‐d]pyrimidines.

E. Elzein, S. Queener, A. Gangjee, 2001 .

Reactions of 6-Aminopyrimidines with Biselectrophiles: Manipulation of Product Composition with Solvent and Pyrimidine Substitution Variation1

A. Vasudevan, F. Mavandadi, A. Gangjee, 1999 .

Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.

V. Cody, D. Green, M. Ihnat, 2009, Bioorganic & medicinal chemistry.

Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity.

D. Green, M. Ihnat, Yibin Zeng, 2005, Bioorganic & medicinal chemistry.

Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.

Yibin Zeng, A. Gangjee, J. McGuire, 2004, Journal of medicinal chemistry.

Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.

Yibin Zeng, A. Gangjee, J. McGuire, 2004, Journal of medicinal chemistry.

Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.

A. Gangjee, J. McGuire, R. Kisliuk, 2000, Journal of medicinal chemistry.

Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.

R. Devraj, L. Barrows, S. Queener, 1994, Journal of medicinal chemistry.

Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase.

V. Cody, A. Gangjee, O. Namjoshi, 2015, Acta crystallographica. Section F, Structural biology communications.

2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors.

Xin Guo, S. Queener, A. Gangjee, 2010, Bioorganic & medicinal chemistry.

Synthesis of a pyrrolo annulated pyrido[2,3‐D]pyrimidine as a potential nonclassical antifolate

A. Gangjee, F. Lin, J. Patel, 1988 .

Synthesis and antitumor evaluation of some 1,3-disubstituted tetrahydropyrimido[4,5-c]isoquinolines†

A. Gangjee, K. Ohemeng, F. Lin, 1986 .

Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.

V. Cody, S F Queener, V Cody, 2000, Journal of medicinal chemistry.

Synthesis of three carbon atom bridged 2,4-diaminopyrrolo[2,3-d]-pyrimidines as nonclassical dihydrofolate reductase inhibitors

S. Queener, A. Gangjee, Zhengqu Ye, 2005 .

Novel 2,4-diamino-5-substituted furo[2,3-d]-pyrimidines as potential antifolates.

R. Devraj, S. Queener, A. Gangjee, 1993, Advances in experimental medicine and biology.

Effect of Bridge Truncation of Classical 2,4-Diamino-5-Substituted Furo [2,3-d] Pyrimidine and 2-Amino-4-Oxo-6-Substituted Pyrrolo [2,3-d] Pyrimidine on Antifolate Activity

A. Gangjee, J. McGuire, R. Kisliuk, 2002 .

Effect of Bridge Region Variation on Antifolate and Antitumor Activity of Classical 5-Substituted 2,4-Diaminofuro(2,3-d)pyrimidines.

R. Devraj, A. Gangjee, J. McGuire, 1996 .

Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents.

V. Cody, A. Gangjee, Wei Li, 2009, Journal of medicinal chemistry.

Synthesis of some 2,4-disubstituted tetrahydropyrimido[4,5-b]quinolines as potential antitumor agents

A. Gangjee, K. Ohemeng, F. Lin, 1985 .

Synthesis of some 1,3,8-trisubstituted pyrimido[4,5-c][2,7]-naphthyridin-6-ones as potential antitumor agents

A. Gangjee, T. Kalman, T. Bardos, 1984 .

Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.

V. Cody, Sudhir Raghavan, S. Queener, 2013, Journal of medicinal chemistry.

The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.

S. Queener, A. Gangjee, R. Kisliuk, 2008, Journal of medicinal chemistry.

Synthesis of 2,4-diamino-6-(thioarylmethyl)pyrido[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.

S F Queener, S. Queener, A. Gangjee, 2001, Bioorganic & medicinal chemistry.

Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.

F. Mavandadi, S. Queener, A. Gangjee, 1997, Journal of medicinal chemistry.

Synthesis and dihydrofolate reductase inhibitory activities of 2,4-diamino-5-deaza and 2,4-diamino-5,10-dideaza lipophilic antifolates.

R. Devraj, S. Queener, A. Gangjee, 1997, Journal of medicinal chemistry.

Novel 2,4-diamino-5-substituted-pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolate inhibitors of dihydrofolate reductases.

F. Mavandadi, S. Queener, A. Gangjee, 1995, Journal of medicinal chemistry.

Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents.

L. Barrows, S. Queener, A. Gangjee, 1993, Journal of medicinal chemistry.

Novel Water-Soluble Substituted Pyrrolo[3,2-d]pyrimidines: Design, Synthesis, and Biological Evaluation as Antitubulin Antitumor Agents

E. Hamel, S. Mooberry, A. Gangjee, 2012, Pharmaceutical Research.

Design, synthesis, and biological evaluation of 2,4-diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors.

Xin Lin, S. Queener, A. Gangjee, 2004, Journal of medicinal chemistry.

Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as

Xin Lin, A. Gangjee, J. McGuire, 2005, Journal of medicinal chemistry.

Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneumocystis carinii and Toxoplasma gondii.

A. Vasudevan, S. Queener, A. Gangjee, 1997, Journal of medicinal chemistry.

Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: Part II.

S. Kurup, A. Gangjee, H. D. Jain, 2008, Anti-cancer agents in medicinal chemistry.

CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase.

Xin Lin, A. Gangjee, Aleem Gangjee, 2005, Journal of medicinal chemistry.

Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: synthesis and biological activities.

N. Zaveri, S. Queener, A. Gangjee, 1995, Journal of medicinal chemistry.

Synthesis and Biological Activities of Tetrahydroquinazoline Analogues of Aminopterin and Methotrexate.

N. Zaveri, S. Queener, A. Gangjee, 1995 .

Nonclassical 5-substituted tetrahydroquinazolines as potential inhibitors of thymidylate synthase†

A. Gangjee, R. Kisliuk, Anil Vasudevant, 1997 .

Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines.

V. Cody, J. Luft, W. Pangborn, 1998, Journal of medicinal chemistry.

Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection.

V. Cody, S. Queener, A. Gangjee, 2019, Bioorganic & medicinal chemistry letters.

Conformationally restricted tricyclic analogues of lipophilic pyrido[2,3‐d]pyrimidine antifolates

F. Mavandadi, S. Queener, A. Gangjee, 2001 .

Substituted pyrrolo[2,3-d]pyrimidines as Cryptosporidium hominis thymidylate synthase inhibitors.

K. Anderson, K. Frey, A. Gangjee, 2013, Bioorganic & medicinal chemistry letters.

5-Arylthio-substituted 2-amino-4-oxo-6-methylpyrrolo[2,3-d]pyrimidine antifolates as thymidylate synthase inhibitors and antitumor agents.

R. Devraj, A. Gangjee, J. McGuire, 1995, Journal of medicinal chemistry.

Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry.

Vivian Cody, V. Cody, J. Luft, 2004, Acta crystallographica. Section D, Biological crystallography.

Synthesis of 2,4-diamino-5,10-dideaza nonclassical antifolates

R. Devraj, A. Gangjee, F. Lin, 1991 .

The synthesis of new 2,4‐diaminofuro[2,3‐d]pyrimidines with 5‐biphenyl, phenoxyphenyl and tricyclic substitutions as dihydrofolate reductase inhibitors

S. Queener, A. Gangjee, N. Dubash, 2000 .

Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii.

S. Queener, A. Gangjee, Y. Zhu, 1996, Journal of Medicinal Chemistry.

The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer

L. Matherly, Z. Hou, A. Gangjee, 2017, Cancer Chemotherapy and Pharmacology.

Synthesis of 2,4‐Diamino‐5,10‐dideaza Nonclassical Antifolates.

A. Gangjee, F. Lin, Devraj Rajesh, 2010 .

Synthesis of a substituted tetrahydropyrimido[4,5-c][2,7]naphthyridine as a tricyclic 5-deaza nonclassical folate

A. Gangjee, K. Ohemeng, 1985 .

6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors.

C. Dann, L. Matherly, Z. Hou, 2015, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.

A. Gangjee, Wei Li, R. Kisliuk, 2008, Journal of medicinal chemistry.

Novel 2-amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase.

A. Gangjee, R. Kisliuk, H. D. Jain, 2005, Bioorganic & medicinal chemistry letters.

The Synthesis of New 2,4‐Diaminofuro[2,3‐d]pyrimidines with 5‐Biphenyl, Phenoxyphenyl and Tricyclic Substitutions as Dihydrofolate Reductase Inhibitors.

S. Queener, A. Gangjee, N. Dubash, 2001 .

Diazoketone and chloromethylketone analogs of methotrexate as potential antitumor agents.

A. Gangjee, T. Kalman, T. Bardos, 1982, Journal of pharmaceutical sciences.

Synthesis and biological activity of 5-chloro-N⁴-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.

M. Ihnat, J. Thorpe, Sudhir Raghavan, 2013, Bioorganic & medicinal chemistry.

Folate Transport and One-Carbon Metabolism in Targeted Therapies of Epithelial Ovarian Cancer

L. Matherly, Z. Hou, A. Gangjee, 2021, Cancers.

A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model

N. Smith, D. Saunders, R. Towner, 2015, BMC Cancer.

Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer

L. Matherly, Z. Hou, A. Gangjee, 2020, Molecular Cancer Therapeutics.

Potent dual thymidylate synthase and dihydrofolate reductase inhibitors: classical and nonclassical 2-amino-4-oxo-5-arylthio-substituted-6-methylthieno[2,3-d]pyrimidine antifolates.

A. Gangjee, Wei Li, Yibin Qiu, 2008, Journal of medicinal chemistry.

A Small Molecule with Anticancer and Antimetastatic Activities Induces Rapid Mitochondrial-Associated Necrosis in Breast Cancer

M. Ihnat, J. Thorpe, A. Gangjee, 2015, The Journal of Pharmacology and Experimental Therapeutics.

A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer

M. Ihnat, J. Thorpe, A. Gangjee, 2015 .

Design, synthesis and preclinical evaluation of 5-methyl-N4-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential.

M. Ihnat, E. Hamel, S. Mooberry, 2018, Bioorganic & medicinal chemistry letters.

The human proton-coupled folate transporter

L. Matherly, Z. Hou, A. Gangjee, 2012, Cancer biology & therapy.

Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents.

V. Cody, Xin Lin, S. Queener, 2018, Bioorganic & medicinal chemistry.

N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents.

M. Ihnat, J. Thorpe, A. Gangjee, 2013, Bioorganic & medicinal chemistry.

The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.

M. Ihnat, J. Thorpe, E. Hamel, 2014, Bioorganic & medicinal chemistry.

Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.

M. Ihnat, J. Thorpe, A. Gangjee, 2012, Bioorganic & medicinal chemistry.

Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance.

E. Hamel, S. Mooberry, Sudhir Raghavan, 2010, Journal of medicinal chemistry.

Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.

V. Cody, Xin A. Zhang, A. Gangjee, 2011, Bioorganic & medicinal chemistry.

AG488 as a therapy against gliomas.

M. Lerner, N. Smith, Jadith Ziegler, 2017, Oncotarget.

Discovery of antitubulin agents with antiangiogenic activity as single entities with multitarget chemotherapy potential.

M. Ihnat, J. Thorpe, E. Hamel, 2014, ACS medicinal chemistry letters.

Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter

Christina Cherian, L. Matherly, Z. Hou, 2013, Cancer Chemotherapy and Pharmacology.

Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.

Satyendra Shenoy, M. Ihnat, J. Thorpe, 2010, Bioorganic & medicinal chemistry.

Synthesis of 2-amino-4-oxo-5-substitutedbenzylthiopyrrolo[2,3-d]-pyrimidines as potential inhibitors of thymidylate synthase †

A. Gangjee, R. Kisliuk, H. D. Jain, 2005 .

Synthesis of classical and nonclassical 2‐amino‐4‐oxo‐6‐benzylthieno‐[2,3‐d]pyrimidines as potential thymidylate synthase inhibitors

A. Gangjee, Yibin Qiu, R. Kisliuk, 2004 .

Synthesis of N-[4-[(2-Amino-6-Methyl-3,4-Dihydro-4-Oxo-7H-Pyrrolo[2,3-d]-Pyrimidin-5-Yl)Methyl]Benzoyl]-L-Glutamic Acid as an Antifolate

Yibin Zeng, A. Gangjee, J. McGuire, 2002 .

Synthesis of Novel, Nonclassical 2-Amino-4-oxo-6-(arylthio)ethylpyrrolo[2,3-d]pyrimidines as Potential Inhibitors of Thymidylate Synthase.

A. Gangjee, R. Kisliuk, N. Dubash, 2001 .

Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

J. Rabinowitz, C. Dann, X. Bao, 2019, Molecular Cancer Therapeutics.

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.

C. Dann, G. Garcia, X. Bao, 2021, Bioorganic & medicinal chemistry.

Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase.

Vivian Cody, Wei Li, V. Cody, 2010, Acta crystallographica. Section D, Biological crystallography.

Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase.

V. Cody, J. Luft, W. Pangborn, 2003, Acta crystallographica. Section D, Biological crystallography.

Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase.

V. Cody, J. Luft, W. Pangborn, 2003, Acta crystallographica. Section D, Biological crystallography.

Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.

W Pangborn, A. Vasudevan, V. Cody, 1998, Journal of medicinal chemistry.

AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization.

M. Ihnat, A. Gangjee, K. Humphries, 2017, Cancer letters.

Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism

L. Matherly, M. Hüttemann, Z. Hou, 2019, Molecular Pharmacology.

The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines.

M. Ihnat, A. Gangjee, O. Namjoshi, 2010, Bioorganic & medicinal chemistry letters.

Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.

E. Hamel, S. Mooberry, Sudhir Raghavan, 2013, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier.

L. Matherly, F. Islam, Z. Hou, 2020, Bioorganic & medicinal chemistry.

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

L. Matherly, Z. Hou, A. Gangjee, 2021, Scientific Reports.

Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site.

Andrew J. Robles, E. Hamel, S. Mooberry, 2023, Bioorganic & medicinal chemistry.

Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.

M. Ihnat, E. Hamel, S. Mooberry, 2021, Bioorganic & medicinal chemistry.

Design, synthesis, and structure-activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells.

E. Hamel, S. Mooberry, A. Gangjee, 2017, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological activities of classical N-[4-[2-(2-amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and its 6-methyl derivative as potential dual inhibitors of thymidylate synthase and dihydrofolate reductase and as potential antitumor agents.

A. Gangjee, J. McGuire, R. Kisliuk, 2003, Journal of Medicinal Chemistry.

Design, synthesis and biological evaluation of 2,4‐diamino‐6‐methyl‐5‐substitutedpyrrolo[2,3‐d]pyrimidines as dihydrofolate reductase inhibitors

S. Queener, A. Gangjee, H. D. Jain, 2005 .

7-Methyl trimethoprim analogues as inhibitors of the folate metabolizing enzymes

Xin Lin, S. Queener, A. Gangjee, 2003 .

7-Methyl Trimethoprim Analogues as Inhibitors of the Folate Metabolizing Enzymes.

Xin Lin, S. Queener, A. Gangjee, 2003 .

Design, Synthesis and Biological Evaluation of 2,4‐Diamino‐6‐methyl‐5‐substituted‐pyrrolo[2,3‐d]pyrimidines as Dihydrofolate Reductase Inhibitors.

S. Queener, A. Gangjee, H. D. Jain, 2005 .

Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants

V. Cody, S. Queener, A. Gangjee, 2013, Antimicrobial Agents and Chemotherapy.

Bicyclic conformationally restricted analogs of nonclassical pyrido[2,3-d] pyrimidines as potential inhibitors of dihydrofolate reductases.

A. Vasudevan, S. Queener, A. Gangjee, 1993, Advances in Experimental Medicine and Biology.

The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.

M. Ihnat, E. Hamel, S. Mooberry, 2015, Bioorganic & medicinal chemistry.

The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex.

V. Cody, A. Gangjee, Lu Lin, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Antifolates -- past, present and future.

A. Gangjee, H. D. Jain, 2004, Current medicinal chemistry. Anti-cancer agents.

Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.

C. Dann, L. Matherly, Z. Hou, 2016, Biochemistry.

Structure based drug design and in vitro metabolism study: Discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent.

E. Hamel, S. Mooberry, A. Gangjee, 2018, Bioorganic & medicinal chemistry.

Intestinal Transport of Aminopterin Enantiomers in Dogs and Humans with Psoriasis Is Stereoselective: Evidence for a Mechanism Involving the Proton-Coupled Folate Transporter

A. Schuler, A. Menter, Christina Cherian, 2012, Journal of Pharmacology and Experimental Therapeutics.

Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

S. Mooberry, A. Gangjee, S. Choudhary, 2016, Molecules.

Sterically induced conformational restriction: Discovery and preclinical evaluation of novel pyrrolo[3,2-d]pyrimidines as microtubule targeting agents.

Taylor A. Gentile, E. Hamel, S. Mooberry, 2018, Bioorganic & Medicinal Chemistry.

Novel Water-Soluble Substituted Pyrrolo[3,2-d]pyrimidines: Design, Synthesis, and Biological Evaluation as Antitubulin Antitumor Agents

E. Hamel, S. Mooberry, A. Gangjee, 2012, Pharmaceutical Research.

The Synthesis of Novel Nonclassical Reversed Bridge Quinazoline Antifolates as Inhibitors of Thymidylate Synthase

A. Gangjee, R. Kisliuk, M. Kothare, 2000 .

Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.

L. Matherly, Z. Hou, A. Gangjee, 2019, Bioorganic & medicinal chemistry.

Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria

L. Matherly, Z. Hou, A. Gangjee, 2023, Journal of medicinal chemistry.

Synthesis and biological activities of (R)- and (S)-N-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride as potent cytotoxic antitubulin agents.

E. Hamel, S. Mooberry, A. Gangjee, 2011, Journal of medicinal chemistry.

Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.

M. Ihnat, A. Gangjee, Nilesh Zaware, 2017, Bioorganic & medicinal chemistry letters.

Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections.

K. Anderson, S. Queener, A. Gangjee, 2013, ACS medicinal chemistry letters.

6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents.

S. Queener, A. Gangjee, Y. Zhu, 1998, Journal of Medicinal Chemistry.

N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase.

S. Queener, A. Gangjee, O. Adair, 2008, Journal of medicinal chemistry.

Regulation of differential proton-coupled folate transporter gene expression in human tumors: transactivation by KLF15 with NRF-1 and the role of Sp1.

L. Matherly, Z. Hou, A. Gangjee, 2019, The Biochemical journal.

M. Ihnat, E. Hamel, A. Gangjee, 2017, Bioorganic & medicinal chemistry.

2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase.

F. Mavandadi, S. Queener, A. Gangjee, 1996, Journal of Medicinal Chemistry.

2-Amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as Nonclassical Antifolate Inhibitors of Thymidylate Synthase.

F. Mavandadi, S. Queener, A. Gangjee, 1997, Journal of medicinal chemistry.

Multitargeted 6-Substituted Thieno[2,3-d]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism.

X. Bao, Jing Li, L. Matherly, 2023, ACS pharmacology & translational science.

N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.

M. Ihnat, J. Thorpe, Sudhir Raghavan, 2012, Bioorganic & medicinal chemistry.

AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization.

M. Ihnat, A. Gangjee, Nilesh Zaware, 2017, Cancer letters.

Structural Characterization of 5-Substituted Pyrrolo[3,2-d]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.

L. Matherly, Z. Hou, A. Gangjee, 2024, Biochemistry.

The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer

L. Matherly, Z. Hou, A. Gangjee, 2017, Cancer Chemotherapy and Pharmacology.

Synthesis and biological evaluation of nonclassical 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines with novel side chain substituents as potential inhibitors of dihydrofolate reductases.

S. Queener, A. Gangjee, Anil Vasudevan, 1997, Journal of medicinal chemistry.