S. Wink

发表

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

B. van de Water, G. Hendriks, H. Vrieling, 2015, Archives of Toxicology.

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

Giulia Callegaro, Bob van de Water, Maarten Coonen, 2019, Archives of Toxicology.

Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases

A. Kopp-Schneider, F. Bois, B. van de Water, 2018, Front. Genet..

Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes

Sylvia E. Le Dévédec, J. Foekens, M. Timmermans, 2019, Nature Communications.

Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses.

B. van de Water, B. Ter Braak, S. Wink, 2022, Toxicology in vitro : an international journal published in association with BIBRA.

Comprehensive Landscape of Nrf2 and p53 Pathway Activation Dynamics by Oxidative Stress and DNA Damage.

B. Water, S. Wink, S. Hiemstra, 2017, Chemical research in toxicology.

Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.

G. Groothuis, E. Danen, B. van de Water, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment.

Bob van de Water, Harry Vrieling, Giel Hendriks, 2014, Chemical research in toxicology.

Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes

J. Foekens, M. Timmermans, M. Smid, 2019, Nature Communications.

Mining a human transcriptome database for chemical modulators of NRF2

J. Corton, D. Bell, B. van de Water, 2020, PloS one.

Toxicogenomics directory of chemically exposed human hepatocytes

R. Stierum, G. Myatt, J. Rahnenführer, 2014, Archives of Toxicology.

Systems Microscopy Approaches in Unraveling and Predicting Drug-Induced Liver Injury (DILI)

B. Water, S. Wink, B. T. Braak, 2018 .

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

Bob van de Water, Steven Wink, B. van de Water, 2016, Archives of Toxicology.

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

Bob van de Water, Steven Wink, B. van de Water, 2018, Archives of Toxicology.

SYSTEMIC COMPARISON OF DICLOFENAC INDUCED GENE EXPRESSION CHANGES IN DIVERSE IN VITRO AND IN VIVO MODELS AND SPECIES

G. Groothuis, J. Meerman, M. Luijten, 2014 .

Functional analysis of high-content high-throughput imaging data

Annette Kopp-Schneider, Bob van de Water, Xiaoqi Jiang, 2017 .

Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells

Bas ter Braak, Bob van de Water, Jan Willem van der Laan, 2015, Breast Cancer Research.

Integration of temporal single cell cellular stress response activity with Logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury.

Sylvia E. Le Dévédec, J. Saez-Rodriguez, J. Hengstler, 2021, Biochemical pharmacology.

FRET biosensor-based kinase inhibitor screen for ERK and AKT activity reveals differential kinase dependencies for proliferation in TNBC cells.

Sylvia E. Le Dévédec, Yinghui Zhang, B. van de Water, 2019, Biochemical pharmacology.

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

B. van de Water, G. Hendriks, H. Vrieling, 2015, Archives of Toxicology.

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

B. van de Water, S. Wink, S. Hiemstra, 2018, Archives of Toxicology.