M. Tsiang

发表

A trimer of dimers is the basic building block for human immunodeficiency virus-1 capsid assembly.

Xiaohong Liu, S. Yant, D. Samuel, 2012, Biochemistry.

Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs

R. Stroud, A. Leavitt, R. Geleziunas, 2009, Proceedings of the National Academy of Sciences.

Regulation of thrombomodulin by tumor necrosis factor-alpha: comparison of transcriptional and posttranscriptional mechanisms.

J. Sadler, S. Lentz, M. Tsiang, 1991, Blood.

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action

Xiaohong Liu, R. Geleziunas, Wayne Huang, 2012, The Journal of Biological Chemistry.

Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation.

Xiaohong Liu, R. Geleziunas, S. Mukund, 2011, Biochemistry.

Conformationally Constrained Tricyclic HIV Integrase Inhibitors

James M. Chen, Xiaowu Chen, M. Tsiang, 2011 .

Functional Requirements for Inhibition of Thrombin by Antithrombin III in the Presence and Absence of Heparin*

C. Gibbs, M. Tsiang, An Jain, 1997, The Journal of Biological Chemistry.

Conversion of thrombin into an anticoagulant by protein engineering

C. Gibbs, S. Coutre, M. Tsiang, 1995, Nature.

Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogues.

J. Sadler, S. Lentz, M. Tsiang, 1990, Biochemistry.

Ligand specificity of human thrombomodulin. Equilibrium binding of human thrombin, meizothrombin, and factor Xa to recombinant thrombomodulin.

J. Sadler, S. Lentz, M. Tsiang, 1992, The Journal of biological chemistry.

Study of Marine Natural Products Including Resorcyclic Acid Lactones from Humicola fuscoatra That Reactivate Latent HIV-1 Expression in an in Vitro Model of Central Memory CD4+ T Cells

Steven T. Loveridge, Helen Yu, R. Geleziunas, 2014, Journal of natural products.

Effects of 5'-terminal modifications on the biological activity of defective interfering RNAs of Sindbis virus

S. Schlesinger, B. Weiss, M. Tsiang, 1988, Journal of virology.

Preclinical Evaluation of GS-9160, a Novel Inhibitor of Human Immunodeﬁciency Virus Type 1 Integrase (cid:1) †

R. Geleziunas, Xiaowu Chen, M. Tsiang, 2009 .

Preclinical Evaluation of GS-9160, a Novel Inhibitor of Human Immunodeficiency Virus Type 1 Integrase

R. Geleziunas, Xiaowu Chen, M. Tsiang, 2008, Antimicrobial Agents and Chemotherapy.

Allosteric effects of a monoclonal antibody against thrombin exosite II.

C. Gibbs, P. E. Bock, D. Tollefsen, 1998, Biochemistry.

Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors.

James M. Chen, Ruby Z Cai, Xiaowu Chen, 2006, Bioorganic & medicinal chemistry letters.

Deletion mapping of sindbis virus DI RNAs derived from cDNAs defines the sequences essential for replication and packaging

R. Levis, Henry Huang, S. Schlesinger, 1986, Cell.

Studies of defective interfering RNAs of Sindbis virus with and without tRNAAsp sequences at their 5' termini

S. Schlesinger, S. Monroe, M. Tsiang, 1985, Journal of virology.

A Cell-Based Strategy To Assess Intrinsic Inhibition Efficiencies of HIV-1 Reverse Transcriptase Inhibitors

K. White, M. Tsiang, M. Abram, 2014, Antimicrobial Agents and Chemotherapy.

Structure-function relationships of the thrombin-thrombomodulin interaction.

J. Sheehan, J. Sadler, S. Lentz, 1993, Haemostasis.

Functional domains of membrane-bound human thrombomodulin. EGF-like domains four to six and the serine/threonine-rich domain are required for cofactor activity.

J. Sadler, S. Lentz, M. Tsiang, 1992, The Journal of biological chemistry.

Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy

C. Gibbs, J. Rooney, J. Toole, 1999, Hepatology.

Effect of substitution on novel tricyclic HIV-1 integrase inhibitors.

Ruby Z Cai, M. Tsiang, C. Kim, 2006, Bioorganic & medicinal chemistry letters.

Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety.

Xiaowu Chen, M. Tsiang, Rachael Lansdown, 2009, Bioorganic & medicinal chemistry letters.

Tricyclic HIV integrase inhibitors: VI. SAR studies of 'benzyl flipped' C3-substituted pyrroloquinolines.

Xiaowu Chen, M. Tsiang, Rachael Lansdown, 2009, Bioorganic & medicinal chemistry letters.

Tricyclic HIV integrase inhibitors: potent and orally bioavailable C5-aza analogs.

Ruby Z Cai, Xiaowu Chen, M. Tsiang, 2008, Bioorganic & medicinal chemistry letters.

Effect of Substitution on Novel Tricyclic HIV‐1 Integrase Inhibitors.

Ruby Z Cai, M. Tsiang, C. Kim, 2006 .

Design, synthesis, and biological evaluation of novel tricyclic HIV-1 integrase inhibitors by modification of its pyridine ring.

M. Tsiang, C. Kim, Sammy Metobo, 2006, Bioorganic & medicinal chemistry letters.

Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile

K. White, Helen Yu, G. Kukolj, 2016, Antimicrobial Agents and Chemotherapy.

Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism.

Roger G. Linington, Helen Yu, R. Geleziunas, 2015, Organic letters.

Combination therapy with lamivudine and famciclovir for chronic hepatitis B–infected Chinese patients: A viral dynamics study

C. Gibbs, S. Yuen, W. Carman, 2000, Hepatology.

Predicting HBEAG loss by HBV DNA early kinetics and HBV genotype during treatment of HBEAG+ chronic hepatitis B (CHB) patients with adefovir dipivoxil (ADV)

M. Wulfsohn, C. Gibbs, A. Neumann, 2003 .

Long-term HBV kinetics classification during treatment with adefovir dipivoxil

M. Wulfsohn, C. Gibbs, A. Neumann, 2002 .

Dynamics analyses provide insight into the influence of precore mutations on the mechanisms of viral CL

C. Gibbs, Huiling Yang, E. Heathcote, 2001 .

Design, Synthesis and Biological Evaluation of Novel Tricyclic HIV-1 Integrase Inhibitors by Modification of Its Pyridine Ring.

M. Tsiang, C. Kim, Sammy Metobo, 2006 .

In vitro resistance selections using elvitegravir, raltegravir, and two metabolites of elvitegravir M1 and M4.

K. White, M. Tsiang, Gregg S. Jones, 2012, Antiviral research.

Long Dissociation of Bictegravir from HIV-1 Integrase-DNA Complexes

K. White, B. Brenner, Devleena Shivakumar, 2021, Antimicrobial Agents and Chemotherapy.

Localization of the single-stranded DNA binding site in the thrombin anion-binding exosite.

J. Sadler, M. Tsiang, Qingyu Wu, 1992, The Journal of biological chemistry.

Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin.

J. Sheehan, J. Sadler, S. Lentz, 1991, Proceedings of the National Academy of Sciences of the United States of America.

International Congress of Drug Therapy in HIV Infection 23-26 October 2016, Glasgow, UK

Raúl Tabarés Gutiérrez, Samit R. Joshi, H. Jessen, 2016, Journal of the International AIDS Society.

Affinities between the Binding Partners of the HIV-1 Integrase Dimer-Lens Epithelium-derived Growth Factor (IN Dimer-LEDGF) Complex

Kerim Babaoglu, Xiaohong Liu, R. Geleziunas, 2009, The Journal of Biological Chemistry.

Functional Mapping of the Surface Residues of Human Thrombin (*)

C. Gibbs, L. Leung, M. Tsiang, 1995, The Journal of Biological Chemistry.

Biochemical characterization of rhinovirus RNA-dependent RNA polymerase.

C. Gibbs, M. Tsiang, Magdeleine Hung, 2002, Antiviral research.

Analysis of hepatitis B virus dynamics and its impact on antiviral development.

C. Gibbs, M. Tsiang, 2004, Methods in molecular medicine.

Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors.

S. Swaminathan, J. Chen, M. Tsiang, 2008, Journal of molecular biology.

Selection of a Suppressor Mutation That Restores Affinity of an Oligonucleotide Inhibitor for Thrombin Using in Vitro Genetics (*)

C. Gibbs, L. Griffin, M. Tsiang, 1995, The Journal of Biological Chemistry.

Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo.

C. Gibbs, S. Coutre, M. Matteucci, 1996, Biochemistry.