Shirley Yu

Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration

Farhad Hafezi, Andreas Wenzel, C. Grimm, 2000, Nature Genetics.

Retinal energy metabolism: Photoreceptors switch between Cori, Cahill, and mini-Krebs cycles to uncouple glycolysis from mitochondrial respiration

O. Schmachtenberg, F. Herberg, Shirley Yu, 2022, bioRxiv.

Identification of beta‐carotene 15,15′‐monooxygenase as a peroxisome proliferator‐activated receptor target gene

N. Copeland, D. Gilbert, N. Jenkins, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Single-Cell Transcriptomic Profiling in Inherited Retinal Degeneration Reveals Distinct Metabolic Pathways in Rod and Cone Photoreceptors

Shirley Yu, François Paquet-Durand, Jie Yan, 2022, bioRxiv.

The level of thymic expression of RPE65 inversely correlates with its capacity to induce experimental autoimmune uveitis (EAU) in different rodent strains.

I. Gery, D. Ham, Shirley Yu, 2006, Experimental eye research.

Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle

D. Bok, D. Hamasaki, Jian-xing Ma, 1998, Nature Genetics.

Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle.

T Michael Redmond, E. Poliakov, Shirley Yu, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Mouse model of human RPE65 P25L hypomorph resembles wild type under normal light rearing but is fully resistant to acute light damage.

Lijin Dong, T Michael Redmond, Shirley Yu, 2015, Human molecular genetics.

Protection of Rpe 65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration

C. Grimm, A. Wenzel, C. Remé, 2000 .

Effect of Leu/Met variation at residue 450 on isomerase activity and protein expression of RPE65 and its modulation by variation at other residues.

T Michael Redmond, E. Poliakov, Shirley Yu, 2007, Molecular vision.