D. Roman

发表

Use of Flow Cytometric Methods to Quantify Protein‐Protein Interactions

Richard R Neubig, R. Neubig, Levi L. Blazer, 2010, Current protocols in cytometry.

Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures

J. Doorn, D. Roman, Christopher R Bodle, 2018, SLAS discovery : advancing life sciences R & D.

Regulator of G Protein Signaling 17 as a Negative Modulator of GPCR Signaling in Multiple Human Cancers

D. Roman, M. Hayes, 2016, The AAPS Journal.

Regulator of G-protein signaling (RGS) proteins as drug targets: Progress and future potentials

D. Roman, J. O'Brien, Joshua C. Wilkinson, 2019, The Journal of Biological Chemistry.

Allosteric Inhibition of the Regulator of G Protein Signaling–Gα Protein–Protein Interaction by CCG-4986

R. Neubig, Levi L. Blazer, D. Roman, 2010, Molecular Pharmacology.

Microfabricated channel array electrophoresis for characterization and screening of enzymes using RGS-G protein interactions as a model system.

Chetwana Rungwanitcha, Robert T Kennedy, John F. Dishinger, 2008, Analytical chemistry.

High-resolution structure of RGS17 suggests a role for Ca2+ in promoting the GTPase-activating protein activity by RZ subfamily members

J. Houtman, D. Roman, J. O'Brien, 2019, The Journal of Biological Chemistry.

Modification and functional inhibition of regulator of G-protein signaling 4 (RGS4) by 4-hydroxy-2-nonenal.

J. Doorn, D. Roman, C. A. Monroy, 2013, Chemical research in toxicology.

Distinct Recognition of Substrates by the Human and Drosophila Serotonin Transporters

E. Barker, D. Roman, K. J. White, 2003, Journal of Pharmacology and Experimental Therapeutics.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets

Stephen P. H. Alexander, C. Southan, D. Fabbro, 2021, British journal of pharmacology.

Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines.

J. Houtman, J. Doorn, Michael R. Miller, 2017, Journal of natural products.

Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

C. Ptak, V. Watts, D. Roman, 2022, Frontiers in Pharmacology.

Expression and purification of recombinant human tyrosine hydroxylase as a fusion protein in Escherichia coli.

J. Doorn, Lydia M. M. Vermeer, D. Roman, 2012, Protein expression and purification.

Differential modulation of mu‐opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Gα subtype dependent

R. Neubig, J. Traynor, D. Roman, 2010, Journal of neurochemistry.

Real-time monitoring of tyrosine hydroxylase activity using a plate reader assay.

J. Doorn, Lydia M. M. Vermeer, D. Roman, 2013, Analytical biochemistry.

Development of a Novel High-Throughput Screen and Identification of Small-Molecule Inhibitors of the Gα–RGS17 Protein–Protein Interaction Using AlphaScreen

D. Roman, D. Mackie, 2011, Journal of biomolecular screening.

Regulators of G protein signaling (RGS) proteins as drug targets: modulating G-protein-coupled receptor (GPCR) signal transduction.

J. Traynor, D. Roman, 2011, Journal of medicinal chemistry.

A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen

R. Neubig, Levi L. Blazer, H. Mosberg, 2009, BMC pharmacology.

Regulators of G protein signaling (RGS) Proteins as Drug Targets: Modulating GPCR Signal Transduction

J. Traynor, D. Roman, 2011 .

Identification of Small-Molecule Inhibitors of RGS4 Using a High-Throughput Flow Cytometry Protein Interaction Assay

R. Neubig, R. Sunahara, J. Traynor, 2007, Molecular Pharmacology.

RABL6A, a Novel RAB-Like Protein, Controls Centrosome Amplification and Chromosome Instability in Primary Fibroblasts

D. Quelle, C. M. Eischen, B. Darbro, 2013, PloS one.

New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling.

V. Watts, D. Roman, M. Hayes, 2015, Biochemical pharmacology.

Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2

K. Druey, B. Chakravarti, R. Fisher, 2021, IUPHAR/BPS Guide to Pharmacology CITE.

RGS17: an emerging therapeutic target for lung and prostate cancers.

D. Roman, Christopher R Bodle, D. Mackie, 2013, Future medicinal chemistry.

Protein Interaction Using AlphaScreen − RGS 17 Protein − α Development of a Novel High-Throughput Screen and Identification of Small-Molecule Inhibitors of the G

D. Roman, D. Mackie, 2011 .

Novel Treatments for Chronic Pain: Moving Beyond Opioids.

D. Roman, J. O'Brien, 2021, Translational research : the journal of laboratory and clinical medicine.

Novel Peptide Ligands of RGS4 from a Focused One‐Bead, One‐Compound Library

R. Neubig, I. Pogozheva, Levi L. Blazer, 2008, Chemical biology & drug design.

Regulators of G protein Signaling (RGS) proteins (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

K. Druey, B. Chakravarti, R. Fisher, 2020, IUPHAR/BPS Guide to Pharmacology CITE.

Regulators of G protein Signaling (RGS) proteins (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

K. Druey, B. Chakravarti, R. Fisher, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Reversible, Allosteric Small-Molecule Inhibitors of Regulator of G Protein Signaling Proteins

R. Neubig, Levi L. Blazer, S. Husbands, 2010, Molecular Pharmacology.

Distinct Molecular Recognition of Psychostimulants by Human and Drosophila Serotonin Transporters

F. Carroll, E. Barker, D. Roman, 2004, Journal of Pharmacology and Experimental Therapeutics.

Assembly of High Order Gαq-Effector Complexes with RGS Proteins*

R. Neubig, T. Kozasa, V. Tesmer, 2008, Journal of Biological Chemistry.

Development of a bimolecular luminescence complementation assay for RGS: G protein interactions in cells.

D. Roman, Christopher R Bodle, J. O'Brien, 2017, Analytical biochemistry.

Evaluation of the Selectivity and Cysteine Dependence of Inhibitors across the Regulator of G Protein–Signaling Family

D. Roman, Christopher R Bodle, M. Hayes, 2018, Molecular Pharmacology.

A High Throughput Screen for RGS Proteins Using Steady State Monitoring of Free Phosphate Formation

D. Roman, C. A. Monroy, D. Mackie, 2013, PloS one.

Polyplexed Flow Cytometry Protein Interaction Assay: A Novel High-Throughput Screening Paradigm for RGS Protein Inhibitors

Richard R Neubig, R. Neubig, D. Roman, 2009, Journal of biomolecular screening.

Stable expression of the human dopamine transporter in N27 cells as an in vitro model for dopamine cell trafficking and metabolism.

J. Doorn, R. Cornell, D. Roman, 2021, Toxicology in Vitro.

Interactions of antidepressants with the serotonin transporter: a contemporary molecular analysis.

E. Barker, C. Walline, D. Roman, 2003, European journal of pharmacology.

Regulator of G Protein Signaling 17 as a Negative Modulator of GPCR Signaling in Multiple Human Cancers

D. Roman, M. Hayes, 2016, The AAPS Journal.

Identification of ligands targeting RGS proteins high-throughput screening and therapeutic potential.

D. Roman, 2009, Progress in molecular biology and translational science.

Identification of FDA-Approved Small Molecules Capable of Disrupting the Calmodulin-Adenylyl Cyclase 8 Interaction through Direct Binding to Calmodulin.

Monica Soto-Velasquez, V. Watts, Val J Watts, 2017, ACS chemical neuroscience.

Mechanism of Action and Structural Requirements of Constrained Peptide Inhibitors of RGS Proteins

R. Neubig, M. Ishii, R. Sunahara, 2006, Chemical biology & drug design.

In vitro protein kinase activity measurement by flow cytometry.

R. Neubig, D. Roman, Donald J Bernsteel, 2008, Analytical biochemistry.

Regulators of G protein Signaling (RGS) proteins (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database

K. Druey, B. Chakravarti, R. Fisher, 2020, IUPHAR/BPS Guide to Pharmacology CITE.

Bias Analyses of Preclinical and Clinical D2 Dopamine Ligands: Studies with Immediate and Complex Signaling Pathways

V. Watts, D. Roman, M. Hayes, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Assembly of High Order Gαq-Effector Complexes with RGS Proteins*

R. Neubig, T. Kozasa, V. Tesmer, 2008, Journal of Biological Chemistry.