N. Fishkin

发表

K. Nakanishi, Y. Jang, J. Sparrow, 2003, Vision Research.

Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E.

K. Nakanishi, R. Allikmets, S. Kim, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate.

K. Nakanishi, R. Allikmets, J. Sparrow, 2005, Proceedings of the National Academy of Sciences of the United States of America.

A2E, a fluorophore of RPE lipofuscin: can it cause RPE degeneration?

K. Nakanishi, Y. Jang, J. Sparrow, 2003, Advances in experimental medicine and biology.

Biosynthetic Studies of A2E, a Major Fluorophore of Retinal Pigment Epithelial Lipofuscin*

K. Nakanishi, S. Ben-Shabat, J. Sparrow, 2002, The Journal of Biological Chemistry.

Bioorganic Studies on Rhodopsins

K. Nakanishi, N. Berova, N. Fishkin, 2002 .

Abstract C160: New class of DNA-alkylating agents with a suitable tolerability profile created for use in antibody-drug conjugates (ADCs).

Emily E. Reid, E. K. Maloney, J. Pinkas, 2013 .

Abstract C164: New tri-glycyl peptide linker offers advantages for maytansinoid antibody-drug conjugates (ADCs).

Rajeeva Singh, Y. Setiady, R. Chari, 2013 .

Abstract C162: Antibody-Drug Conjugates (ADCs) with novel IGN DNA-alkylating agents display potent antigen-specific activity against hematologic and solid tumor xenograft models.

Emily E. Reid, E. K. Maloney, J. Pinkas, 2013 .

Novel Lipofuscin Bisretinoids Prominent in Human Retina and in a Model of Recessive Stargardt Disease*

A. Pande, J. Pande, J. Sparrow, 2009, The Journal of Biological Chemistry.

Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing.

E. K. Maloney, Rajeeva Singh, Y. Setiady, 2015, Bioconjugate chemistry.

Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates.

J. Pinkas, T. Keating, R. Chari, 2016, Bioconjugate chemistry.

Effect of Linker Stereochemistry on the Activity of Indolinobenzodiazepine Containing Antibody-Drug Conjugates (ADCs).

E. K. Maloney, Rui Wu, R. Chari, 2019, ACS medicinal chemistry letters.

Abstract 647: SeriMabs: N-terminal serine modification enables modular, site-specific payload incorporation into antibody-drug conjugates (ADCs)

E. K. Maloney, J. Pinkas, T. Keating, 2015 .

A New Class of Antibody–Drug Conjugates with Potent DNA Alkylating Activity

E. K. Maloney, J. Pinkas, Rajeeva Singh, 2016, Molecular Cancer Therapeutics.

Design and synthesis of artificial phospholipid for selective cleavage of integral membrane protein.

K. Nakanishi, S. Fujii, Yasuo Suzuki, 2005, Chemical communications.

Solution and biologically relevant conformations of enantiomeric 11-cis-locked cyclopropyl retinals.

K. Nakanishi, N. Berova, G. Pescitelli, 2002, Journal of the American Chemical Society.

A New Triglycyl Peptide Linker for Antibody–Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells

Rajeeva Singh, Y. Setiady, Rui Wu, 2016, Molecular Cancer Therapeutics.

Absolute configurational determination of an all-trans-retinal dimer isolated from photoreceptor outer segments.

K. Nakanishi, N. Berova, G. Pescitelli, 2004, Chirality.

Terpene Trilactones from Ginkgo biloba Are Antagonists of Cortical Glycine and GABAA Receptors*

A. Kriegstein, K. Nakanishi, L. Ivić, 2003, Journal of Biological Chemistry.

Chapter 19 – CD and Visual Science

K. Nakanishi, N. Berova, N. Fishkin, 2004 .

Primary events in dim light vision: a chemical and spectroscopic approach toward understanding protein/chromophore interactions in rhodopsin.

K. Nakanishi, N. Berova, N. Fishkin, 2004, Chemical record.

On the bioactive conformation of the rhodopsin chromophore: absolute sense of twist around the 6-s-cis bond.

Tao Wang, K. Nakanishi, N. Berova, 2001, Chemistry.

A2-rhodopsin: a new fluorophore isolated from photoreceptor outer segments.

Koji Nakanishi, K. Nakanishi, Y. Jang, 2003, Organic & biomolecular chemistry.

The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model

S. Jockusch, N. Turro, Y. Jang, 2007, Proceedings of the National Academy of Sciences.

Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid.

B. Rittmann, J. Sparrow, Yalin Wu, 2011, Journal of the American Chemical Society.

IMGN779, a CD33-Targeted Antibody-Drug Conjugate (ADC) with a Novel DNA-Alkylating Effector Molecule, Induces DNA Damage, Cell Cycle Arrest, and Apoptosis in AML Cells.

A. Romanelli, W. Krystal, N. Fishkin, 2015 .

A novel pathway for maytansinoid release from thioether linked antibody-drug conjugates (ADCs) under oxidative conditions.

E. K. Maloney, Rajeeva Singh, R. Chari, 2011, Chemical communications.

Abstract 2644: Antibody-drug conjugates (ADCs) with a novel DNA-alkylating agent, DGN462, are highly potent in vitro and in vivo against human cancer models

E. K. Maloney, R. Chari, N. Fishkin, 2014 .

On the mechanism of isomerization of all-trans-retinol esters to 11-cis-retinol in retinal pigment epithelial cells: 11-fluoro-all-trans-retinol as substrate/inhibitor in the visual cycle.

R. Rando, N. Fishkin, R. Yefidoff, 2005, Bioorganic & medicinal chemistry.

Rpe 65 Leu 450 Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A 2 E and isoA 2 E

K. Nakanishi, R. Allikmets, S. Kim, 2004 .

Targeted Maytansinoid Conjugate Improves Therapeutic Index for Metastatic Breast Cancer Cells.

K. Burgess, Feng Li, Zheng Li, 2018, Bioconjugate chemistry.

Synthesis and Spectroscopic Characterization of Photo‐affinity Peptide Ligands to Study Rhodopsin–G Protein Interaction †

K. Nakanishi, P. Henklein, O. Ernst, 2008, Photochemistry and photobiology.