Chengsong Xie

发表

Absence of DJ‐1 causes age‐related retinal abnormalities in association with increased oxidative stress

H. Cai, J. Hollyfield, B. Bell, 2017, Free radical biology & medicine.

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

Ping He, Veerle Baekelandt, Renée Vancraenenbroeck, 2013, Human molecular genetics.

Genetic ablation of dynactin p150Glued in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice

H. Cai, Lixin Sun, Jia Yu, 2018, Molecular Neurodegeneration.

Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin

H. Cai, B. Howell, Chengsong Xie, 2009, Molecular Brain.

Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3.

W. Markesbery, P. Davies, M. Lovell, 2005, Journal of Alzheimer's disease : JAD.

Longitudinal Metabolomics Profiling of Parkinson’s Disease-Related α-Synuclein A53T Transgenic Mice

X. Chen, H. Cai, Lixin Sun, 2015, PloS one.

Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning.

H. Cai, Lixin Sun, Jia Yu, 2019, Cell reports.

Oxidative stress regulation by DJ-1 in the retinal pigment epithelium.

H. Cai, Xiaoping Yang, V. Bonilha, 2014, Advances in experimental medicine and biology.

Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction

A. Singleton, Mary B Makarious, C. Blauwendraat, 2022, Nature Communications.

Parkinson’s disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging

H. Cai, Lixin Sun, Shengdi Chen, 2020, Molecular Neurodegeneration.

LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1 -mediated signalling pathways.

H. Cai, Lixin Sun, V. Koliatsos, 2016, Human molecular genetics.

Title : Leucine-rich Repeat Kinase 2 regulates Sec 16 A at ER exit sites to allow ER-Golgi export

H. Cai, Lixin Sun, Jia Yu, 2014 .

Mice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopietic function

H. Cai, Jichun Chen, K. Keyvanfar, 2007, Journal of Neuroimmunology.

Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons.

Michael J. O'Donovan, N. Chub, H. Cai, 2013, Human molecular genetics.

Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation

H. Cai, Lixin Sun, Jia Yu, 2015, The Journal of Neuroscience.

Leucine‐rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER–Golgi export

X. Chen, H. Cai, Lixin Sun, 2014, The EMBO journal.

Acrolein is increased in Alzheimer’s disease brain and is toxic to primary hippocampal cultures

W. Markesbery, M. Lovell, Chengsong Xie, 2001, Neurobiology of Aging.

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

H. Cai, Lixin Sun, Chengsong Xie, 2010, Molecular Brain.

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

H. Cai, Lixin Sun, J. Troncoso, 2009, Neuron.

AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression

H. Cai, Chengsong Xie, H. J. Cho, 2018, Translational Neurodegeneration.

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation.

H. Cai, Lixin Sun, Jia Yu, 2014, The Journal of clinical investigation.

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

Nicole A. Crowley, D. Lovinger, H. Cai, 2014, Nature Neuroscience.

Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis

H. Cai, Lixin Sun, V. Baekelandt, 2009, The Journal of Neuroscience.

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

Ming Zhan, Nancy M Bonini, Myriam Gorospe, 2008, Proceedings of the National Academy of Sciences.

Protection against amyloid beta peptide toxicity by zinc

W. Markesbery, M. Lovell, Chengsong Xie, 1999, Brain Research.

Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response

Samuel J. Hinshaw, X. Chen, H. Cai, 2015, PloS one.

The Chaperone Activity of Heat Shock Protein 90 Is Critical for Maintaining the Stability of Leucine-Rich Repeat Kinase 2

H. Cai, Lixin Sun, G. Chiosis, 2008, The Journal of Neuroscience.

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

Patrick G. A. Pedrioli, P. Cohen, H. Cai, 2012, PloS one.

Amyotrophic Lateral Sclerosis 2-Deficiency Leads to Neuronal Degeneration in Amyotrophic Lateral Sclerosis through Altered AMPA Receptor Trafficking

J. Zhu, R. Huganir, H. Cai, 2006, The Journal of Neuroscience.

Activation of protein kinase C modulates BACE1-mediated β-secretase activity

H. Cai, Chengsong Xie, Hoon Shim, 2008, Neurobiology of Aging.

Activation of protein kinase C modulates BACE1-mediated beta-secretase activity.

H. Cai, Chengsong Xie, Hoon Shim, 2008, Neurobiology of aging.

Wilms’ tumor suppressor (WT1) is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer’s disease

W. Markesbery, M. Lovell, S. Xiong, 2003, Brain Research.

A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons.

H. Cai, Lixin Sun, Jia Yu, 2014, Human molecular genetics.

Decreased base excision repair and increased helicase activity in Alzheimer's disease brain

W. Markesbery, M. Lovell, Chengsong Xie, 2000, Brain Research.

Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer’s disease

W. Markesbery, M. Lovell, B. Buchholz, 2002, Neurobiology of Aging.

Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice.

H. Cai, Xiaoping Yang, J. Hollyfield, 2015, Experimental eye research.

Genetic ablation of dynactin p150Glued in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice

H. Cai, Lixin Sun, Jia Yu, 2018, Molecular Neurodegeneration.

No apparent transmission of transgenic α–synuclein into nigrostriatal dopaminergic neurons in multiple mouse models

X. Chen, H. Cai, Lixin Sun, 2015, Translational Neurodegeneration.

Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.

D. Lovinger, H. Cai, Lixin Sun, 2015, Human molecular genetics.

ALDH1A1 regulates postsynaptic μ–opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling

H. Cai, Lixin Sun, Jia Yu, 2019, Scientific Reports.

Loss of ALS2 Function Is Insufficient to Trigger Motor Neuron Degeneration in Knock-Out Mice But Predisposes Neurons to Oxidative Stress

Ahmet Hoke, H. Cai, H. Wen, 2005, The Journal of Neuroscience.

ALS2/Alsin Knockout Mice and Motor Neuron Diseases

H. Cai, Chengsong Xie, Xian Lin, 2008, Neurodegenerative Diseases.

AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression

H. Cai, Chengsong Xie, H. J. Cho, 2018, Translational Neurodegeneration.

Correction to: Parkinson’s disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging

H. Cai, Lixin Sun, Shengdi Chen, 2020, Molecular Neurodegeneration.

Protection against amyloid beta peptide and iron/hydrogen peroxide toxicity by alpha lipoic acid.

W. Markesbery, M. Lovell, S. Xiong, 2003, Journal of Alzheimer's disease : JAD.

Deficiency in endocannabinoid synthase DAGLB contributes to Parkinson’s disease and dopaminergic neuron dysfunction

D. Lovinger, H. Cai, P. Chan, 2021, bioRxiv.

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

Nicole A. Crowley, D. Lovinger, H. Cai, 2014, Nature Neuroscience.

Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease

M A Lovell, W R Markesbery, W. Markesbery, 2005, Journal of neurochemistry.

ALDH1A1 regulates postsynaptic μ–opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling

H. Cai, Lixin Sun, Jia Yu, 2019, Scientific Reports.

Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease

C Xie, M A Lovell, W R Markesbery, 1998, Neurology.

Decreased thioredoxin and increased thioredoxin reductase levels in Alzheimer's disease brain.

W. Markesbery, M. Lovell, S. Gabbita, 2000, Free radical biology & medicine.

Expression of glutathione-S-transferase isozyme in the SY5Y neuroblastoma cell line increases resistance to oxidative stress.

T. Montine, W. Markesbery, Jun-tao Guo, 2001, Free radical biology & medicine.

Acrolein, a product of lipid peroxidation, inhibits glucose and glutamate uptake in primary neuronal cultures.

W. Markesbery, M. Lovell, Chengsong Xie, 2000, Free radical biology & medicine.

Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation.

H. Cai, Lixin Sun, Jia Yu, 2014, The Journal of clinical investigation.