Hailin Zhang

发表

Mechanisms and Estrogenic Regulation Ventromedial Hypothalamic Neurons: Ionic Histamine-Induced Excitatory Responses in Mouse

D. Pfaff, L. Kow, V. Tuohy, 2015 .

Autoregressive spectral analysis of cortical electroencephalographic signals in a rat model of post-traumatic epilepsy

Qingzhong Jia, Qingzhong Jia, Hailin Zhang, 2015, Neurological research.

Characterization of the effects of Cl− channel modulators on TMEM16A and bestrophin-1 Ca2+ activated Cl− channels

Dongyang Huang, N. Gamper, Hailin Zhang, 2015, Pflügers Archiv - European Journal of Physiology.

Volume-regulated Cl- current: contributions of distinct Cl- channel and localized Ca2+ signals.

Dongyang Huang, N. Gamper, Hailin Zhang, 2019, American journal of physiology. Cell physiology.

The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels.

N. Gamper, L. Ooi, Bo-yi Liu, 2010, The Journal of clinical investigation.

Activation of TMEM16A by natural product canthaxanthin promotes gastrointestinal contraction

Hailin Zhang, Hailong An, Qiushuang Ji, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

PIP2 Activates KCNQ Channels, and Its Hydrolysis Underlies Receptor-Mediated Inhibition of M Currents

Diomedes E Logothetis, D. Logothetis, Coeli M B Lopes, 2003, Neuron.

Tannic acid modulates excitability of sensory neurons and nociceptive behavior and the Ionic mechanism.

Hailin Zhang, Huiran Zhang, Jiaxi Xu, 2015, European journal of pharmacology.

Membrane Depolarization Increases Membrane PtdIns(4,5)P2 Levels through Mechanisms Involving PKC βII and PI4 Kinase*

Guohong Zhang, Hailin Zhang, Jiaxi Xu, 2011, The Journal of Biological Chemistry.

Depolarization Increases Phosphatidylinositol (PI) 4,5-Bisphosphate Level and KCNQ Currents through PI 4-Kinase Mechanisms*

Hailin Zhang, Xiaona Du, Xuan Zhang, 2010, The Journal of Biological Chemistry.

Phosphatidylinositol 4,5-bisphosphate hydrolysis mediates histamine-induced KCNQ/M current inhibition.

Bo-yi Liu, Huiling Liang, Li Liu, 2008, American journal of physiology. Cell physiology.

Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles.

Hailin Zhang, G. Pitt, Eric Q. Wei, 2017, Journal of molecular and cellular cardiology.

Voltage-gated sodium channels were differentially expressed in human normal prostate, benign prostatic hyperplasia and prostate cancer cells

N. Wang, Hailin Zhang, Chuan Wang, 2014, Oncology letters.

Arctigenin, a novel TMEM16A inhibitor for lung adenocarcinoma therapy.

Hailin Zhang, Hailong An, Sai Shi, 2020, Pharmacological research.

Pre-treatment of a single high-dose of atorvastatin provided cardioprotection in different ischaemia/reperfusion models via activating mitochondrial KATP channel.

Bo Li, Hailin Zhang, W. Cui, 2015, European journal of pharmacology.

LRRCA8A and ANO1 contribute to serum-induced VRAC in a Ca2+-dependent manners.

Hailin Zhang, Yani Liu, Huiran Zhang, 2020, Journal of pharmacological sciences.

Sensorineural Hearing Loss and Mitochondrial Apoptosis of Cochlear Spiral Ganglion Neurons in Fibroblast Growth Factor 13 Knockout Mice

Hailin Zhang, Guoqiang Gu, Junming Tang, 2021, Frontiers in Cellular Neuroscience.

Distinct sites on G protein beta gamma subunits regulate different effector functions.

D. Logothetis, M. Linder, Hailin Zhang, 2002, The Journal of biological chemistry.

Carbon monoxide inhibits inward rectifier potassium channels in cardiomyocytes

Asif Ahmed, Hailin Zhang, Yuchun Gu, 2014, Nature Communications.

Piezo2 channel in nodose ganglia neurons is essential in controlling hypertension in a pathway regulated directly by Nedd4-2.

Huiping Bai, Hailin Zhang, D. Kong, 2020, Pharmacological research.

Arachidonic Acid Activates Kir2.3 Channels by Enhancing Channel-Phosphatidyl-inositol 4,5-bisphosphate Interactions

U. Mirshahi, Bo-yi Liu, Hailin Zhang, 2008, Molecular Pharmacology.

Genistein inhibits voltage-gated sodium currents in SCG neurons through protein tyrosine kinase-dependent and kinase-independent mechanisms

Qingzhong Jia, Bo-yi Liu, Huiling Liang, 2008, Pflügers Archiv - European Journal of Physiology.

Molecular basis for genistein-induced inhibition of Kir2.3 currents

Qingzhong Jia, Guohong Zhang, Bo-yi Liu, 2008, Pflügers Archiv - European Journal of Physiology.

Ginsenoside Rb1, a novel activator of the TMEM16A chloride channel, augments the contraction of guinea pig ileum

Hailin Zhang, Shuai Guo, Jinlong Qi, 2017, Pflügers Archiv - European Journal of Physiology.

Identification of Resveratrol, an Herbal Compound, as an Activator of the Calcium-Activated Chloride Channel, TMEM16A

Hailin Zhang, Jinlong Qi, Hailong An, 2017, The Journal of Membrane Biology.

Development and validation of HTS assay for screening the calcium-activated chloride channel modulators in TMEM16A stably expressed CHO cells

Y. Wang, Hailin Zhang, Bingcai Guan, 2014, Analytical and Bioanalytical Chemistry.

G protein-coupled receptor signaling to Kir channels in Xenopus oocytes.

G. Liapakis, J. González-Maeso, D. Logothetis, 2014, Current pharmaceutical biotechnology.

of Kir2 Channels 4,5-Bisphosphate-induced Gating Kinetics Phosphatidylinositol The Cytosolic GH Loop Regulates the

Xuanyu Meng, Shouqin Lü, Hailin Zhang, 2013 .

Kir 2 Channels 4 , 5-Bisphosphate-induced Gating Kinetics Phosphatidylinositol The Cytosolic GH Loop Regulates the Molecular Biophysics :

D. Logothetis, Xuanyu Meng, Shouqin Lü, 2012 .

The Cytosolic GH Loop Regulates the Phosphatidylinositol 4,5-Bisphosphate-induced Gating Kinetics of Kir2 Channels*

D. Logothetis, Xuanyu Meng, Shouqin Lü, 2012, The Journal of Biological Chemistry.

Fusion of Ssm6a with a protein scaffold retains selectivity on NaV1.7 and improves its therapeutic potential against chronic pain

Qunyuan Xu, Huimeng Lei, Hailin Zhang, 2017, Chemical biology & drug design.

Inhibition of Kv7/M Channel Currents by the Local Anesthetic Chloroprocaine

Qingzhong Jia, Hailin Zhang, Senming Zhao, 2015, Pharmacology.

Characteristic Interactions with Phosphatidylinositol 4,5-Bisphosphate Determine Regulation of Kir Channels by Diverse Modulators*

D. Logothetis, Coeli M B Lopes, T. Rohacs, 2004, Journal of Biological Chemistry.

Selective inhibition of Kir currents by antihistamines.

Qingzhong Jia, Bo-yi Liu, Hailin Zhang, 2007, European journal of pharmacology.

Dorsal root ganglia control nociceptive input to the central nervous system

D. Jaffe, Rosmaliza Ramli, N. Gamper, 2021, bioRxiv.

Inflammatory mediator bradykinin increases population of sensory neurons expressing functional T-type Ca2+ channels

Dongyang Huang, N. Gamper, Hailin Zhang, 2016, Biochemical and biophysical research communications.

TMEM16A protein attenuates lipopolysaccharide-mediated inflammatory response of human lung epithelial cell line A549

P. Zhang, Honglin Li, Xixin Yan, 2014, Experimental lung research.

FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner

Hailin Zhang, G. Pitt, Xiao Yu, 2016, Channels.

NGF Inhibits M/KCNQ Currents and Selectively Alters Neuronal Excitability in Subsets of Sympathetic Neurons Depending on their M/KCNQ Current Background

Qingzhong Jia, P. Delmas, L. Rodat-Despoix, 2008, The Journal of general physiology.

Activation of the Cl− Channel ANO1 by Localized Calcium Signals in Nociceptive Sensory Neurons Requires Coupling with the IP3 Receptor

S. Baldwin, J. Lippiat, N. Gamper, 2013, Science Signaling.

Potassium Channel Conductance Is Involved in Phenylephrine-Induced Spontaneous Firing of Serotonergic Neurons in the Dorsal Raphe Nucleus

Jing Wang, Hailin Zhang, Xiaona Du, 2022, Frontiers in Cellular Neuroscience.

Critical Determinants of the G Protein γ Subunits in the Gβγ Stimulation of G Protein-activated Inwardly Rectifying Potassium (GIRK) Channel Activity*

Luying Peng, J. Hirsch, D. Logothetis, 2003, Journal of Biological Chemistry.

Suppression of KV7/KCNQ potassium channel enhances neuronal differentiation of PC12 cells

Dongyang Huang, Hailin Zhang, Xiaona Du, 2016, Neuroscience.

Divalent Cations Modulate TMEM16A Calcium-Activated Chloride Channels by a Common Mechanism

Mengwen Jia, Hailin Zhang, Hailong An, 2013, The Journal of Membrane Biology.

Direct or Indirect Regulation of Calcium-Activated Chloride Channel by Calcium

Hailin Zhang, Yani Liu, Hailong An, 2011, The Journal of Membrane Biology.

TMEM16A-inhibitor loaded pH-responsive nanoparticles: a novel dual-targeting antitumor therapy for lung adenocarcinoma.

J. Cui, Hailin Zhang, Liang Qiu, 2020, Biochemical pharmacology.

Visualization of a Functional Gαq-Green Fluorescent Protein Fusion in Living Cells

T. Hughes, D. Logothetis, Hailin Zhang, 2001, The Journal of Biological Chemistry.

Transcriptional Regulation of Voltage-Gated Sodium Channels Contributes to GM-CSF-Induced Pain

N. Gamper, Dandan Zhang, Hailin Zhang, 2019, The Journal of Neuroscience.

Transcriptional Regulation of Voltage-Gated Sodium Channels Contributes to GM-CSF-Induced Pain

N. Gamper, Dandan Zhang, Hailin Zhang, 2018, The Journal of Neuroscience.

Electrophysiological and pharmacological characterization of a novel and potent neuronal Kv7 channel opener SCR2682 for antiepilepsy

Huanming Chen, Hailin Zhang, Yani Liu, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Antihistamine mepyramine directly inhibits KCNQ/M channel and depolarizes rat superior cervical ganglion neurons

Guohong Zhang, Bo-yi Liu, Hailin Zhang, 2008, Neuropharmacology.

Redox-Dependent Modulation of T-Type Ca2+ Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance P

Dongyang Huang, C. Peers, N. Gamper, 2016, Antioxidants & redox signaling.

A transient receptor potential channel expressed in taste receptor cells

Liquan Huang, R. Margolskee, M. Rong, 2002, Nature Neuroscience.

Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions

Cheng He, D. Logothetis, Hailin Zhang, 1999, Nature Cell Biology.

Repressor element 1–silencing transcription factor drives the development of chronic pain states

I. Wood, N. Gamper, N. Buckley, 2019, Pain.

EGF enhances the migration of cancer cells by up-regulation of TRPM7.

Hailin Zhang, Bingcai Guan, Yani Liu, 2011, Cell calcium.

The Role of Potassium Channel Activation in Celecoxib-Induced Analgesic Action

Dongyang Huang, Hailin Zhang, Jinlong Qi, 2013, PloS one.

Activation of Epidermal Growth Factor Receptor Inhibits KCNQ2/3 Current through Two Distinct Pathways: Membrane PtdIns(4,5)P2 Hydrolysis and Channel Phosphorylation

Qingzhong Jia, Bo-yi Liu, Huiling Liang, 2007, The Journal of Neuroscience.

Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission

D. Jaffe, Dongyang Huang, N. Gamper, 2014, PAIN®.

Procyanidin B1, a novel and specific inhibitor of Kv10.1 channel, suppresses the evolution of hepatoma.

Hailin Zhang, Hailong An, Sai Shi, 2020, Biochemical pharmacology.

Neuropathic Injury–Induced Plasticity of GABAergic System in Peripheral Sensory Ganglia

N. Gamper, Hailin Zhang, Xiaona Du, 2021, Frontiers in Pharmacology.

Alterations in Conserved Kir Channel-PIP2 Interactions Underlie Channelopathies

Jian Yang, D. Logothetis, Coeli M B Lopes, 2002, Neuron.

Regulation of CCL5 Expression in Smooth Muscle Cells Following Arterial Injury

M. Fu, Jianguo Liu, Hailin Zhang, 2012, PloS one.

Identification of a Potassium Channel Site That Interacts with G Protein βγ Subunits to Mediate Agonist-induced Signaling*

Cheng He, D. Logothetis, Hailin Zhang, 1999, The Journal of Biological Chemistry.

N‐terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits

D. Logothetis, Hailin Zhang, Kim W. Chan, 2003, The EMBO journal.

Lack of Negatively Charged Residues at the External Mouth of Kir2.2 Channels Enable the Voltage-Dependent Block by External Mg2+

D. Logothetis, Hailin Zhang, Suhua Zhang, 2014, PloS one.

Lack of Negatively Charged Residues at the External Mouth of Kir2.2 Channels Enable the Voltage-dependent Block by External Mg 2+2014) Lack of Negatively Charged Residues at the External Mouth of Kir2.2 Channels Enable the Voltage- Dependent Block by External Mg

D. Logothetis, Hailin Zhang, Suhua Zhang, 2022 .

Assaying phosphatidylinositol bisphosphate regulation of potassium channels.

D. Logothetis, Coeli M B Lopes, T. Rohacs, 2002, Methods in enzymology.

Root Ganglion Neurons Chloride Current in Subpopulations of Mouse Dorsal Axotomy-Induced Expression of Calcium-Activated

X. Navarro, S. Baldwin, D. Santos, 2015 .

Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats

Hailin Zhang, Xiaona Du, Chao Wang, 2011, Molecular pain.

Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators.

Fan Zhang, Qingzhong Jia, Kewei Wang, 2011, European journal of medicinal chemistry.

Activation of neuronal Kv7/KCNQ/M-channels by the opener QO58-lysine and its anti-nociceptive effects on inflammatory pain in rodents

Fan Zhang, Yan Song, Gang Li, 2016, Acta Pharmacologica Sinica.

Three pairs of weak interactions precisely regulate the G‐loop gate of Kir2.1 channel

D. Logothetis, Hailin Zhang, Hailong An, 2016, Proteins.

Activation of Ca2+‐activated Cl− channel ANO1 by localized Ca2+ signals

N. Gamper, Hailin Zhang, Xiaona Du, 2014, The Journal of physiology.

Delineating an extracellular redox-sensitive module in T-type Ca2+ channels

Dongyang Huang, C. Peers, N. Gamper, 2020, The Journal of Biological Chemistry.

Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice

Jing Wang, Dongyang Huang, Yu Zhang, 2021, Cell reports.

Local GABAergic signaling within sensory ganglia controls peripheral nociceptive transmission

Y. Yanagawa, J. Deuchars, D. Jaffe, 2017, The Journal of clinical investigation.

Fibroblast growth factor 13 stabilizes microtubules to promote Na+ channel function in nociceptive DRG neurons and modulates inflammatory pain

Bo-yi Liu, Hailin Zhang, Chuan Wang, 2020, Journal of advanced research.

M‐type K+ channels in peripheral nociceptive pathways

D. Jaffe, N. Gamper, Hailin Zhang, 2017, British journal of pharmacology.

Identification of Critical Residues Controlling G Protein-gated Inwardly Rectifying K+ Channel Activity through Interactions with the βγ Subunits of G Proteins*

Cheng He, D. Logothetis, Hailin Zhang, 2002, The Journal of Biological Chemistry.

Inhibition of M/Kv7 Currents Contributes to Chloroquine-Induced Itch in Mice

Ludi Zhang, Hailin Zhang, Zhanfeng Jia, 2020, Frontiers in Molecular Neuroscience.

Inducible Fgf13 ablation enhances caveolae-mediated cardioprotection during cardiac pressure overload

L. Mao, Hailin Zhang, G. Pitt, 2017, Proceedings of the National Academy of Sciences.

Kv7.4 Channel Contribute to Projection-Specific Auto-Inhibition of Dopamine Neurons in the Ventral Tegmental Area

Jing Wang, N. Gamper, Ludi Zhang, 2019, Front. Cell. Neurosci..

Identification of Resveratrol, an Herbal Compound, as an Activator of the Calcium-Activated Chloride Channel, TMEM16A

Hailin Zhang, Jinlong Qi, Hailong An, 2017, The Journal of Membrane Biology.

Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization

E. Kobrinsky, D. Logothetis, Hailin Zhang, 2000, Nature Cell Biology.

Two-electrode voltage clamp.

Hailin Zhang, Bingcai Guan, Xingjuan Chen, 2013, Methods in molecular biology.

Divalent Cations Modulate TMEM16A Calcium-Activated Chloride Channels by a Common Mechanism

Mengwen Jia, Hailin Zhang, Hailong An, 2013, The Journal of Membrane Biology.

GABAB receptors inhibit low-voltage activated and high-voltage activated Ca(2+) channels in sensory neurons via distinct mechanisms.

Dongyang Huang, C. Peers, N. Gamper, 2015, Biochemical and biophysical research communications.

Specificity of Gβγ Signaling Depends on Gα Subunit Coupling with G-Protein-Sensitive K+ Channels

D. Logothetis, R. Rusinova, Bo-yi Liu, 2009, Pharmacology.

Gβ Residues That Do Not Interact with Gα Underlie Agonist-independent Activity of K+ Channels*

T. Hébert, D. Logothetis, L. Robillard, 2002, The Journal of Biological Chemistry.

Gbeta residues that do not interact with Galpha underlie agonist-independent activity of K+ channels.

T. Hébert, D. Logothetis, L. Robillard, 2002, Journal of Biological Chemistry.

Selective Modulation of K+ Channel Kv7.4 Significantly Affects the Excitability of DRN 5-HT Neurons

Yongxue Zhang, Hailin Zhang, Xiaona Du, 2017, Front. Cell. Neurosci..

Involvement of Protein Kinase A and C in Norepinephrine- and Angiotensin II-Induced Modulation of Cardiac IKs

Hailin Zhang, Jiaxi Xu, Xiaona Du, 2013, Pharmacology.

Selective targeting of M‐type potassium Kv7.4 channels demonstrates their key role in the regulation of dopaminergic neuronal excitability and depression‐like behaviour

Li Li, Hui Sun, Xiaona Du, 2017, British journal of pharmacology.

Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats

Hailin Zhang, Xiaona Du, Chao Wang, 2011 .

Distinct Sites on G Protein βγ Subunits Regulate Different Effector Functions*

D. Logothetis, M. Linder, Hailin Zhang, 2002, The Journal of Biological Chemistry.

Transient Receptor Potential Cation Channel Subfamily Vanilloid 4 and 3 in the Inner Ear Protect Hearing in Mice

Hailin Zhang, Zhanfeng Jia, P. Lv, 2019, Front. Mol. Neurosci..

Selective activation of vascular Kv7.4/Kv7.5 K+ channels by fasudil contributes to its vasorelaxant effect

Yuan-yuan Zhang, Hailin Zhang, L. Chu, 2016, British journal of pharmacology.

The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels.

N. Gamper, L. Ooi, Bo-yi Liu, 2010, Journal of Clinical Investigation.

Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents

H. Zhang, H. Liang, J. Xu, 2013, Neuroscience.

Sympathetic Neurons Depending on their M/KCNQ Current Background NGF Inhibits M/KCNQ Currents and Selectively Alters Neuronal Excitability in Subsets of

J. Luther, Qingzhong Jia, P. Delmas, 2015 .

Specificity of Gβγ Signaling Depends on Gα Subunit Coupling with G-Protein-Sensitive K+ Channels

D. Logothetis, R. Rusinova, Bo-yi Liu, 2009, Pharmacology.

NGF Inhibits M/KCNQ Currents and Selectively Alters Neuronal Excitability in Subsets of Sympathetic Neurons Depending on their M/KCNQ Current Background

Qingzhong Jia, P. Delmas, Bo-yi Liu, 2008, The Journal of general physiology.

M‐type K+ channels in peripheral nociceptive pathways

D. Jaffe, E. Stevens, N. Gamper, 2017, British journal of pharmacology.

Activation of KCNQ2/3 Potassium Channels by Novel Pyrazolo[1,5-a]pyrimidin-7(4H)-One Derivatives

Fan Zhang, Jinlong Qi, Xiaona Du, 2011, Pharmacology.

Modulation mechanism of PKC upon inwardly rectifying potassium channels: Modulation mechanism of PKC upon inwardly rectifying potassium channels

Hailin Zhang, Xuan Zhang, Xiaowei Du, 2009 .