J. Egebjerg

发表

An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: Kinetic binding studies with the ALI/VFL–SI/TT mutant

C. Sánchez, K. Hansen, H. Zhong, 2009, Neuroscience Letters.

Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist.

P. Krogsgaard‐Larsen, K. Frydenvang, J. Egebjerg, 2001, European journal of pharmacology.

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Caleb Webber, Guy B. Williams, Mara Cercignani, 2019, Brain : a journal of neurology.

N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands.

J. Greenwood, S. Traynelis, K. Hansen, 2008, Journal of medicinal chemistry.

HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells

A. Mørk, J. Lotharius, T. Sager, 2010, Journal of neurochemistry.

Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice

T. Werge, P. Celada, J. Nielsen, 2017, Journal of psychiatry & neuroscience : JPN.

Enantioselective Proteins: Selection, Binding Studies and Molecular Modeling of Antibodies with Affinity towards Hydrophobic BINOL Derivatives

K. Mortensen, B. Schiøtt, T. Skrydstrup, 2007, Chembiochem : a European journal of chemical biology.

Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.

J. Greenwood, A. A. Jensen, R. Clausen, 2007, Journal of medicinal chemistry.

Binding sites of the antibiotics pactamycin and celesticetin on ribosomal RNAs.

R. Garrett, J. Egebjerg, 1991, Biochimie.

LRRK2 exonic variants associated with Parkinson’s disease augment phosphorylation levels for LRRK2-Ser1292 and Rab10-Thr73

Sarah Elschenbroich, F. Oppermann, M. Hentzer, 2018, bioRxiv.

R. Nisticò, F. Blandini, J. Egebjerg, 2014, Front. Pharmacol..

Pharmacological characterization of ligands at recombinant NMDA receptor subtypes by electrophysiological recordings and intracellular calcium measurements.

K. Hansen, H. Bräuner‐Osborne, J. Egebjerg, 2008, Combinatorial chemistry & high throughput screening.

Crystal structure of the kainate receptor GluR5 ligand‐binding core in complex with (S)‐glutamate

P. Naur, B. Vestergaard, J. Kastrup, 2005, FEBS letters.

Parkinson's Progression Markers Initiative brain autopsy program.

P. Muglia, J. Jankovic, M. Mintun, 2022, Parkinsonism & related disorders.

The Parkinson's progression markers initiative (PPMI) – establishing a PD biomarker cohort

Norbert Schuff, Arthur W. Toga, John Seibyl, 2018, Annals of clinical and translational neurology.

Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau

E. Sigurdsson, J. Falsig, L. Pedersen, 2018, Alzheimer's & dementia.

Inflammatory biomarkers in Alzheimer's disease plasma

Magda Tsolaki, Edward T. Bullmore, Gareth J. Barker, 2019, Alzheimer's & Dementia.

(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology.

J. Greenwood, P. Krogsgaard‐Larsen, K. Hansen, 2003, Journal of medicinal chemistry.

Ligands for Glutamate Receptors: Design and Therapeutic Prospects

P. Krogsgaard‐Larsen, U. Madsen, J. Egebjerg, 2000 .

Awards for research on Rett syndrome: towards a therapeutic breakthrough

R. Morris, J. Egebjerg, 2020, The Lancet Neurology.

Respiratory modelling: a causal probabilistic modelling representation

Ewart R. Carson, Steen Andreassen, R. Summers, 1993 .

CRM1 Mediates the Export of ADAR1 through a Nuclear Export Signal within the Z-DNA Binding Domain

J. Kjems, J. Nilsson, C. Damgaard, 2001, Molecular and Cellular Biology.

Changes in KCNQ2 immunoreactivity in the amygdala in two rat models of temporal lobe epilepsy.

J. Bastlund, J. Egebjerg, T. Stensbøl, 2005, Brain research. Molecular brain research.

Characterization of a new AMPA receptor radioligand, [3H]2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid.

P. Krogsgaard‐Larsen, N. Diemer, U. Madsen, 1999, European journal of pharmacology.

Highly Specific and Sensitive Target Binding by the Humanized pS396-Tau Antibody hC10.2 Across a Wide Spectrum of Alzheimer's Disease and Primary Tauopathy Postmortem Brains.

C. Christoffersen, J. Falsig, L. Pedersen, 2022, Journal of Alzheimer's disease : JAD.

Longitudinal clinical and biomarker characteristics of non-manifesting LRRK2 G2019S carriers in the PPMI cohort

Yen F. Tai, P. Muglia, J. Jankovic, 2022, npj Parkinson's Disease.

Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI).

Yen F. Tai, P. Muglia, J. Jankovic, 2019, Parkinsonism & related disorders.

The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener.

F. Ashcroft, P. Wahl, B. Pirotte, 2002, Diabetes.

Selectivity of 3H‐MADAM binding to 5‐hydroxytryptamine transporters in vitro and in vivo in mice; correlation with behavioural effects

C. Halldin, C Halldin, P. H. Andersen, 2004, British journal of pharmacology.

Deorphanization of GPRC6A: A Promiscuous l-α-Amino Acid Receptor with Preference for Basic Amino Acids

J. Greenwood, K. Hansen, P. Wellendorph, 2005, Molecular Pharmacology.

1‐(3‐(9H‐Carbazol‐9‐yl)‐1‐propyl)‐4‐(2‐methoxyphenyl)‐4‐piperidinol, a novel subtype selective inhibitor of the mouse type II GABA‐transporter

C. Thomsen, J. Egebjerg, P. O. Sørensen, 1997, British journal of pharmacology.

Ligands for glutamate receptors: design and therapeutic prospects.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, U. Madsen, 2000, Journal of medicinal chemistry.

Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids.

F. Acher, K. Hansen, G. Roda, 2005, Journal of medicinal chemistry.

Selective RNA editing and subunit assembly of native glutamate receptors

J. Morrison, R. Puchalski, S. Heinemann, 1994, Neuron.

Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA

S. Heinemann, B. Bettler, I. Hermans-Borgmeyer, 1991, Nature.

CRM1 Mediates the Export of ADAR1 through a Nuclear Export Signal within the Z-DNA Binding Domain

J. Kjems, J. Nilsson, C. Damgaard, 2001, Molecular and Cellular Biology.

CRM 1 Mediates the Export of ADAR 1 through a Nuclear Export Signal within the Z-DNA Binding Domain

J. Kjems, J. Nilsson, C. Damgaard, 2001 .

Cloning of a putative glutamate receptor: A low affinity kainate-binding subunit

C. Stevens, S. Heinemann, B. Bettler, 1992, Neuron.

Structure of ionotropic glutamate receptors

J. Egebjerg, H. Jensen, 2001 .

Resolution, absolute stereochemistry, and enantiopharmacology of the GluR1-4 and GluR5 antagonist 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.

P. Krogsgaard‐Larsen, U. Madsen, J. Egebjerg, 1999, Chirality.

Attachment sites of primary binding proteins L1, L2 and L23 on 23 S ribosomal RNA of Escherichia coli.

R. Garrett, J. Christiansen, J. Egebjerg, 1991, Journal of molecular biology.

Protein L18 binds primarily at the junctions of helix II and internal loops A and B in Escherichia coli 5 S RNA. Implications for 5 S RNA structure.

R A Garrett, R. Garrett, N. Larsen, 1989, Journal of molecular biology.

Domain VI of Escherichia coli 23 S ribosomal RNA. Structure, assembly and function.

R. Garrett, H. Leffers, T. Christensen, 1988, Journal of molecular biology.

Regulation of Sodium Channel Function by Bilayer Elasticity

A. Hansen, J. A. Lundbæk, O. Andersen, 2004, The Journal of general physiology.

The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.

J. Greenwood, K. Hansen, R. Clausen, 2004, European journal of pharmacology.

The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin.

M. Langgård, C. Bundgaard, J. Stavenhagen, 2014, Bioorganic & medicinal chemistry letters.

Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor–ligand complex

M. Langgård, S. Thirup, M. Garcia-Alai, 2014, Acta crystallographica. Section D, Biological crystallography.

ASF/SF2 and SC35 regulate the glutamate receptor subunit 2 alternative flip/flop splicing

J. Egebjerg, Trine Elkjær Crovato, 2005, FEBS letters.

Neurological disease mutations compromise a C-terminal ion pathway in the Na+/K+-ATPase

P. Nissen, H. Khandelia, J. P. Morth, 2010, Nature.

A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission

T. Werge, C. Christoffersen, J. Nielsen, 2017, Translational Psychiatry.

Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology.

J. Greenwood, P. Krogsgaard‐Larsen, B. Frølund, 2005, Bioorganic & medicinal chemistry.

Antagonist properties of a phosphono isoxazole amino acid at glutamate R1-4 (R,S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid receptor subtypes.

P. Krogsgaard‐Larsen, S. Traynelis, P. Wahl, 1998, Molecular pharmacology.

Ionotropic glutamate-like receptor δ2 binds d-serine and glycine

P. Naur, B. Vestergaard, L. Olsen, 2007, Proceedings of the National Academy of Sciences of the United States of America.

Ionotropic glutamate-like receptor delta2 binds D-serine and glycine.

P. Naur, B. Vestergaard, L. Olsen, 2007, Proceedings of the National Academy of Sciences of the United States of America.

Ca2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR6.

S. Heinemann, J. Egebjerg, Stephen F. Heinemann, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Tweaking Agonist Efficacy at N-Methyl-d-aspartate Receptors by Site-Directed Mutagenesis

J. Greenwood, K. Hansen, E. Bjerrum, 2005, Molecular Pharmacology.

Tweaking agonist efficacy at NMDA receptors by site-directed mutagenesis

K. Hansen, E. Bjerrum, R. Clausen, 2005 .

The selective activation of the glutamate receptor GluR5 by ATPA is controlled by serine 741.

T. Liljefors, P. Krogsgaard‐Larsen, J. Egebjerg, 2003, Molecular pharmacology.

The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations

P. Nissen, J. P. Morth, H. Poulsen, 2009, Philosophical Transactions of the Royal Society B: Biological Sciences.

Clinical and dopamine transporter imaging characteristics of non-manifest LRRK2 and GBA mutation carriers in the Parkinson's Progression Markers Initiative (PPMI): a cross-sectional study

Yen F. Tai, A. Singleton, P. Muglia, 2020, The Lancet Neurology.

A six‐domain structural model for Escherichia coli translation initiation factor IF2. Characterisation of twelve surface epitopes

K. Mortensen, H. U. Sperling-Petersen, J. Egebjerg, 1998, Biochemistry and molecular biology international.

Characterization of the binding sites of protein L11 and the L10.(L12)4 pentameric complex in the GTPase domain of 23 S ribosomal RNA from Escherichia coli.

R. Garrett, S. Douthwaite, A. Liljas, 1990, Journal of molecular biology.

Primer-directed deletions in 5S ribosomal RNA.

R. Garrett, J. Christiansen, B. Vester, 1988, Methods in enzymology.

Analysis of RNA-protein complexes in vitro

J. Kjems, J. Christiansen, J. Egebjerg, 1998 .

Resolution, absolute stereochemistry and molecular pharmacology of the enantiomers of ATPA.

P. Krogsgaard‐Larsen, U. Madsen, B. Ebert, 1999, European journal of pharmacology.

Distribution and pharmacology of alanine–serine–cysteine transporter 1 (asc‐1) in rodent brain

L. Helboe, C. Thomsen, J. Egebjerg, 2003, The European journal of neuroscience.

Altered function of hippocampal CA1 pyramidal neurons in the rTg4510 mouse model of tauopathy.

N. O. Dalby, C. Volbracht, A. B. Elvang, 2014, Journal of Alzheimer's disease : JAD.

Dimerization of ADAR2 is mediated by the double-stranded RNA binding domain.

F. Nielsen, Rasmus Jorgensen, H. Poulsen, 2006, RNA.

Phosphorylation of the Na+,K+‐ATPase and the H+,K+‐ATPase

P. Nissen, H. Poulsen, P. Morth, 2010, FEBS letters.

Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors.

P. Krogsgaard‐Larsen, J. Jaroszewski, K. Strømgaard, 2002, Journal of medicinal chemistry.

Partial Agonism and Antagonism of the Ionotropic Glutamate Receptor iGLuR5

T. Liljefors, A. Schousboe, P. Naur, 2007, Journal of Biological Chemistry.

Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model

C. Volbracht, L. Helboe, J. Egebjerg, 2017, Brain Research.

Distribution of serotonin receptor 5-HT6 mRNA in rat neuronal subpopulations: A double in situ hybridization study

L. Helboe, J. Egebjerg, I. D. Jong, 2015, Neuroscience.

Location of the Antidepressant Binding Site in the Serotonin Transporter

O. Taboureau, L. Olsen, K. Hansen, 2009, Journal of Biological Chemistry.

Structural Correlates of Ionotropic Glutamate Receptor Function

L. Wollmuth, S. Traynelis, K. Hansen, 2008 .

A single nucleotide polymorphism in the human serotonin transporter introduces a new site for N-linked glycosylation

U. Gether, P. Plenge, J. Egebjerg, 2009, Neuropharmacology.

Hippocampal CA1 region shows differential regulation of gene expression in mice displaying extremes in behavioral sensitization to amphetamine: relevance for psychosis susceptibility?

N. Datson, M. Didriksen, E. D. de Kloet, 2011, Psychopharmacology.

Glutamate and gaba receptors and transporters : structure,function and pharmacology

A. Schousboe, P. Krogsgaard‐Larsen, J. Egebjerg, 2001 .

A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures

L. Olsen, J. Kastrup, K. Frydenvang, 2015, Neuroscience.

Correlation of the expression of kainate receptor subtypes to responses evoked in cultured cortical and spinal cord neurones

J. Lambert, B. Ebert, J. Egebjerg, 2002, Brain Research.

Characteristics of AMPA receptor‐mediated responses of cultured cortical and spinal cord neurones and their correlation to the expression of glutamate receptor subunits, GluR1‐4

J. Lambert, J. Egebjerg, Weiguo Dai, 2001, British journal of pharmacology.

Uncompetitive antagonism of AMPA receptors: Mechanistic insights from studies of polyamine toxin derivatives.

K. Strømgaard, J. Egebjerg, I. Mellor, 2006, Journal of medicinal chemistry.

Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus.

J. Kastrup, M. Gajhede, H. A. Ernst, 2010, Protein expression and purification.

Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core.

M. Mayer, E. Gouaux, T. Liljefors, 2002, Journal of molecular biology.

Intron sequence directs RNA editing of the glutamate receptor subunit GluR2 coding sequence.

S. Heinemann, V. Kukekov, J. Egebjerg, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Modern methods for probing RNA structure.

J. Kjems, J. Egebjerg, 1998, Current opinion in biotechnology.

Synthesis, theoretical and structural analyses, and enantiopharmacology of 3-carboxy homologs of AMPA.

J. Greenwood, P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, 2004, Chirality.

Towards rational design of AMPA receptor ligands: An integrated medicinal, computational, biostructural and molecular pharmacological approach

J. Greenwood, P. Krogsgaard‐Larsen, J. Kastrup, 2002 .

Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX.

E. Gouaux, T. Liljefors, J. Greenwood, 2003, Journal of medicinal chemistry.

A Binding Site Tyrosine Shapes Desensitization Kinetics and Agonist Potency at GluR2

Matthew T. Geballe, P. Naur, B. Vestergaard, 2005, Journal of Biological Chemistry.

Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2.

J. Kastrup, S. Traynelis, J. Egebjerg, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Assembly of proteins and 5 S rRNA to transcripts of the major structural domains of 23 S rRNA.

R. Garrett, B. Porse, L. Ostergaard, 1998, Journal of molecular biology.

Cloning, expression and characterization of a sialidase gene from Arthrobacter ureafaciens

J. Egebjerg, Søren Christensen, 2005, Biotechnology and applied biochemistry.

Larger intercellular variation in (Q/R) editing of GluR6 than GluR5 revealed by single cell RT‐PCR

Wei Dai, J. Lambert, J. Egebjerg, 2000, Neuroreport.

Antibiotic interactions at the GTPase‐associated centre within Escherichia coli 23S rRNA.

R. Garrett, S. Douthwaite, J. Egebjerg, 1989, The EMBO journal.

GluR2 ligand‐binding core complexes: importance of the isoxazolol moiety and 5‐substituent for the binding mode of AMPA‐type agonists

E. Gouaux, T. Liljefors, J. Kastrup, 2002, FEBS letters.

A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index

Karen H. Adams, E. Bullmore, F. Turkheimer, 2021, Biological psychiatry. Cognitive neuroscience and neuroimaging.

Structure and accessibility of domain I of Escherichia coli 23 S RNA in free RNA, in the L24-RNA complex and in 50 S subunits. Implications for ribosomal assembly.

R. Garrett, H. Leffers, A. Christensen, 1987, Journal of molecular biology.

Effects of Topiramate on Kainate‐ and Domoate‐Activated [14C]Guanidinium Ion Flux Through GluR6 Channels in Transfected BHK Cells Using Cytostar‐T Scintillating Microplates

R. Shank, J. Egebjerg, F. Poulsen, 2000, Epilepsia.

Recruitment of β-arrestin2 to the dopamine D2 receptor: Insights into anti-psychotic and anti-parkinsonian drug receptor signaling

J. Javitch, U. Gether, E. Urizar, 2008, Neuropharmacology.

A tetrazolyl-substituted subtype-selective AMPA receptor agonist.

J. Greenwood, P. Krogsgaard‐Larsen, J. Kastrup, 2007, Journal of medicinal chemistry.

Mutational Mapping and Modeling of the Binding Site for (S)-Citalopram in the Human Serotonin Transporter*

O. Taboureau, L. Olsen, K. Hansen, 2009, The Journal of Biological Chemistry.

Levetiracetam attenuates hippocampal expression of synaptic plasticity-related immediate early and late response genes in amygdala-kindled rats

H. Leffers, C. Sánchez, Henrik Leffers, 2010, BMC Neuroscience.

Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H- tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist.

P. Krogsgaard‐Larsen, B. Bang-Andersen, K. Frydenvang, 2000, Chirality.

Design, Synthesis, and Pharmacological Characterization of Polyamine Toxin Derivatives: Potent Ligands for the Pore‐Forming Region of AMPA Receptors

K. Strømgaard, J. Egebjerg, U. Bølcho, 2006, ChemMedChem.

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Tobias C. Wood, Karen H. Adams, C. Webber, 2019, Brain : a journal of neurology.

Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease

Karen H. Adams, E. Bullmore, F. Turkheimer, 2023, Journal of Neuroinflammation.

Immunochemical determination of the cellular content of polypeptide chain release factor RF3 in Escherichia coli.

K. Mortensen, H. U. Sperling-Petersen, J. Egebjerg, 1997, Biochimie.

Memantine potentiates hippocampal theta oscillations at a therapeutic dose in anesthetized mice: A mechanistic link to its cognitive-enhancing properties

C. Bundgaard, P. Francis, C. Volbracht, 2012, Neuropharmacology.